Tag: M.W=150-200

Jin, Xiang-xiang published the artcileA chalcone-syringaldehyde hybrid inhibits triple-negative breast cancer cell proliferation and migration by inhibiting CKAP2-mediated FAK and STAT3 phosphorylation, Computed Properties of 134-96-3, the publication is Phytomedicine (2022), 154087, database is CAplus and MEDLINE.

Although triple-neg. breast cancer (TNBC) accounts for only 15% of breast cancer cases, it is associated with a high relapse rate and poor outcome after standard treatment. Currently, the effective drugs and treatment strategies for TNBC remain limited, and thus, developing effective treatments for TNBC is pressing. Several studies have demonstrated that both chalcone and syringaldehyde have anticancer effect, but their potential anti-TNBC bioactivity are still unknown. The present study aimed to synthesize a chalcone-syringaldehyde hybrid (CSH1) and explore its potential anti-TNBC effects and the underlying mol. mechanism. Cell cytotoxicity was determined by 3-(4,5-dimethythiazol)-2,5-diphenyltetrazolium bromide (MTT). The activity of cell proliferation was measured by colony formation assay and 5-ethynyl-2′-deoxyuridine (EdU) staining assay. Cell cycle distribution and cell apoptosis were determined by fluorescence-activated cell sorter (FACS). The situation of DNA damage was observed using fluorescence microscopy. The ability of cell-matrix adhesion, migration and invasion was detected using cell adhesion assay and transwell assay. Transcriptome sequencing was performed to find out the changed genes. Levels of various signaling proteins were assessed by western blotting. CSH1 treatment triggered DNA damage and inhibited DNA replication, cell cycle arrest, and cell apoptosis via suppressing signal transducer and activator of transcription 3 (STAT3) phosphorylation. Whole genome RNA-seq anal. suggested that 4% of changed genes were correlated to DNA damage and repair, and nearly 18% of changed genes were functionally related to cell adhesion and migration. Exptl. evidence indicated that CSH1 treatment significantly affected the distribution of focal adhesion kinase (FAK) and its phosphorylation, resulting in cell-matrix-adhesion reduction and migration inhibition of TNBC cells. Further mechanistic studies indicated that CSH1 inhibited TNBC cell proliferation, adhesion, and migration by inhibiting cytoskeleton-associated protein 2 (CKAP2)-mediated FAK and STAT3 phosphorylation signaling. These results suggest that CKAP2-mediated FAK and STAT3 phosphorylation signaling is a valuable target for TNBC treatment, and these findings also reveal the potential of CSH1 as a prospective TNBC drug.

Phytomedicine published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Computed Properties of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kumar, Ashwini Prem published the artcileRational design, molecular docking, dynamic simulation, synthesis, PPAR-γ competitive binding and transcription analysis of novel glitazones, COA of Formula: C9H10O4, the publication is Journal of Molecular Structure (2022), 133354, database is CAplus.

Over the last decade, peroxisome proliferator-activated receptor (PPAR-γ) has emerged as one of the important therapeutic targets in several metabolic and neurodegenerative disorders. The remarkable progress in drug discovery has resulted in designing novel PPAR-γ activators. Thiazolidinediones, also known as glitazones, have been demonstrated to play a significant role in treating several neurodegenerative diseases, diabetes, and cancer. Despite its wide range of adverse effects, glitazones orchestrate significant pharmacol. activities. In this backdrop, we designed and synthesized novel glitazones for potential PPAR-γ binding activity. The synthesized novel compounds were structurally analyzed using 1H NMR, 13C NMR and FT-IR. The interaction binding modes, binding free energy, and crucial amino acids involved in interactions of designed compounds with the target protein were studied using mol. docking. Further, mol. dynamic modeling was used to evaluate the stability of the best-docked complexes. TR-FRET, an in vitro PPAR-γ competitive binding assay, was performed to confirm the affinity of the well-docked compounds for the target protein. It demonstrated that the compounds explicitly bind to the PPAR-γ ligand-binding domain to exhibit pharmacol. activity. The cytotoxicity of synthesized compounds was performed and confirmed the PPAR-γ transcription activity on SH-SY5Y cell lines

Journal of Molecular Structure published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, COA of Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dalla Cort, Antonella published the artcileInherently Chiral Uranyl-Salophen Macrocycles: Computer-Aided Design and Resolution, COA of Formula: C10H14O, the publication is Journal of Organic Chemistry (2005), 70(24), 9814-9821, database is CAplus and MEDLINE.

A flipping motion rapidly inverts the bent structure of uranyl-salophen compounds and, consequently, causes fast enantiomerization of nonsym. substituted derivatives This process was previously slowed by introducing bulky substituents in the imine bond region. Since the resulting complexes dissociate upon chromatog. treatment, an alternative approach to the design and synthesis of robust, nonflipping uranyl-salophen compounds is here described. Such an approach is based on the idea that the flipping motion would be blocked by connecting the para positions with respect to the phenoxide oxygens by polymethylene bridges of suitable length. Anal. of a number of uranyl-salophen compounds by mol. mechanics, while showing that bulky substituents in the imine bond region cause severe distortions of the ligand backbone, suggested that the best chain lengths are those that fit the gap between the phenoxide rings without altering the natural geometry of the parent uranyl-salophen compound Calculations showed that such chains are those composed of 12 and 13 methylene units. Accordingly, chiral uranyl-salophen macrocycles bridged with 12- and 13-methylene chains, [UO₂(L)] (H₂L = I, n = 1, 2; R = i-Pr, R’ = Ph), were synthesized in fairly good yields and resolved by chiral HPLC.

Journal of Organic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bhattacharya, Aditya published the artcile“Haliranium Ion”-Induced Intermolecular Friedel-Crafts Alkylation in HFIP: Synthesis of β,β-Diaryl α-Halo carbonyl Compounds, HPLC of Formula: 93-04-9, the publication is European Journal of Organic Chemistry (2021), 2021(33), 4737-4749, database is CAplus.

Herein, a highly regio- and diastereoselective haliranium ion-induced intermol. Friedel-Crafts reaction of α,β-unsaturated carbonyl compounds in HFIP is reported. The operationally simple and mild method affords the synthetically useful β,β-diarylated α-halo carbonyl compounds in good yields after a very short reaction time. As an application, a few examples of β,β-diarylated olefins are prepared in excellent yields. Based on the exptl. results and a qual. study of 1D-NMR-experiments, a plausible reaction mechanism is proposed.

European Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, HPLC of Formula: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhou, Jun published the artcileExtended phenothiazines: synthesis, photophysical and redox properties, and efficient photocatalytic oxidative coupling of amines, Recommanded Product: 2-Methoxynaphthalene, the publication is Chemical Science (2022), 13(18), 5252-5260, database is CAplus and MEDLINE.

Herein authors successfully developed a ring-fusion approach to extend the conjugation length of phenothiazines and synthesized a series of novel extended phenothiazines. The intriguing π-conjugation length-dependent photophys. and redox properties of these extended phenothiazines, and their photocatalytic performance towards visible-light-driven oxidative coupling reactions of amines were systematically investigated. As compared with the conventional phenothiazine (PTZ), all the extended phenothiazines displayed reversible redox behavior and maintained a strong excited-state reduction potential as well. Consequently, phenothiazines with longer effective conjugation lengths could efficiently catalyze the oxidative coupling of amines to imines under visible-light irradiation; by comparison, the shorter PTZ could only catalyze such reactions in the presence of UV light. Moreover, one PTZ showed superior catalytic performance which can result in better yields within a shorter reaction time, and in a broad substrate scope. Finally, a direct and efficient conversion of amines to imines under sunlight in an air atm. was successfully realized. Authors believe that their study including the new phenothiazine modification methodol. and the newly developed extended phenothiazine-based photocatalysts will open up a new way to develop novel phenothiazine-based materials for optoelectronic and catalytic applications.

Chemical Science published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C3H8N2S, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Salgado-Ramos, Manuel published the artcileSustainable and non-conventional protocols for the three-way valorisation of lignin from grape stalks, Related Products of ethers-buliding-blocks, the publication is Chemical Engineering and Processing (2022), 109027, database is CAplus.

The main goal of this work is the exploitation of the lignin fraction present in grape stalks (GS) to produce high-value-added chems. via non-conventional and sustainable means in a three-way valorisation process. Firstly, delignification using NaOH and natural deep eutectic Solvents (NaDESs), via microwave-assisted extraction (MAE), was performed using a bicomponent (choline chloride + lactic acid) and a tricomponent (choline chloride + lactic acid + glycerol) NaDES and giving engaging MAE results in terms of delignification (around 80%). The liquid fractions obtained from MAE, using NaDESs and NaOH, were analyzed, with all of them displaying promising antioxidant activity compared to the standards Subsequently, oxidation was carried out via microwave (MW) heating, with the lignins that were isolated after the delignification step mainly yielding long-chain fatty acids (LCFA), which are valuable for bio-fuel production However, when GS was used as the starting material, 16% weight of bioaroms. (mainly vanillin and syringaldehyde) was produced. Oxidation therefore provides two further pathways for the exploitation of the lignin fraction from this lignocellulosic waste.

Chemical Engineering and Processing published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Han published the artcileRelationship between volatile components of green pepper and its freshness, COA of Formula: C10H14O, the publication is Shipin Kexue (Beijing, China) (2016), 37(7), 66-71, database is CAplus.

Volatile components of green pepper stored in refrigerator at (4±1)°C for different periods were evaluated by head space solid-phase micro extraction-gas chromatog.-mass spectrometry (HS-SPME-GC-MS). Soluble solid content, weight loss ratio and vitamin C content and were analyzed to probe into the relationship of pepper freshness and its volatile components. The results showed that green pepper could be kept fresh at (4±1)°C for 15 days. The characteristic odor components of fresh green pepper were hexyl octanoate, (E,E)-2,4-decadienal and 3-octanone, whereas those of rotten green pepper were α-myrcene, α-phellandrene, (E)-α-famesene, 2-propenoic acid, 3-phenyl-Et ester, hexadecanoic acid, Et ester and n-decanoic acid with variation thresholds of 6.54, 13.47, 32.78, 7.74, 9.10 and 17.13 μg/L, resp. These results can provided a theor. basis for judging the freshness of pepper by changes of the volatile components and accordingly for developing smart refrigerator to monitor the freshness of green pepper.

Shipin Kexue (Beijing, China) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sheng, Yuanyuan published the artcileEthanol organosolv lignin from different agricultural residues: Toward basic structural units and antioxidant activity, Category: ethers-buliding-blocks, the publication is Food Chemistry (2022), 131895, database is CAplus and MEDLINE.

The growing interest in the substitution of synthetic food antioxidants by natural ones has fostered research on vegetable sources and the screening of raw materials for identifying new antioxidants. Special attention is focused on their extraction from inexpensive or residual sources from agricultural industries. Herein, the antioxidant activities of lignin obtained from 4 residual sources were investigated. The obtained lignin samples were characterized by different anal. techniques evaluating their chem. structure, phenolic content, thermal behavior and mol. weight The antioxidant activity of the analyzed lignins was evaluated by the DPPH assay, the radical ABTS assay, and trivalent iron reduction method. It was found t that lignin antioxidants could scavenge free radicals and reduce oxidants. The high correlation between antioxidant capacity and its total phenol content indicated that phenolic hydroxyl groups were the main contributors to these lignins antioxidant activity.

Food Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C19H14Cl2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pancrazzi, Francesco published the artcileOxidative Dearomatization of Phenols and Polycyclic Aromatics with Hydrogen Peroxide Triggered by Heterogeneous Sulfonic Acids, Application In Synthesis of 93-04-9, the publication is European Journal of Organic Chemistry (2021), 2021(39), 5407-5414, database is CAplus.

Authors report herein a method for the oxidative dearomatization of phenols and bare polycyclic arenes into the corresponding quinoid derivatives using hydrogen peroxide. The reaction is catalyzed by sulfonic acids and best results were achieved using heterogenized species. The best results using phenols were achieved using a hybrid material, namely a perfluorinated polymer functionalized with sulfonic acid groups supported on silica. The dearomatization of polycyclic aromatic hydrocarbons performed better using the polymeric acid catalyst. These methods operate under mild conditions, using mild and benign oxidants and thus minimizing the formation of waste.

European Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Application In Synthesis of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lin, Dan-Dan published the artcileStimulation of Bathyarchaeota in enrichment cultures by syringaldehyde, 4-hydroxybenzaldehyde and vanillin under anaerobic conditions, HPLC of Formula: 134-96-3, the publication is International Biodeterioration & Biodegradation (2022), 105409, database is CAplus.

Bathyarchaeota covering about 25 subgroups are a newly discovered archaeal phylum with widespread in anaerobic environments including marine sediments, soils and subsurface petroleum reservoirs. Although recent studies showed that Bathyarchaeota can use lignin as an energy source to get enrichment, there is a lack of the pure culture and thus the understanding about Bathyarchaeota is still based on genomic information. In this study, lignin and three aldehyde compounds, namely syringaldehyde, 4-hydroxybenzaldehyde, and vanillin, which were recognized as the metabolic intermediates of lignin biodegradation, were used as substrates to enrich Bathyarchaeota from mangrove sediments, and enrichment cultures of Bathyarchaeota was successfully established in the laboratory The changes in gene-copy numbers, microbial composition and consumption of the substrates indicated that the syringaldehyde significantly stimulated the growth of Bathyarchaeota in the enrichment culture. Meanwhile, the relative abundance of Bathyarchaeota was as high as 97.13% in term of the archaeal composition, especially bathyarchaeotal genome subgroup-6 accounted for more than 99.9% in Bathyarchaeota, and 4.74 mmol L^-1 methane were also detected in the enrichment culture amended with syringaldehyde as a substrate after about 117 days of incubation, compared to 4-HBA (3.75 mmol L^-1) and VA (3.75 mmol L^-1). This work will facilitate the design of high-efficiency enrichment cultures and understanding about the metabolic and ecol. functions of Bathyarchaeota in nature.

International Biodeterioration & Biodegradation published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, HPLC of Formula: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem