Tag: M.W=150-200

Cano, Carolina; Pavon, Javier; Serrano, Antonia; Goya, Pilar; Paez, Juan Antonio; Rodriguez de Fonseca, Fernando; Macias-Gonzalez, Manuel published the artcile< Novel Sulfamide Analogs of Oleoylethanolamide Showing In Vivo Satiety Inducing Actions and PPARα Activation>, Electric Literature of 10305-42-7, the main research area is sulfamide oleoylethanolamide analog preparation peroxisome proliferator activated receptor.

Long chain saturated and unsaturated alkyl sulfamide and Pr sulfamide derivatives, analogs of oleoylethanolamide, were synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPARα) activators. Addnl., the anorexic effects of the new compounds were studied in vivo in food-deprived rats. Among the active compounds N-octadecyl-N’-propylsulfamide was identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentration-dependent activator of PPARα.

Journal of Medicinal Chemistry published new progress about Peroxisome proliferator-activated receptor α Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Electric Literature of 10305-42-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Xiaohuan; Deng, Zhijie; Tang, Pingping published the artcile< Direct Dehydroxytrifluoromethoxylation of Alcohols>, Application In Synthesis of 52244-70-9, the main research area is trifluoromethyl alkyl ether chemoselective preparation; etherification alc trifluoromethyl toluenesulfonate mediated cesium fluoride; dehydroxytrifluoromethylation primary secondary alc trifluoromethyl toluenesulfonate; fluoroformate intermediate dehydroxytrifluoromethylation alc trifluoromethyl toluenesulfonate; alcohols; nucleophilic substitution; synthetic methods; trifluoromethoxylation; trifluoromethyl arylsulfonate.

Primary alcs. and selected secondary alcs. underwent chemoselective direct dehydroxytrifluoromethoxylation with trifluoromethyl p-toluenesulfonate mediated by CsF and tetramethylammonium bromide in HMPA/DMA at 30-100° to yield trifluoromethyl ethers. The trifluoromethylation reaction is operationally simple and scalable, and proceeds under mild reaction conditions to provide access to a wide range of trifluoromethyl ethers from alcs.; functionalized natural products such as a deoxycholic acid-derived triol and pleuromutilin were also used as substrates.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Liqiang; Sun, Pengli; Yan, Fulin published the artcile< Melamine-trisulfonic acid-catalyzed trimethylsilylation of alcohols and phenols>, Application In Synthesis of 52244-70-9, the main research area is alc trimethylsilylation melamine sulfonic acid catalyst; phenol trimethylsilylation melamine sulfonic acid catalyst; silyl ether preparation environmentally benign chem.

A highly convenient method for the trimethylsilylation of alcs. and phenols via treatment by hexamethyldisilazane in the presence of melamine trisulfonic acid as a catalyst was developed. A wide variety of hydroxyl groups were selectively protected under solvent-free conditions.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chu, Guo-Hua; Milano, Shawn; Kluth, Lisa; Rhodes, Michael; Boni, Riccardo; Johnson, David A.; Li, Pui-Kai published the artcile< Structure-activity relationship studies of the amide functionality in (p-O-sulfamoyl)-N-alkanoyl tyramines as estrone sulfatase inhibitors>, SDS of cas: 52244-70-9, the main research area is sulfamoylalkanoyl tyramine preparation estrone sulfatase inhibition.

Recently, we reported the synthesis and biochem. studies of a series of (p-O-sulfamoyl)-N-alkanoyl tyramines as nonsteroidal estrone sulfatase inhibitors. One of the most potent inhibitors in this series is (p-O-sulfamoyl)-N-tridecanoyl tyramine (I) with an IC50 value of 61.3 nM. In this study, we synthesized four analogs of this compound to investigate the structure-activity relationships of the amide functionality in (p-O-sulfamoyl)-N-tridecanoyl tyramine. Replacement of the amide functionality with an ethylene moiety resulted in complete loss of sulfatase inhibitory activity (IC50 of 61.3 nM vs. >20 μM). The keto, hydroxy, and ester analogs were 8-15 times less in affinity to the sulfatase than inhibitor I. However, their inhibitory activities are significantly higher than the ethylene analog. The results suggest that the amide functionality is favorable for sulfatase inhibitory activity and that there may be a hydrogen bonding component to the enzyme interaction in this region.

Steroids published new progress about Structure-activity relationship, enzyme-inhibiting. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bam, Radha; Pollatos, Alexandros S.; Moser, Austin J.; West, Julian G. published the artcile< Mild olefin formation via bio-inspired vitamin B12 photocatalysis>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is haloalkane cobalamin catalyst regioselective photochem dehydrohalogenation; alkene preparation; alkyl sulfonate cobalamin catalyst regioselective photochem olefination; olefin preparation.

A light-driven B12-based catalytic system that leverages this reactivity to convert alkyl electrophiles to olefins under incredibly mild conditions using only earth abundant elements was reported. Further, this process exhibited a high level of regioselectivity, producing terminal olefins in moderate to excellent yield and exceptional selectivity. Finally, it was able to access a hitherto-unknown transformation, remote elimination, using two cobalt catalysts in tandem to produce subterminal olefins with excellent regioselectivity. Together, vitamin B12 to be a powerful platform for developing mild olefin-forming reactions was showed.

Chemical Science published new progress about Alkanesulfonates Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sano, H.; Nishimura, J. published the artcile< Product class 11: dimethylenecyclobutenes and quinodimethanes>, Name: 3-Methoxy-2-methylbenzaldehyde, the main research area is review dimethylene cyclobutene preparation organic synthesis; quinodimethane preparation organic synthesis review.

A review of methods to prepare dimethylenecyclobutenes and quinodimethanes.

Science of Synthesis published new progress about Cycloalkenes Role: SPN (Synthetic Preparation), PREP (Preparation) (dimethylene-). 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Name: 3-Methoxy-2-methylbenzaldehyde.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Prasad, J. V. N. Vara; Markoski, Larry J.; Boyer, Fred E.; Domagala, John M.; Ellsworth, Edmund L.; Gajda, Christopher; Hagen, Susan E.; Tait, Bradley D.; Lunney, Elizabeth A.; Tummino, Peter J.; Ferguson, Donna; Holler, Tod; Hupe, Donald; Nouhan, Carolyn; Gracheck, Stephen J.; VanderRoest, Steven; Saunders, James; Iyer, K.; Sinz, M. published the artcile< Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydro-2-pyranones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety>, Quality Control of 10305-42-7, the main research area is HIV protease inhibitor sulfamate hydroxyphenylethyloxopyranylthiophenyl ester preparation; virucide sulfamate hydroxyphenylethyloxopyranylthiophenyl ester preparation; structure activity sulfamate hydroxyphenylethyloxopyranylthiophenyl ester preparation.

Dihydropyran-2-ones possessing a sulfamate moiety at the 4-position of a phenylthio ring were designed to reach S3′ pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing 3-(2-tert-butyl-5-methyl-4-sulfamate) phenylthio moiety were established. SAR of various sulfamate analogs including HIV protease binding affinities, antiviral activities and therapeutic indexes will be described. An example compound thus prepared and tested was sulfamic acid 4-[[5,6-dihydro-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-methyl-2-oxo-2H-pyran-3-yl]thio]-5-(1,1-dimethylethyl)-2-methylphenyl ester.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Quality Control of 10305-42-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pingali, Harikishore; Jain, Mukul; Shah, Shailesh; Basu, Sujay; Makadia, Pankaj; Goswami, Amitgiri; Zaware, Pandurang; Patil, Pravin; Godha, Atul; Giri, Suresh; Goel, Ashish; Patel, Megha; Patel, Harilal; Patel, Pankaj published the artcile< Discovery of a highly orally bioavailable c-5-[6-(4-methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is methanesulfonylhexyldioxanecarboxylic acid preparation hypoglycemic hypolipidemic.

A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted Ph group as a lipophilic tail have been prepared as agonists of PPARα and γ. C-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evindar, Ghotas; Satz, Alexander L.; Bernier, Sylvie G.; Kavarana, Malcolm J.; Doyle, Elisabeth; Lorusso, Jeanine; Taghizadeh, Nazbeh; Halley, Keith; Hutchings, Amy; Kelley, Michael S.; Wright, Albion D.; Saha, Ashis K.; Hannig, Gerhard; Morgan, Barry A.; Westlin, William F. published the artcile< Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists>, Related Products of 52244-70-9, the main research area is amide arylalkoxyphenyl biarylalkoxyphenyl aryloxyphenyl preparation sphingosine phosphate receptor agonist; imidazole arylalkoxyphenyl biarylalkoxyphenyl preparation sphingosine phosphate receptor agonist.

In a search for potent and selective sphingosine-1-phosphate receptor agonists, the previously reported phenylamide and phenylimidazole scaffolds were utilized to explore extensive side-chain modifications to generate new mol. entities. A number of designed mols. demonstrated good selectivity and excellent in vitro and in vivo potency in both mouse and rat models. Oral administration of the lead mol. I (PPI-4667) demonstrated potent and dose-responsive lymphopenia.

Bioorganic & Medicinal Chemistry Letters published new progress about Amides, alkoxylated Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhagwat, Shripad S.; Gude, Candido; Boswell, Clay; Contardo, Nicolina; Cohen, David S.; Dotson, Ronald; Mathis, Janice; Lee, Warren; Furness, Patricia; Zoganas, Harry published the artcile< Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-[3-(3-pyridinyl)propyl]octanoic acid and analogs>, Application of C11H16O2, the main research area is chlorophenylsulfonylaminopyridinylpropyloctanoic acid preparation thromboxane antagonist; arylsulfonylaminopyridinylpropyloctanoic acid analog preparation thromboxane antagonist; thromboxane receptor antagonist synthase inhibitor arylsulfonylaminopyridinylpropyloctanoic.

The title compound [I, A = (CH2)2CO2H, B = (CH2)3Py, X = Cl; Py = 3-pyridyl] (II) and its analogs were synthesized and found to possess two activities, the inhibition of the biosynthesis of thromboxane A2 and antagonism of its receptors. Thus, II was prepared via arylsulfonylation of Et 6-amino-2-[(3-pyridinyl)propyl)]hexanoate, reduction, Wittig reaction with Ph3P:CHCO2Me, and treatment with NaBH4/CoCl2/MeOH. The in vitro and in vivo profile of these compounds as thromboxane receptor antagonists (TxRAs) and thromboxane synthase inhibitors (TxSls) is described. II and its analogs I [A = CO2H, NHCOCO2H, (CH2)3OH, SCH2CO2H, etc., B = (CH2)2OPy, CH2CH:CHPy, (CH2)2Im, X = F, OMe, N3, CF3, SO2Me; Im = 1-imidazolyl] displayed very potent TxRA activity in human washed platelets (IC50 ≈ 10-7-10-9 M) and dog saphenous vein (pA2 ≈ 9) and also potent TxSl activity (IC50 ≈ 10-9 M). The good bioavailability and the long duration of action of some of these compounds was demonstrated using ex vivo measurement of the TxRA and TxSl activities upon oral administration to guinea pigs. I [A = (CH2)2CO2H, B = (CH2)2OPy, X = Cl; A = SCH2CO2H, B = (CH2)3Py, X = Cl] and II potently inhibited arachidonic acid induced bronchoconstriction in guinea pigs.

Journal of Medicinal Chemistry published new progress about Thromboxane receptor TBXA2R Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem