Tag: M.W=150-200

Sahiba, Nusrat published the artcileA facile biodegradable chitosan-SO₃H catalyzed acridine-1,8-dione synthesis with molecular docking, molecular dynamics simulation and density functional theory against human topoisomerase II beta and Staphylococcus aureus tyrosyl-tRNA synthetase, SDS of cas: 134-96-3, the publication is Journal of Molecular Structure (2022), 133676, database is CAplus.

An efficient and ecobenign pseudo one-pot multicomponent synthesis of I [R = Me, Et, Ph, etc,] was investigated using biodegradable and heterogeneous catalyst, chitosan-SO₃H under ambient reaction conditions. The highly proficient reaction of dimedone, aldehydes, and ammonium acetate in aqueous ethanol using chitosan-SO₃H catalyst at room temperature showed high yields in short reaction time. The bioactivity of mols. was further studied through mol. docking and mol. dynamics simulations, protein-ligand interaction energy calculations and DFT studies. Among all, acridinedione compounds I [R = 4-methoxyphenyl], I [R = 4-cyanophenyl], I [R = 4-hydroxyphenyl] and I [R = 4-(benzyloxy)phenyl] (- 10.8 kcal/mol), I [R = 3-nitrophenyl], I [R = 4-nitrophenyl], I [R = 3,4-dimethoxyphenyl]were the most potent against Human Topoisomerase II beta (3QX3) and Staphylococcus aureus (S. aureus) tyrosyl-tRNA synthetase (1JIJ), resp. and displayed good binding affinity and interaction pattern. Easy availability of substrate and catalyst, use of biodegradable and recyclable polymeric solid acid catalyst, avoid the use of toxic and metallic reagents, operational simplicity, no need of column chromatog., easy workup, clean reaction profile, high yields (70-95%) and purity in short time period (3-12 min) with wide substrate scope (32 derivatives including 10 novel) and broad spectrum of bioactivity are notable advantages of the present protocol.

Journal of Molecular Structure published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, SDS of cas: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ibrahim, A. Mohammed published the artcileAntimicrobial new Schiff base polyesters: design, thermal, and structural characterizations, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Polymer Bulletin (Heidelberg, Germany) (2022), 79(2), 1119-1132, database is CAplus.

In this work, a series of isovanillin-or syringaldehyde-based new Schiff base monomers were synthesized and polymerized using terephthaloyl chloride by solution condensation polymerization technique. Both the monomers and polymers were characterized by FT-IR, ¹H-NMR, and ¹³C-NMR. The thermal and mol. weight properties were determined by thermogravimetric anal. (TGA) and Gel permeation chromatog. (GPC). The antimicrobial activities of the polyesters were evaluated based on min. inhibition concentration against bacteria such as Escherichia coli, Vibrio parahaemolyticus, and staphylococcus aureus as well as fungi such as Candida albicans and Aspergillus niger. The results of inhibition zones showed that new Schiff base polyesters had good antimicrobial activity.

Polymer Bulletin (Heidelberg, Germany) published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Osorio-Gonzalez, Carlos S. published the artcileInhibitor degradation by Rhodosporidium toruloides NRRL 1588 using undetoxified wood hydrolysate as a culture media, Product Details of C9H10O4, the publication is Biomass and Bioenergy (2022), 106419, database is CAplus.

Lignocellulosic biomass has been identified as a renewable and sustainable feedstock to produce liquid hydrolyzates as a suitable substrate to produce a variety of compounds through biochem. processes. Nevertheless, the main challenge to using this substrate is the hydrolysis needed to release fermentable sugars. This pretreatment leads to the production of microbial toxic compounds such as furans, phenols and organic acids. In this work, an oleaginous yeast, R. toruloides NRRL 1588, was used to study its ability to degrade inhibitors in C5 and C6 wood hydrolyzates obtained from forestry residues. The study showed that R. toruloides NRRL 1588 can grow, accumulate lipids, and degrade up to 8.01 mgL-1 h-1 of furfural, 5.63 mgL-1 h-1 of 5-hydroxy Me furfural, 1.70 mgL-1 h-1 of levulinic acid, 1.15 mgL-1 h-1 of syringaldehyde, 0.67 mgL-1 h-1 of vanillin, and 1.03 mgL-1 h-1 of vanillic acid. This work confirms the robustness of R. toruloides NRRL 1588 when grows in wood hydrolyzates containing inhibitory compounds

Biomass and Bioenergy published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Product Details of C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhao, Guangkuan published the artcileA Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters, COA of Formula: C11H10O, the publication is Organic Letters (2020), 22(15), 5822-5827, database is CAplus and MEDLINE.

A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/Bronsted acid pair mechanism, we also report a catalytic enantioselective example of the reaction.

Organic Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C12H17NS2, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gonzalez-Dominguez, Raul published the artcileHigh-Throughput Method for Wide-Coverage and Quantitative Phenolic Fingerprinting in Plant-Origin Foods and Urine Samples, HPLC of Formula: 134-96-3, the publication is Journal of Agricultural and Food Chemistry (2022), 70(25), 7796-7804, database is CAplus and MEDLINE.

The use of mass spectrometry is currently widespread in polyphenol research because of its sensitivity and selectivity, but its usual high cost, reduced robustness, and nonavailability in many anal. laboratories considerably hinder its routine implementation. Herein, we describe the optimization and validation of a high-throughput, wide-coverage, and robust metabolomics method based on reversed-phase ultra-high-performance liquid chromatog. with diode array detection for the identification and quantification of 69 phenolic compounds and related metabolites covering a broad chem. space of the characteristic secondary metabolome of plant foods. The method was satisfactorily validated following the Food and Drug Administration guidelines in terms of linearity (4-5 orders of magnitude), limits of quantification (0.007-3.6 mg L^-1), matrix effect (60.5-124.4%), accuracy (63.4-126.7%), intraday precision (0.1-9.6%), interday precision (0.6-13.7%), specificity, and carryover. Then, it was successfully applied to characterize the phenolic fingerprints of diverse food products (i.e., olive oil, red wine, strawberry) and biol. samples (i.e., urine), enabling not only the detection of many of the target compounds but also the semi-quantification of other phenolic metabolites tentatively identified based on their characteristic absorption spectra. Therefore, this method represents one step further toward time-efficient and low-cost polyphenol fingerprinting, with suitable applicability in the food industry to ensure food quality, safety, authenticity, and traceability.

Journal of Agricultural and Food Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, HPLC of Formula: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lorenc, Chris published the artcileAcid mediated deprotection of N-isopropyl tertiary amides, Application of 2-Isopropylanisole, the publication is Tetrahedron Letters (2015), 56(10), 1280-1282, database is CAplus.

Tertiary amides containing an N-iso-Pr group were selectively deprotected by heating in methanesulfonic acid. The N-iso-Pr group was removed selectively in the presence of other groups on the amide nitrogen such as Me, primary alkyl, or aryl. The putative iso-Pr cation was trapped by Friedel-Crafts alkylation of anisole when the latter was included as a co-solvent.

Tetrahedron Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Stasse, Margot published the artcileElaboration of double emulsion-based polymeric capsules for fragrance, Category: ethers-buliding-blocks, the publication is Colloid and Polymer Science (2021), 299(2), 179-191, database is CAplus.

Abstract: We aim at encapsulating fragrances made of a variety of lipophilic species to slow down their diffusion. Our strategy is to develop capsules by polymerizing the water intermediate phase of an oil-in-water-in-oil double emulsion. In other terms, our system consists in a direct emulsion of fragrance (O1) in a water phase (W) containing monomer, initiator, and cross-linker. To obtain the double emulsion, this direct emulsion, stabilized by a hydrophilic surfactant, is itself dispersed in an external lipophilic solvent used in perfumery (O2) and stabilized by a lipophilic surfactant. Polymerization of the intermediate water phase aims at obtaining a 3D network. Differently from nowadays-proposed capsules, this strategy allows polymerization only taking place in the water phase rather in the phase containing the fragrance. Moreover, the obtained 3D network is supposed to play the role of an effective barrier limiting the diffusion of the inner lipophilic species towards either the external solvent or air. Such an approach implies the combination of a formulation step to elaborate the double emulsion using two antagonistic surfactants, a hydrophilic one and a lipophilic one, and of the polymerization of the intermediate phase. Insertion of the polymerizable species in the double emulsion shall not destabilize it. Some monomers exhibiting interfacial affinity and interfering with the formulation of the double emulsion have to be avoided. By varying the nature of the monomers and the cross-linker to monomer ratio, capsules with high encapsulation efficiencies and with various mech. properties have been obtained.

Colloid and Polymer Science published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C8H8N2OS, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Furuya, Takeru published the artcileFluorination of Boronic Acids Mediated by Silver(I) Triflate, Computed Properties of 929626-18-6, the publication is Organic Letters (2009), 11(13), 2860-2863, database is CAplus and MEDLINE.

A regiospecific Ag-mediated fluorination reaction of aryl- and alkenylboronic acids and esters is reported. The fluorination reaction uses com. available reagents, does not require the addition of exogenous ligands, and can be performed on a multigram scale. This report discloses the first practical reaction sequence from arylboronic acid to aryl fluorides.

Organic Letters published new progress about 929626-18-6. 929626-18-6 belongs to ethers-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ester,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-(Methoxycarbonyl)-5-methylphenyl)boronic acid, and the molecular formula is C9H11BO4, Computed Properties of 929626-18-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tao, Zhonglin published the artcileEnantioselective, Lewis Base-Catalyzed Sulfenocyclization of Polyenes, Product Details of C10H14O, the publication is Journal of the American Chemical Society (2018), 140(10), 3569-3573, database is CAplus and MEDLINE.

A sulfenium-ion-initiated, catalytic, enantioselective polyene cyclization is described. Homogeranylarenes and ortho-geranylphenols undergo polycyclization in good yield, diastereoselectivity, and enantioselectivity. The stereodetermining step is the generation of an enantiomerically enriched thiiranium ion from a terminal alkene and a sulfenylating agent in the presence of a chiral Lewis basic catalyst. The use of hexafluoroisopropyl alc. as the solvent is crucial to obtain good yields. The thioether moiety resulting from the reaction can be subsequently transformed into diverse oxygen and carbon functionality postcyclization. The utility of this method is demonstrated by the enantioselective syntheses of (+)-ferruginol (I) and (+)-hinokiol (II).

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C6H6N2O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gomez-Cruz, Irene published the artcileCombined Extraction and Ethanol Organosolv Fractionation of Exhausted Olive Pomace for Bioactive Compounds, Formula: C9H10O4, the publication is Advanced Sustainable Systems (2022), 6(4), 2100361, database is CAplus.

The olive pomace oil extracting industry generates large amounts of exhausted olive pomace (EOP), a lignocellulosic waste that needs to be managed according to sustainable criteria. The aim of this work is to devise an integrated strategy to valorize EOP by applying two-step extraction, and to evaluate the effect of an ethanol organosolv pretreatment on the delignification and enzymic hydrolysis of the extracted EOP. Once the extraction and organosolv pretreatment conditions are selected, solubilized lignin is recovered from the pretreatment liquor using different methods. In addition to those organosolv lignin samples, a lignin-rich solid is obtained after enzymic saccharification of the pretreated solid. All the lignin samples are fully characterized aiming at further valorization. The selected two-step aqueous extraction (85 °C, 90 min, 10% biomass) removes 89% of the extractives content in raw EOP and achieves the full recovery of phenols and mannitol content in that fraction, 4.7 mg gallic acid equivalent per g EOP and 4.5 mg g^-1 EOP, resp. The organosolv pretreatment (50% ethanol catalyzed with 1% H₂SO₄, 140 °C, 60 min, 15% biomass) results in a delignified solid with 81% of enzymic digestibility and a high purity organosolv lignin (>71%), rich in guaiacyl units.

Advanced Sustainable Systems published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem