Tag: M.W=150-200

Liu, Runzeng published the artcileSynthetic phenolic antioxidants: A review of environmental occurrence, fate, human exposure, and toxicity, Computed Properties of 121-00-6, the main research area is review synthetic phenolic antioxidants environmental occurrence human exposure toxicity.

Synthetic phenolic antioxidants (SPAs) are widely used in various industrial and com. products to retard oxidative reactions and lengthen product shelf life. In recent years, numerous studies have been conducted on the environmental occurrence, human exposure, and toxicity of SPAs. Here, we summarize the current understanding of these issues and provide recommendations for future research directions. SPAs have been detected in various environmental matrixes including indoor dust, outdoor air particulates, sea sediment, and river water. Recent studies have also observed the occurrence of SPAs, such as 2,6-di-tert-butyl-4-methylphenol (BHT) and 2,4-di-tert-butyl-phenol (DBP), in humans (fat tissues, serum, urine, breast milk, and fingernails). In addition to these parent compounds, some transformation products have also been detected both in the environment and in humans. Human exposure pathways include food intake, dust ingestion, and use of personal care products. For breastfeeding infants, breast milk may be an important exposure pathway. Toxicity studies suggest some SPAs may cause hepatic toxicity, have endocrine disrupting effects, or even be carcinogenic. The toxicity effects of some transformation products are likely worse than those of the parent compound For example, 2,6-di-tert-butyl-p-benzoquinone (BHT-Q) can cause DNA damage at low concentrations Future studies should investigate the contamination and environmental behaviors of novel high mol. weight SPAs, toxicity effects of coexposure to several SPAs, and toxicity effects on infants. Future studies should also develop novel SPAs with low toxicity and low migration ability, decreasing the potential for environmental pollution.

Environmental Science & Technology published new progress about Adipose tissue. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Computed Properties of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kawashima, Yutaka published the artcileStructure-activity studies of 3-benzoylpropionic acid derivatives suppressing adjuvant arthritis, Application In Synthesis of 622-86-6, the main research area is antiarthritic benzoylpropionate.

3-Benzoylpropionic acid derivatives possess an immunomodulative activity and suppress adjuvant arthritis. To understand how substituents affect the biol. activity, the quant. structure-activity relationships of 30 compounds were analyzed by the adaptive least-squares method. For the suppressing activity in rats, the electronic effects and the structural feature of the substituent on benzene ring were suggested to be important. To reinforce and confirm the correlation, 4 addnl. compounds of phenoxybutyric acid derivatives were synthesized and tested with the rat adjuvant-induced arthritis. These compounds were found to have potent suppressing activity.

Chemical & Pharmaceutical Bulletin published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application In Synthesis of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aranapakam, Venkatesan published the artcileSynthesis and Structure-Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis, Category: ethers-buliding-blocks, the main research area is arylsulfonylpiperidinehydroxamic acid preparation matrix metalloproteinase inhibitor structure activity.

A series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized and their structure-activity relationships determined Among the several compounds synthesized, I turned out to be a potent, selective, and an orally active MMP inhibitor in the clin. relevant advanced rabbit osteoarthritis model. Pharmacokinetics and metabolism data are reported.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ali, Shoukath M. published the artcileEndoxifen is a new potent inhibitor of PKC: A potential therapeutic agent for bipolar disorder, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is endoxifen preparation PKC inhibitor bipolar disorder.

Protein kinase C (PKC) plays a major role in regulation of both pre and postsynaptic neurotransmission. Excessive activation of PKC results in symptoms related to bipolar disorder. Tamoxifen, a widely used breast cancer drug is known to inhibit PKC and demonstrate antimanic properties in human. We describe herein the synthesis of endoxifen, a tamoxifen active metabolite and compared its PKC inhibitory activity with that of tamoxifen. Endoxifen exhibited fourfold higher potency compared to tamoxifen.

Bioorganic & Medicinal Chemistry Letters published new progress about Antipsychotics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Saxena, Shaiphali published the artcileComparative GC-MS and FT-IR analysis of Portulaca oleracea L. and Portulaca quadrifida L. leaf extracts, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is Portulaca oleracea quadrifida leaf extract bioactive phytochem GCMS FTIR.

Quality assurance (QA) is an essential task in pharmacognostic field to promote the product standardization. The present study is focused upon phytoconstituent anal. of aqua-methanol leaf extracts of Portulaca oleracea L. and Portulaca quadrifida L. via GC-MS (gas chromatog.-mass spectrometry) and FT-IR (Fourier transform-IR) spectroscopy for formulation of quality medicines and other products. The GC-MS unveiled 72 and 86 bioactive compounds (both major and tracer) of several categories like terpenoids, phenols, steroids, flavonoids, fatty acids, nucleoside, vitamins, etc. The FT-IR chromatogram confirmed various functional groups peaks (cm-1) of amines (-NH2), alcs. (-OH), carboxylic acids (-COOH), ketones (C=O), etc. The present study provides a futuristic platform for researchers to pursue pharmaceutical and food safety assessments and a proper weed management plan.

Pharma Innovation published new progress about Bioactive agents. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Glennon, Richard A. published the artcileIdentification and exploitation of the σ-opiate pharmacophore, Formula: C8H9ClO, the main research area is alkylation reduction phenylpropylamine; amine alkylmethylphenylethyl sigma receptor; benzeneethanamine alkylmethyl psychotomimetic sigma receptor; benzomorphan receptor binding; phenylpropylamine alkyl psychotomimetic sigma receptor; reduction alkylation phenylpropylamine; psychotomimetic sigma receptor phenylpropylamine alkyl; sigma receptor psychotomimetic phenylpropylamine alkyl; structure activity phenylpropylamine benzomorphan.

Reductive alkylation of PhCH2CH(NH2)Me gave (R)- and (S)-RR1NCHMeCH2Ph [I; R = Et, Pr, Bu, CH2Ph, CHMePh, CH2CH2Ph, (CH2)3Ph, (CH2)4Ph, (CH2)5Ph, C:CHPh, CH2OPh, etc.; R1 = H, Me]. E.g., alkylation of (R)-PhCH2CH(NH2)Me with PhCH2CH2CHO gave (R)-PhCH2CH2CH2NHCHMeCH2Ph. I were tested for their affinity to σ-receptors and their psychotomimetic activity; the structure-activity relationship was discussed. The role of I as a component of a benzomorphan structure was studied; the presence of a 1-phenyl-2-aminopropane nucleus was sufficient for binding at the σ-site, provided that the terminal amine is not a tertiary amine.

Journal of Medicinal Chemistry published new progress about Psychotomimetics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Guo, Hongguang published the artcileHigh Potential of Methane Production from Coal by Fungi and Hydrogenotrophic Methanogens from Produced Water, Name: 4-Hydroxy-3-tert-butylanisole, the main research area is methane coal fungus hydrogenotrophic methanogen water bacteria organic.

Studying in situ microorganisms is essential to understand the formation of biogenic coalbed methane (CBM). Only a few studies have studied the fungi community inhabiting in coal seams although fungi degrade refractory compounds and solubilize coal and even work with methanogens to produce methane. Produced H2O was collected from Qinshui Basin and used as the source of microflora to degrade coal. The function of fungi was analyzed by inhibition of bacteria with antibiotics. The inhibition of bacteria in the microcosms significantly increased the methane yield. Fungi were more favorable to cooperate with hydrogenotrophic methanogens when bacteria were inhibited as Methanobacterium were the predominant archaea accounting for 45.98-86.98% of the sequence reads. The relatively unchanged fungal community and high volatile fatty acids (VFAs) yields (48.70-85.72%) in the presence of antibiotics might contribute to H2 production to facilitate hydrogenotrophic methanogenesis. On the contrary, the dominant methanogens in microcosms without antibiotics gradually changed from Methanobacterium (89.85%) to Methanoceta (46.19%) and finally to Methanobacterium (87.72%). The bacterial community and organic intermediates have also changed greatly over time, which can be the reason for the succession of the methanogens. Probably fungi in produced H2O can play an important role in coal biodegradation to produce VFAs and H2 that support hydrogenotrophic methanogenesis, which could be neg. impacted by the existence of bacteria.

Energy & Fuels published new progress about Acetoanaerobium. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Name: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Barluenga, J. published the artcileFriedel-Crafts reactions of beta-substituted organomercury(II) compounds, Safety of 2-Isopropylanisole, the publication is Anales de Quimica (1968-1979) (1977), 73(7-8), 1032-4, database is CAplus.

Alkylation of aromatic rings (e.g. in PhOMe) with β-oxymercuric compounds (e.g. AcOCHMeCH₂HgBr) in the presence of a Lewis acid (e.g. AlCl₃) gave, besides alkylarom. compounds (e.g. o-MeOC₆H₄CHMe₂), β-functionalized alkylarom. compounds (e.g. o-MeOC₆H₄CH₂CHMe(OAc)].

Anales de Quimica (1968-1979) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wada, Yuuki published the artcileEnantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts, Name: (3-Methoxy-5-methylphenyl)boronic acid, the publication is RSC Advances (2019), 9(54), 31654-31658, database is CAplus and MEDLINE.

Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers via dynamic kinetic resolution using bifunctional organocatalysts was afforded brominated axially chiral cyanoarenes I [R = H, Me, CF₃, etc.; R¹ = F, Br, OMe, etc.]. Sequential addition of a brominating reagent in several portions at an optimized temperature was effective in accomplishing high enantioselectivities.

RSC Advances published new progress about 725251-81-0. 725251-81-0 belongs to ethers-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Methoxy-5-methylphenyl)boronic acid, and the molecular formula is C11H22N2O4, Name: (3-Methoxy-5-methylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Danielski, Renan published the artcileA non-conventional approach for obtaining phenolic antioxidants from red guava (Psidium guajava L.) by-products, Related Products of ethers-buliding-blocks, the publication is Journal of Food Processing and Preservation (2022), 46(6), e16502, database is CAplus.

The recovery of phenolic antioxidants from agro-industrial byproducts using non-conventional techniques is a powerful tool to explore the bioactive potential of natural sources. Therefore, it is imperative to analyze the most suitable method to investigate a plant material’s phenolic composition This study used ultra-turrax (UTE), ultrasonic bath (BUAE), and pressurized liquid (PLE) for soluble phenolic extraction from guava’s pulp and processing waste. UTE at 25°C for 1 h yielded the highest concentration of total phenolics and flavonoids from guava pulp, while PLE for 30 min at 60°C/10 MPa presented the best performance for flavonoids and condensed tannins recovery from guava waste. PLE produced extracts with 39 phenolics and high antioxidant capacity. Besides, scopoletin, resveratrol, and naringin are being reported for the first time in this fruit. These results suggest possible alternatives for the recovery of bioactive compound, which may be used to develop nutraceuticals and/or functional foods. Practical applications : Upon guava processing, 30% of fruit’s total volume is lost in the form of byproducts (seeds, peels, and pulp leftovers). Evidence points out that this fraction, along with guava’s pulp, is rich in phenolics with antioxidant properties. An extraction procedure should be conducted to recover these compounds However, conventional techniques are laborious, time-consuming, and they generally use a large amount of toxic organic solvent. Ultra-turrax-UTE, ultrasonic bath-BUAE, and pressurized liquid-PLE are non-conventional approaches that make possible the reduction of solvents and the recovery of selected phenolics not possible with conventional techniques. These extracts could be further applied to lipid-rich foods as a natural antioxidant system and/or as an ingredient in the development of nutraceuticals and functional foods.

Journal of Food Processing and Preservation published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem