Tag: M.W=150-200

Di Franco, Thomas published the artcileSynthesis of E-Alkyl Alkenes from Terminal Alkynes via Ni-Catalyzed Cross-Coupling of Alkyl Halides with B-Alkenyl-9-borabicyclo[3.3.1]nonanes, Category: ethers-buliding-blocks, the main research area is alkene preparation; alkyl halide alkenylborabicyclononane Suzuki Miyaura coupling Ni catalyst.

The first Ni-catalyzed Suzuki-Miyaura coupling of alkyl halides with alkenyl-(9-BBN) reagents is reported. Both primary and secondary alkyl halides including alkyl chlorides can be coupled. The coupling method can be combined with hydroboration of terminal alkynes, allowing the expedited synthesis of functionalized alkyl alkenes from readily available alkynes with complete (E)-selectivity in one pot. The method was applied to the total synthesis of (±)-Recifeiolide, a natural macrolide.

Organic Letters published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hameury, Sophie published the artcileBis(ether-functionalized NHC) Nickel(II) Complexes, Trans to Cis Isomerization Triggered by Water Coordination, and Catalytic Ethylene Oligomerization, SDS of cas: 622-86-6, the main research area is crystal structure imidazolylidene nickel preparation conformer oligomerization catalyst ethylene; mol structure imidazolylidene nickel preparation conformer oligomerization catalyst ethylene.

The new Ni(II) complexes containing NHC ligands N-substituted by a CH2CH2OR ether group (R = Me or Ph) [NiCl2{ImMes(C2OMe)}2] (6, Im = C3H2N2; Mes = mesityl; C2OMe = CH2CH2OMe), [NiCl2{ImBu(C2OMe)}2] (7), [NiBr2{ImDiPP(C2OMe)}2] (8, Dipp = 2,6-diisopropylphenyl), [NiBr2{ImMes(C2OMe)}2] (9), [NiBr2{ImBu(C2OMe)}2] (10), [NiBr2{ImMes(C2OPh)}2] (18; C2OPh = CH2CH2OPh), [NiI2{ImDiPP(C2OMe)}2] (21), [NiI2{ImMes(C2OMe)}2] (22), and [NiI2{ImBu(C2OMe)}2] (23) were synthesized in good yields and fully characterized by NMR spectroscopy and x-ray diffraction anal. The reaction conditions were optimized and further applied to thioether or nonfunctionalized NHC ligands, affording [NiBr2{ImDiPP(C2SPh)}2] (19, C2SPh = CH2CH2SPh) and [NiBr2{ImDiPPBu}2] (20), resp. Equilibrium involving syn/anti isomers were unveiled for complexes [NiCl2{ImDiPP(C2OMe)}2] (5), 6-10, and 18-23. Reactions of 6 and 20 with a halide abstractor afforded the dicationic aquo complexes cis-[Ni{ImMes(C2OMe)}2(H2O)2][PF6]2 (27) and cis-[Ni{ImDiPPBu}2(H2O)2][PF6]2 (28), in which a cis arrangement of the carbene ligands is evidenced, which contrasts with that in their precursors. These mols. represent rare examples of Ni aquo NHC complexes and of complexes with two cis monodentate NHC ligands. The new complexes reported in this work (15 crystal structures) displayed moderate activities as precatalysts for ethylene oligomerization and favored dimerization.

Organometallics published new progress about Aluminoxanes, Me Role: CAT (Catalyst Use), USES (Uses). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Khalaf, Juhienah published the artcileDesign, Synthesis, and Diversification of 3,5-Substituted Enone Library, Quality Control of 127972-00-3, the main research area is enone combinatorial library preparation; bromoenone preparation boronic acid Suzuki coupling; terminal alkyne bromoenone Sonogashira coupling; triazole preparation.

This paper describes the synthesis of a 300 member library of 3,5-substituted enones, e.g., I. The synthesis starts with six different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Addnl. a small series of triazoles, e.g., II, were synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component anal. to examine its diversity.

ACS Combinatorial Science published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Quality Control of 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Zhao published the artcileAsymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination, Safety of 2-Methoxy-5-methylphenylboronic acid, the main research area is amine rhodium catalyst tandem chemoselective enantioselective reductive amination.

A general asym. route for the one-pot synthesis of chiral γ-branched amines through the highly enantioselective isomerization of allylamines, followed by enamine exchange and subsequent chemoselective reduction was reported. This protocol was suitable for establishing various tertiary stereocenters, including those containing dialkyl, diaryl, cyclic, trifluoromethyl, difluoromethyl, and silyl substituents, which allowed for a rapid and modular synthesis of many chiral γ-branched amines. To demonstrate the synthetic utility, Terikalant and Tolterodine were synthesized using this method with high levels of enantioselectivity.

Nature Communications published new progress about Amines, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Safety of 2-Methoxy-5-methylphenylboronic acid.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Erkin, A. V. published the artcileAryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms, Safety of (2-Chloroethoxy)benzene, the main research area is hydroxyethylsulfanyl pyrimidine aryl ether hydrochloride salt preparation fungicidal activity.

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

Russian Journal of General Chemistry published new progress about Fungicides. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Safety of (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Minjian published the artcileDesign, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton’s tyrosine kinase (BTK) inhibitors, Safety of 3-Phenoxyazetidine hydrochloride, the main research area is pyrrolopyrimidine preparation Brutons tyrosine kinase mol docking antitumor activity; B-Cell lymphomas; BTK inhibitor; Kinase selectivity.

Here, four key regions where inhibitors bind to BTK were identified by analyzing the existing crystal structures of BTK complexes. Then, a scaffold-based mol. design work flow was established by integrating fragment-growing method, deep learning-based framework XGraphBoost and mol. docking, leading to four compounds that showed potency against BTK. Optimization of compounds I and II led to the discovery of the potent BTK inhibitor compound III by using in vitro potency and pharmacokinetic (PK) studies to prioritize the compounds Compound III exhibited great BTK inhibition activity (IC50 = 0.7 nM) along with high oral absorption. Moreover, compound III demonstrated excellent kinase selectivity, especially over EGFR kinase, and low toxicity. In a TMD8 xenograft model, compound III significantly inhibited tumor growth (TGI = 104%) at a dosage of 50 mg/kg, indicating its potential as a novel therapeutic option for B-cell lymphomas.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 301335-39-7 belongs to class ethers-buliding-blocks, name is 3-Phenoxyazetidine hydrochloride, and the molecular formula is C9H12ClNO, Safety of 3-Phenoxyazetidine hydrochloride.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ting, Pauline C. published the artcileThe synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists, Name: (2-Chloroethoxy)benzene, the main research area is benzimidazolyl piperidinylcarbonyl piperidine preparation; H3 receptor antagonist structure activity human.

A structure-activity relationship study of the lead piperazinylcarbonylpiperidine I, resulted in the identification of 4-benzimidazolyl-piperidinylcarbonyl-piperidine II, as a histamine-3 (H3) receptor antagonist. Addnl. optimization of II led to the identification of compounds e.g., III with good in vivo activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Histamine H3 receptor antagonists. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Niederer, Kyle A. published the artcileOxidative photocatalytic homo- and cross-coupling of phenols: Nonenzymatic, catalytic method for coupling tyrosine, Quality Control of 121-00-6, the main research area is phenol homo cross coupling oxidative photocatalytic method safety eyewear; oxidation potential nucleophilicity homo cross coupling reaction mechanism; tyrosine coupling cyclic voltammetry fluorescence quenching crystal structure; Oxidative coupling; cross-coupling; phenol coupling; photocatalysis; tyrosine dimerization.

An oxidative photocatalytic method for phenol-phenol homo- and cross-coupling is described, and isolated yields of 16-97% are obtained. Measured oxidation potentials and computed nucleophilicity parameters support a mechanism of nucleophilic attack of one partner onto the oxidized neutral radical form of the other partner. Our understanding of this model permitted the development of cross-coupling reactions between nucleophilic phenols/arenes and easily oxidized phenols with high selectivity and efficiency. A highlight of this method is that one equivalent of each coupling partner is utilized. Building on these findings, a nonenzymic, catalytic method for coupling tyrosine was also developed. Due to the high intensity of the light source it is highly recommended that impact resistant sunglasses be worn when placing a reaction in the photochem. bay.

ACS Catalysis published new progress about Cross-coupling reaction. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gupta, Ramesh C. published the artcileNovel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor, Category: ethers-buliding-blocks, the main research area is piperidine cyanothiazolidinoylmethyl hydrazino derivative preparation dipeptidyl peptidase inhibition activity; hydrazinopiperidine DPPIV inhibitor structure activity relationship insulin release stimulator.

A novel class of N-substituted 4-hydrazino piperidine derivatives containing chiral cyanothiazolidinoyl moieties were designed, synthesized and evaluated for DPP IV inhibition. The SAR studies on the N-substituted piperidines led to the discovery of compound I as a potent DPP IV inhibitor (IC50 88 nM), which is highly selective over other peptidases. In vivo efficacy indicates that compound I stimulates insulin release in response to glucose load and improves glucose tolerance in n5-STZ and Zucker Diabetic Fatty (ZDF) rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrazines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Junhui published the artcileComparative (co-)pyrolytic performances and by-products of textile dyeing sludge and cattle manure: Deeper insights from Py-GC/MS, TG-FTIR, 2D-COS and PCA analyses, Category: ethers-buliding-blocks, the main research area is kinetic copyrolysis gas char textile dyeing sludge cattle manure; Cattle manure; Char functional groups; Gaseous products; Kinetics; Textile dyeing sludge.

Not only does pyrolysis recover energy and value-added byproducts but also reduces waste stream volume The low volatiles and high ash contents of textile dyeing sludge (TDS) limit its mono-pyrolysis performance. This study aimed to conduct an in-depth anal. of its co-pyrolytic performance with cattle manure (CM). The co-pyrolysis enhanced the volatiles emission from the early devolatilization stage whose reaction mechanism shifted from a diffusion model to a reaction-order model. The further cracking of macromol. materials was mainly elucidated by the reaction-order model. The temperature dependency of the co-pyrolytic gases was of the following order: aliphatic hydrocarbons > CO2 > alcs., phenols, ethers, aldehydes, ketones, and carboxylic acids. The main co-pyrolytic volatile products were coumaran and 4-vinylguaiacol. The relative content of guaiacol-type components could be enhanced by co-pyrolysis and lowering the operational temperature to 450°C. The interaction of co-pyrolysis enriched the char aromaticity. Our findings provide practical insights into the control and application opportunities and limitations on the high value-added energy and products from the co-pyrolysis of TDS and CM.

Journal of Hazardous Materials published new progress about Alcohols Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), FORM (Formation, Nonpreparative), PROC (Process). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem