Tag: M.W=150-200

Bowles, Mark R.; Eyles, Darryl W.; Hampson, Edith C. G. M.; Pond, Susan M. published the artcile< Quantitation of paraquat in biological samples by radioimmunoassay using a monoclonal antibody>, HPLC of Formula: 52244-70-9, the main research area is paraquat determination biol sample monoclonal antibody; RIA paraquat urine blood bronchoalveolar lavage.

The authors have developed a sensitive and specific RIA for the quant. determination of paraquat in plasma, urine, and bronchoalveolar lavage fluid using a monoclonal antibody. The synthesis of the iodinated paraquat tracer is novel and less complicated than a previously reported method. Regardless of the type of biol. sample analyzed, the sensitivity of the assay was 0.46 ng/mol in a 200-μL aliquot. The results correlated well with those of another assay performed in a sep. laboratory Paraquat concentrations were determined in plasma and in urine of a dog over several days after the i.v. administration of 7.48 mg paraquat cation/kg and in bronchoalveolar lavage fluid obtained 34 h after the 2-h infusion was discontinued. Concentrations of paraquat measured ranged from 14.1 to 0.03 μg/mL in plasma and 2034 to 0.36 μg/mL in urine. Concentrations of paraquat in plasma obtained at various times after the ingestion of paraquat by three patients ranged from 51.0 to 0.010 μg/mL.

Fundamental and Applied Toxicology published new progress about Alveolus. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, HPLC of Formula: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Achar, Tapas Kumar; Zhang, Xinglong; Mondal, Rahul; Shanavas, M. S.; Maiti, Siddhartha; Maity, Sabyasachi; Pal, Nityananda; Paton, Robert S.; Maiti, Debabrata published the artcile< Palladium-Catalyzed Directed meta-Selective C-H Allylation of Arenes: Unactivated Internal Olefins as Allyl Surrogates>, Computed Properties of 52244-70-9, the main research area is pyrimidine styrenyl preparation diastereoselective regioselective DFT; arene olefin selective allylation palladium catalyst; C−H activation; allylic compounds; olefins; palladium; reaction mechanisms.

Palladium(II)-catalyzed meta-selective C-H allylation of arenes RC6H4(CH2)nXR1 [R = H, 3-Me, 3-Br, 4-F, etc.; R1 = 2-(pyrimidin-5-yl)phenoxy, 2-(pyridin-3-yl)phenoxy, 2-(8-nitroquinolin-3-yl)phenoxy, etc.; X = SO2, C(O), Si(i-Pr)2, CH2; n = 1-4] including 2-(pyrimidin-5-yl)phenyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate has been developed utilizing synthetically inert unactivated acyclic internal olefins R2CH2CH=CHCH2R3 [R2 = Me, Et, n-Pr, pentyl, etc.; R3 = Me, COOMe, [[(1S,2R,5S)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy]carbonyl, etc.] as allylic surrogates. The strong σ-donating and π-accepting ability of pyrimidine-based directing group facilitates the olefin insertion by overcoming inertness of the typical unactivated internal olefins. Exclusive allyl over styrenyl products, e.g., (E)-I selectivity as well as E stereoselectivity were achieved with broad substrate scope, wide functional-group tolerance, and good to excellent yields. Late-stage functionalizations of pharmaceuticals were demonstrated. Exptl. and computational studies shed light on the mechanism and point to key steric control in the palladacycle, thus determining product selectivities.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Computed Properties of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dix, Stefan; Jakob, Michael; Hopkinson, Matthew N. published the artcile< Deoxytrifluoromethylthiolation and Selenylation of Alcohols by Using Benzothiazolium Reagents>, Related Products of 52244-70-9, the main research area is trifluoromethylthio methylbenzothiazolium triflate aliphatic alc deoxytrifluoromethylthiolation; trifluoromethylselenyl methylbenzothiazolium triflate aliphatic alc deoxytrifluoromethylselenylation; alcohols; fluorine; reagent development; trifluoromethylselenyl group; trifluoromethylthio group.

Aliphatic compounds substituted with medicinally important trifluoromethylthio (SCF3) and trifluoromethylselenyl (SeCF3) groups were synthesized directly from alcs. by using the new benzothiazolium salts BT-SCF3 and BT-SeCF3. These bench-stable fluorine-containing reagents are facile to use and can be prepared in two steps from non-fluorinated heteroaromatic starting materials. To the best of our knowledge, these are the first reported examples in which the metal-free deoxytrifluoromethylthiolation process and similarly efficient trifluoromethylselenylation reactions proceeded under mild conditions using BT-SCF3 and BT-SeCF3 resp.

Chemistry – A European Journal published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Plaumann, H. P.; Keay, B. A.; Rodrigo, R. published the artcile< The regiospecific lithiation of aromatic acetals>, Name: 3-Methoxy-2-methylbenzaldehyde, the main research area is lithiation aromatic acetal regioselective; substituent effect lithiation aromatic acetal; deprotonation aromatic acetal substituent effect; benzaldehyde ortho substituted.

The reaction of 11 di-Me aromatic acetals with alkyllithiums are described. In compounds with substituents ortho to the acetal very little deprotonation occurred, whereas with no substituent present lithiation occurred readily. E.g., I (R = H, R1 = OMe) with Me3CLi (-23°), MeI, and acid gave 95% II, whereas no reaction occurred when I (R = OMe, R1 = H) was treated similarly. The reaction provides a facile entry to 2,3- and 2,3,4-substituted benzaldehydes.

Tetrahedron Letters published new progress about Aryl aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Name: 3-Methoxy-2-methylbenzaldehyde.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Yi-Ning; Liu, Ye; Yang, Han-Han; Zhang, Wen-Fu; Lu, Xiao-Bing published the artcile< Intramolecular Partners in Asymmetric Catalysis Copolymerization: Highly Enantioselective and Controllable at Enhanced Temperatures and Low Loadings>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is asym catalyst polymerization enantioselective controllable alternating chiral; Asymmetric Ring-Opening Copolymerization; Bifuctional Bimetallic Catalyst; High Molecular Weight Polyester; Intramolecular Synergistic Catalysis; Low Loadings.

Asym. copolymerization of meso-epoxide and anhydride is a powerful strategy for preparing various isotactic polyesters with two contiguous stereogenic centers. However, the previous binary systems suffered from slow rates at low loadings, poor enantioselectivities and transesterification reactions at enhanced temperatures Herein, we report novel dinuclear aluminum complexes with multiple chiralities and ammonium salts anchored on ligand frameworks. These bifunctional catalysts exhibit high activities and enantioselectivities for epoxides/anhydrides copolymerizations at harsh conditions via intramolecularly synergistic catalysis, affording polyesters with unprecedented mol. weights and narrow distributions. Notably, no transesterification reactions were observed, significantly different from the binary catalyst/cocatalyst pairs. This study represents a rare example regarding temperature-independent asym. induction for preparing chiral polymers from achiral monomers.

Angewandte Chemie, International Edition published new progress about Chirality. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F. published the artcile< Methods for the construction of linear 1,7-diarylheptanoids; synthesis of di-O-methylcentrolobol and precursors (synthetic and biosynthetic) to the meta,meta-bridged biphenyls myricanol and myricanone>, Application In Synthesis of 52244-70-9, the main research area is heptanoid diaryl; arylheptanoid; centrolobol analog; myricanol open chain analog; myricanone open chain analog; Grignard reaction phenylpropanal arylhaloalkane; propanal phenyl Grignard reaction; oxazine salt Grignard reaction; dithiane lithiation diarylheptanoid.

Grignard couplings of arylhaloalkanes with arylpropanals or oxazonium salts and the reactions of arylhaloalkanes with lithiated dithianes were used to prepare 1,7-diarylheptanoids, including synthetic and biosynthetic precursors of meta,meta-bridged biphenyls and related macrocyclic ethers. Thus, 4-(2-benzyloxy-3,4-dimethoxy)-1-bromobutane was treated with Mg and the product was treated with 4-PhCH2OC6H4(CH2)2CHO to give the desired alc. I (X = H, OH; R = R3 = OCH2Ph, R1 = R2 = OMe). Similarly, 4-MeOC6H4(CH2)4Br was treated with Mg and the Grignard reagent produced was treated with the oxazine salt II to give the desired ketone I (X = O, R = R1 = H, R2 = R3 = OMe). 4-(2,3,4-Trimethoxyphenyl)-1-iodobutane reacted with lithiated 2-[2-(p-methoxyphenyl)ethyl]-1,3-dithiane to give after oxidation the desired ketone I (X = O, R = R1 = R2 = R3 = OMe).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Alcohols Role: USES (Uses). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yu, Jianjin; Li, Chao-Jun; Zeng, Huiying published the artcile< Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is palladium catalyzed ortho selective alkylation phenol alc dearomatization rearomatization; aromaticity; cross-coupling; palladium; reaction mechanisms; synthetic methods.

Phenols are common precursors and core structures of a variety of industrial chems. ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcs. by a dearomatization-rearomatization strategy, with water as the sole byproduct. Various substituted phenols and primary alcs. were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.

Angewandte Chemie, International Edition published new progress about Alkylation. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pelter, Andrew; Ward, Robert S.; Rao, Ramohan R. published the artcile< An approach to the biomimetic synthesis of aryltetralin lignans>, Application of C11H16O2, the main research area is cyclization quinone methide ketal; Lewis acid cyclization catalyst; aryltetralin; tetralin aryl.

The BF3 catalyzed cyclization of 3-(arylpropyl)quinone-methide ketals I (R, R1, R2 = H, OMe) affords a mild biomimetic route to aryltetralins II. I were prepared from the corresponding 4-arylbutanoic acids in 5 steps.

Tetrahedron published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Jing; Li, Yang; Zhang, Fuyuan; Hu, Chenchen; Chen, Yiyun published the artcile< Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)-H Functionalization under Mild Reaction Conditions>, Electric Literature of 52244-70-9, the main research area is visible light redox reaction carbon hydrogen bond functionalization; C−H functionalization; alkoxyl radicals; allylic compounds; photochemistry; reaction mechanisms.

Reported herein is the first visible-light-induced formation of alkoxyl radicals from N-(alkoxy)phthalimides, and the Hantzsch ester as the reductant is crucial for the reaction. The selective hydrogen atom abstraction by the alkoxyl radical enables C(sp3)-H allylation and alkenylation reactions under mild reaction conditions at room temperature Broad substrate variations, including a structurally complex steroid, undergo the C(sp3)-H functionalization reaction effectively with high regioselectivity and chemoselectivity. The synthesis of the target compounds was achieved using 2-[(phenylsulfonyl)methyl]-2-propenoic acid Et ester as a starting material in a reaction with 2-[2-[(4-methylphenyl)methoxy]ethoxy]-1H-isoindole-1,3(2H)-dione [i.e., cyclic N-(alkoxy)imide, phthalimide] derivatives Under optimized conditions tris[2-(2-pyridinyl-κN)phenyl-κC]iridium(1+) um(1+) hexafluorophosphate(1-) [i.e., fac-Ir(ppy)3] was used as a catalyst. The title compounds thus formed included 2-[[(2E)-3-phenyl-2-propen-1-yl]oxy]ethanol derivatives, γ-(2-hydroxyethoxy)-α-(methlyene)benzenebutanoic acid esters,.

Angewandte Chemie, International Edition published new progress about Aliphatic alcohols, radicals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schenkels, Peter; Duine, Johannis A. published the artcile< Nicotinoprotein (NADH-containing) alcohol dehydrogenase from Rhodococcus erythropolis DSM 1069: an efficient catalyst for coenzyme-independent oxidation of a broad spectrum of alcohols and the interconversion of alcohols and aldehydes>, Product Details of C11H16O2, the main research area is Rhodococcus alc dehydrogenase NADH oxidation alc aldehyde.

Extracts from benzyl-alc.-grown Rhodococcus erythropolis DSM 1069 showed NAD(P)-independent, N,N-dimethyl-4-nitrosoaniline (NDMA)-dependent alc. dehydrogenase activity. The enzyme exhibiting this activity was purified to homogeneity and characterized. It appears to be a typical nicotinoprotein as it contains tightly bound NADH acting as cofactor instead of coenzyme. Other characteristics indicate that it is highly similar to the known nicotinoprotein alc. dehydrogenase (np-ADH) from Amycolatopsis methanolica: it is a homotetramer of 150 kDa; N-terminal amino acid sequencing (22 residues) showed that 77% of these amino acids are identical in the two enzymes; it has optimal activity at pH 7.0; it lacks NAD(P)H-dependent aldehyde reductase activity; it catalyzes the oxidation of a broad range of (preferably) primary and secondary alcs., either aliphatic or aromatic, and formaldehyde, with the concomitant reduction of the artificial electron acceptor NDMA. NDMA could be replaced by an aldehyde, but not formaldehyde, the substrate specificity of the enzyme for the aldehydes reflecting that for the corresponding alcs. The latter also applied to the low aldehyde dismutase activity displayed by the enzyme. From this, together with the results of the induction studies, it is concluded that np-ADH functions as the main alc.-oxidizing enzyme in the dissimilation of many, but not all, alcs. by R. erythropolis and may also catalyze coenzyme-independent interconversion of alcs. and aldehydes under certain circumstances. It is anticipated that the enzyme may be of even wider significance since structural data indicate that np-ADH is also present in other (nocardioform) actinomycetes.

Microbiology (Reading, United Kingdom) published new progress about Alcohols Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem