Tag: M.W=150-200

Hamby, Taylor B. published the artcileControlling Ni redox states by dynamic ligand exchange for electroreductive C(sp³)-C(sp²) coupling, Category: ethers-buliding-blocks, the publication is Science (Washington, DC, United States) (2022), 376(6591), 410-416, database is CAplus and MEDLINE.

Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are appealing but limited to specific substrate classes. Here, electroreductive XEC of previously incompatible electrophiles including tertiary alkyl bromides, aryl chlorides, and aryl/vinyl triflates are reported. The reactions rely on the merger of an electrochem. active complex that selectively reacts with alkyl bromides through 1e^– processes and an electrochem. inactive Ni⁰(phosphine) complex that selectively reacts with aryl electrophiles through 2e^– processes. Accessing Ni⁰(phosphine) intermediates is critical to the strategy but is often challenging. Here, a previously unknown pathway for electrochem. generating these key complexes at mild potentials through a choreographed series of ligand-exchange reactions has been uncovered. The mild methodol. is applied to the alkylation of a range of substrates including natural products and pharmaceuticals.

Science (Washington, DC, United States) published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ivancev-Tumbas, Ivana published the artcileAdsorption of organic pollutants from the aqueous phase using graphite as a model adsorbent, Formula: C11H10O, the publication is Adsorption Science & Technology (2020), 38(7-8), 286-303, database is CAplus.

Although graphite is not effective as an adsorbent in water treatment, it provides a homogenous, non-porous, carbonaceous structure that is ideal for studying fundamental adsorption mechanisms. High-purity graphite powder (C content 99.5%) was oxidized in an ozone stream, producing a near-surface oxygen content of 5.9 at.%, and was used together with the virgin material to establish adsorption isotherms for organic compounds in aqueous solutions We examined how the aromaticity and substituents of the adsorptives affect adsorption on the model-activated carbon surface. For both virgin and oxidized graphite, the adsorption capacity for the aromatic compounds decreased in the order 1-naphthol > 2-methoxynaphthalene > naphthalene > anisole > phenol, with significant differences in the adsorption capacities of the two graphite species observed only for anisole, naphthalene, and 1-naphthol. The Freundlich constantsfor the five compounds on virgin graphite were 23.9, 10.3, 5.5, 1.4, and 0.8 (nmol mg^-1 )/(μmol L^-1)n, resp. Naphthalene and 1-naphthol were slightly more adsorbed on the virgin material, whereas oxidized graphite had marginally better adsorption properties for anisole. The results underline the importance of dispersive and Π-Π interactions in the adsorption of organic compounds on carbonaceous adsorbents; a second aromatic ring in 1-naphthol and 2-methoxynaphthalene greatly increased the adsorption capacity for these compounds compared with their one-ring counterparts phenol and anisole. Differences were also observed in the adsorption of compounds containing hydroxyl or methoxy substituents, which have electron-donating properties (a resonance effect) but different electron-withdrawal characteristics (caused by induction). Two amino acids occurring as zwitterions, L-tryptophan and L-tyrosine, were also tested as adsorptives. L-Tryptophan, which has a larger aromatic system, achieved higher loading on graphite, suggesting an adsorption mechanism primarily governed by dispersive and Π-Π interactions for these two ionic compounds as well.

Adsorption Science & Technology published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Caldarelli, Marina published the artcileUse of acridinium-based photocatalyst in the Giese-type coupling of arylboronic acids with electron poor olefins, Application In Synthesis of 93-04-9, the publication is Tetrahedron Letters (2022), 153978, database is CAplus.

The development of a visible light-mediated Giese-type reaction using arylboronic acids as aryl radical source was described. The synthetic protocol capitalizes on the employment of environmentally benign metal-free catalyst to forge Csp²-Csp³ bonds. Applications of the methodol. to the synthesis of aminoesters and the anti-inflammatory drug nabumetone, either in batch or in flow, was also reported.

Tetrahedron Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Application In Synthesis of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hickey, Deirdre M. B. published the artcileSynthesis of thyroid hormone analogs. Part 3. Iodonium salt approaches to SK & F L-94901, Application of 2-Isopropylanisole, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1988), 3103-11, database is CAplus.

The key step in the synthesis of the title compound L–I, a novel, selective, and potent thyromimetic, is the formation of the hindered diaryl ether moiety. This paper describes an investigation into the formation of the required diaryl ether by copper-catalyzed reaction both of sym. iodonium salts, e.g. R₂I⁺ O₂CCF₃, and mixed iodonium salts II (R¹ = H, R² = OMe; R¹ = R² = H, OMe) with protected dibromotyrosine 4,3,5-HO(Br)₂C₆H₂CH₂CH(NHCOCF₃)CO₂Me. The importance of the counterion of the iodonium salt is discussed. This work is extended to a large-scale synthesis of SK & F L-94901 (I).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Van Tamelen, E. E. published the artcileBiogenetic-type total synthesis of (±)-triptonide and (±)-triptolide, Product Details of C10H14O, the publication is Journal of the American Chemical Society (1982), 104(6), 1785-6, database is CAplus.

A biogenetic-type total synthesis of the naturally occurring anticancer agents triptolide (I; R = H, R¹ = OH) and triptonide (I; RR¹ = O) was carried out via cyclization of aromatic β-oxo ester II.

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C7H13BrSi, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yakan, Hasan published the artcilePotential thiosemicarbazone-based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations, Product Details of C9H10O4, the publication is Journal of Biochemical and Molecular Toxicology (2022), 36(5), e23018, database is CAplus and MEDLINE.

A new series of thiosemicarbazone derivatives (1-11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform IR, ¹H-NMR (NMR), ¹³C-NMR spectroscopic methods and elemental anal. Cytotoxic effects of target compounds were determined by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide assay and compound 1 showed significant cytotoxic activity against both MCF-7 and MDA-MB-231 cells, with half-maximal inhibitory concentration values of 2.97 μM and 6.57 μM, resp. Moreover, in this study, the anticholinergic and antidiabetic potentials of these compounds were investigated. To this aim, the effect of the newly synthesized thiosemicarbazone derivatives on the activities of acetylcholinesterase (AChE) and αglycosidase (α-Gly) was evaluated spectrophotometrically. The title compounds demonstrated high inhibitory activities compared to standard inhibitors with K_i values in the range of 122.15-333.61 nM for α-Gly (K_i value for standard inhibitor = 75.48 nM), 1.93-12.36 nM for AChE (K_i value for standard inhibitor = 17.45 nM). Antiproliferative activity and enzyme inhibition at the mol. level were performed mol. docking studies for thiosemicarbazone derivatives 1M17, 5FI2, and 4EY6, 4J5T target proteins with protein data bank identification with (1-11) compounds were docked for anticancer and enzyme inhibition, resp.

Journal of Biochemical and Molecular Toxicology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C10H15NS, Product Details of C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gilmartin, Philip H. published the artcileVanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products, HPLC of Formula: 2944-47-0, the publication is Organic Letters (2020), 22(8), 2914-2919, database is CAplus and MEDLINE.

A mild and efficient method for the vanadium-catalyzed intramol. coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor.

Organic Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, HPLC of Formula: 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bridoux, Alexandre published the artcileDesign, synthesis, and biological evaluation of bifunctional thyrointegrin inhibitors: new anti-angiogenesis analogs, Computed Properties of 2944-47-0, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2011), 26(6), 871-882, database is CAplus and MEDLINE.

Context: Inhibition of pathol. angiogenesis. Objective: Obtaining new transactivator, bifunctional, thyroid antagonist, non-toxic anti-angiogenic compounds Materials and methods: In silico drug design, synthesis in bulk and biol. evaluation in chick chorioallantoic membrane (CAM) model. Results: Significant inhibition (range 65-73%) at 0.25-2.0 μg/mL doses. Discussion and conclusion: The synthesis of compounds (9), (10), and (11) incorporating long-chain moieties guanidine, urea, Me amine and, Pr amine substitutions, resp., into the core mol. framework of tetrac (tetraiodothyroacetic acid) were undertaken. The evaluation of the anti-angiogenic bioactivity of these compounds in the CAM model revealed no loss of activity in comparison with tetrac and XT199, which showed nearly 86% inhibition at dose levels of 1 and 0.5 μg/mL, resp., and validated the concept.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Computed Properties of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kubczak, Malgorzata published the artcileHippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity, Quality Control of 134-96-3, the publication is Scientific Reports (2022), 12(1), 1095, database is CAplus and MEDLINE.

Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents. They are also rich in nutrients that improve the human diet. Growing demands for these compounds make it important to seek new sources for them. Hippophae rhamnoides L. is known as a plant with health-promoting properties. In this study we investigated the chem. composition and biol. properties of bioactive components of ethanol extracts from leaves and twigs of H. rhamnoides L. Chem. components such as the total content of phenolic compounds, vitamins and amino acids and the antioxidant activities of these compounds in cellular and cell-free systems were assessed. The results suggest that the studied extracts are rich in bioactive compounds with potent antioxidant properties. Cytotoxicity and hemotoxicity assays showed that the extracts had low toxicity on human cells over the range of concentrations tested. Interaction with human serum albumin was investigated and conformational changes were observed Our results indicate that leaf and twig extracts of H. rhamnoides L. should be considered as a non-toxic source of bioactive compounds which may be of interest to the food, pharmaceutical and cosmetic industries.

Scientific Reports published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Quality Control of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tomioka, Hideo published the artcileButtressing effect in carbene chemistry. Effect of 3-alkyl groups on the reactions of 2-alkoxydiphenylcarbenes, Related Products of ethers-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1991), 471-7, database is CAplus.

Irradiation of 3,2-R(MeO)C₆H₃CPh:N₂ (I; R = H) in Et₂O at 10° gave 3-phenyldihydrofuran (II; R = H) and a small amount of 3,2-R(MeO)C₆H₃CHPhR¹ [III; R¹ = H, R = EtOCHMe (IV)]; IV was the major product when the irradiation was carried out in an Et₂O matrix at -196°. With I (R = alkyl) the reaction patterns were dramatically changed. Only II (R = alkyl) were formed in Et₂O at +10 or -196°. This was due to the buttressing effect of R, which prevents the 2-MeO group from lying in the plane of the Ph ring in the precursor mols. and assists the MeO group in rotating around the C-O bond toward the carbene center after elimination of N. The effect of buttressing on the generation of carbene in MeOH is also discussed.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C8H7ClO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem