Tag: M.W=150-200

Adams, Theodore C.; Combs, Donald W.; Daves, G. Doyle Jr.; Hauser, Frank M. published the artcile< 7-Amino-5-(methylamino)heptanoic acid: a potential putrescine hapten>, Electric Literature of 52244-70-9, the main research area is heptanoic acid amino aminomethyl; aminoheptanoic acid aminomethyl.

H2N(CH2)2CH(CH2NH2)(CH2)3CO2H was prepared in three steps from R(CH2)3CHO (R = C6H4OMe-4, CH:CH2, CCH) by condensation with NCCH2CO2Et and KCN to form R(CH2)3CH(CN)CH2CN. Oxidation of the latent carboxyl substituent R and catalytic reduction of the succinonitrile groups completed the synthesis.

Journal of Organic Chemistry published new progress about 52244-70-9. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger published the artcile< Development of a New Class of Nonimidazole Histamine H3 Receptor Ligands with Combined Inhibitory Histamine N-Methyltransferase Activity>, COA of Formula: C11H16O2, the main research area is piperidinoalkanamine derivative preparation histamine receptor methyltransferase.

In search of novel ways to enhance histaminergic neurotransmission in the central nervous system, a new class of nonimidazole histamine H3 receptor ligands were developed that simultaneously possess strong inhibitory activity on the main histamine metabolizing enzyme, histamine N-methyltransferase (HMT). The novel compounds contain an aminoquinoline moiety, which is an important structural feature for HMT inhibitory activity, connected by different spacers to a piperidino group (for H3 receptor antagonism). Variation of the spacer structure provides two different series of compounds One series, having only an alkylene spacer between the basic centers, led to highly potent HMT inhibitors with moderate to high affinity at human histamine H3 receptors. The second series possesses a p-phenoxypropyl spacer, which may be extended by another alkylene chain. This latter series also showed strong inhibitory activity on HMT, and in most cases, the H3 receptor affinity even surpassed that of the first series. One of the most potent compounds with this dual mode of action is 4-(4-(3-piperidinopropoxy)phenylamino)quinoline (hH3, Ki = 0.09 nM; HMT, IC50 = 51 nM). This class of compounds showed high antagonist potency and good H3 receptor selectivity in functional assays in guinea pig on H1, H2, and H3 receptors. Because of low or missing in vivo activity of two selected compounds, the proof of concept of these valuable pharmacol. tools for the supposed superior overall enhancing effect on histaminergic neurotransmission failed to appear hitherto.

Journal of Medicinal Chemistry published new progress about Drug screening. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Maillard, Ludovic T.; Benohoud, Meryem; Durand, Philippe; Badet, Bernard published the artcile< A New Supported Reagent for the Parallel Synthesis of Primary and Secondary O-Alkyl Hydroxylamines through a Base-Catalyzed Mitsunobu Reaction>, Formula: C11H16O2, the main research area is supported hydroxyphthalimide parallel synthesis hydroxylamine Mitsunobu reaction; alkylation Mitsunobu alc polymer supported hydroxyphthalimide.

The growing field of applications of O-alkyl hydroxylamines in medicinal chem. and chem. biol. has motivated the search for a parallel synthesis. A solid-phase approach based on the alkylation by alcs. of a new supported N(hydroxy)phthalimide reagent using a Mitsunobu reaction followed by methylaminolysis was optimized. This study points out the importance of the linker and a specific base effect for the Mitsunobu reaction. A large variety of alcs. can be used to give with moderate to high yields diverse O-alkyl hydroxylamines in high purity.

Journal of Organic Chemistry published new progress about Hydroxylamines Role: SPN (Synthetic Preparation), PREP (Preparation) (O-alkyl derivatives). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tidwell, Thomas T. published the artcile< Oxidation of alcohols to carbonyl compounds via alkoxysulfonium ylides: the Moffat, Swern, and related oxidations>, Electric Literature of 52244-70-9, the main research area is review Compound; review Related; review Moffatt; review Oxidation; review Ylides; review Alkoxysulfonium; review Carbonyl; review Alc; review Swern; review Oxidation.

A review of the article Oxidation of alcs. to carbonyl compounds via alkoxysulfonium ylides: the Moffat, Swern, and related oxidations

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cano, Carolina; Paez, Juan Antonio; Goya, Pilar; Serrano, Antonia; Pavon, Javier; Rodriguez de Fonseca, Fernando; Suardiaz, Margarita; Martin, Maria Isabel published the artcile< Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide>, Recommanded Product: n-Propylsulphamoyl chloride, the main research area is anandamide sulfamide derivative preparation CB1 receptor affinity structure activity.

Arachidonyl and linoleyl sulfamide derivatives have been synthesized and their potential cannabimimetic properties evaluated in in vitro functional and binding assays. Replacement of the ethanolamide moiety of anandamide by -CH2NHSO2NH-R (R = saturated or unsaturated long chain alkyl, adamantyl derivative) considerably reduces the CB1 receptor activity and only some of the compounds showed modest cannabinoid properties in binding assays. The new compounds were also tested as inhibitors of the FAAH enzyme but were inactive.

European Journal of Medicinal Chemistry published new progress about Cannabinoid receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Recommanded Product: n-Propylsulphamoyl chloride.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lu, Jiayu; Wang, Xiangjun; Ge, Shuai; Hou, Yajing; Lv, Yuexin; He, Huaizhen; Wang, Cheng published the artcile< Synthesis and evaluation of new potential anti-pseudo-allergic agents>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is anti pseudo allergy mubritinib MRGPRX2 receptor; B10-S; MRGPRX2; Mast cells; Mubritinib; Pseudo-allergy.

Pseudo-allergic reactions frequently occur following clin. drug use and sometimes even cause mortal danger. Mas-related G-protein-coupled receptor member X2 (MRGPRX2) is a novel receptor that mediates pseudo-allergy and is an important target in the treatment of allergies. However, to date, there are no synthetic small-mol. inhibitors that prevent anaphylactoid reactions through this pathway. Our preliminary research suggested that B10-S and mubritinib effectively inhibited LAD2 cells. Therefore, two novel derivatives were synthesized by integrating the active substructures of B10-S and mubritinib, according to the mol. docking results. The antiallergic inhibitory effects of the two compounds were preliminarily evaluated in vitro using β-hexosaminidase release, histamine release, and intracellular Ca2+ mobilization assays, and their binding sites on MRGPRX2 were analyzed by mol. docking. Both substances inhibited β-hexosaminidase and histamine release in LAD2 cells and decreased intracellular Ca2+ by inhibiting MRGPRX2 in MRGPRX2-HEK293 cells treated with C48/80 in a dose-dependent manner. The docking results suggested that the mols. could competitively bind to the active site on MRGPRX2 and Glu141, which were combined by C48/80. Our study indicated that the two compounds have potential anti-allergic properties, which may provide evidence that will facilitate the development of synthetic mols. with anti-pseudo-allergic activity for clin. use in the future.

Bioorganic & Medicinal Chemistry Letters published new progress about Allergy. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rodrigues, Fabio M. S.; Kucmierczyk, Peter K.; Pineiro, Marta; Jackstell, Ralf; Franke, Robert; Pereira, Mariette M.; Beller, Matthias published the artcile< Dual Rh-Ru Catalysts for Reductive Hydroformylation of Olefins to Alcohols>, SDS of cas: 52244-70-9, the main research area is alc preparation regioselective chemoselective; olefin reductive hydroformylation rhodium ruthenium catalyst; alcohols; homogeneous catalysis; rhodium; ruthenium; tandem reactions.

An active and selective dual catalytic system to promote domino hydroformylation-reduction reactions is described. Apart from terminal, di- and trisubstituted olefins, for the first time the less active internal C-C double bond of tetrasubstituted alkenes can also be utilized. As an example, 2,3-dimethylbut-2-ene is converted into the corresponding n-alc. with high yield (90 %) as well as regio- and chemoselectivity (>97 %). Key for this development is the use of a combination of Rh complexes with bulky monophosphite ligands and the Ru-based Shvo’s complex. A variety of aromatic and aliphatic alkenes can be directly used to obtain mainly linear alcs.

ChemSusChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhou, Yali; Xu, Xingjun; Sun, Hongwei; Tao, Guanyu; Chang, Xiao-Yong; Xing, Xiangyou; Chen, Bo; Xu, Chen published the artcile< Development of highly efficient platinum catalysts for hydroalkoxylation and hydroamination of unactivated alkenes>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is platinum catalyst preparation; alkenyl alc platinum catalyst intramol hydroalkoxylation; alkene alc platinum catalyst intermol hydroalkoxylation; aminoalkene platinum catalyst intramol hydroamination; amine alkene platinum catalyst intramol hydroamination.

The design and discovery of “”donor-acceptor””-type platinum catalysts that were highly effective in both hydroalkoxylation and hydroamination of unactivated alkenes over a broad range of substrates under mild conditions were described. A number of alkene substitution patterns were accommodated, including tri-substituted, 1,1-disubstituted, (E)-disubstituted, (Z)-disubstituted and even mono-substituted double bonds. Detailed mechanistic investigations suggested a plausible pathway that included an unexpected dissociation/re-association of the electron-deficient ligand to form an alkene-bound “”donor-acceptor””-type intermediate. These mechanistic studies helped to understand the origins of the high reactivity exhibited by the catalytic system and provided a foundation for the rational design of chiral catalysts towards asym. hydrofunctionalization reactions.

Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ferry, Angelique; Guinchard, Xavier; Retailleau, Pascal; Crich, David published the artcile< Synthesis, Characterization, and Coupling Reactions of Six-Membered Cyclic P-Chiral Ammonium Phosphonite-Boranes; Reactive H-Phosphinate Equivalents for the Stereoselective Synthesis of Glycomimetics>, Reference of 52244-70-9, the main research area is protecting group phosphonite borane disaccharide glycoside synthesis phostone phosphonylation; alkaloid glycoside disaccharide glycomimetic coupling phosphonite borane stereoselective synthesis.

Stereoselective syntheses of P-chiral ammonium phosphonite-borane complexes in the gluco- and manno-like series have been developed from P(V) phostone derivatives The coupling reactions of these phostone donors with alcs. have been investigated with particular emphasis on the influence of protecting groups and conditions on stereoselectivity. The phosphonite-borane complexes may be applied directly in the coupling reactions and the products oxidized in situ to give phostone-mimetics of disaccharides. On the basis of these studies, successful protocols were established for the synthesis of β-gluco and α- and β-manno-configured phostones of primary alcs, e.g. I . Deprotection of the dimeric compounds leads to novel families of α- or β-(1→6)-linked glycomimetics.

Journal of the American Chemical Society published new progress about Alkaloids Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Reference of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Shuguang; Wang, Yunxiang; Zhang, Jing; Zhao, Xiansi; Xu, Shihong published the artcile< Chemical components of edible oil fume in kitchen and its genotoxicity on Drosophila>, SDS of cas: 52244-70-9, the main research area is edible oil fume genotoxicity Drosophila.

The chem. components of the condensate of edible oil fume in kitchen and its genotoxicity on Drosophila were studied. The chem. components were analyzed by gas chromatog. and mass spectra (GC/MS) and the genotoxicity was studied by sex linked recessive lethal (SLRL) test in Drosophila. A total of 74 organic compounds were found in samples of condensed oil from the fume in kitchen. It included hydroxy acids, hydrocarbons, alcs., esters, aldehydes, ketones, aromatic compounds, and steroids, etc. The total mutagenicity rates in SLRL test induced by the samples at concentrations of 110, 320 and 960 mg/L were 0.1732%, 0.4306% and 0.1707% resp. The sterility rates of the first broods were 2.564%, 2.056% and 2.845% at above 3 concentrations resp. (P <0.05, as compared with the control). The mutagenicity rate of the second brood at 320 mg/L was 0.530% and of condensate of the third brood at 110 mg/L was 0.540% (P <0.001). Some of the compounds in the condensate of edible oil fume had high recessive lethal effect and genotoxic effect on the reproductive system of Drosophila. Weisheng Yanjiu published new progress about Alcohols Role: ADV (Adverse Effect, Including Toxicity), BSU (Biological Study, Unclassified), BIOL (Biological Study). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem