Tag: M.W=200-250

Kulhanek, Jiri published the artcile3,4-Dinitrothiophene as a central unit of quadrupolar push-pull-push systems, Recommanded Product: 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2017), 53(1), 46-53, database is CAplus.

A series of quadrupolar D-π-A-π-D mols. bearing methoxythiophene terminal donor and systematically enlarged/varied π-linkers, e.g., I was synthesized by employing cross-coupling and Knoevenagel reactions. 3,4-Dinitrothiophene was utilized as a central acceptor unit in quadrupolar D-π-A-π-D push-pull-push chromophores. Optical properties were studied by electronic absorption spectra. Fundamental optoelectronic properties were investigated by semiempirical PM7 calculations It was shown that by varying the p-conjugated system the longest wavelength absorption maxima could be shifted from 341 to 489 nm. The calculated HOMO-LUMO gaps were found within the range of 6.69-7.29 eV, while the second-order mol. polarizabilities could be tuned from 0.038 to 1.578 × 10-27 esu.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 596819-12-4. 596819-12-4 belongs to ethers-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ether,Boronate Esters,Boronic acid and ester, name is 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C11H17BO3S, Recommanded Product: 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Higashi, Lois S. published the artcileEmpirical relations between disulfide bond lengths, (nitrogen or carbon)-carbon-sulfur-sulfur torsion angles, and substituents in aromatic disulfides. Crystal and molecular structure of 3,3′-dihydroxydi-2-pyridyl disulfide, Name: Formamidine disulfide dihydrochloride, the publication is Journal of the American Chemical Society (1978), 100(26), 8101-6, database is CAplus.

In the 21 reported crystal structures of sym. disulfides whose sulfur atoms are bound to sp² carbon atoms, an empirical relationship is found between the S-S bond length and the X-C-S-S (X = C or N) torsion angle. The C-S-S-C torsion angles are generally within about 20° of 90° in those mols. In addition, it is noted that the less frequently encountered X-C-S-S angles near 90° occur only when one strongly electron-donating substituent is present in a position β to the disulfide group in each of the R groups of the RSSR mol., or when both β positions on each R group are substituted, independent of electron negativity. A relatively neutral or electron-withdrawing group in only one β position of each R group (or any substituents at any more distant positions) allows the X-C-S-S torsion angles to be near 0°, and the S-S bond, therefore, to be short. This result is supported by the crystal and mol. structure of 3,3′-dihydroxydi-2-pyridyl disulfide, which has been determined by single-crystal x-ray diffraction techniques using counter methods, and has been refined by full-matrix least-squares procedures to a final conventional R index of 0.035. The yellow monoclinic crystals form in the space group P2₁/c with a = 7.165 (1) Å,b = 7.656(1) Å,c = 19.517(3) Å,β = 96.77(1)°, and four mols. per unit cell. The average N-C-S-S torsion angle (9°) indicates that the S-S bond (2.0180(7) Å) is nearly in the plane of each pyridine ring. The C-S-S-C torsion angle is 93.2°, and the average S-C bond length is 1.782 Å. The empirical rules presented also successfully describe the 11 transition metal ion complexes involving these disulfides whose structures are known. The C-S-S-C torsion angle has a role in governing the S-S bond length, but is important only when X-C-S-S is within about 20° of 90° or when C-S-S-C deviates by about 40° or more from 90°.

Journal of the American Chemical Society published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Name: Formamidine disulfide dihydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xue, Cuihua published the artcileNovel p-phenylene-vinylene-dithienylene type copolymer: potential red-emitting materials, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Synthetic Metals (2004), 145(1), 67-73, database is CAplus.

The p-phenylene-vinylene-dithienylene type copolymers (PPV-DT) with or without cyano group on the vinylene moiety were synthesized by Wittig-Horner-Emmons reaction and palladium-catalyzed homo-coupling reaction. The photophys. and optoelectronic properties of these copolymers as potential red-emitting materials were discussed.

Synthetic Metals published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C11H8F2, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cheng, Faxiang published the artcilePoly(2-methoxy-5-(2′-ethylhexyloxy)-p-phenylene vinylene) synthesized by bromine methylation, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Huagong Xinxing Cailiao (2010), 38(6), 49-51, database is CAplus.

Poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV) was successfully synthesized using p-methoxy phenol and 1-bromo-2-ethylhexane through the reactions of etherification, bromine methylation and de-hydrogen bromide. The number average mol. weight of MEH-PPV was 5.7×10⁴. The structure of intermediates and MEH-PPV were characterized by FTIR, ¹HNMR and UV-Vis. The structure of intermediates and MEH-PPV was consistent with the reported in the literature.

Huagong Xinxing Cailiao published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Blank, Benoit published the artcileAn efficient method for the selective iridium-catalyzed monoalkylation of (hetero)aromatic amines with primary alcohols, Computed Properties of 52818-63-0, the publication is Advanced Synthesis & Catalysis (2008), 350(5), 749-758, database is CAplus.

An efficient multi-gram scale synthesis protocol of a variety of P,N ligands is described. The synthesis is achieved in a two-step reaction. First, the amine is deprotonated and subsequently the chlorophosphine is added to yield the corresponding P,N ligand. Deprotonation of the amine is normally achieved with BuLi at low temperature, but for the preparation of ligands with a 2,2′-dipyridylamino backbone and phosphines with a high steric demand KH has to be employed in combination with reaction temperatures of 110°C for the salt metathesis step. The reaction of two equivalent of a selected P,N ligand with one equivalent of the iridium complex [IrCl(cod)]₂ (cod = 1,5-cyclooctadiene) affords P,N ligand-coordinated iridium complexes in quant. yield. X-Ray single crystal structure anal. of one of these complexes reveals a monomeric five-coordinated structure in the solid state. The iridium complexes were used to form catalysts for the N-alkylation of aromatic amines with alcs. The catalyst system was optimized by studying 8 different P,N ligands, 9 different solvents and 14 different bases. Systematic variation of the substrate to base and the amine to alc. ratios as well as the catalyst loading led to optimized catalytic reaction conditions. The substrate scope of the developed catalytic protocol was shown by synthesizing 20 different amines of which 12 could be obtained in isolated yields higher than 90%. A new efficient catalyst system for the selective monoalkylation of primary aromatic and heteroaromatic amines with primary aromatic, heteroaromatic as well as aliphatic alcs. has been established. The reaction proceeds with rather moderate catalyst loadings.

Advanced Synthesis & Catalysis published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Computed Properties of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yang, Wei published the artcileStructure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model, Application In Synthesis of 338454-30-1, the publication is European Journal of Medicinal Chemistry (2021), 112842, database is CAplus and MEDLINE.

Ferroptosis is a new type of programmed cell death discovered recently and has been demonstrated to be involved in a number of human diseases such as ischemic stroke. Ferroptosis inhibitors are expected to have potential to treat these diseases. Herein, we report the identification of promethazine derivatives as a new type of ferroptosis inhibitors. Structure-activity relationship (SAR) analyses led to the discovery of the most potent compound 2-(1-(4-(4-methylpiperazin-1-yl)phenyl)ethyl)-10H-phenothiazine (51), which showed an EC₅₀ (half maximal effective concentration) value of 0.0005μM in the erastin-induced HT1080 cell ferroptosis model. In the MCAO (middle cerebral artery occlusion) ischemic stroke model, 51 presented an excellent therapeutic effect. This compound also displayed favorable pharmacokinetic properties, in particular, a good ability to permeate the blood-brain barrier. Overall, 51 could be a promising lead compound for the treatment of ferroptosis related diseases and deserves further investigations.

European Journal of Medicinal Chemistry published new progress about 338454-30-1. 338454-30-1 belongs to ethers-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (4-(Benzyloxy)-3-methylphenyl)boronic acid, and the molecular formula is C25H29N9O3, Application In Synthesis of 338454-30-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Xiao-Chang published the artcileSynthesis, Properties, and Application of New Luminescent Polymers with Both Hole and Electron Injection Abilities for Light-Emitting Devices, HPLC of Formula: 146370-51-6, the publication is Chemistry of Materials (1999), 11(6), 1568-1575, database is CAplus.

New luminescent polymers that contain both electron-withdrawing cyano groups and electron-rich moieties, triphenylamine (TPA) or tetraphenyldiaminobiphenyl (TPD), were synthesized by Knoevenagel condensation of 1,4-bis(cyanomethyl)-2-[(2-ethylhexyl)oxy]-5-methoxybenzene with the dialdehyde of TPA or TPD, resp. The polymers were characterized by NMR, FT-IR, microanal., GPC, DSC, and TGA. Efficient orange photoluminescence was observed with an absolute quantum efficiency of 48% for the TPA incorporated polymer (TPA-CNPPV). Cyclic voltammetry investigation showed that the polymers presented reversible oxidation and reduction with relatively low potentials, which suggested that the polymers have both good electron and hole injection abilities. We demonstrated an effective approach to synthesize polymers with the triad properties of efficient photoluminescence, good hole injection and high electron-affinity properties, which are highly desirable for application in light-emitting devices. This point was supported by the demonstration of a single layer light-emitting device with a configuration of ITO/TPA-CNPPV/Al, in which good external quantum efficiency (0.1%) and bright luminance of 2100 cd/m² was achieved. Multilayer LEDs using the polymers as the active layers and different charge injection/transporting layers were also investigated.

Chemistry of Materials published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, HPLC of Formula: 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Bingxin published the artcileWhite light emission transparent polymer nanocomposites with novel poly(p-phenylene vinylene) derivatives and surface functionalized CdSe/ZnS NCs, Formula: C15H24O2, the publication is Dyes and Pigments (2013), 99(1), 192-200, database is CAplus.

A series of new polymers with conjugated poly(p-phenylene vinylene) units and non-conjugated poly(p-xylylene) units containing vinyl and carboxyl groups were synthesized. The monodisperse CdSe/ZnS nanocrystals with a red light emission were prepared by using the phosphine-free precursors. A novel fluorescent polymer and 5-(2-methacryloylethyloxymethyl)-8-quinolinol were dispersed in vinyl monomers containing CdSe/ZnS NCs to successfully fabricate transparent bulk nanocomposites by in situ polymerization The 5-(2-methacryloylethyloxymethyl)-8-quinolinol mols. can be coordinated to the surface of CdSe/ZnS nanocrystals to form a metalloquinolate with green light emission at about 500 nm, while the red light emission of nanocrystals remained after the polymerization process. The efficient white light emitting polymer nanocomposites with color coordinates (0.32, 0.34) can be obtained when the weight ratio of nanocrystals to 5-(2-methacryloylethyloxymethyl)-8-quinolinol is 10:1. A charge transfer from the photoexcited metalloquinolates to the nanocrystals was observed in the system.

Dyes and Pigments published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Formula: C15H24O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Chuanzhi published the artcileDiscovery and Mechanistic Studies of a General Air-Promoted Metal-Catalyzed Aerobic N-Alkylation Reaction of Amides and Amines with Alcohols, Product Details of C13H14N2O, the publication is Journal of Organic Chemistry (2011), 76(14), 5759-5773, database is CAplus and MEDLINE.

The thermodynamically unfavorable anaerobic dehydrogenative alc. activation to aldehydes and hydridometal species is the bottleneck in metal-catalyzed N-alkylations due to a general and unnoticed catalyst deactivation by amines/amides. Thus, different from the anaerobic dehydrogenation process in borrowing hydrogen or hydrogen autotransfer reactions that require noble metal complexes or addition of capricious ligands for catalyst activation, the water-producing, exothermic, metal-catalyzed aerobic alc. oxidation is thermodynamically more favorable and the most effective and advantageous aldehyde generation protocol. This leads to a general and advantageous air-promoted metal-catalyzed aerobic N-alkylation methodol. that effectively uses many simpler, less expensive, more available, and ligand-free metal catalysts that were inactive under typical anaerobic borrowing hydrogen conditions, avoiding the use of preformed metal complexes and activating ligands and the exclusive requirement of inert atm. protection. This aerobic method is quite general in substrate scope and tolerates various amides, amines, and alcs., revealing its potentially broad utilities and interests in academy and industry. In contrast to the commonly accepted borrowing hydrogen mechanism, based on a thorough mechanistic study and supported by the related literature background, a new mechanism analogous to the relay race game that has never been proposed in metal-catalyzed N-alkylation reactions is presented.

Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Product Details of C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chou, Hsuan-Liang published the artcileChain composition dependence of optoelectronic properties for MEH-PV/DPO-PV copolymers, Computed Properties of 146370-51-6, the publication is Guoli Taiwan Daxue Gongcheng Xuekan (2003), 111-119, database is CAplus.

The copolymerization of 5-methoxy-2-((2′-ethyl-hexyl)-oxy)-p-phenylenevinylene (MEH-PV) and 2,3-diphenyl-5-octyl-1,4-phenylenevinylene (DPO-PV) via the Gilch route tended to form an alternative copolymer. As a result, the emission color of electroluminescence (EL) of MEH-PPV could be adjusted from orange-red to blue-green by copolymerization, however, the turn-on voltage of the prepared light-emitting diode device was increased and the EL efficiency was decreased with the content of DPO-PV in copolymer.

Guoli Taiwan Daxue Gongcheng Xuekan published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Computed Properties of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem