Tag: M.W=150-200

Barekati-Goudarzi, Mohamad published the artcileHeterogeneous and Homogeneous Components in Gas-Phase Pyrolysis of Hydrolytic Lignin, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is homogeneous gas pyrolysis hydrolytic lignin.

Pyrolysis of hydrolytic lignin (HL) in the newly designed, gas phase continuous droplet evaporation (CDE) and continuous atomization (CA) reactors, was studied. The products distribution was strongly dependent on the heterogeneous character of either delivery of lignin solution into CDE reactor (in-situ formation of solid phase) or sampling conditions using quartz wool in both CDE and CA reactors. The effect of residence time, initial concentration of HL solution and injection temperature on products distribution in CDE reactor was investigated and discussed in terms of mass and heat transfer limitation. The exptl. data confirm that at low initial mass delivery rates of lignin (micrograms per s) and by increasing initial lignin concentration (up to 40 times), the formation of phenolics is slightly intensified (6 times). However, the solid surface or any condense phase that forms in-situ during reaction in the gas phase may largely govern the pyrolysis processes. The detailed exptl. examination of homogeneous pyrolysis of lignin in both gas-phase reactors by implication of diverse anal. techniques (GC, GPC, LDI, FTIR, EPR, NMR) revealed break down of HL macromols. into oligomer-fragments after pyrolysis at negligible amounts of phenolics detected. A mechanistic interpretation of primary steps for formation of dominant intermediate products – oligomers and oligomer stable radicals, is represented.

ACS Sustainable Chemistry & Engineering published new progress about Heat transfer. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sun, Zhendong published the artcileButylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells, Application In Synthesis of 121-00-6, the main research area is butylated hydroxyanisole isomer adipogenesis; 3T3-L1 cells; Adipogenesis; Butylated hydroxyanisole (BHA) isomers; Lipogenesis; Obesity.

Butylated hydroxyanisole (BHA) isomers, as the widely used anthropogenic antioxidants in food, have been revealed to induce endocrine disrupting effects, while the mechanism how BHA isomers regulate the lipogenic differentiation remains to be elucidated. Using 3T3-L1 differentiation model, the effects of BHA isomers, including 2-tert-butyl-4-hydroxyanisole (2-BHA), 3-tert-butyl-4-hydroxyanisole (3-BHA) and their mixture (BHA), on adipogenesis were tested. The results showed that 3-BHA and BHA promoted adipocyte differentiation and enhanced the cellular lipid accumulation through the regulation of the transcriptional and protein levels of the adipogenetic biomarkers, while 2-BHA had no effect. The effective window for 3-BHA induced lipogenesis was the first four days during 3T3-L1 differentiation. BHA isomers showed no binding affinities for peroxisome proliferator activated receptor γ (PPARγ). Instead, the upstream of PPARγ signaling pathway, i.e. the phosphorylation of cAMP-response element binding protein (CREB), upregulation of CAAT/enhancer-binding proteins β (C/EBPβ) and elevated cell proliferation during postconfluent mitosis stage were induced by 3-BHA exposure. Altogether, this study revealed the adipogenic effect of 3-BHA through interference with the upstream events of the PPARγ signaling pathway. The authorized usage of BHA as food additives and its occurrence in human sera can potentially contribute to the incidence of obesity, which is of high concern.

Journal of Hazardous Materials published new progress about Adipogenesis. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nagappan, Beemkumar published the artcileInfluence of antioxidant additives on performance and emission characteristics of beef tallow biodiesel-fuelled C.I engine, Related Products of ethers-buliding-blocks, the main research area is antioxidant additive emission characteristic beef tallow biodiesel; Biodiesel; Emission. Butylated hydroxyanisole; Enzyme catalyst; Performance; Transesterification.

This work analyses the performance and emission characteristics of biofuelled compression ignition (C.I) engine with the implementation of an antioxidant. Using the transesterification process with sodium hydroxide as a catalyst, the beef tallow Me ester (BTME) was obtained from the beef tallow oil. Poor phys. properties of biodiesel (beef tallow oil (BTO)) namely high viscosity and d. cause atomization problems leading to higher smoke, hydrocarbon and carbon monoxide emissions. The purpose of this work is to enhance the performance aspects, to limit smoke emissions from BTO operation and to examine the possibility of direct use of neat BTO in CI engine. This research paves a way of investing the impact of binary blends of BHA and BTO on the research engine. The experiments were conducted on a single-cylinder four-stroke C. I engine using the following fuel compositions: 20% of BTME mixed with 80% diesel (B20), 1000 ppm mono-phenolic antioxidant (butylated hydroxyanisole (BHA)) mixed with the blends of B20 (B20 + BHA), and 100% diesel. Based on the exptl. results, it was found that the brake thermal efficiency (BTE) increases by 1.8% and the brake specific fuel consumption (BSFC) decreases by 2.5% for the fuel blend B20 + BHA when compared with that for B20 fuel blend. Compared with the B20 blend, the blend B20 + BHA emits 12.2% lesser nitrogen oxide due to breaking chain reactions, scavenging the initiating radicals and reducing the concentration of reactive radicals.

Environmental Science and Pollution Research published new progress about Biodiesel fuel. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Felfoldi, K. published the artcileChemistry of 1,3-bifunctional compounds. XXIV. Preparation and pharmacology of cycloalkylaminopropyl trimethoxybenzoates, Application of (2-Chloroethoxy)benzene, the main research area is cycloalkylaminopropyl trimethoxybenzoate preparation pharmacol.

Nineteen title compounds I (R = CHMe2, CH2Ph, CH2CH2CHPh2, etc.; n = 1,2,3, or 4) were synthesized by reaction of aminoalcs. with 3,4,5-trimethoxybenzoyl chloride [4521-61-3] and were tested for various pharmacol. activities. I (R = CH2CH:CHPh, n = 1, ·HCl [41788-00-5] was the most active compound; it had significant vasodilatory activity in the isolated rat heart.

Acta Physica et Chemica published new progress about Bronchodilators. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application of (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Chia-Chi published the artcileA machine learning-driven approach for prioritizing food contact chemicals of carcinogenic concern based on complementary in silico methods, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is food contact chems toxicogenomics machine learning QSAR; Food contact chemical; Machine learning; Quantitative structure-activity relationship; Structural alert; Toxicogenomics; Weight-of-evidence.

Carcinogenicity is one of the most critical endpoints for the risk assessment of food contact chems. (FCCs). However, the carcinogenicity of FCCs remains insufficiently investigated. To fill the data gap, the application of standard exptl. methods for identifying chems. of carcinogenic concerns from a large set of FCCs is impractical due to their resource-intensive nature. In contrast, computational methods provide an efficient way to quickly screen chems. with carcinogenic potential for subsequent exptl. validation. Since every model was developed based on a limited number of training samples, the use of single models for carcinogenicity assessment may not cover the complex mechanisms of carcinogenesis. This study proposed a novel machine learning-based weight-of-evidence (WoE) model for prioritizing chem. carcinogenesis. The WoE model can nonlinearly integrate complementary computational methods of structural alerts, quant. structure-activity relationship models and in silico toxicogenomics models into a WoE-score. Compared to the best single method, the WoE model gained 8% and 19.7% improvement in the area under the receiver operating characteristic curve (AUC) value and chem. coverage, resp. The prioritization of 1623 FCCs concludes 44 chems. of high carcinogenic concern. The machine learning-based WoE approach provides a fast and comprehensive way for prioritizing chems. of carcinogenic concern.

Food and Chemical Toxicology published new progress about Carcinogenicity. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yan, Yang-Yang published the artcileCharacteristics of enriched components from thermal dissolution extracts of Zhaotong lignite using solid phase microextraction, Quality Control of 121-00-6, the main research area is lignite polydimethylsiloxane thermal dissolution solid phase microextraction.

Due to the low concentration of minor compounds and the detection limit of instruments, numerous compounds in the thermal dissolution (TD) extract of coals cannot be detected. Therefore, it is necessary to introduce solid phase microextraction (SPME) for sampling before anal., which can enrich compounds in mixtures with similar mol. structures and exclude interferences from other components. In this work, partial species in the TD extract of Zhaotong lignite were enriched by SPME with a polydimethylsiloxane (PDMS) coating. The enrichment characteristics of the coating on TD extract were examined by gas chromatog.-mass spectrometry (GC-MS). Nitrogen-containing compounds and sulfur-containing compounds were removed from the enriched species, and the content of aliphatic hydrocarbons increased from 30.0% to 93.2% after enrichment. Oxygenated aromatic compounds with structures similar to the long-chain siloxane bonds of PDMS were also enriched. This study establishes a SPME method and provides a basis for the anal. of lignite and its derivatives

Fuel published new progress about Coating process. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Richter, Reinhard published the artcileDimethylformamide-catalyzed decarboxylation of alkyl chloroformates. A synthesis of primary alkyl chlorides, COA of Formula: C8H9ClO, the main research area is alkyl chloroformate decarboxylation DMF catalyst; chloride alkyl.

Chloroformates prepared from primary aliphatic alcs. readily decompose on heating with catalytic amounts of DMF, thereby giving CO2 and ∼90% alkyl chlorides RCl [R = Me(CH2)nCH2 (n = 5, 8, 10), Me(CH2)7CH:CH(CH2)7CH2, PhOCH2CH2, BuCHEtCH2], Cl2Z [Z = (CH2)10, cis- and trans-1,4-cyclohexanediyldimethylene, 1,4-CH2C6H4CH2, CH2CCCH2] and I. Reactions at 3-5° yield formimidate chlorides as labile intermediates which dissociate on heating into DMF and alkyl chlorides. Formimidates II (X = Cl, BF4) were prepared from trans-1,4-bis(hydroxymethyl)cyclohexane.

Journal of Organic Chemistry published new progress about Decarboxylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, COA of Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Childers, Wayne published the artcileNovel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells, Computed Properties of 622-86-6, the main research area is structure preparation compound reversing phenotype Gaucher disease; Diphenylethanono; Gaucher disease; Lysosomal storage disease; Neuronopathic; Phenotypic screening.

Gaucher disease (GD) results from inherited mutations in the lysosomal enzyme β-glucocerobrosidase (GCase). Currently available treatment options for Type 1 GD are not efficacious for treating neuronopathic Type 2 and 3 GD due to their inability to cross the blood-brain barrier. In an effort to identify small mols. which could be optimized for CNS penetration we identified tamoxifen from a high throughput phenotypic screen on Type 2 GD patient-derived fibroblasts which reversed the disease phenotype. Structure activity studies around this scaffold led to novel mols. that displayed improved potency, efficacy and reduced estrogenic/antiestrogenic activity compared to the original hits. Here we present the design, synthesis and structure activity relationships that led to the lead mol. Compound 31.

Bioorganic & Medicinal Chemistry Letters published new progress about Gaucher disease. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Computed Properties of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Ning published the artcileChanges of amygdalin and volatile components of apricot kernels during the ultrasonically-accelerated debitterizing, Related Products of ethers-buliding-blocks, the main research area is amygdalin apricot kernel ultrasonic debitterizing; Amygdalin; Apricot kernels; Debitterizing; Epimerization; Volatile components.

Ultrasound has been regarded as an efficient novel technique for debitterizing of the apricot kernels, but its influence is severely concerned on the possible epimerization of D-amygdalin to the L-amygdalin, a more potentially toxigenic compound Considering this, the experiments were conducted to investigate the epimerization of D-amygdalin and the volatile components in the debitterizing water, which were separated and identified by the high performance liquid chromatog. (HPLC) and gas chromatog. with a mass spectrometer (GC-MS), resp. The results indicate that the ultrasonically-debitterizing did not cause the epimerization of D-amygdalin to the L-amygdalin, while the procedure can be greatly accelerated due to the rapid mass transfer and degradation of D-amygdalin induced by ultrasound irradiation In addition, the water from the ultrasonically-debitterizing of apricot kernels exerted more aromas compared with that of the conventional debitterizing, which might have more applications about this kind of water. In a word, ultrasound can be safely applied in the debitterizing industry of apricot kernels.

Ultrasonics Sonochemistry published new progress about Ultrasonication. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Arrieta, Oscar published the artcileClinical Impact of the COVID -19 Pandemic in Mexican Patients with Thoracic Malignancies, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is COVID19 pandemic thoracic malignancy Mexico; Coronavirus disease 2019; Lung cancer; Pandemic; Severe acute respiratory syndrome coronavirus 2; Thoracic neoplasms.

Accumulated evidence indicates that patients with lung cancer are a vulnerable population throughout the pandemic. Limited information is available in Latin America regarding the impact of the pandemic on medical care. The goal of this study was to describe the clin. and social effect of COVID-19 on patients with thoracic cancer and to ascertain outcomes in those with a confirmed diagnosis. This cohort study included patients with thoracic neoplasms within a single institution between March 1, 2020, and Feb. 28, 2021. All variables of interest were extracted from electronic medical records. During this period, the Depression Anxiety and Stress Scale 21 (DASS-2) was applied to evaluate and identify more common psychol. disorders. The mean age for the total cohort (n = 548) was 61.5 ± 12.9 years; non-small cell lung cancer was the most frequent neoplasm (86.9%), advanced stages predominated (80%), and most patients were under active therapy (82.8%). Any change in treatment was reported in 23.9% of patients, of which 78.6% were due to the COVID-19 pandemic. Treatment delays (≥7 days) were the most frequent modifications in 41.9% of cases, followed by treatment suspension at 37.4%. Patients without treatment changes had a more prolonged progression-free survival and overall survival (hazard ratio [HR] 0.21, p < .001 and HR 0.28, p < .001, resp.). The mean DASS-21 score was 10.45 in 144 evaluated patients, with women being more affected than men (11.41 vs. 9.08, p < .001). Anxiety was reported in 30.5% of cases, followed by depression and distress in equal proportions (18%). Depressed and stressed patients had higher odds of experiencing delays in treatment than patients without depression (odds ratio [OR] 4.5, 95% confidence interval [CI] 1.53-13.23, p = .006 and OR 3.18, 95% CI 1.2-10.06, p = .006, resp.). Treatment adjustments in patients with thoracic malignancies often occurred to avoid COVID-19 contagion with detrimental effects on survival. Psychol. disorders could have a role in adherence to the original treatment regimen. Oncologist published new progress about Adenocarcinoma. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem