Tag: M.W=150-200

Kim, Yong-Hak published the artcileDegradation of alkyl ethers, aralkyl ethers, and dibenzyl ether by Rhodococcus sp. strain DEE5151, isolated from diethyl ether-containing enrichment cultures, Application In Synthesis of 622-86-6, the main research area is Rhodococcus ether biodegradation.

Twenty strains isolated from sewage sludge were found to degrade various ethers, including alkyl ethers, aralkyl ethers, and dibenzyl ether. In Rhodococcus strain DEE5151, induction of ether degradation needed substrates exhibiting at least one unsubstituted Cα-methylene moiety as the main structural prerequisite. The cleavage reaction observed with anisole, phenetole, and dibenzyl ether indicates that the initial oxidation occurs at such resp. Cα positions. Di-Et ether-induced strain DEE5151 degraded dibenzyl ether via intermediately accumulated benzoic acid. Phenetole seems to be subject also to another ether-cleaving enzyme. Other strains of this group showed different enzymic activities towards the substrate classes investigated.

Applied and Environmental Microbiology published new progress about Aromatic ethers Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application In Synthesis of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Davies, Christopher J. published the artcileUse of Suzuki cross-coupling as a route to 2-phenoxy-6-iminopyridines and chiral 2-phenoxy-6-(methanamino)pyridines, Related Products of ethers-buliding-blocks, the main research area is anisyl boronic acid carbonyl bromopyridine Suzuki coupling; phenoxycarbonylpyridine derivative preparation diisopropylaniline imination; phenoxyiminopyridine derivative preparation crystal structure methyllithium nucleophilic addition reduction; pyridine phenoxyimino derivative preparation trimethylaluminum nucleophilic addition reduction; methanaminopyridine phenoxy derivative preparation crystal structure.

The anisyl boronic acids I (R1 = R2 = H; R1 = H, R2 = Ph; R1 = Me, R2 = H; R1 = Cl, R2 = H; R1 = t-Bu, R2 = H), have been employed in Suzuki cross-coupling reactions with either 2-bromo-6-formylpyridine or 2-bromo-6-acetylpyridine generating, following a facile deprotection step, the 2-phenoxy-6-carbonylpyridines II (R1 = R2 = H; R1 = Me, R2 = H; R1 = Cl, R2 = H; R1 = t-Bu, R2 = H) and III (R1 = R2 = H; R1 = H, R2 = Ph). Condensation reactions of II and III with 2,6-diisopropylaniline proceed smoothly to give the corresponding 2-phenoxy-6-iminopyridines. Reduction of the imino unit of the imines derived from II (and concomitant C-C bond formation) can be achieved by treatment with trimethylaluminum or methyllithium which, following hydrolysis, furnishes the racemic chiral 2-phenoxy-6-(methanamino)pyridines IV (R1 = R2 = H; R1 = Me, R2 = H; R1 = Cl, R2 = H; R1 = t-Bu, R2 = H). This work represents a straightforward and rapid synthetic route to libraries of sterically and electronically variable phenoxy-substituted imino- and methanamino-pyridines, which are expected to act as useful ligands or proligands for late and early transition metal-mediated alkene polymerization catalysis.

Tetrahedron published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation) (pyridinylmethyl). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Purtsas, Alexander published the artcileIron-Catalyzed Oxidative C-O and C-N Coupling Reactions Using Air as Sole Oxidant, Application In Synthesis of 121-00-6, the main research area is tertiary arylamine phenol hexadecafluorophthalocyanine iron catalyst regioselctive oxidative coupling; diaryl ether preparation; phenothiazine tertiary arylamine hexadecafluorophthalocyanine iron catalyst regioselctive oxidative coupling; phenothiazinyl aryl amine preparation; phenolphenothiazine hexadecafluorophthalocyanine iron catalyst regioselctive oxidative coupling; phenothiazinylphenol preparation; C−H activation; air; homogeneous catalysis; iron; oxidative amination.

The oxygenation of tertiary arylamines, and the amination of tertiary arylamines and phenols was described. The key step of these coupling reactions was an iron-catalyzed oxidative C-O or C-N bond formation which generally provides the corresponding products in high yields and with excellent regioselectivity. The transformations were accomplished using hexadecafluorophthalocyanine-iron(II) (FePcF16) as catalyst in the presence of an acid or a base additive and require only ambient air as sole oxidant.

Chemistry – A European Journal published new progress about Aromatic ethers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yue, Yuanyuan published the artcileElectrooxidative double C-H/C-H coupling of phenols with 3-phenylbenzothiophenes: facile access to benzothiophene derivatives, Computed Properties of 121-00-6, the main research area is benzothiophene preparation; phenol phenylbenzothiophene electrooxidative oxidant catalyst free.

An efficient electrooxidative double C-H/C-H coupling of phenols with 3-phenylbenzothiophene has been developed under external oxidant- and catalyst-free conditions. This strategy could enable the highly tunable access to benzothiophene derivatives and exhibited broad substrate generality under mild conditions. The reaction is likely to proceed via the cross-coupling of the p-methoxylphenol radical and the 3-phenylbenzothiophene radical cation.

Organic & Biomolecular Chemistry published new progress about Electrooxidative coupling reaction. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Computed Properties of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hodgetts, Kevin J. published the artcileDiscovery of N-(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1) Receptor Antagonist, Application In Synthesis of 127972-00-3, the main research area is pyrazine preparation SAR CRF 1 receptor antagonist; orally active corticotropin releasing factor 1 receptor antagonist.

The design, synthesis, and structure-activity relationships of a novel series of pyrazines, acting as corticotropin releasing factor-1 (CRF-1) receptor antagonists, are described. Synthetic methodologies were developed to prepare a number of substituted pyrazine cores utilizing regioselective halogenation and chemoselective derivatization. Noteworthy, an efficient 5-step synthesis was developed for the lead compound I (NGD 98-2), which required no chromatog. Compound I was characterized as an orally bioavailable, brain penetrant, and highly selective CRF-1 receptor antagonist. Occupancy of rat brain CRF-1 receptors was quantified using ex vivo receptor occupancy assays, using both brain tissue homogenates as well as brain slices receptor autoradiog. Behaviorally, oral administration of I significantly antagonized CRF-induced locomotor activity at doses as low as 10 mg/kg and dose-dependently reduced the restraint stress-induced ACTH increases.

Journal of Medicinal Chemistry published new progress about Homo sapiens. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Application In Synthesis of 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Limberger, Jones published the artcileStereoselective synthesis of (E)-3,3-diaryl and (E)-3-aryl-3-aryloxy allylamines and allylalcohols from trans-cinnamyl chloride and alcohol, Formula: C8H11BO3, the main research area is diaryl allylamine regioselective diastereoselective preparation Suzuki coupling; aryl aryloxy allylamine regioselective diastereoselective preparation Ullmann coupling; allylalc diaryl regioselective diastereoselective preparation Suzuki coupling; aryloxy aryl allylalc regioselective diastereoselective preparation Ullmann coupling.

The regio and stereoselective synthesis of (E)-3,3-diaryl and (E)-3-aryl-3-aryloxy allylamines and allylalcs was described. The starting materials were the non-expensive com. available cinnamyl alc. and chloride. The bromination/dehydrobromination sequence furnished the (E)-3-bromo-3-phenylallyl amines and alc. as single regioisomers and with high stereoselectivity (>98%). These vinyl bromides were used as substrates in cross-coupling reactions furnishing the arylated products with good to excellent yields and total E-configuration retention. Regio and stereospecifically trisubstituted olefins and vinyl ethers by Suzuki cross-coupling and Ullmann vinylation were produced.

RSC Advances published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Formula: C8H11BO3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cerezo, Vanessa published the artcileSynthesis of 5-arylhistidines via a Suzuki-Miyaura cross-coupling, Synthetic Route of 127972-00-3, the main research area is histidine aryl regioselective synthesis microwave irradiation arylation bromination; bromohistidine Suzuki Miyaura cross coupling arylboronic acid palladium catalyst.

Microwave irradiation efficiently promoted the Suzuki-Miyaura reaction of a 5-bromohistidine with various arylboronic acids in the presence of a palladium catalyst. This methodol. allowed the synthesis of histidines substituted at position 5 of the imidazole ring with a Ph, a substituted Ph, a pyridyl or a thienyl ring. The corresponding 5-arylhistidines were obtained in moderate to good yields.

Tetrahedron published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Synthetic Route of 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pontillo, Joseph published the artcileSynthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor, Safety of 2-Methoxy-5-methylphenylboronic acid, the main research area is gonadotropin releasing hormone receptor antagonist aryl triazinedione preparation; aza uracil triazinedione preparation preparation gonadotropin releasing hormone receptor.

Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds One compound was identified as potent gonadotropin-releasing hormone receptor antagonist from this series.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship (gonadotropin-releasing hormone receptor antagonistic). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Safety of 2-Methoxy-5-methylphenylboronic acid.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

De Smet, Gilles published the artcileSelective Nickel-Catalyzed Hydrodeacetoxylation of Aryl Acetates, Related Products of ethers-buliding-blocks, the main research area is aromatic alc magnesium catalyst acetoxylation; aryl acetate preparation nickel catalyst chemoselective hydrodeacetoxylation green chem; anisole preparation; Aryl Acetates; C−O Bond Activation; Hydrodeacetoxylation; Nickel Catalysis; Renewable Resources.

Ni-catalyzed hydrodeacetoxylation of aryl acetates (Ar-OAc) with HBpin in a green carbonate solvent selectively delivered the corresponding deoxygenated arenes (ArH). The method was also applicable to highly challenging guaiacyl and syringyl acetates, leaving -OMe groups intact without arene reduction Renewable 4-propylguaiacol obtained from pine could also be transformed without significant loss in yield vs. oil derived feedstock. The observed chemoselectivity for Ar-OAc vs. ArO-Ac bond cleavage was rationalized based on mechanistic experiments and DFT calculations ArOH side-product formation was attributed to direct competitive Ni-catalyzed reduction of the C=O bond. Hydrodeacyloxylation of a set of aryl alkanoates featured interesting chemoselectivity with a dramatic influence of the length and structure of the alkyl chain on catalysis.

Angewandte Chemie, International Edition published new progress about Aromatic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palvoelgyi, Adam Mark published the artcileCounterion-Enhanced Pd/Enamine Catalysis: Direct Asymmetric α-Allylation of Aldehydes with Allylic Alcohols by Chiral Amines and Achiral or Racemic Phosphoric Acids, Product Details of C11H16O2, the main research area is aldehyde allyl alc palladium phosphoric acid amine chiral allylation; enal stereoselective preparation.

We report a straightforward and efficient Pd/enamine catalytic procedure for the direct asym. α-allylation of branched aldehydes. The use of simple chiral amines and easily prepared achiral or racemic phosphoric acids, together with a suitable Pd-source resulted in a highly active and enantioselective catalyst system for the allylation of various α-branched aldehydes with different allylic alcs. The reported procedure could provide an easy access to both product antipodes. Furthermore, two possible orthogonal derivatizations of the enantioenriched aldehydes were performed without any decrease in enantioselectivity.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem