Tag: M.W=150-200

Denning, Derek M.; Pedowitz, Nichole J.; Thum, Matthew D.; Falvey, Daniel E. published the artcile< Uncaging alcohols using UV or visible light photoinduced electron transfer to 9-phenyl-9-tritylone ethers>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is uncaging alc UV visible light photoinduced electron transfer; phenyl tritylone ether.

The clean and efficient photorelease of primary and secondary alcs. is reported from the deprotection of a new photoremovable protecting group, the 9-phenyltritylone (PTO) group. Deprotection is initiated by 350 nm excitation of the PTO chromophore in the presence of triethylamine or using 447 nm light in the presence of a visible light absorbing photocatalyst and triethylamine. Laser flash photolysis results are reported in support of a proposed deprotection mechanism for the release of alcs. on a ca. 20 μs time scale.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Junjun; Hua, Kaimin; Liu, Xiaofang; Deng, Yuchao; Wei, Baiyin; Wang, Hui; Sun, Yuhan published the artcile< Selective Production of Linear Aldehydes and Alcohols from Alkenes using Formic Acid as Syngas Surrogate>, Quality Control of 52244-70-9, the main research area is alkene formic acid rhodium regioselective hydroformylation catalyst; aldehyde linear preparation; formic acid alkene rhodium Shvo regioselective hydroxymethylation catalyst; alc linear preparation; formic acid; hydroformylation; hydroxymethylation; linear alcohol; tandem reaction.

Performing carbonylation without the use of carbon monoxide for high-value-added products is an attractive yet challenging topic in sustainable chem. Herein, effective methods for producing linear aldehydes or alcs. selectively with formic acid as both carbon monoxide and hydrogen source have been described. Linear-selective hydroformylation of alkenes proceeds smoothly with up to 88% yield and >30 regioselectivity in the presence of single Rh catalyst. Strikingly, introducing Ru into the system, the dual Rh/Ru catalysts accomplish efficient and regioselective hydroxymethylation in one pot. The present processes utilizing formic acid as syngas surrogate operate simply under mild condition, which opens a sustainable way for production of linear aldehydes and alcs. without the need for gas cylinders and autoclaves. As formic acid can be readily produced via CO2 hydrogenation, the protocols represent indirect approaches for chem. valorization of CO2.

Chemistry – A European Journal published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Atkinson, Robert S.; Green, Richard H. published the artcile< 1,5-Hydride shifts in acyclic systems containing α,β-unsaturated ketones and p-methoxyphenyl groups>, Reference of 52244-70-9, the main research area is ketone unsaturated rearrangement mechanism; hydride shift rearrangement ketone.

D-labeling showed that the acid-catalyzed rearrangement of p-HOC6H4(CH2)2CR2CH2CH:CHCOMe (I, R = H) to 2-(p-hydroxyphenyl)cyclohexyl Me ketone involved an intramol. H shift. A similar rearrangement was observed for I (R = Me) and its aromatic Me ether but not analogous products were obtained from p-MeOC6H4CHR(CH2)2CH:CHCOMe (R = H, p-MeOC6H4) under the same reaction conditions.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Hydride shift. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Reference of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Herdman, Christine A.; Devkota, Laxman; Lin, Chen-Ming; Niu, Haichan; Strecker, Tracy E.; Lopez, Ramona; Liu, Li; George, Clinton S.; Tanpure, Rajendra P.; Hamel, Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G. published the artcile< Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization>, Recommanded Product: 3-Methoxy-2-methylbenzaldehyde, the main research area is preparation benzosuberene tubulin polymerization inhibitor.

The discovery of 3-methoxy-9-(3′,4′,5′-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol (a benzosuberene-based analog referred to as KGP18) was originally inspired by the natural products colchicine and combretastatin A-4 (CA4). The relative structural simplicity and ease of synthesis of KGP18, coupled with its potent biol. activity as an inhibitor of tubulin polymerization and its cytotoxicity (in vitro) against human cancer cell lines, has resulted in studies focused on new analog design and synthesis. The goal was to probe the relationship of structure to function in this class of anticancer agents. A series of twenty-two new benzosuberene-based analogs of KGP18 was designed and synthesized. These compounds vary in their methoxylation pattern and sep. incorporate trifluoromethyl groups around the pendant aryl ring for the evaluation of the effect of functional group modifications on the fused six-membered aromatic ring. In addition, the 8,9-saturated congener of KGP18 has been synthesized to assess the necessity of unsaturation at the carbon atom bearing the pendant aryl ring. Six of the mols. from this benzosuberene-series of compounds were active (IC50 < 5 μM) as inhibitors of tubulin polymerization while four analogs were comparable (IC50 approx. 1 μM) in their tubulin inhibitory activity to CA4 and KGP18. The potency of a bis-trifluoromethyl analog I and the unsaturated KGP18 derivative II as inhibitors of tubulin assembly along with their moderate cytotoxicity suggested the potential utility of these compounds as vascular disrupting agents (VDAs) to selectively target microvessels feeding tumors. Accordingly, water-soluble and DMSO-soluble phosphate prodrug salts of each were synthesized for preliminary in vivo studies to assess their potential efficacy as VDAs. Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Recommanded Product: 3-Methoxy-2-methylbenzaldehyde.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fatori, D.; Hunter, W. M. published the artcile< Radioimmunoassay for serum paraquat>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is paraquat determination serum radioimmunoassay; radioimmunoassay paraquat tracer serum.

Two variants of a radioimmunoassay for the bipyridylium herbicide paraquat (I) [4685-14-7] are described. Both employ antiserum raised to I-BSA which was covalently linked to particulate solid-phase support media. The rapid assay for clin. use employed a 3H-labeled I tracer, required no agitation and yielded results in the range 10-2500 ng/mL serum in 20 min from receipt of sample. The more sensitive assay, designed for research purposes, employed a 125-iodinated tracer, required 2 h continuous agitation but can detect I at 091 ng/mL in simple aqueous solution or 0.25 ng/mL serum. Results from rapid clin. assay agree well with the existing colorimetric method.

Clinica Chimica Acta published new progress about Blood analysis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hernan-Gomez, Alberto; Rodriguez, Monica; Parella, Teodor; Costas, Miquel published the artcile< Electrophilic Iron Catalyst Paired with a Lithium Cation Enables Selective Functionalization of Non-Activated Aliphatic C-H Bonds via Metallocarbene Intermediates>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is diazoester alkyl substituted iron lithium intramol alkylation catalyst; cyclopentane ester stereoselective preparation; C−H activation; carbenes; iron; lithium; reaction mechanisms.

Combining an electrophilic iron complex [Fe(Fpda)(THF)]2 [Fpda=N,N’-bis(pentafluorophenyl)-o-phenylenediamide] with the pre-activation of α-alkyl-substituted α-diazoesters reagents by LiAl(ORF)4 [ORF= OC(CF3)3] provides unprecedented access to selective iron-catalyzed intramol. functionalization of strong alkyl C(sp3)-H bonds. Reactions occur at 25 °C via α-alkyl-metallocarbene intermediates, and with activity/selectivity levels similar to those of rhodium carboxylate catalysts. Mechanistic investigations reveal a crucial role of the lithium cation in the rate-determining formation of the electrophilic iron-carbene intermediate, which then proceeds by concerted insertion into the C-H bond.

Angewandte Chemie, International Edition published new progress about Alkylation catalysts (intramol.). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sasaki, Shigeki; Kurosaki, Fumie; Haradahira, Terushi; Yamamoto, Fumihiko; Maeda, Jun; Okauchi, Takashi; Suzuki, Kazutoshi; Suhara, Tetsuya; Maeda, Minoru published the artcile< Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains>, Application In Synthesis of 52244-70-9, the main research area is carbon 11 phenylalkylamine brain NMDA receptor PET.

Two new 11C-labeled ligands, N-(3-(4-hydroxyphenyl)propyl)-3-(4-methoxyphenyl)propylamine ([11C]2) and N-(3-(4-hydroxyphenyl)butyl)-3-(4-methoxyphenyl)butylamine ([11C]3) were designed based on bis(phenylalkyl)-amines which have been reported as polyamine site antagonists with high-selectivity for NR1A/2B NMDA receptors, and radiolabelling of the corresponding phenol precursors with [11C]methyl iodide was readily accomplished. The in vitro inhibition experiments using rat brain slices showed that [11C]2 and [11C]3 share the binding sites with spermine and/or ifenprodil but not with CP-101,606, a highly potent NR2B-selective NMDA antagonist, and that divalent cations such as Zn2+ produced significant inhibition of both [11C]2 and [11C]3 bindings. I.v. injection of [11C]3 in mice showed almost homogenous distribution throughout the brain. Attempts to block the tracer uptake of [11C]3 by pre-injection with the unlabeled 3 or spermine in rats were unsuccessful, but a small decrease in the cerebral uptake of [11C]3 by co-treatment with the unlabeled 3 was observed in a monkey PET study. The present findings indicate that none of these 11C-labeled analogs have potential for PET study of binding sites on the N-methyl-D-aspartate (NMDA) receptors.

Biological & Pharmaceutical Bulletin published new progress about Brain. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Fenglin; Chen, Ke; Zhang, Yao; He, Yuli; Wang, Yi-Ming; Zhu, Shaolin published the artcile< Remote Migratory Cross-Electrophile Coupling and Olefin Hydroarylation Reactions Enabled by in Situ Generation of NiH>, Related Products of 52244-70-9, the main research area is nickel catalyzed reductive cross electrophile coupling; migratory electrophile coupling olefin hydroarylation ligand nickel controlled; diarylalkane structurally diverse preparation regioselectivity.

A highly efficient strategy for remote reductive cross-electrophile coupling has been developed through the ligand-controlled nickel migration/arylation. This general protocol allows the use of abundant and bench-stable alkyl bromides and aryl bromides for the synthesis of a wide range of structurally diverse 1,1-diarylalkanes in excellent yields and high regioselectivities under mild conditions. Authors also demonstrated that alkyl bromide could be replaced by the proposed olefin intermediate while using Pr bromide/Mn0 as a potential hydride source.

Journal of the American Chemical Society published new progress about Alkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (1,1-diarylalkanes). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nouaille, Augustin; Pannecoucke, Xavier; Poisson, Thomas; Couve-Bonnaire, Samuel published the artcile< Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis>, Name: 4-(4-Methoxyphenyl)-1-butanol, the main research area is trisubstituted fluoroalkene preparation stereoselective ruthenium catalyst; terminal alkene fluoroalkene cross metathesis.

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Author’s thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, found as the Me 2-fluoroacrylate. Authors reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with Me 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products.

Advanced Synthesis & Catalysis published new progress about Catalysis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Name: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Boutin, Sophie; Maltais, Rene; Roy, Jenny; Poirier, Donald published the artcile< Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency>, Application In Synthesis of 56724-03-9, the main research area is androstane D ring derivative preparation HSD10 inhibitor; 17β-HSD10; Alzheimer disease; Enzyme; Inhibitor; Solid-phase synthesis; Steroid.

17Beta-Hydroxysteroid dehydrogenase type 10 (17β-HSD10) is the only mitochondrial member of 17β-HSD family. This enzyme can oxidize estradiol (E2) into estrone (E1), thus reducing concentration of this neuroprotective steroid. Since 17β-HSD10 possesses properties that suggest a possible role in Alzheimer’s disease, its inhibition appears to be a therapeutic strategy. After we identified the androsterone (ADT) derivative I as a first steroidal inhibitor of 17β-HSD10, new analogs were synthesized to increase the metabolic stability, to improve the selectivity of inhibition over 17β-HSD3 and to optimize the inhibitory potency. From six D-ring derivatives of I (17-C=O), two compounds (17β-H/17α-OH and 17β-OH/17α-CCH) were more metabolically stable and did not inhibit the 17β-HSD3. Moreover, solid phase synthesis was used to extend the mol. diversity on the 3β-piperazinylmethyl group of the steroid base core. Eight over 120 new derivatives were more potent inhibitors than I for the transformation of E2 to E1, with the 4-(4-trifluoromethyl-3-methoxybenzyl)piperazin-1-ylmethyl-ADT (D-3,7) being 16 times more potent (IC50 = 0.14μM). Finally, D-ring modification of D-3,7 provided 17β-OH/17α-CCH derivative and 17β-H/17α-OH derivative, which were more potent inhibitor than I (1.8 and 2.4 times, resp.).

European Journal of Medicinal Chemistry published new progress about Alzheimer disease. 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Application In Synthesis of 56724-03-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem