Tag: M.W=150-200

Cerezo, Vanessa published the artcileSolid-phase synthesis of 5-arylhistidines via a microwave-assisted Suzuki-Miyaura cross-coupling, Synthetic Route of 127972-00-3, the main research area is arylhistidine peptide solid phase synthesis; bromohistidine arylboronic acid Suzuki Miyaura reaction solid phase microwave.

Microwave irradiation efficiently promoted the solid-phase Suzuki-Miyaura reaction of a 5-bromohistidine with various arylboronic acids in the presence of a palladium catalyst. This methodol. allowed the synthesis of peptides bearing a histidine residue substituted at position 5 of the imidazole ring with a Ph, a substituted Ph, a pyridyl, or a thienyl ring, as well as with the benzene ring of a tyrosine residue.

Tetrahedron published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Synthetic Route of 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yoo, Kihyun published the artcileEnantioselective synthesis of (R)-tolterodine via CuH-catalyzed asymmetric conjugate reduction, Application of 2-Methoxy-5-methylphenylboronic acid, the main research area is tolterodine asym preparation; diarylacrylonitrile stereoselective preparation conjugate reduction copper reductive amination.

An efficient and highly enantioselective method for the preparation of (R)-tolterodine (I) is described. The synthesis was performed by CuH-catalyzed asym. conjugate reduction of a β,β-diaryl-substituted unsaturated nitrile as a key step, which is prepared by a stereoselective hydroarylation of alkynenitrile with aryl boronic acid. The synthesis was accomplished without employing the protection-deprotection sequence.

Journal of Organic Chemistry published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Application of 2-Methoxy-5-methylphenylboronic acid.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zheng, Dagui published the artcileNMP-mediated chlorination of aliphatic alcohols with aryl sulfonyl chloride for the synthesis of alkyl chlorides, Name: (2-Chloroethoxy)benzene, the main research area is aliphatic alc arylsulfonyl chloride NMP chlorination; alkyl chloride preparation.

NMP-mediated chlorination of aliphatic alcs. has been developed for the synthesis of alkyl chlorides. This facile, efficient and practical approach used simple and readily available aryl sulfonyl chlorides as the chlorination reagent for the construction of C-Cl bond in good to excellent yields with mild conditions and broad substrate scope.

Synthetic Communications published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Peng-Cheng published the artcileOxidative phenol-arene and phenol-phenol cross-coupling using periodic acid, Application of 4-Hydroxy-3-tert-butylanisole, the main research area is biaryl preparation; arene phenol oxidative cross coupling reaction; phenol oxidative cross coupling reaction; naphthol phenol oxidative cross coupling reaction.

A simple, metal-free protocol for unsym. biaryl coupling using H5IO6 is reported. H5IO6 was evaluated for a novel application in the oxidative cross-coupling of phenol-arene, phenol-phenol, and phenol-naphthol compounds ROH (R = 2,6-dimethoxyphenyl, 2-naphthyl, 5,6,7,8-tetrahydronaphthalen-2-yl, etc.) and R1H (R1 = 2,4,5-trimethoxyphenyl, 2-methoxynaphth-1-yl, N,N-dibenzyl-4-aminophenyl, etc.). In this work, most of the couplings were completed within 30 min at ambient temperature 30 coupling products, e.g., 4-(2-(dimethylamino)naphthalen-1-yl)-2,6-dimethylphenol were conveniently obtained using only 0.5 equiv of H5IO6 in HFIP. A mechanism by which the transformation occurs is proposed.

Tetrahedron published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application of 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Kai published the artcileSelective demethoxylation of guaiacol to alkylphenols in supercritical methanol over a HT-MoS2 catalyst, Synthetic Route of 121-00-6, the main research area is demethoxylation guaiacol alkylphenol supercritical methanol HTMoS catalyst.

The high value-added products such as alkyl substituted phenols (A-Ps) are very important from lignin-derived feedstocks. Herein, the selective conversion of guaiacol, an important chem. of lignin-derived bio-oil, to A-Ps over hydrothermally synthesized bulk MoS2 (HT-MoS2) was examined under supercritical methanol conditions without any gaseous hydrogen input. HRTEM confirms the formation of MoS2 with the nanosheet-like structure and XPS anal. exhibited the presence of Mo5+ and S2-2 species which are likely the active species for demethoxylation (DMO) and alkylation of guaiacol. The possible reaction pathways along with their plausible intermediates of guaiacol conversion are proposed. The HT-MoS2 catalyst can be reused up to 4 catalytic runs without loss of its catalytic activity.

Catalysis Today published new progress about Alkylphenols Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Synthetic Route of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tian, Qingqiang published the artcileSelective C-F Bond Etherification of Trifluoromethylalkenes with Phenols, Quality Control of 121-00-6, the main research area is phenoxydifluoromethyl alkene preparation chemoselective insecticidal mol docking.

A novel protocol for the C-F bond etherification of trifluoromethylalkenes and phenols was reported. A variety of alkenyl difluoroaryloxy ethers were obtained with good chemoselectivity and functional group tolerance. DFT calculation results and control experiments suggested that metal ion Cs+ might be involved in this defluorooxylation. Furthermore, the desired product exhibited a good insecticidal activity.

Journal of Organic Chemistry published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Seoyoung published the artcileNickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides, SDS of cas: 622-86-6, the main research area is chloroarene alkyl chloride nickel pyridine biscyanocarboxamidine cross electrophile coupling; alkylarene preparation.

Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross-electrophile coupling of aryl chlorides with alkyl chlorides has remained a challenge. We report here the first general approach to this transformation. The key to productive, selective cross-coupling is the use of a small amount of iodide or bromide along with a recently reported ligand, pyridine-2,6-bis(N-cyanocarboxamidine) (PyBCamCN). The scope of the reaction is demonstrated with 35 examples (63 ± 16% average yield), and we show that the Br- and I- additives act as cocatalysts, generating a low, steady-state concentration of more-reactive alkyl bromide/iodide.

Journal of the American Chemical Society published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Yandong published the artcileElectrochemical Cross-Dehydrogenative Coupling between Phenols and β-Dicarbonyl Compounds: Facile Construction of Benzofurans, COA of Formula: C11H16O2, the main research area is benzofuran preparation; phenol beta dicarbonyl electrochem cross dehydrogenative coupling cyclocondensation; benzofurans; cross-dehydrogenative coupling; electrochemistry; phenols; reaction mechanisms.

Preparative electrochem. synthesis is an ideal method for establishing green, sustainable processes. The major benefits of an electro-organic strategy over that of conventional chem. synthesis are the avoidance of reagent waste and mild reaction conditions. Here, an intermol. cross-dehydrogenative coupling between phenols and β-dicarbonyl compounds has been developed to build various benzofurans under undivided electrolytic conditions. Neither transition metals nor external chem. oxidants are required to facilitate the dehydrogenation and dehydration processes. The key factor in success was the use of nBu4NBF4 as the electrolyte and hexafluoroisopropanol as the solvent, which play key roles in the cyclocondensation step. This electrolysis is scalable and can be used as a key step in drug synthesis. On the basis of several exptl. results, the mechanism, particularly of the remarkable anodic oxidation and cyclization process, was illustrated.

Chemistry – A European Journal published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kamitanaka, Tohru published the artcile[3+2] Coupling of Quinone Monoacetals with Vinyl Ethers Effected by Tetrabutylammonium Triflate: Regiocontrolled Synthesis of 2-Oxygenated Dihydrobenzofurans, SDS of cas: 121-00-6, the main research area is dihydrobenzofuran preparation diastereoselective regioselective; quinone monoacetal vinyl ether coupling tetrabutylammonium triflate catalyst.

The synthesis of 2-oxygenated dihydrobenzofurans I (R = H, Me, t-Bu, OMe, NHAc; R1 = H, Me, t-Bu; R2 = Me, Et; R3 = H, OMe; X = -CH2-, -O-; n = 0, 1), II (R4 = Et, i-Pr; R5 = H, Me) involving the [3+2] coupling of quinone monoacetals III with vinyl ethers IV has been realized by tetrabutylammonium triflate catalysis. The reaction involves a new activation method of the acetal moiety in quinone monoacetals III under acid-free conditions affording the highly oxygenated dihydrobenzofurans I, II. This new activation mode was achieved by using the triflate anion catalyst for stabilization of the highly reactive cationic intermediate.

Organic Letters published new progress about [3+2] Cycloaddition reaction catalysts (regio-, stereoselective). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, SDS of cas: 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jang, Doo Ok published the artcileHighly selective catalytic Friedel-Crafts acylation and sulfonylation of activated aromatic compounds using indium metal, Computed Properties of 622-86-6, the main research area is arene catalytic Friedel Crafts acylation acid chloride indium activator; sulfonyl chloride aryl sulfonylation arene indium activator; aryl ketone preparation selective; sulfone aryl preparation selective.

The Friedel-Crafts acylation of activated benzenes with various aromatic and aliphatic acid chlorides was studied in the presence of indium metal. The reaction was accomplished in high isolated yields under solvent or solvent-less conditions. The method is also applicable for preparing diaryl sulfones from aromatic compounds and aryl sulfonyl chlorides.

Tetrahedron Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Computed Properties of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem