Tag: M.W=150-200

Zhang, Xiaoping published the artcileAn efficient turn-on fluorescence chemosensor system for Zn(II) ions detection and imaging in mitochondria, Synthetic Route of 134-96-3, the publication is Journal of Photochemistry and Photobiology, B: Biology (2022), 112485, database is CAplus and MEDLINE.

Mitochondria-targetable fluorescent chemosensors, Rhodamine-B and rhodamine 6G bearing syringaldehyde based receptors were designed and synthesized for efficient chemosensing of Zinc(II) ions. The probes showed the very selective naked eye color change to pink from colorless upon addition of Zinc(II) ions, further these probes showing turn-on fluorescence enhancement with Zn(II) ions by opening of rhodamine spirolactam. The probes are very sensitive towards Zn(II) ions among other ions. These probes RBS and R6S will be applicable to detect zinc ions upto the low level concentration 0.18 and 0.19 nano molar resp. The affinity of these sensors RBS and R6S for Zinc (II) ions was found to be in the range of 1.12 x 104 M-1 and 7.28 x 104 M-1 resp. 1H-nmr titrations of the probes with Zn(II) ions clearly indicating the spiroring opening of the spirolactam. DFT calculations supporting that the perceived photophys. changes of the probes on appendage of the zinc ions. Probes RBS and R6S are useable for selective staining mitochondria. Both of the probes are applicable to reveal labile Zn(II) in live Hela and MCF-7 cells via fluorescence imaging. RBS and R6S are also finding application on quantification of Zinc(II) ions inside mitochondria via fluorescence imaging.

Journal of Photochemistry and Photobiology, B: Biology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C16H12O, Synthetic Route of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pandiarajan, Karuppiah published the artcileMultinuclear magnetic resonance spectroscopic and semiempirical molecular orbital (AM1) studies of substituted anisoles, Formula: C10H14O, the publication is Bulletin of the Chemical Society of Japan (1994), 67(10), 2639-46, database is CAplus.

¹³C, ¹⁵N, and ¹⁷O NMR spectra have been recorded for 4-nitroanisole , its 2-methyl-, 2-chloro-, 2-bromo-, 2-iodo-, 2,6-dimethyl-, 2,6-dichloro-, 2,6-dibromo-, and 2,6-diiodo-derivatives, also nitrobenzene , its 3-methyl-, 3-chloro-, 3-bromo-, and 3-iodo-derivatives and 3,5-dichloro- and 3,5-dibromo-derivatives Anal. of the chem. shifts of carbon bearing nitro group and nitro oxygens in these compounds suggests that presence of one substituent ortho- to the methoxyl group enhances its resonance interaction with the benzene ring whereas presence of two ortho-substituents inhibits this resonance. However, in no case the resonance is completely inhibited. The extent of enhancement or inhibition is almost independent of the nature of the ortho-substituent. This conclusion has also been arrived by analyzing the reported chem. shifts of the para-carbons in 2,6-disubstituted and 2-substituted anisoles and the corresponding carbons in m-disubstituted benzenes. Though evidence could not be obtained for steric enhancement of resonance using methoxyl oxygen chem shifts, anal. of these chem. shifts in di-ortho-substituted anisoles and 3,5-dimethylnitrobenzene furnishes evidence for steric inhibition of resonance. However, ¹⁵N chem. shifts are of no use in studying these phenomena. Semiempirical MO calcns using AM1 Hamiltonian suggest that the methoxyl group is coplanar with the benzene ring in anisole, 4-nitroanisole and 2-substituted-4-nitroanisoles but is perpendicular to the benzene ring in 2,6-disubstituted-4-nitroanisoles. Moreover, in 2-substituted-4-nitroanisoles the O-Me group is anti to the 2-substituent.

Bulletin of the Chemical Society of Japan published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Xue-wei published the artcileEcotoxicological effects of 50 kinds of fragrance materials on Microcystis aeruginosa, Category: ethers-buliding-blocks, the publication is Zhongguo Huanjing Kexue (2021), 41(3), 1429-1435, database is CAplus.

In the present study, the 50 fragrance materials were performed to determine the ecol. toxicity on Microcystis aeruginosa. The influence of four fragrance materials (2-methoxynaphthalene, thymol, myrcene and indole) on the content of chlorophyll a and soluble protein, superoxide dismutase (SOD) activity, catalase (CAT) activity and malondialdehyde (MDA) content were also studied. The results showed that 2-methoxynaphthalene, thymol, myrcene and indole can significantly inhibit the growth of Microcystis aeruginosa under high concentration exposure, and the half-effect concentration E_yC₅₀ value was 1.81, 1.26, 0.55 and 1.40 mg/L, resp., showing an obvious dose-effect relationship. At a treatment concentration of 1 mg/L, 2-methoxynaphthalene and thymol significantly inhibited the content of chlorophyll a and soluble protein (P<0.0001). Exposure to 2-methoxynaphthalene resulted in a significant decrease in SOD activity (P<0.0001), the other two antioxidant enzymes had no significant effect (P>0.05); Thymol significantly inhibited POD activity (P<0.0001), and myrcene also reduced SOD activity (P<0.01). The activities of POD and CAT of Microcystis aeruginosa treated with indole were significantly lower than those of the control group (P<0.0001). Studies showed that these four fragrance materials inhibited the antioxidant enzyme activity, accumulate excessive MDA, and destroyed the content and function of chlorophyll, which in turn leads to the abnormal growth of algae. 2-methoxynaphthalene, thymol and indole are aromatic compounds, and myrcene was an olefin. The difference in structure of the four fragrance compounds resulted to the different effects on antioxidant enzymes. 2-Methoxynaphthalene was a synthetic fragrance. Although thymol, myrcene and indole were all natural flavors, they were mostly prepared by artificial synthesis. The current findings will enrich the fundamental data for evaluating the risk and toxicity of fragrance materials on the ecosystems. Because of their unique aromatic odor, aromatic compounds have become a large category of fragrance materials and are widely used. However, the aromatic ring is stable and difficult to degrade, so we need to pay more attention to the ecol. safety of the fragrance materials with aromatic ring structure.

Zhongguo Huanjing Kexue published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C25H34N4O2S, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kaye, Esther G. published the artcileA Green-Absorbing, Red-Fluorescent Phenalenone-Based Photosensitizer as a Theranostic Agent for Photodynamic Therapy, Recommanded Product: 2-Methoxynaphthalene, the publication is ACS Medicinal Chemistry Letters (2021), 12(8), 1295-1301, database is CAplus and MEDLINE.

Phenalenone is a synthetically accessible, highly efficient photosensitizer with a near-unity singlet oxygen quantum yield. Unfortunately, its UV absorption and lack of fluorescence has made it unsuitable for fluorescence-guided photodynamic therapy against cancer. In this work, we synthesized a series of phenalenone derivatives containing electron-donating groups to red-shift the absorption spectrum and bromine(s) to permit good singlet oxygen production via the heavy-atom effect. Of the derivatives synthesized, the phenalenone containing an amine at the 6-position with bromines at the 2- and 5-positions (OE19) exhibited the longest absorption wavelength (i.e., green) and produced both singlet oxygen and red fluorescence efficiently. OE19 induced photocytotoxicity with nanomolar potency in 2D cultured PANC-1 cancer cells as well as light-induced destruction of PANC-1 spheroids with minimal dark toxicity. Overall, OE19 opens up the possibility of employing phenalenone-based photosensitizers as theranostic agents for photodynamic cancer therapy.

ACS Medicinal Chemistry Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Guo, Ying published the artcileA ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system, Category: ethers-buliding-blocks, the publication is Research on Chemical Intermediates (2015), 41(11), 8651-8664, database is CAplus.

A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.

Research on Chemical Intermediates published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zawadiak, Jan published the artcileThe liquid-phase oxidation of isomeric methoxy-(1-methylethyl)benzenes with oxygen to the hydroperoxides, Computed Properties of 2944-47-0, the publication is International Journal of Chemical Kinetics (2004), 37(1), 10-16, database is CAplus.

The kinetics of liquid-phase oxidation of 1-methoxy-2-(1-methylethyl)benzene (1a), 1-methoxy-3-(1-methylethyl)benzene (1b), and 1-methoxy-4-(1-methylethyl)benzene (1c) with oxygen as oxidant to yield the corresponding 1-methyl-1-(2-methoxyphenyl)ethyl (2a), 1-methyl-1-(3-methoxyphenyl)ethyl (2b), and 1-methyl-1-(4-methoxyphenyl)ethyl (2c) hydroperoxides was studied. The oxidizabilities of 1a, 1b, and 1c were established over the temperature range 50-120°C. The overall activation energies of oxidation were determined for 1b and 1c over the temperature range 50-120°C. Thermal stability of 2a and 2b and the initiating properties of hydroperoxides 2a, 2b, and 2c were studied. Long-term noncatalytic oxidations of 1b and 1c to resp. hydroperoxides were carried out.

International Journal of Chemical Kinetics published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C6H8O6, Computed Properties of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Choi, Won-Sik published the artcileSynthesis and antifungal activities of isopropylphenyl derivatives, Quality Control of 2944-47-0, the publication is Han’guk Eungyong Sangmyong Hwahakhoeji (2007), 50(3), 178-186, database is CAplus.

42 Compounds such as ester, sulfonyl ester, phosphoryl ester and ether derivatives of 4-isopropylphenol and 2-isopropylphenol were synthesized. These derivatives were identified by IR, GC/MS and ¹H-NMR spectra. Their in vitro antifungal activities were tested against 10 plant pathogenic fungi. Among them, several compounds showed potent in vitro antifungal activity. The selected compounds showing potent in vitro antifungal activity were tested for their in vivo antifungal activities against 5 plant diseases such as rice blast, rice sheath blast, cucumber anthracnose, cucumber gray mold and tomato late blight. As a result, 2-isopropylphenyl piperonylate (I) showed a potent in vivo antifungal activity against cucumber anthracnose and tomato late blight, 4-isopropylphenyl 4-methoxybenzenesulfonate (II) effectively inhibited the development of rice blast.

Han’guk Eungyong Sangmyong Hwahakhoeji published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Quality Control of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Favre-Godal, Quentin published the artcileExtensive Phytochemical Assessment of Dendrobium fimbriatum Hook (Orchidaceae), Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Natural Product Communications (2022), 17(3), 1934578X221074526, database is CAplus.

Dendrobium fimbriatum Hook is an important medicinal and ornamental orchid that may lead to important drugs and cosmetics. In this study, 2 anal. strategies were combined to describe the detailed composition of a hydroethanolic extract of the whole plant. The CARAMEL approach, based on centrifugal partition chromatog. and NMR data interpretation, allowed the rapid dereplication of 21 major constituents, mainly including polyols, nucleosides, zwitterionic compounds, phenolic compounds, and organic acids. Further semipreparative high-performance liquid chromatog. and spectroscopic analyses led to the isolation of 6 addnl. compounds; 4 phenanthrenes (plicatol B, hircinol, plicatol A, and plicatol C), 1 bibenzyl (3�4-dihydroxy-3,5�dimethoxybibenzyl), and 1 furostanol saponin (protodioscin), as well as a new phenanthrene derivative, plicatol D. A total of 28 metabolites were structurally elucidated, among which 23 are described for this species for the first time.

Natural Product Communications published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Yifan published the artcileElectron transfer capacity of humic acid in soil micro and macro aggregates in response to mulching years, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Science of the Total Environment (2022), 154927, database is CAplus and MEDLINE.

Plastic film mulching can help farmers meet food production requirements and even increase output. Although the environmental impact of this mulch has received attention, uncertainty remains about certain soil components and the course of its long-term effects. In particular, it is not clear whether the long-term use of mulching film will affect the electron transfer capacity (ETC) of natural organic matter in the soil. This study evaluated the electron-accepting capacity (EAC) and electron-donating capacity (EDC) of soil humic acid (HA) in different-size aggregates in response to different film mulching years (0-6 years). The EAC of HA in the soil showed a downward trend as mulching years increased, while the EDC fluctuated. EAC decline in microaggregates (MIA) was more significant than that of macroaggregates (MAA). Film mulching changes the phys. and chem. properties of soil and the activity of enzymes, changes the chem. structure of HA, and ultimately affects HA electron transfer. In addition, compared with that in MAA, the chem. structure of soil HA in MIA has a stronger correlation with enzyme activity and ETC and thus is more significantly affected by mulching. These results provide an in-depth understanding of the role of HA in soil aggregates of different sizes in processes related to the agricultural soil environment under mulching conditions.

Science of the Total Environment published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C17H14F3N3O2S, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kitamura, Seiya published the artcileRational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa, Safety of 2-Isopropylanisole, the publication is Journal of Medicinal Chemistry (2016), 59(10), 4790-4799, database is CAplus and MEDLINE.

The virulence factor cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) is secreted by Pseudomonas aeruginosa and is the founding member of a distinct class of epoxide hydrolases (EHs) that triggers the catalysis-dependent degradation of the CFTR. We describe here the development of a series of potent and selective Cif inhibitors by structure-based drug design. Initial screening revealed 1a (KB2115), a thyroid hormone analog, as a lead compound with low micromolar potency. Structural requirements for potency were systematically probed, and interactions between Cif and 1a were characterized by X-ray crystallog. On the basis of these data, new compounds were designed to yield addnl. hydrogen bonding with residues of the Cif active site. From this effort, three compounds were identified that are 10-fold more potent toward Cif than our first-generation inhibitors and have no detectable thyroid hormone-like activity. These inhibitors will be useful tools to study the pathol. role of Cif and have the potential for clin. application.

Journal of Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem