Tag: M.W=150-200

Ting, Pauline C. published the artcileThe synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists, Name: (2-Chloroethoxy)benzene, the main research area is benzimidazolyl piperidinylcarbonyl piperidine preparation; H3 receptor antagonist structure activity human.

A structure-activity relationship study of the lead piperazinylcarbonylpiperidine I, resulted in the identification of 4-benzimidazolyl-piperidinylcarbonyl-piperidine II, as a histamine-3 (H3) receptor antagonist. Addnl. optimization of II led to the identification of compounds e.g., III with good in vivo activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Histamine H3 receptor antagonists. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Niederer, Kyle A. published the artcileOxidative photocatalytic homo- and cross-coupling of phenols: Nonenzymatic, catalytic method for coupling tyrosine, Quality Control of 121-00-6, the main research area is phenol homo cross coupling oxidative photocatalytic method safety eyewear; oxidation potential nucleophilicity homo cross coupling reaction mechanism; tyrosine coupling cyclic voltammetry fluorescence quenching crystal structure; Oxidative coupling; cross-coupling; phenol coupling; photocatalysis; tyrosine dimerization.

An oxidative photocatalytic method for phenol-phenol homo- and cross-coupling is described, and isolated yields of 16-97% are obtained. Measured oxidation potentials and computed nucleophilicity parameters support a mechanism of nucleophilic attack of one partner onto the oxidized neutral radical form of the other partner. Our understanding of this model permitted the development of cross-coupling reactions between nucleophilic phenols/arenes and easily oxidized phenols with high selectivity and efficiency. A highlight of this method is that one equivalent of each coupling partner is utilized. Building on these findings, a nonenzymic, catalytic method for coupling tyrosine was also developed. Due to the high intensity of the light source it is highly recommended that impact resistant sunglasses be worn when placing a reaction in the photochem. bay.

ACS Catalysis published new progress about Cross-coupling reaction. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gupta, Ramesh C. published the artcileNovel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor, Category: ethers-buliding-blocks, the main research area is piperidine cyanothiazolidinoylmethyl hydrazino derivative preparation dipeptidyl peptidase inhibition activity; hydrazinopiperidine DPPIV inhibitor structure activity relationship insulin release stimulator.

A novel class of N-substituted 4-hydrazino piperidine derivatives containing chiral cyanothiazolidinoyl moieties were designed, synthesized and evaluated for DPP IV inhibition. The SAR studies on the N-substituted piperidines led to the discovery of compound I as a potent DPP IV inhibitor (IC50 88 nM), which is highly selective over other peptidases. In vivo efficacy indicates that compound I stimulates insulin release in response to glucose load and improves glucose tolerance in n5-STZ and Zucker Diabetic Fatty (ZDF) rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrazines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Junhui published the artcileComparative (co-)pyrolytic performances and by-products of textile dyeing sludge and cattle manure: Deeper insights from Py-GC/MS, TG-FTIR, 2D-COS and PCA analyses, Category: ethers-buliding-blocks, the main research area is kinetic copyrolysis gas char textile dyeing sludge cattle manure; Cattle manure; Char functional groups; Gaseous products; Kinetics; Textile dyeing sludge.

Not only does pyrolysis recover energy and value-added byproducts but also reduces waste stream volume The low volatiles and high ash contents of textile dyeing sludge (TDS) limit its mono-pyrolysis performance. This study aimed to conduct an in-depth anal. of its co-pyrolytic performance with cattle manure (CM). The co-pyrolysis enhanced the volatiles emission from the early devolatilization stage whose reaction mechanism shifted from a diffusion model to a reaction-order model. The further cracking of macromol. materials was mainly elucidated by the reaction-order model. The temperature dependency of the co-pyrolytic gases was of the following order: aliphatic hydrocarbons > CO2 > alcs., phenols, ethers, aldehydes, ketones, and carboxylic acids. The main co-pyrolytic volatile products were coumaran and 4-vinylguaiacol. The relative content of guaiacol-type components could be enhanced by co-pyrolysis and lowering the operational temperature to 450°C. The interaction of co-pyrolysis enriched the char aromaticity. Our findings provide practical insights into the control and application opportunities and limitations on the high value-added energy and products from the co-pyrolysis of TDS and CM.

Journal of Hazardous Materials published new progress about Alcohols Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), FORM (Formation, Nonpreparative), PROC (Process). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

He, Zhen published the artcileSulfoxide-mediated oxidative cross-coupling of phenols, Quality Control of 121-00-6, the main research area is phenol nucleophile sulfoxide mediator oxidative cross coupling regioselective; arylphenol preparation; benzofuran preparation; hydroxy teraryl preparation.

A metal-free, oxidative coupling of phenols with various nucleophiles, including arenes, 1,3-diketones and other phenols was reported. Cross-coupling was mediated by a sulfoxide which inverts the reactivity of the phenol partner. Crucially, the process showed high selectivity for cross-vs. homo-coupling and allowed efficient access to a variety of aromatic scaffolds including biaryls, benzofurans and through an iterative procedure aromatic oligomers.

Chemical Science published new progress about Benzofurans Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nilsson, Aake published the artcileElectrolytically initiated selective aliphatic hydrogen exchange in 4-isopropylanisole, Product Details of C10H14O, the publication is Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1988), B42(6), 378-83, database is CAplus.

Anodic oxidation of 4-isopropylanisole in CF₃COOH-d was observed to promote the exchange of the Me H of the iso-Pr group. No aliphatic H exchange was detected when 2-isopropylanisole and 4-ethylanisole were treated in the same way. Oxidation products from constant potential electrolysis of 4-isopropylanisole and 2-isopropylanisole were identified.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Singh, Bhagat published the artcileReduced Phenalenyl in Catalytic Dehalogenative Deuteration and Hydrodehalogenation of Aryl Halides, HPLC of Formula: 93-04-9, the publication is Journal of Organic Chemistry (2021), 86(10), 7242-7255, database is CAplus and MEDLINE.

Dehalogenative deuteration reactions are generally performed through metal-mediated processes. This report demonstrates a mild protocol for hydrodehalogenation and dehalogenative deuteration of aryl/heteroaryl halides (39 examples) using a reduced odd alternant hydrocarbon phenalenyl under transition metal-free conditions and has been employed successfully for the incorporation of deuterium in various biol. active compounds The combined approach of exptl. and theor. studies revealed a single electron transfer-based mechanism.

Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C65H82N2O18S2, HPLC of Formula: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Katoh, Takahiro published the artcileSynthesis of DL-standishinal and its related compounds for the studies on structure-activity relationship of inhibitory activity against aromatase, Related Products of ethers-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2007), 15(7), 2736-2748, database is CAplus and MEDLINE.

DL-Standishinal (I), an aromatase inhibitor isolated from Thuja standishii, was synthesized in 15 steps from p-formylanisole via an acid catalyzed aldol reaction of (±)-12-hydroxy-6,7-secoabieta-8,11,13-trien-6,7-dial (II). It was found that the aldol condensation of II proceeded in excellent yield with the protonic catalyst such as d-camphorsulfonic acid in CH₂Cl₂. Moreover, structure-activity relationship of I and its related compounds, such as (±)-O-methylferruginol (III), was studied, and it was revealed that the isomers having cis-configuration on the A/B-ring generally exhibited more potent inhibitory activities against aromatase than those with trans-configuration.

Bioorganic & Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Samir Ali, Sameh published the artcileExploring the potential of a newly constructed manganese peroxidase-producing yeast consortium for tolerating lignin degradation inhibitors while simultaneously decolorizing and detoxifying textile azo dye wastewater, Formula: C9H10O4, the publication is Bioresource Technology (2022), 126861, database is CAplus and MEDLINE.

MnP-YC4, a newly constructed manganese peroxidase-producing yeast consortium, has been developed to withstand lignin degradation inhibitors while degrading and detoxifying azo dye. MnP-YC4 tolerance to major biomass-derived inhibitors was promising. MnP induced by lignin was found to be highly related to dye decolorization by MnP-YC4. Simulated azo dye-containing wastewater supplemented with a lignin co-substrate (3,5-Dimethoxy-4-hydroxybenzaldehyde) decolorized up to 100, 91, and 76% at final concentrations of 20, 40, and 60%, resp. MnP-YC4 effectively decolorized the real textile wastewater sample, reaching up to 91.4%, and the COD value decreased significantly during the decolorization, reaching 7160 mg/l within 7 days. A possible dye biodegradation pathway was proposed based on the degradation products identified by UV-vis, FTIR, GC/MS, and HPLC techniques, beginning with azo bond cleavage and eventually mineralized to CO₂ and H₂O. When compared to the phytotoxic original dye, the phytotoxicity of MnP-YC4 treated dye-containing wastewater samples confirmed the nontoxic nature.

Bioresource Technology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Category: ethers-buliding-blocks.

Zhao, Ke;Du, Yu;Peng, Qiong;Yu, Wen-Hao;Wang, Bi-Qin;Feng, Chun;Xiang, Shi-Kai research published 《 Regiodivergent C-H Arylation of Triphenylene Derivatives Controlled by Electronic Effects of Diaryliodonium Salts》, the research content is summarized as follows. A regiodivergent C-H arylation of triphenylene derivatives with diaryliodonium salts was developed. The regiodivergence was controlled by electronic effects of diaryliodonium salts. When the aryl(mesityl)iodonium salts bearing strong electron-donating groups at the para-position of aryl groups were used, the arylation reactions occurred ortho to amide groups. However, if the aryl(mesityl)iodonium salts bearing electron-withdrawing groups or weak electron-donating groups at the para-position of aryl groups were utilized, the arylation reactions occurred meta to amide groups.

Category: ethers-buliding-blocks, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem