Tag: M.W=150-200

Kochi, Jay K. published the artcileAlkenes from halides and epoxides by reductive eliminations with chromium(II) complexes, Product Details of C8H9ClO, the main research area is CHROMIUM REDUCTIVE ELIMINATION; COMPLEX; ALKENE FROM ALKYL HALIDE; ALKYL HALIDE ALKENE FROM; REDUCTIVE ELIMINATION HALIDE; EPOXIDE REDUCTIVE ELIMINATION.

A variety of β-substituted alkyl halides and epoxides are reductively eliminated in high yields to alkenes by Cr(II) en at room temperature The reducing agent is easily prepared in situ from chromous salts and ethylenediamine. Reductive elimination and protolytic reduction of β-substituted alkyl halides by chromous reagent proceed by similar mechanisms, and involve free radicals and alkylchromium species as intermediates. In the former process, β-substituents such as OH, OPh, OAc, tosyloxy, Br, Cl, NH2 and trimethylammonium groups are readily eliminated from the β-substituted alkylchromium intermediate to generate alkene. Protolytic reduction of the alkylchromium species is a significant competing reaction only with such β-substituents as CN, benzamido and phthalimido groups. Factors which determine the effect of groups on the relative rates of reductive elimination and protolytic reduction of the alkylchromium species are discussed. The formation of a free radical by an initial ligand transfer of halogen from the alkyl halide to chromous ion is enhanced by β-bromo and trimethylammonium groups. Neighboring group participation by these groups in homolytic processes to form bromine or trimethylammonium-bridged alkyl radicals as intermediates is postulated. Cr(II)en is a more powerful reductant than Cr(II) and the scale of relative reactivity of various halides is compressed in the former relative to the latter. o-Diiodobenzene is reduced by Cr(II)en stepwise to benzene, and benzyne does not appear to be an intermediate in the reaction. 55 references.

Tetrahedron published new progress about Elimination reaction. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Product Details of C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hayashi, Naoto published the artcileElongation of Phenoxide C-O Bonds Due to Formation of Multifold Hydrogen Bonds: Statistical, Experimental, and Theoretical Studies, SDS of cas: 127972-00-3, the main research area is elongation phenoxide carbon oxide bonds due formation multifold hydrogen.

Statistical studies using the Cambridge Structural Database have revealed that there are several elongated phenoxide C-O bonds. They are characterized by the formation of 3-fold (or occasionally 2-fold) hydrogen bonds to the phenoxide oxygen atoms, and their mean bond length extends up to 1.320 Å, which is quite different from the theor. predicted carbon-oxygen bond length of C6H5O- (1.26 Å). Elongated phenoxide C-O bonds associated with the formation of 3-fold hydrogen bonds were also observed in the X-ray structures of proton-transfer complexes (2X-O-)(TEAH+)s derived from 5′-X-substituted 5,5”-dimethyl-1,1′:3′,1”-terphenyl-2,2′,2”-triols (2X-OHs, where X = NO2, CN, COOCH3, Cl, F, H, and CH3) and triethylamine (TEA). By comparing the X-ray structures, C-O bond elongation was found to be only slightly affected by an electron-withdrawing substituent at the para position (X). This along with strong bathochromic shifts of N-H(···O-) and O-H(···O-) stretching vibrations in the IR spectra indicates that the elongated C-O bonds in (2X-O-)(TEAH+)s essentially have single-bond character. This is further confirmed by MO calculations on a model complex, showing that the neg. charged phenoxide oxygen atom is no longer conjugated to the central benzene ring, and the NICS values of the three benzene rings are virtually identical. However, C-O bond elongation in (2X-O-)(TEAH+)s was considerably influenced by a change in the hydrogen-bond geometry. This also suggests that hydrogen bonds significantly affect phenoxide C-O bond elongation.

Journal of Organic Chemistry published new progress about Bathochromic effect. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, SDS of cas: 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mizuno, Kazuhiko published the artcileA convenient synthesis of aryl vinyl ethers by use of tetrabutylammonium hydrogen sulfate, Synthetic Route of 622-86-6, the main research area is aryl vinyl ether; dehydrohalogenation haloethoxybenzene.

RC6H4OCH:CH2 (I; R = H, Me, Me3C, MeO, CN, halo, benzo) were prepared by dehydrohalogenation of RC6H4OCH2CH2X (II) in the presence of Bu4N+ HSO4- (III). Thus, 50% aqueous NaOH and 5 mmol III were added to a solution of 5 mmol II (R = 4-Me3C, X = Cl) in C6H6 and the mixture stirred 1 h at room temperature to give 97% I (R = 4-Me3C). Similarly prepared were 10 addnl. I.

Synthesis published new progress about Dehydrohalogenation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Synthetic Route of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ogata, Koki published the artcilePilot production of chrome-tanned leather without formation of hexavalent chromium by treatment with a combination of inhibitors, Related Products of ethers-buliding-blocks, the main research area is ascorbic acid inhibitor chrome tanned leather phys mech property.

A combination of inhibitors, namely a mixture of 1.0mmol of 3(2)-t-butyl-4-hydroxyanisole, 0.01 mmol of ascorbic acid, and 0.001mmol of collagen peptide exhibiting complete inhibition of C6+ formation on a laboratory-scale, was applied to produce chrome-tanned upper leather without formation of Cr6+ in the actual manufacturing line of a tanner. In this study, the following two methods were used for application of the combined inhibitor; (1) spraying with the combined inhibitor solution before finishing, using twice the volume of the dry leather weight after fat-liquoring; and (2) coating with base-coat containing the combined inhibitor before top coating in the finishing process, using twice the volume of the dry leather weight Each inhibitor-treated leather contained chem. components similar to those of typical leather produced without the combined inhibitor, and exhibited perfect inhibition of Cr6+ formation, even if heat-aged. In addition, the phys. strength of the inhibitor-treated leathers was higher than that of leather produced usually without inhibitor. In particular, the surface strength (ball burst) of the treated leathers was twice that of the untreated leather. These results indicate that this combination of inhibitors could be effectively applied to industrially produce Cr-tanned leather not only without C6+ formation but also with an improved phys. strength.

Journal of the Society of Leather Technologists and Chemists published new progress about Adhesion, physical. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Corsano, S. published the artcileNew pyridazinones: synthesis and correlation between structure and α-blocking activity, COA of Formula: C8H9ClO, the main research area is structure activity correlation pyridazinone adrenoreceptor; piperazinylpyridazinone preparation adrenoreceptor blocking.

The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinones, I (R = H, Me, Ph, R1 = Cl; R = Me, R1 = H), II (R = H, Me, Ph, R1 = Cl, R2 = H, OMe; R = R1 = H, R2 = OMe; R = Me, R1 = H, R2 = H, OMe), III (R2 = H, OMe), has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferens.

European Journal of Medicinal Chemistry published new progress about Receptors Role: RCT (Reactant), RACT (Reactant or Reagent). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, COA of Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Felix e Silva, Altiery published the artcileAntibacterial and antibiofilm activities and synergism with florfenicol from the essential oils of Lippia sidoides and Cymbopogon citratus against Aeromonas hydrophila, Product Details of C11H16O2, the main research area is Lippia Cymbopogon Aeromonas essential oils; antimicrobial; aquaculture; biofilm; carvacrol; citral.

Aeromonas hydrophila is an opportunistic bacterium, with a high capacity for biofilm production, which can cause severe damage in aquaculture. The objective of this study was to identify the chem. compounds of the essential oils of Lippia sidoides (EOLS) and Cymbopogon citratus (EOCC), and to evaluate the biocidal, antibiofilm and synergistic action with the antimicrobial florfenicol of these essential oils (EOs) against A. hydrophila. The antibacterial activity of EOLS and EOCC was verified by the min. bactericidal concentration and by the action of these EOs against both forming and consolidated biofilms. The synergistic activity of EOs with florfenicol was performed using the checkerboard technique. The main component of EOLS and EOCC was carvacrol (44.50%) and α-citral (73.56%), resp. Both EOs showed weak inhibitory activity (≥3125.00 μg ml-1). Two bacterial isolates were able to produce biofilm, and EOLS and EOCC acted upon the bacterial isolates to prevent biofilm formation. A bactericidal effect was verified for EOLS in the previously consolidated biofilm for both isolates and for EOCC in only one of the isolates. In general, EOLS had a synergistic effect with florfenicol, while EOCF had an additive effect. Both EOs were able to interfere with biofilm formation and did not have an antagonistic effect in combination with florfenicol. The best results were found for EOLS, which showed a synergistic effect with florfenicol and the ability to interfere in the formation of consolidated biofilm. This study highlights the potential of EOLS and EOCC to interfere in biofilm and act in synergy with florfenicol to reduce the occurrence of A. hydrophila. Development of these compounds may contribute to the development of herbal medicines in aquaculture.

Journal of Applied Microbiology published new progress about Aeromonas hydrophila. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reddy, S. M. published the artcileSynthesis and antimicrobial activity studies of microwave irradiated in (4-chlorophenyl)(6-methylpyridin-3-yl) derivatives, Application of 1-(4-Methoxypyridin-2-yl)ethan-1-amine, the main research area is pyrazine pyridine preparation antibacterial antifungal.

A series of pyrazine and pyridine derivatives was synthesized and evaluated for their antimicrobial activities against two gram-pos. bacteria (Staphylococcus aureus, Bacillus subtilis) and two gram-neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) and two fungi (Aspergillus niger and Aspergillus fumigatus) strains using cup plate method.

Pharma Chemica published new progress about Antibacterial agents. 58088-65-6 belongs to class ethers-buliding-blocks, name is 1-(4-Methoxypyridin-2-yl)ethan-1-amine, and the molecular formula is C8H12N2O, Application of 1-(4-Methoxypyridin-2-yl)ethan-1-amine.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pereira, Ulisses A. published the artcileInhibition of Enterococcus faecalis biofilm formation by highly active lactones and lactams analogs of rubrolides, Recommanded Product: 2-Methoxy-5-methylphenylboronic acid, the main research area is Enterococcus biofilm inhibition rubrolide analog; Anti-biofilm activity; Quorum sensing antagonist; Rubrolides; γ-Alkylidene-γ-lactams; γ-Alkylidene-γ-lactones; γ-Hydroxy-γ-lactams.

Seven β-aryl substituted γ-alkylidene-γ-lactones analogs of rubrolides were synthesized from mucobromic acid and converted through a lactamization with isobutylamine into their corresponding γ-hydroxy-γ-lactams (76-85%). These lactams were converted into (Z)- and (E)-γ-alkylidene-γ-lactams (23-45%). All compounds were fully characterized by IR, NMR (1H and 13C), COSY and HETCOR bidimensional experiments, and NOE difference spectroscopy experiments when necessary. Evaluation of these three different classes of compounds against Enterococcus faecalis biofilm formation showed that all classes are active and the highest biofilm inhibition activity was caused by lactam 13f (IC50 = 0.76 μg/mL). Moreover, in almost all cases at least one of the lactams is more active than its correspondent γ-alkylidene-γ-lactone. The use of rubrolides as a lead structure has proven successful for the identification of new compounds displaying novel antibacterial activities, namely biofilm inhibition, which have the potential for the development of antimicrobial drugs targeted to inhibition of the initial stages of bacterial infections, rather than bacterial viability. Such drugs are less prompt to induce bacterial resistance, being therefore a more cost-effective investment for pharmaceutical research.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Recommanded Product: 2-Methoxy-5-methylphenylboronic acid.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Xintong published the artcileEfficient synthesis of chiral biaryls via asymmetric Suzuki-Miyaura cross-coupling of ortho-bromo aryl triflates, Application In Synthesis of 127972-00-3, the main research area is biaryl preparation Suzuki coupling palladium benzoxaphosphole.

Efficient asym. Suzuki-Miyaura coupling of ortho-bromo aryl triflates with various arylboronic acids were described, providing a series of chiral biaryl triflates in high yields and up to 91% ee under mild conditions. The aryl triflates could be easily transformed to various chiral biaryl products by further derivatization. A one-pot tandem asym. cross-coupling/cross-coupling sequence was also achieved by using a single palladium catalyst, demonstrating the versatility of this method for preparation of chiral biaryl products. Under optimized conditions the synthesis of the target compounds was achieved using palladium(II) acetate and (2S,3S)-4-(2,6-dimethoxyphenyl)-3-(1,1-dimethylethyl)-2,3-dihydro-2-methyl-1,3-benzoxaphosphole as catalyst and ligand combination. Starting materials included 1,1,1-trifluoromethanesulfonic acid 1-bromo-2-naphthalenyl ester and B-(9-phenanthrenyl)boronic acid, B-(5-pyrenyl)boronic acid, B-(1,2-dihydro-5-acenaphthylenyl)boronic acid, B-[[1,1′-biphenyl]-2-yl]boronic acid, B-(2-formylphenyl)boronic acid. The title compounds thus formed included chiral biaryl derivatives, such as 1,1,1-trifluoromethanesulfonic acid, (1S)-[1,1′-binaphthalen]-2-yl ester.

Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Application In Synthesis of 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Karak, Milandip published the artcilePalladium-catalyzed hydrodehalogenation of butenolides: An efficient and sustainable access to β-arylbutenolides, HPLC of Formula: 127972-00-3, the main research area is arylbutenolide preparation; boronic acid halobutenolide hydrodehalogenation palladium catalyst.

Several α-unsubstituted β-arylbutenolides I (R = 4-F, 3-Cl, 4-MeO, etc.) have been prepared in 69-92% yield by reductive dehalogenation of α-halo-β-arylbutenolides. The latter were assembled in a single-step from α,β-dihalobutenolides, which are accessible on a large-scale from biomass-derived furfural. This dehalogenation protocol is illustrated by a new synthesis of the marine antibiotics rubrolide E and F, and 3”-bromorubrolide F.

Tetrahedron Letters published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, HPLC of Formula: 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem