Tag: M.W=200-250

Busch, M. published the artcileReactions of diazonium salts with thioureas and derivatives, Related Products of ethers-buliding-blocks, the publication is Journal fuer Praktische Chemie (Leipzig) (1938), 173-85, database is CAplus.

cf. Ber. 34, 320(1901). PhNHNHCSNHPh (I) in Me₂CO at -5°, treated with PhN₂Cl in Me₂CO, gives a vigorous evolution of N₂, with the formation of the HCl salt, decomposes 205°, of S-phenyl-1,4-diphenylthiosemicarbazide (II), PhNHNHC(SPh):NPh, m. 75°. II is easily degraded by alkali into I and PhSH. The mother liquor from II yields benzeneazophenyliminomethane thiophenyl ether (III), PhN:NC(SPh):NPh, red, m. 115°; this is the oxidation product of II and is formed from II with H₂O₂ or yellow HgO; III gives II with (NH₄)₂S. The p-nitrophenyl homolog of II forms a HCl salt (IV), pale yellow, decomposes 205°; the free base is so susceptible to hydrolysis that NH₄OH in EtOH gives (p-O₂NC₆H₄S)₂. With HCHO IV yields the diphenyldihydrotriazole ether of p-nitrothiophenol, PhN.N:C(SC₆H₄NO₂).NPh.CH₂, m. 127°; BzH gives the tri-Ph homolog, PhN.N:C(SC₆H₄NO₂).NPh.CHPh, brownish rose, m. 124°. The red azo compound m. 118°. (PhNH)₂CS and p-O₂NC₆H₄N₂Cl (V) in EtOH-Me₂CO at -5° give S-p-nitrophenyldiphenylisothiourea (VI), PhNHC(SC₆H₄NO₂):NPh, light yellow, m. 131°; on recrystallization from EtOH partial decomposition occurs into (PhNH)₂CO and p-O₂NC₆H₄SH; alkali gives complete hydrolysis. The p-Br derivative of VI, p-BrC₆H₄NH(CSC₆H₄NO₂):NPh, light yellow, m. 158°, results in 75% yield from p-BrC₆H₄NHCSHPh. CS(NH₂)₂ and PhN₂Cl in Me₂CO give [H₂NC(:NH)S]₂.2HCl, m. 173-4° (decomposition). V gives 84% of the compound H₂NC(:NH)SN:NC₆H₄NO₂ as the HCl salt; this salt decomposes in absolute EtOH at room temperature PhNHCO₂Et and V in Me₂CO at -5° give the p-nitrophenyl ether of p-nitrobenzenediazohydrosulfide (VII), O₂NC₆H₄N:NSC₆H₄NO₂, citron-yellow, decomposes 142°; it results in varying amounts by coupling different thiourethans with V. PhN:C(SH)OCH₂Ph and V in EtOH-Me₂CO give VII; in C₆H₆ there results the compound PhNHCOSC₆H₄NO₂, m. 158°.

Journal fuer Praktische Chemie (Leipzig) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Naidu, Ajay B. published the artcileAn efficient intermolecular BINAM-copper(I) catalyzed Ullmann-type coupling of aryl iodides/bromides with aliphatic alcohols, Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Tetrahedron Letters (2008), 49(19), 3147-3151, database is CAplus.

A wide range of alkyl aryl ethers are synthesized from the corresponding aryl iodides and aliphatic alcs. through Ullmann-type intermol. coupling reactions in the presence of a catalytic amount of easily available BINAM-CuI complex. Less reactive aryl bromides also reacted with aliphatic alcs. under identical conditions to give good yields of the alkyl aryl ethers without increasing the reaction temperature and time.

Tetrahedron Letters published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wei, Peter E. published the artcileNew vulcanizing agents for ethylene-propylene elastomers. III, Formula: C2H8Cl2N4S2, the publication is Rubber Chemistry and Technology (1966), 39(4), 1094-104, database is CAplus.

Perchloro-3a,4,7,7a-tetrahydro-4,7-methanonindene and perchloro-1,1′ -bis (2,2′ – cyclopentene) vulcanized ethylene-propylene rubber (I) when used in combination with S and Fe2O3. Vulcanization of I by octachlorocyclopentene (II)-S-Fe2O3 was enhanced by the presence of dithiodiformamidine-2HCl, phenylenediamine-HCl, diaminotoluene-2HCl, diaminophenol-2HCl, dichlorodimethylhydantoin, and trichloroisocyanuric acid. A vulcanization mechanism was given for the II-S-Fe2O3 system which proposes the formation of SF4, which abstracts H. Synergistic effects were observed with I vulcanization with II and tert-Bu2O2. The tensile strength of the polymers was most affected by the synergism.

Rubber Chemistry and Technology published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C8H15NO, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Moutaoukil, Zakaria published the artcileN-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes, Formula: C13H14N2O, the publication is Organic & Biomolecular Chemistry (2022), 20(4), 831-839, database is CAplus and MEDLINE.

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides was developed employing novel pentamethylcyclopentadienylruthenium(II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex I was proved to be particularly effective with a broad range of substrates with low catalyst loading (0.1-2.5 mol%) and high functional group tolerance under mild conditions. A total of 52 N-alkylated organonitrogen compounds including biol. relevant scaffolds were synthesized from (hetero)aromatic and aliphatic amines, amides and sulfonamides using alcs. or diols as alkylating agents in up to 99% isolated yield, even on gram-scale reactions. In the case of sulfonamides, it was the first example of N-alkylation employing a transition-metal complex bearing NHC ligands.

Organic & Biomolecular Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ziegler, E. published the artcileSyntheses of heterocyclics. XLI. Cyclic dichloromalonyl compounds, Formula: C2H8Cl2N4S2, the publication is Monatshefte fuer Chemie (1962), 1376-82, database is CAplus.

cf. ibid. 1062-4; CA 57, 9850b. The method of Baeyer and Bloem (Ber. Deut. Chem. Ges. 15, 2150 (1882)) for chlorination of 4-hydroxycarbostyril (I) was examined in various solvents. Thus, 60 g. I was heated to boiling in a mixture of 220 ml. dioxane, 100 ml. concentrated HCl, and 40 ml. H₂O. After heating was stopped, 200 ml. 30% H₂O₂ was quickly added. After 15 min. the oil which separated gradually crystallized to give 91% 3,3-dichloro-2,4-dioxo-1,2,3,4-tetrahydroquinoline (II), m. 175° (C₆H₆). Yields in other solvents were: H₂O-AcOH, 70%; EtOH, 58%. The following substituted 2,4-dioxo-1,2,3,4-tetrahydroquinolines were prepared in the same way (yield, m.p.): 3,3-dichloro-6,8-dimethyl, quant., 215° (C₆H₆); 1-methyl-3-benzyl-3-chloro (III), 97%, 136.0-6.5° (MeOH). 5,5-Dichlorobarbituric acid, m. 211-15° (dilute HCl), was prepared similarly in 80% yield from barbituric acid, while 5 g. 1-phenyl-3-methyl-2-pyrazolin-5-one was converted in 96% yield to its 4,4-dichloro derivative (IV), m. 61° (dilute alc.). A suspension of 40 g. I in 100 ml. dioxane was heated to 50°, stirred, and 55 ml. SO₂Cl₂ added slowly. Solution began and the mixture was boiled for a short time, cooled, and treated with 300 ml. ice-H₂O to give 96% II. The following 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives were prepared from the corresponding 4-hydroxycarbostyrils (yield, m.p.): 3,3-dichloro-6-fluoro, quant., 119° (EtOH); 3,3-dichloro-1-phenyl (V), quant., 200° (PhCl); 3,3-dichloro-1-benzyl (VI), quant., 122° (EtOH); 3-benzyl-3-chloro, 96%, 186° (AcOH). 5-Chlorobarbituric acid, m. 280-90° (decomposition) (H₂O), was similarly prepared in 79% yield. I (4 g.) in 25 ml. dioxane and 15 ml. H₂O was treated with Cl at 80° for 10-15 min., cooled, and 30 ml. H₂O added to give 96% 3,3,6-trichloro-2,4-dioxo-1,2,3,4-tetrahydroquinoline, m. 230-2° (EtOH). II (3 g.) was dissolved in 30 ml. EtOH and 10 ml. AcOH by boiling and 3 g. Zn dust added in small portions. Decolorization began in a few min., after which 150 ml. H₂O was added to precipitate 96.5% 3-chloro-4-hydroxycarbostyril (VII), which sintered at 270° and m. 275-80° (decomposition) (EtOH). Also prepared (name, starting compound, yield, m.p.) were: 1-phenyl-3-methyl-4-chloro-2-pyrazolin-5-one, IV, 94%, 153°; 1-phenyl-3-chloro-4-hydroxycarbostyril, V, quant., 264° (EtOH); 1-benzyl-3-chloro-4-hydroxycarbostyril, VI, quant., 253-4° (BuOH); 1-methyl-3-benzyl-4-hydroxycarbostyril, III, 86%, 213°. VII also was prepared in 94% yield by treating 0.2 g. II with 10 ml. 5% I in dioxane and 0.5 ml. concentrated HCl. CS(NH₂)₂ (3 g.) was partly dissolved in 40 ml. absolute EtOH and 1 ml. alc. HCl by heating at 50°, then the solution of II was added in small portions. Cooling caused precipitation of 2.5 g. diamidino disulfide dihydrochloride, m. 170° (decomposition).

Monatshefte fuer Chemie published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C22H18O2, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ge, Chenyang published the artcileUnsymmetrical indazolyl-pyridinyl-triazole ligand-promoted highly active iridium complexes supported on hydrotalcite and its catalytic application in water, Formula: C13H14N2O, the publication is Green Chemistry (2018), 20(8), 1805-1812, database is CAplus.

Herein, an indazolyl-pyridinyl-triazole ligand was synthesized and its Ir complex supported on hydrotalcite was characterized via x-ray power diffraction (XRD), XPS, energy dispersive X-ray (EDX) spectroscopy and TEM. This new heterogeneous catalyst bearing the unsym. indazolyl-pyridinyl-triazole ligand exhibits high catalytic activity in H₂O. Both functionalized amines and imines were obtained from the challenging selective reaction of benzylamines with arylamines through transfer hydrogenation and dehydrogenation under clean conditions. In particular, this catalyst system showed good recovery performance in H₂O. Mechanistic studies showed that this transformation occurs via amine dehydrogenation, hydrolysis and condensation processes. The direct capture of the reaction intermediate provides sufficient proof for this process.

Green Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ram, M. K. published the artcileFabrication and characterization of poly[(2-methoxy-5-(2′-ethyl-hexyloxy)phenylene vinylene] (MEH-PPV) Langmuir-Schaefer films and their application as photoelectrochemical cells, Product Details of C15H24O2, the publication is Synthetic Metals (2001), 122(2), 369-378, database is CAplus.

The Langmuir monolayer behavior of poly[2-methoxy-5-(2′-ethyl-hexyloxy)phenylenevinylene] (MEH-PPV) conducting polymer in a subphase containing various anions was investigated at the air-water interface. The Langmuir-Schaefer (LS) films were prepared in deionized water that showed the min. area per mol., and were found to be essential for the formation of Langmuir monolayer at the air-water interface of MEH-PPV conjugated polymer. The LS films of MEH-PPV were investigated by using UV-VIS absorption, electrochem. and at. force microscopic techniques. A uniform deposition of monolayers was shown by optical technique, whereas a higher number of monolayers resulted in the tiny island morphol. in MEH-PPV LS films. The influence of concentration of anions on the redox properties of the LS films was studied by cyclic voltammetric measurements. The nature of anions in electrochem. investigation revealed the significant changes in the redox properties of the MEH-PPV LS films. The photoelectrochem. current transient of MEH-PPV LS films was compared with those obtained by the solution cast technique. This work also focused on the influence of the nature of the electrolytes, the applied potential, the type of the film and the presence of dissolved oxygen on the photoelectrochem. properties of MEH-PPV conducting polymer.

Synthetic Metals published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Product Details of C15H24O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kreutzberger, Alfred published the artcileCondensations of α,α¹-dithiobisformamidine with β-diketones, COA of Formula: C2H8Cl2N4S2, the publication is Liebigs Annalen der Chemie (1981), 532-7, database is CAplus.

[H₂NC(:NH)S]₂ reacted with 1-(2-furyl)-4,4,4-trifluoro-1,3-butanedione to give 14% disulfide I and 20% ketone II. MeCOCH₂COCF₃ similarly gave 16% thione III.

Liebigs Annalen der Chemie published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, COA of Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kunzek, Herbert published the artcileSelectively S-protected cysteine peptides. IV. Synthesis of cysteine peptides using the S-ethylthio protecting group. II, Formula: C2H8Cl2N4S2, the publication is Journal fuer Praktische Chemie (Leipzig) (1980), 322(2), 186-98, database is CAplus.

S-Guanylthiocysteine was treated with RSH (R = Et, Me₂CH) to give H-Cys(SR)-OH, which were treated with R¹F [R¹ = p-PhC₆H₄CMe₂O₂C (Bpoc), PhCMe₂O₂C (Ppoc)] to give R¹-Cys(R)-OH (R = Et, R¹ = Bpoc, Ppoc; R = CHMe₂, R¹ = Ppoc). Bpoc-Cys(SEt)-OH and Ppoc-Cys(SEt)-OH were used in the conventional solution synthesis of H-Val-Cys(SEt)-Ala-Leu-OCMe₃, which was coupled to BOC-Cys(SEt)-Cys(Dpm)-Ala-Gly-OH (BOC = Me₃CO₂C, Dpm = CHPh₂) by dicyclohexylcarbodiimide/N-hydroxybenzotriazole to give BOC-Cys(SEt)-Cys(Dpm)Ala-Gly-Val-Cys(SEt)-Ala-Leu-OCM₃ (I). In the above synthesis, the EtS group was stable in all steps, including deprotection of Bpoc and Ppoc group. I was EtS-deblocked by HSCH₂CH₂OH to give BOC-Cys-Cys(Dpm)-Ala-Gly-Val-Cys-Ala-Leu-OCMe₃, which was oxidized to give protected insulin A 6-13 analog II.

Journal fuer Praktische Chemie (Leipzig) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Karmel, Caleb published the artcileIridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand, Category: ethers-buliding-blocks, the publication is Angewandte Chemie, International Edition (2020), 59(15), 6074-6081, database is CAplus and MEDLINE.

The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities dictated by steric effects, such as the borylation of C-H bonds, were poor in many cases. The authors report that the silylation of five-membered-ring heteroarenes occurs with high sterically derived regioselectivity when catalyzed by the combination of [Ir(cod)(OMe)]₂ (cod = 1,5-cyclooctadiene) and a phenanthroline ligand or a new pyridyl-imidazoline ligand that further increases the regioselectivity. The silylation reactions with these catalysts produce high yields of heteroarylsilanes from functionalization at the most sterically accessible C-H bonds of these rings under conditions that the borylation of C-H bonds with previously reported catalysts formed mixtures of products or products that are unstable. The heteroarylsilane products undergo cross-coupling reactions and substitution reactions with ipso selectivity to generate heteroarenes that bear halogen, aryl, and perfluoroalkyl substituents.

Angewandte Chemie, International Edition published new progress about 1073339-22-6. 1073339-22-6 belongs to ethers-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ether,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(4-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C11H17BO3S, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem