Tag: M.W=200-300

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 588-96-5 as follows. Recommanded Product: 588-96-5

Example 2.1(2-{4-[1 -(4-Ethoxy-phenyl)-piperidin-4-yl1-phenyl)-1 -methyl-ethyl Vacetamide3.0 mL Toluene/tert-butanol (5:1 ) are added to a mixture of 130 mg (0.50 mmol) N-[1 – methyl-2-(4-piperidin-4-yl-phenyl)-ethyl]-acetamide (VIII.1 ), 100 mg (0.50 mmol) 1 – bromo-4-ethoxy-benzene, 80 mg (0.83 mmol) sodium tert-butyrat, 20 mg (0.040 mmol) X-Phos and 10 mg (0.040 mmol) palladium(ll) acetate. The mixture is stirred for 10 min at 150C under microwave irradiation in a sealed tube. After that time, the mixture is poured into 1 mL 0.1 N HCl . 1 mL cone, ammonia is added and the mixture is extracted with ethyl acetate (3x). The combined organic layers are dried over sodium sulphate and the solvent is removed in vacuo. The residue is purified by column chromatography (silica gel; DCM/MeOH 19:1 ) to yield the desired product. C2 H32N2O2 (M = 380.5 g/mol), ESI-MS: 381 [M+H]+

According to the analysis of related databases, 588-96-5, the application of this compound in the production field has become more and more popular.

Reference of 112970-44-2, A common heterocyclic compound, 112970-44-2, name is 2-Bromo-3-methoxyaniline, molecular formula is C7H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of Intermediate iSA (3.25 g, 16.09 mmol) and potassium 0-ethyl carbonodithioate (6.45 g, 40.2 mmol) in DMF (20 mL) was heated at 135 C under argon for 6.0 h. HPLC and LCMS indicated a completion of the reaction. The mixture was cooled to room temperature, diluted with 20 mL water, followed by addition of 30 mL 1.0 N HC1. The precipitate formed was collected by filtration, washed with water, dried under vacuum and then chased with toluene (3X) to yield Intermediate 15B (3.1 g, 15.71 mmol, 98 % yield) as a brown solid. It was used for the next step without further purification. ?H NMR (500MHz, DMSO-d6) 13.77 (br. s., 1H), 7.38 (t, J=8.1 Hz, 1H), 6.94 (t, J=8.1 Hz, 2H), 3.91 (s, 3H); LC-MS: method A, RT = 1.63 mm, MS (ESI) m/z:198.0(M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 27060-75-9, name is 1-Bromo-4-methoxy-2-methylbenzene, molecular formula is C8H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Bromo-4-methoxy-2-methylbenzene

General procedure: In a microwave tube were added a suspension of Pd(dba)2 (5mol%), tBu3PHBF4 (10mol%), NaOH (2eq), aryl bromide (1.2eq) and alpha-tetralone (1.0eq) in a mixture of degassed dioxane/water (4:1, v/v, 2-4mL) and heated under Ar and microwave irradiation (100W of initial power, 100C, 60min, infrared probe). Then, the mixture was allowed to cool to rt, diluted in AcOEt, washed with saturated NH4Cl solution, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude material was purified by silica gel column with n-hexane:AcOEt (95:5) as solvent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 27060-75-9, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27060-75-9, name is 1-Bromo-4-methoxy-2-methylbenzene, A new synthetic method of this compound is introduced below., Product Details of 27060-75-9

a 4-Bromo-3-bromomethylanisole To a stirred solution of 4-bromo-3-methylanisole (100 g, 497 mmol) in dry dichloromethane (500 mL) was added N-bromosuccinimide (97 g, 545 mmol) followed by benzoyl peroxide (6 g, 25 mmol). The reaction was gently refluxed with a 150 watt flood lamp with reflector placed approximately 12 inches from the reaction flask. After 24 h the reaction was concentrated by rotary evaporation to half its volume and allowed to sit for 4 h. The white precipitate which formed was filtered off and rinsed with a small volume of dichloromethane. The filtrate was concentrated to dryness and the remaining solid was triturated with hexanes and filtered. Drying under vacuum gave the title compound (100.25 g, 72%) as white needles: GC tR=6.56 min (HP 530 mum*20 m methylsilicone column, He carrier flow 20 mL/min, 100 C. initial temp., 1 min initial time, 10 C./min rate, 200 C. final temp., 1 min final time); 1H NMR (400 MHz, CDCl3) delta 7.44 (d, J=10 Hz, 1H), 6.99 (d, J=3 Hz, 1H), 6.73 (dd, 1H), 4.55 (s, 2H), 3.80 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29578-39-0, name is 1-Bromo-3-fluoro-5-methoxybenzene, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

To a solution of 1-bromo-3-fluoro-5-methoxybenzene (15 g,73.16 rnmol), tris(2-methylphenyl)phosphane (1.781 g, 5.85rnmol) and ethyl acrylate (11.90 mL, 109.74 mmcl) in TEA (135 mL) was added palladium(II) acetate (0.329 g, 1.46 nimnol) at room temperature under nitrogen atmosphere, and the mixturewas stirred at 90C for 2 days. The solvent was evaporated under reduced pressure, the residue was diluted with water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried overmagnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give ethyl (E)-3-(3-fluoro-5- methoxyphenyl)acrylate (14.2 g, 63.3 mmcl, 87%) as a colorless oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 5414-19-7,Some common heterocyclic compound, 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane, molecular formula is C4H8Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrileA solution of 2-(4-phenylthiazol-2-yl)acetonitrile (0.84 g, 4.19 mmol) in THF (25 ml.) was cooled to 0 C. NaH was added (0.5 g, 60% dispersion in oil) portionwise over 10 min. The resulting mixture was allowed to warm up to room temperature and stirred for 20 min. 2-Bromoethyl ether (1.58 ml_, 12.5 mmol) was added dropwise. The reaction mixture was further stirred at room temperature for 1 h and then quenched with saturated NH4CI solution. The reaction mixture was diluted with EtOAc and the organic layer was washed with H20 and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel 60-120 mesh, eluent 4-8% EtOAc in petroleum ether) to afford 4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrile (0.97 g, yield 85%) as a yellow solid: 1 H NMR (300 MHz, CDCI3) delta 7.91 -7.94 (m, 2H), 7.51 (s, 1 H), 7.37-7.48 (m, 3H), 4.07-4.14 (m, 2H), 3.87-3.96 (m, 2H), 2.32-2.43 (m, 4H). MS (ESI) m/z: Calculated for C15H14N2OS: 270.08; found: 271 .2 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-(2-bromoethoxy)ethane, its application will become more common.

Related Products of 19056-40-7, These common heterocyclic compound, 19056-40-7, name is 4-Bromo-3-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the solution of 4-bromo-3-methoxyaniline (17.4 g, 86.6 mmol) in dichloromethane (117 mL) cooled to 0 °C was added diisopropylethylamine (22.4 g, 173.2 mmol) and the mixture was stirred for 10 mm. To this mixture methylchloroformate (9.8 g, 103.9 mmol) was added dropwise. The reaction mixture was warmed gradually to room temperature and stirring continued for 2 h. Upon completion of the reaction, it was quenched with ice cold water (100 mL) and diluted with ethyl acetate (200 mL). The organic layer was washed with brine solution (100 mL), dried over sodium sulfate and concentrated under reduced pressure to affordmethyl (4-bromo-3-methoxyphenyl)carbamate (13 g, 58percent yield) as light yellow solid. LCMS (ESI) m/e 258.0 [(M), calcd for C9H9BrNO3, 258.0]; LC/MS retention time (method A): tp. = 1.68 min.

Statistics shows that 4-Bromo-3-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 19056-40-7.

Synthetic Route of 588-96-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 588-96-5, name is p-Bromophenetole, This compound has unique chemical properties. The synthetic route is as follows.

Example I.1 2-{-4-[1-(4-Ethoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide 60 mg (0.23 mmol) N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide (VI.1) are added to a mixture of 46 mg (0.23 mmol) 1-bromo-4-ethoxy-benzene, 91 mg (97%, 0.92 mmol) sodium tert-butyrat, 28 mg (0.09 mmol) 2-(di-tert-butylphosphino)biphenyl and 21 mg (0.02 mmol) tris-(dibenzylidenaceton)-dipalladium(0) in 1.0 mL 1,4-dioxane. The mixture is stirred for 1.5 h at 120 C. in a microwave oven. After that time, the solvent is removed in vacuo and the residue is purified by HPLC (column: Waters XBridge 50; eluent A: water+0.3% NH4OH, eluent B: MeOH) to yield the desired product. C24H32N2O2 (M=380.5 g/mol) ESI-MS: 381 [M+H]+Rt (HPLC): 2.15 min (method C)

The chemical industry reduces the impact on the environment during synthesis p-Bromophenetole. I believe this compound will play a more active role in future production and life.

Related Products of 36805-97-7, A common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, molecular formula is C11H25NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of 4-bromo-3-methylbenzoic acid (10 g, 46.5 mmol) was heated to 80 C. and N,N-dimethylformamide di-tert-butyl acetal (44.6 mL, 186.0 mmol) was added dropwise over 30 minutes under a nitrogen atmosphere; stirring was continued at this temperature for 1.5 h. The reaction mixture was allowed to cool and then washed with water (1*), saturated NaHCO3 (1*), and brine (1*). The organic layer was dried (Na2SO4) and concentrated to afford tert-Butyl 4-bromo-3-methylbenzoate (as an off-white oil (8.8 g, 70%). ESI-MS m/e 311.9 (M+CH3CN+1).

The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89521-55-1, name is 3-(Benzyloxy)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

To a stirred solution of 3- benzyloxybenzene-1,2 -diamine (1 g, 4.67 mmol) in AcOH (20 mL) was added with tetramethoxymethane (0.95 g, 7 mmol) in one portion at 20 oC. The solution was stirred overnight. Then the mixture was concentrated in vacuo. The residue was purified by prep-HPLC (neutral condition) to afford 4-benzyloxy-2- methoxy-1H- benzimidazole (0.7 g, 56%) as a white powder. LCMS (M+H+) m/z: Calcd: 255.11; Found: 255.1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.