Tag: M.W=150-200

Park, Jae-Min published the artcileEarly Life History of Lefua costata (Cypriniformes : Balitoridae) from Korea., SDS of cas: 121-00-6, the main research area is Early life history; Egg development; Juveniles; Larvae; Lefua costata.

The purpose of this study is to observe the early life history of Korean Lefua costata and use the result as basic taxonomic research data for balitorid fish. The fertilized eggs were light green color with completely circle shape and mean size was 1.21±0.06 mm (n=30). Immediately after hatching, the size of the larvae was 2.81±0.11 mm (n=5) in mean length, with egg yolk. On the 3rd day after hatching, the preflexion larvae had a mean length of 4.64±0.09 mm (n=5), and their mouth was opened to start feeding. On the 8th day after hatching, a mean length of the postflexion larvae was 9.43±0.46 mm (n=5), the distal part of the notochord was bent to 45°, and 16 fin rays were developed on the caudal fin. On the 31st day after hatching, a mean length of juveniles was 22.3±0.85 mm (n=5), and the number of fin rays was the same as that of adult fish with (iv8) dorsal fins and (iii8) anal fins.

Development & reproduction published new progress about Early life history; Egg development; Juveniles; Larvae; Lefua costata. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, SDS of cas: 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Morgan, David L. published the artcileEnd-quenching of quasiliving polyisobutylene with phenoxy derivatives for direct chain end functionalization, Product Details of C8H9ClO, the main research area is end quenching quasiliving polyisobutylene phenoxy derivative chain end functionalization.

Various functional alkyl phenoxy derivatives were used to end-quench TiCl4-catalyzed quasiliving isobutylene polymerizations initiated from 2-chloro-2,2,4-trimethylpentane or 5-tert-butyl-1,3-di(2-chloro-2-propyl)benzene at -70°C in 40/60 (volume/volume) hexane/methyl chloride. Quant. end-capping was observed from mono-alkylation of the phenoxy derivatives in para position. The quenching reactions were tolerant of phenoxy derivatives bearing a primary halide, allowing for direct functionalization of polyisobutylene with primary chloride and bromide end groups. Electrophilic aromatic substitution on phenoxy alkyls such as anisole, and subsequent in situ cleavage of the alkyl-oxygen bond, provided single-pot synthesis of phenol telechelic polyisobutylene.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about end quenching quasiliving polyisobutylene phenoxy derivative chain end functionalization. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Product Details of C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Aijun published the artcileImproved synthesis of nefazodone from phenol, Related Products of ethers-buliding-blocks, the main research area is nefazodone improved preparation; triazolone phenoxyethyl derivative nefazodone intermediate preparation.

A route for the synthesis of nefazodone (I) is reported. Nefazodone was obtained with an overall yield of 37.2% from phenol. The key steps involve the improved synthesis of 5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3(2H)-one (II), a key intermediate. The phenol was etherified with 1,2-dichloroethane (75%), followed by iodination-amination with NaI and CH3OH-NH3 (85.7%), acylation with Et chloroformate (95.7%) and cyclization with propionylhydrazine (83.6%).

Transactions of Tianjin University published new progress about nefazodone improved preparation; triazolone phenoxyethyl derivative nefazodone intermediate preparation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Van Velzen, P. N. T. published the artcileIon structures and relaxation of vibrationally excited ions as studied by photodissociation, Quality Control of 622-86-6, the main research area is photodissociation spectra phenol hexene.

Photodissociation spectra of the m/2 94 ions from PhOH, PhOEt, bicyclo[2.2.2]oct-2-ene-5,7-dione, and 2-phenoxyethyl chloride were given. The spectra of the ions from the bicyclo compound and from 2-phenoxyethyl chloride were essentially different from those of the ions from PhOH and PhOEt. The two different spectra were ascribed to structures I and II, resp. The photodissociation spectra of 1-hexene is strongly pressure dependent suggesting the existence of an ion mixture

Lecture Notes in Chemistry published new progress about photodissociation spectra phenol hexene. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Quality Control of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Horton, Martin N. published the artcileSynthesis of [D5-ethyl]-tamoxifen; a mechanistic probe of tamoxifen induced hepatic DNA adduct formation, Related Products of ethers-buliding-blocks, the main research area is tamoxifen deuterated.

Tamoxifen which incorporates a fully deuterated Et group, [D5-ethyl]-tamoxifen, has been synthesized in order to probe the mechanism of tamoxifen induced hepatic DNA adduct formation. The pentadeuteroethyl group was introduced into the tamoxifen structure by treatment of the ketone precursor 1-[4-(2-chloroethoxy)phenyl]-2-phenylethanone, as its sodium enolate, with [D5]-iodoethane.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about tamoxifen deuterated. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chiellini, Grazia published the artcileA high-affinity subtype-selective agonist ligand for the thyroid hormone receptor, Recommanded Product: 2-Isopropylanisole, the publication is Chemistry & Biology (1998), 5(6), 299-306, database is CAplus and MEDLINE.

Thyroid hormones regulate many different physiol. processes in different tissues in vertebrates. Most of the actions of thyroid hormones are mediated by the thyroid hormone receptor (TR), which is a member of the nuclear receptor superfamily of ligand-activated transcription regulators. There are two different genes that encode two different TRs, TRα and TRβ, and these two TRs are often co-expressed at different levels in different tissues. Most thyroid hormones do not discriminate between the two TRs and bind both with similar affinities. The authors have designed and synthesized a thyroid hormone analog that has high affinity for the TRs and is selective in both binding and activation functions for TRβ over TRα. The compound, GC-1, was initially designed to solve synthetic problems that limit thyroid hormone analog preparation, and contains several structural changes with respect to the natural hormone 3,5,3′-triiodo-L-thyronine (T₃). These changes include replacement of the three iodines with Me and iso-Pr groups, replacement of the biaryl ether linkage with a methylene linkage, and replacement of the amino-acid sidechain with an oxyacetic-acid sidechain. The result of this study show that GC-1 is a member of a new class of thyromimetic compounds that are more synthetically accessible than traditional thyromimetics and have potentially useful receptor binding and activation properties. The TRβ selectivity of GC-1 is particularly interesting and suggests that GC-1 might be a useful in vivo probe for studying the physiol. roles of the different thyroid hormone receptor isoforms.

Chemistry & Biology published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Rozas, Robinson published the artcileSolvent effects on the molecular structure of isolated lignins of Eucalyptus nitens wood and oxidative depolymerization to phenolic chemicals, Synthetic Route of 134-96-3, the publication is Polymer Degradation and Stability (2022), 109973, database is CAplus.

The aim of the present work was to study the effect of a solvent/water mixture on the structural characteristics of extracted lignin from Eucalyptus nitens, and to relate the functional groups and inter unit linkages present in the lignin with the distribution of phenolic compounds obtained after its alk. oxidation The high content of β-O-4′ substructures linked to a S unit in organosolv lignins of E. nitens lignin could be linked to the high yield of syringaldehyde in its alk. oxidation Kraft lignin oxidation gives rise to lower content of syringaldehyde when compared with organosolv lignins. This might be due to the higher proportion of condensed structures, mainly β-β’ (∼42%) and spirodienone (∼14%). Fukui functions showed that the regions with higher probability for an electrophilic attack on lignin would be located on Ph rings and on the phenolic -OH group (benzylic position), whereas nucleophilic attacks in some cases were located over the double bond and ring. This work contributed to a better description of the proposed oxidative depolymerization mechanisms.

Polymer Degradation and Stability published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Synthetic Route of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Washington, Jack B. published the artcileTrialkylammonium salt degradation: implications for methylation and cross-coupling, Name: 2-Methoxynaphthalene, the publication is Chemical Science (2021), 12(20), 6949-6963, database is CAplus and MEDLINE.

This study presented a mechanistic degradation anal. of N,N,N-trimethylanilinium salts and highlighted implications for synthetic applications of this important class of salts. Kinetic degradation studies, in both solid and solution phases, had delivered insights into phys. and chem. parameters affecting anilinium salt stability. ¹H NMR kinetic anal. of salt degradation had evidenced thermal degradation to Me iodide and parent aniline, consistent with a closed-shell S_N2-centered degradative pathway, and Me iodide being key reactive species in applied methylation procedures. Furthermore, effect of halide and non-nucleophilic counterions on salt degradation had been investigated, along with deuterium isotope and solvent effects. New mechanistic insights had enabled investigation of use of trimethylanilinium salts in O-methylation and in improved cross-coupling strategies. Finally, detailed computational studies had helped highlight limitations in current state-of-the-art of solvation modeling of reaction in which bulk medium undergoes exptl. observable changes over reaction timecourse.

Chemical Science published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C14H10O4, Name: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Geduk, Aysun Sener published the artcileLC-MS/MS phenolic composition of peach (Prunus persica L. Batsch) extracts and an evaluation of their antidiabetic, antioxidant, and antibacterial activities, Related Products of ethers-buliding-blocks, the publication is South African Journal of Botany (2022), 636-645, database is CAplus.

Peaches contain high amounts of polyphenol compounds The consumption of peaches gives protection against various conditions such as obesity, diabetes, cardiovascular and bacterial diseases, and inflammation. The present study aimed to examine the phytochem. compounds and the antioxidant, antibacterial, anti-α-glucosidase, and anti-α-amylase activities of the different extracts (methanol, ethanol, and hexane) of fresh red peach collected from the Mersin province in Turkey. In this study, chem. compositions of methanol and ethanol extracts prepared from peach pulp were studied by using liquid chromatog.-mass spectrometry (LC-MS/MS). Thirteen metabolites: quinic acid, fumaric acid, aconitic acid, protocatechuic acid, salicylic acid, chlorogenic acid, rutin, isoquercitrin, hesperidin, astragalin, nicotiflorin, quercetin, and amentoflavone, were identified in ethanol extracts and also these phenolic compounds, excluding salicylic acid, were identified in the methanol extract The ethanol extract showed the most activity in all enzyme inhibition and in antibacterial and antioxidative activity assays, which is mainly due to its rich phenolic content. The most dominant compounds determined in ethanol extract were quinic acid, chlorogenic acid, fumaric acid, and isoquercitrin resp. According to the results of this study, ethanol extract in particular is a potential ingredient to be used in food-derived antidiabetic and antibacterial formulations.

South African Journal of Botany published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Organ, Michael G. published the artcilePd-PEPPSI-IHept^Cl: A General Purpose, Highly Reactive Catalyst for the Selective Coupling of Secondary Alkyl Organozincs, Synthetic Route of 2944-47-0, the publication is Chemistry – A European Journal (2016), 22(41), 14531-14534, database is CAplus and MEDLINE.

Pd-PEPPSI-IHept^Cl, a new, very bulky yet flexible Pd-NHC complex was evaluated in the Negishi coupling of secondary alkylzinc reactants with a wide variety of oxidative addition partners in high yields and excellent selectivity. The desired, direct reductive elimination branched products I [Ar = 2-pyridyl, 5-indolyl, 3-benzo[b]thiophenyl, etc.], II and e.g., III, were obtained with no sign of migratory insertion across electron-rich and electron poor aromatics and all forms of heteroaromatics (5- and 6-membered). Impressively, there was no impact of substituents at the site of reductive elimination (i.e., ortho or even di-ortho), which was not yet been demonstrated by another catalyst system to date.

Chemistry – A European Journal published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem