Tag: M.W=200-250

Yu, Xiaochun published the artcileManganese Dioxide Catalyzed N-Alkylation of Sulfonamides and Amines with Alcohols under Air, Quality Control of 52818-63-0, the publication is Organic Letters (2011), 13(23), 6184-6187, database is CAplus and MEDLINE.

By simply running the reactions under air and solvent-free conditions using catalytic amounts of manganese dioxide, a practical and efficient N-alkylation method for a variety of sulfonamides and amines using alcs. as green alkylating reagents was developed.

Organic Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C4H6O3, Quality Control of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhao, Lifeng published the artcileNovel hyperbranched polyphenylene vinylenes with nitro group: synthesis, characterization and photophysical properties, Safety of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Huazhong Shifan Daxue Xuebao, Ziran Kexueban (2013), 47(1), 63-67, database is CAplus.

Novel PPV derivates with nitro group were designed and successfully synthesized through Gilch reaction. The reaction intermediate and polymers were characterized by ¹H NMR, GPC and Elemental Anal. (EA). The photophysics properties, thermal property, electrochem. property were investigated, these polymers are soluble in common organic solvents and they have good thermal stability. The onset weights loss temperature of polymers were 386.6, 370.4 and 397.8°C for P₁, P₂ and P₃, resp. In comparison with the solution absorption spectra, the absorption bands of polymers (P₁, P₂ and P₃) in thin films were red-shifted. These polymers may be promising materials for solar cells.

Huazhong Shifan Daxue Xuebao, Ziran Kexueban published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C10H20N2O6S2, Safety of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhao, Lifeng published the artcileNovel hyperbranched poly (phenylene vinylene) s containing four arms: Synthesis, characterization and properties of photophysics, Formula: C15H24O2, the publication is Huazhong Shifan Daxue Xuebao, Ziran Kexueban (2012), 46(1), 45-48, 100, database is CAplus.

Novel PPVs derivates were designed and successfully synthesized through Gilch reaction. The reaction intermediates and polymers were characterized by ¹H NMR, GC-MS or GPC and Elemental Anal. (EA). Their optical properties, thermal properties, electrochem. properties were investigated. These polymers were soluble in common organic solvents and they have good thermal stability. The onset weights loss temperature of the three polymers were found to be 371.7, 386.6 and 391.8°C for P₁, P₂ and P₃, resp. Compared with their spectra absorption in chloroform, the absorption bands of polymers P₁, P₂ and P₃ in thin films were red-shifted. These polymers would be promising materials for luminescent materials or solar cells.

Huazhong Shifan Daxue Xuebao, Ziran Kexueban published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C3H6O2, Formula: C15H24O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Xiaohui published the artcileEfficient and practical catalyst-free-like dehydrative N-alkylation of amines and sulfinamides with alcohols initiated by aerobic oxidation of alcohols under air, Application of N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Tetrahedron (2016), 72(2), 264-272, database is CAplus.

We developed simple and practical N-alkylation reactions of amines and sulfinamides with primary and secondary alcs. by using only catalytic amounts of air as the initiator without adding any external catalysts. This method has advantages of simple conditions, easy operation, and comparatively wider scope of substrates, providing an efficient and green catalyst-free-like alc.-based dehydrative N-alkylation method. Mechanistic studies revealed that air initiated the reactions by aerobic oxidation of the alcs. to the key initiating aldehydes or ketones in the presence of bases.

Tetrahedron published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Application of N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Huang, Ming published the artcileRuthenium(II) complexes with N-heterocyclic carbene-phosphine ligands for the N-alkylation of amines with alcohols, Related Products of ethers-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2021), 19(15), 3451-3461, database is CAplus and MEDLINE.

Metal hydride complexes are key intermediates for N-alkylation of amines with alcs. by the borrowing hydrogen/hydrogen autotransfer (BH/HA) strategy. Reactivity tuning of metal hydride complexes could adjust the dehydrogenation of alcs. and the hydrogenation of imines. Herein we report ruthenium(II) complexes with hetero-bidentate N-heterocyclic carbene (NHC)-phosphine ligands, which realize smart pathway selection in the N-alkylated reaction via reactivity tuning of [Ru-H] species by hetero-bidentate ligands. In particular, complex I·BArF^– with a Ph wingtip group and BArF^– counter anion, is shown to be one of the most efficient pre-catalysts for this transformation (temperature is as low as 70°C, neat conditions and catalyst loading is as low as 0.25 mol%). A large variety of (hetero)aromatic amines and primary alcs. were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields. Notably, aliphatic amines, challenging methanol and diamines could also be transformed into the desired products. Detailed control experiments and d. functional theory (DFT) calculations provide insights to understand the mechanism and the smart pathway selection via [Ru-H] species in this process.

Organic & Biomolecular Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

McBride, Christopher M. published the artcileDesign, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990, Application In Synthesis of 596819-12-4, the publication is Journal of Medicinal Chemistry (2014), 57(21), 9124-9129, database is CAplus and MEDLINE.

Utilizing structure-based drug design, a novel dihydropyridopyrimidinone series which exhibited potent Hsp90 inhibition, good pharmacokinetics upon oral administration, and an excellent pharmacokinetic/pharmacodynamic relation in vivo was developed from a com. hit. The exploration of this series led to the selection of NVP-HSP990 as a development candidate.

Journal of Medicinal Chemistry published new progress about 596819-12-4. 596819-12-4 belongs to ethers-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ether,Boronate Esters,Boronic acid and ester, name is 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C11H17BO3S, Application In Synthesis of 596819-12-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sun, Xiaobo published the artcileSynthesis and characterization of poly(1,4-phenylenevinylene) derivatives containing liquid crystalline oxadiazole groups, COA of Formula: C15H24O2, the publication is Journal of Applied Polymer Science (2004), 91(1), 396-403, database is CAplus.

Two novel poly(1,4-phenylenevinylene) (PPV) derivatives containing liquid crystalline oxadiazole side chains were prepared by a dehydrochlorination process. The homopolymer poly[2-methoxy-5-((2-methoxy-phenyl)-5-hexyloxy-phenyloxy-1,3,4-oxadiazole)-1,4-phenylenevinylene] (HO-PE₆) is insoluble in common solvents, whereas the copolymer poly[2-methoxy-5-((2-methoxy-phenyl)-5-hexyloxy-phenyloxy-1,3,4-oxadiazole)-(2-methoxy-5-(2′-ethylhexyloxy))-1,4-phenylenevinylene] (CO-PE₆) is soluble in common solvents such as chloroform, THF, and p-xylene. The mol. structure of CO-PE₆ was confirmed by FTIR, ¹H-NMR, UV-vis spectroscopy, and polarized light microscopy. CO-PE₆ showed a maximum emission at 556 nm in chloroform and at 564 nm in solid film, when excited at 450 nm. The maximum electroluminescence emission of the device indium-tin oxide (ITO)CO-PE₆/Al is at 555 nm. The turn-on voltage of LEDs based on CO-PE₆ and MEH-PPV is 6.5 and 8.5 V, resp. The electron mobility of CO-PE₆ is higher than that of MEH-PPV based on the results of current-voltage and electrochem. behavior of both MEH-PPV and CO-PE₆.

Journal of Applied Polymer Science published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is Al2H32O28S3, COA of Formula: C15H24O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Zhen Gang published the artcileZrCl₄/Hantzsch 1,4-dihydropyridine as a new and efficient reagent combination for the direct reductive amination of aldehydes and ketones with weakly basic amines, Application of N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Chinese Chemical Letters (2007), 18(4), 458-460, database is CAplus.

ZrCl₄/Hantzsch 1,4-dihydropyridine is a mild and highly efficient reagent combination for the direct reductive amination. Weakly basic amines such as anilines substituted by electron-withdrawing group and heteroaromatic amines can be reductively alkylated with electron rich aldehydes and ketones under mild conditions to form the secondary amines in excellent yields.

Chinese Chemical Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Application of N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sunagawa, Genshun published the artcileDecomposition of benzylamine derivatives. II, SDS of cas: 52818-63-0, the publication is Yakugaku Zasshi (1952), 1570-4, database is CAplus.

cf. C.A. 46, 11210c. 2-Aminopyrimidine (I) (15 g.), 8.7 g. HCO₂H, and 18.4 g. BzH, heated 21 hrs. at 150-60°, cooled, extracted with 80 ml. dilute HCl, the aqueous layer washed with Et₂O, adjusted to pH 7-8, and the precipitate recrystallized from alc. give 18.5 g. 2-benzylaminopyrimidine (II), m. 82.5-3.5°; similarly are prepared the 2-(p-chlorobenzylamino)- (III), m. 127-8°, and 2-(p-nitrobenzylamino)pyrimidine (IV), m. 153-4°. Heating 10 g. p-MeOC₆H₄CHO, 9 g. 2-formamidopyrimidine, and 10 ml. (CH₂OH)₂ 8 hrs. at 170-80° and extracting the product as in the preparation of II gives 14.9 g. 2-(p-methoxybenzylamino)pyrimidine (V), m. 108-9°; 2-(p-MeOC₆H₄CH₂NH)C₅H₄N (VI) m. 124°; 33.2 g. PhNH₂, 10.5 g. NaHCO₃, and 10 ml. water heated with 15.7 g. p-MeOC₆H₄CH₂Cl, cooled, and the product extracted with Et₂O, washed with saturated NaCl solution, and distilled gave 16.6 g. p-MeOC₆H₄CH₂NHPh (VII), b_2.5 170-7°, m. 64-5° (from alc.); reaction of NaNH₂ and II, and treatment of the Na salt with Me₂NCH₂CH₂Cl gave p-RC₆H₄CH₂NR’R” [(VIII), R = H, R’ = 2-pyrimidyl (IX), R” = Me₂NCH₂CH₂ (X)] (XI), b₁₀ 180-4° (HCl salt, m. 204-5°); similarly, III gives VIII (R = Cl, R’ = IX, R” = X) (XII), b₃ 185-90° (HCl salt, m. 163-4°). Treating 22.5 g. anisaldoxime in 94% alc. and 170 ml. water with 60 g. Zn powder and 160 ml. 50% AcOH dropwise, heating 3 hrs. at 30-40°, cooling, alkalinizing and steam-distilling gave 20 g. p-MeOC₆H₄CH₂NH₂.HCl (XIII), m. 230-1°; heating 7.8 g. XI and 3.1 g. Me₂NCH₂CH₂Cl 1 hr. at 100°, alkalinizing, extracting with Et₂O, and distilling gave 2.2 g. (VIII, R = MeO, R’ = H, R” = X), b₁₇ 173-5° (HCl salt, m. 192-3°). Heating II, XI.HCl, and XIII, resp. with 10% HCl 5 hrs. gave unchanged raw materials; 10 g. VI yielded 0.7 g. 2-H₂NC₆H₄N (XIV), m. 57°, and 0.9 g. (p-MeOC₆H₄)₂CH₂ (XV), m. 52° (test for the presence of HCHO was pos.); 10 g. V gave 0.05 g. XV and 1.2 g. XIV; 10 g. VII gave 0.1 g. XV, HCHO, and 0.7 g. PhNH₂, b₁₀ 66° (benzoylated to 1.3 g. C₁₃H₁₁ON, m. 161°).

Yakugaku Zasshi published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C11H22N2O4, SDS of cas: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ryu, Jung-Yi published the artcileMobility characteristics of novel oligomer structuralized by biphenyl conjugated with electron donating units, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2009), 15(4), 504-509, database is CAplus.

Oligomers containing biphenyl backbone were prepared by using Wittig reaction and their optical properties were characterized. The drift mobility of oligomers was measured by using TOF method. The drift mobility showed elec. field-dependent character and coincidence with Poole-Frankel relation.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem