Tag: M.W=200-250

Ramachandran, Rangasamy published the artcileRuthenium(II) carbonyl complexes designed with arsine and PNO/PNS ligands as catalysts for N-alkylation of amines via hydrogen autotransfer process, Application of N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Journal of Organometallic Chemistry (2015), 130-140, database is CAplus.

A series of phosphine-functionalized hydrazone/thiosemicarbazone ligands and their corresponding ruthenium(II) carbonyl complexes of the type [RuCl(CO)(AsPh₃)(L)] [L = 2-(2-(diphenylphosphino)benzylidene)benzoic acid hydrazone (PNO-BHy), 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone (PNO-NHy), 2-(2-(diphenylphosphino)benzylidene)-2-furoic hydrazone (PNO-FHy), 2-(2-(diphenylphosphino)benzylidene)-4-ethyl-3-thiosemicarbazone (PNS-EtTs), 2-(2-(diphenylphosphino)benzylidene)-4-cyclohexyl-3-thiosemicarbazone (PNS-CyTs)] have been synthesized based on the ligands with different electronic and steric effects. These complexes were characterized by elemental analyses and various spectral methods. The solid-state structure of the ruthenium PNS-EtTs complex was determined by single-crystal X-ray diffraction method. In all of the complexes, the ligand was bound to the Ru(II) center via the PNO/PNS donor atoms. All the ruthenium(II) complexes were demonstrated as highly efficient catalysts for the synthesis of secondary amines/amides by the coupling of primary amines/amides with alcs. at low catalyst loading, and the maximum yield was obtained up to 98%. The N-alkylation reaction can be readily carried out under moderate conditions, and release of water is the sole byproduct. In addition, the effects of substituents on the ligand, solvents, base and catalyst loading on the catalytic activity of the complexes have been investigated. Advantageously, only one equivalent of the alc. was consumed in the process.

Journal of Organometallic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Application of N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kirchnerova, Jitka published the artcileThe mechanism of the electrochemical oxidation of thiourea, Related Products of ethers-buliding-blocks, the publication is Analytica Chimica Acta (1981), 83-95, database is CAplus.

Cyclic voltammetry and potentiostatic coulometry were used to study the electrochem. oxidation of thiourea [62-56-6] in aqueous solutions of HNO₃, HNO₃-NH₄NO₃, and NH₄NO₃-NH₄OH in MeCN. These studies were carried out at glassy C and/or Pt working electrodes. In MeCN, the cyclic voltammograms show 1 oxidation peak at ±0.6 V and a reduction peak at -0.1 V. In aqueous solutions up to about pH 6, there is a 2nd oxidation peak at 1.3 V which is irreversible and its height is sensitive to acidity. These experiments have confirmed that in acidic and neutral solutions, the oxidation of thiourea proceeds via a slow 1-electron transfer reaction producing a (NH₂)₂CS radical cation [61347-13-5]. Further direct oxidation of this radical takes place only at higher potentials (∼1.2 V) and involves hydration and proton-transfer equilibrium Otherwise, C,C‘-dithiodiformamidinium ion [64035-50-3] is formed by a fast dimerization reaction. Coulometric and chronopotentiometric measurements showed that in strong acid, the 2nd oxidation step involves 1 electron, while at lower acidities the further oxidation involving 3 (and possibly 5 electrons) proceeds in 2 (or 3) steps of very similar potential.

Analytica Chimica Acta published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Maurer, Hans published the artcileToxicological detection of ethylenediamine and piperazine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry, Formula: C13H14N2O, the publication is Fresenius’ Zeitschrift fuer Analytische Chemie (1988), 331(7), 744-56, database is CAplus.

A gas chromatog.-mass spectrometric procedure for the detection of the ethylenediamine and piperazine antihistamines and their metabolites in urine after acid hydrolysis, extraction and acetylation is described for adeptolon, antazoline, bamipine, buclizine, chlorcyclizine, chloropyramine, cinnarizine, clemizole, cyclizine, etodroxizine, histapyrrodine, hydroxyzine, meclozine, mepyramine, oxatomide, and tripelenamine. The acetylated extract was analyzed by computerized gas chromatog.-mass spectrometry. Using ion chromatog. with the selective ions m/z 58, 72, 85, 125, 165, 183, 198, and 201, the possible presence of ethylenediamine or piperazine antihistamines or their metabolites was indicated. The identity of pos. signals in the reconstructed ion chromatograms was then confirmed by a visual or computerized comparison of the stored full mass spectra with the reference spectra. The chromatograms, reference mass spectra, and gas chromatog. retention indexes (OV-101) are documented. The procedure presented was integrated in a general screening procedure (general unknown anal.) for several groups of drugs.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Patriciu, Oana-Irina published the artcileSynthesis of nitro N,N’-dipyridinylamines via oxidative nucleophilic substitution of hydrogen, Quality Control of 52818-63-0, the publication is Synthesis (2007), 3868-3876, database is CAplus.

The amination of 3-nitropyridines with aromatic amides generated from various aminopyridine derivatives proceeded unexpectedly in the position para to the nitro group, giving the oxidative nucleophilic substitution of hydrogen (ONSH) derived compounds After optimization, this reaction allowed easy access to interesting 3-nitro-substituted N,N’-dipyridinylamines.

Synthesis published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Quality Control of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Donthireddy, S. N. R. published the artcile[(PPh₃)₂NiCl₂]-Catalyzed C-N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Journal of Organic Chemistry (2021), 86(9), 6994-7001, database is CAplus and MEDLINE.

Com. available [(PPh₃)₂NiCl₂] was found to be an efficient catalyst for the mono-N-alkylation of (hetero)aromatic amines, employing alcs. to deliver diverse secondary amines, including the drug intermediates chloropyramine and mepyramine in excellent yields (up to 97%) via the borrowing hydrogen strategy. This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy was also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.

Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sahin, Neslihan published the artcileNovel N-Alkylbenzimidazole-Ruthenium (II) complexes: Synthesis and catalytic activity of N-alkylating reaction under solvent-free medium, Synthetic Route of 52818-63-0, the publication is Applied Organometallic Chemistry (2019), 33(2), n/a, database is CAplus.

In this article, direct N-alkylation reactions of amines with alcs. derivatives have been investigated. For this purpose, a new series ruthenium (II) complexes bearing N-coordinated benzimidazole complexes with have been synthesized and fully characterized by elemental anal., FT-IR, ¹H NMR and, ¹³C NMR spectroscopies. Addnl., the structures of the complexes have been confirmed by X-ray crystallog. Although the N-alkylating reaction is usually performed in toluene, the catalytic study of complexes has carried out no addnl. solvent and alc. acted both as solvent and reactant of alkylating by using a little excess of alcs. Surprisingly, conversion and selectivity of amine product for alkylation reaction have been seen high in medium solvent-free relative to in toluene.

Applied Organometallic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Synthetic Route of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Madhiri, Nicholas published the artcileOxyhalogen-sulfur chemistry: kinetics and mechanism of oxidation of formamidine disulfide by acidic bromate, Safety of Formamidine disulfide dihydrochloride, the publication is Physical Chemistry Chemical Physics (2003), 5(19), 4149-4156, database is CAplus.

The kinetics and mechanism of the oxidation of formamidine disulfide, FDS, a dimer and major metabolite of thiourea, by bromate were studied in acidic media. In excess bromate conditions the reaction displays an induction period before formation of Br. The stoichiometry of the reaction is: 7BrO₃^– + 3[H₂N(HN:)CS-]₂ + 9H₂O → 6NH₂CONH₂ + 6SO₄^2- + 7Br^– + 12H⁺ (A). In excess oxidant conditions, however, the bromide formed in reaction A reacts with bromate to give Br and a final stoichiometry of: 14BrO₃^– + 5[H₂N(HN:)CS-]₂ + 8H₂O → 10NH₂CONH₂ + 10SO₄^2- + 7Br₂ + 6H⁺ (B). The direct reaction of Br and FDS was also studied and its stoichiometry is: 7Br₂ + [H₂N(HN:)CS-]₂ + 10H₂O → 2NH₂CONH₂ + 2SO₄^2- + 14Br^– + 18H⁺ (C). The overall rate of reaction A, as measured by the rate of consumption of FDS, is second order in acid concentrations, indicating the dominance of oxyhalogen kinetics which control the formation of the reactive species HBrO₂ and HOBr. The reaction proceeds through an initial cleavage of the S-S bond to give the unstable sulfenic acids which are then rapidly oxidized through the sulfinic and sulfonic acids to give sulfate. The formation of Br coincides with formation of sulfate because the cleavage of the C-S bond to give sulfate occurs at the sulfonic acid stage only. The mechanism derived is the same as that derived for the bromate-thiourea reaction, suggesting that FDS is an intermediate in the oxidation of thiourea to its oxo-acids as well as to sulfate.

Physical Chemistry Chemical Physics published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Safety of Formamidine disulfide dihydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yigit, Beyhan published the artcileActive ruthenium(II)-NHC complexes for alkylation of amines with alcohols using solvent-free conditions, Computed Properties of 52818-63-0, the publication is Polyhedron, database is CAplus.

A series of new ruthenium(II) complexes bearing N-heterocyclic carbene ligands with benzylic groups were prepared by transmetallation reactions between silver(I) N-heterocyclic carbene complexes and [RuCl₂(p-cymene)]₂. All of the obtained complexes were characterized by FT-IR, ¹H NMR and ¹³C NMR spectroscopy, and the mol. structure of compound 3c was also determined by x-ray crystallog. These ruthenium complexes were tested for the alkylation of aromatic amines with a wide range of primary alcs. under solvent-free conditions using the hydrogen borrowing strategy. All of the compounds tested here showed excellent catalytic activity for these reactions and N-monoalkylated products were obtained selectively using 2.5 mol% of the ruthenium complexes.

Polyhedron published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C39H35N5O8, Computed Properties of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ratajczak, H. M. published the artcilePolarographic studies on aqueous formamidine disulfide solutions. I, Category: ethers-buliding-blocks, the publication is Electrochimica Acta (1975), 20(6-7), 427-9, database is CAplus.

The polarog. reduction of [H2NC(:NH)S]2 (I) in aqueous solution, prepared by oxidation of CS(NH2)2 with H2O2 and by in situ polarog. oxidation of CS(NH2)2 with Ce(IV), was dependent on the acidity of the solution and 3 reduction waves were observed The wave at lowest limiting current was assigned to reduction of the protonated formamidine disulfide [(NH2)2CS]22+ and the second wave to the reduction of a less protonated form. The wave at highest limiting current was due to the reduction of a polysulfide compound formed by reaction of S, from the minor decomposition of I, with I.

Electrochimica Acta published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sunagawa, Genshun published the artcileSynthesis of organic bases. VI. Synthesis of thonzylamine, HPLC of Formula: 52818-63-0, the publication is Takamine Kenkyusho Nenpo (1952), 36-9, database is CAplus.

cf. C.A. 48, 8777d. Thonzylamine (I) was prepared by the following 3 routes: (a) Heating anisaldehyde, 2-aminopyridine (Ia), and HCO₂H gave 2-(p-methoxybenzylamino)pyridine (II), m. 108-9°, which, converted to the Na salt and treated with Me₂NCH₂CH₂Cl (III), gave 96% I, b₃ 191-3°. (b) 2-Formylaminopyridine and anisaldehyde in ethylene glycol gave 73.1% II which with III gave I, (lower yield than method a). (c) Ia and III in the presence of NaNH₂ yielded 29.4% N,N-Dimethyl-N’-(2-pyrimidyl)ethylenediamine, b₃ 90-5°, which was converted to the N’-formyl compound, b₆ 121-5° (96.4% yield), and finally heated with anisaldehyde in glycol to give I.

Takamine Kenkyusho Nenpo published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C3H6O2, HPLC of Formula: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem