Tag: M.W=50-100

Bai, Yu published the artcileTunable synthesis of propylene glycol ether from methanol and propylene oxide under ambient pressure, SDS of cas: 1589-47-5, the publication is Kinetics and Catalysis (2011), 52(3), 386-390, database is CAplus.

A series of basic and acidic ionic liquids, 1-butyl-3-methylimidazolium hydroxide (BMIMOH), 1-acetyl-3-methylimidazolium chloride (AcMIMCl) and AcMIMCl-FeCl₃, or analogs of AcMIMCl, namely 1-potassium acetate-3-methylimidazolium chloride (KAcMIMCl), 1-potassium (sodium, ammonium) acetate-3-methylimidazolium hydroxides (KAcMIMOH, NaAcMIMOH and NH₄AcMIMOH), were prepared and used as catalysts for catalytic synthesis of propylene glycol ether via reaction of propylene oxide (PO) with methanol under mild reaction conditions. KAcMIMOH exhibited outstanding catalytic performance with 94.2% of conversion of PO and 99.1% of selectivity to 1-methoxy-2-propanol (MP-2) at 60°C and ambient pressure for 4 h. However, AcMIMCl-FeCl₃ showed a good catalysis performance with high selectivity to 2-methoxy-1-propanol (MP-1). The tunable synthesis of MP-2 or MP-1 catalyzed by basic compound KAcMIMOH or acidic ionic liquid AcMIMCl-FeCl₃ was realized.

Kinetics and Catalysis published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, SDS of cas: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De, Chunyan published the artcileHighly selective synthesis of propylene glycol ether from methanol and propylene oxide catalyzed by basic ionic liquid, Related Products of ethers-buliding-blocks, the publication is Journal of Chemical Technology and Biotechnology (2011), 86(1), 105-108, database is CAplus.

Propylene glycol ether is expected to be a safe substitute for toxic ethylene glycol ether usually used in industry owing to its negligible toxicity. Although catalysis of solid acids or bases for the synthesis of the ether can avoid separation of catalysts, liquid waste treatment and corrosion problems, it suffers from drawbacks, e.g. lower activity and selectivity to target product, high reaction pressure and temperature In order to solve these problems, a basic ionic liquid, namely choline hydroxide was prepared and used as a catalyst for synthesis of the ether via atom-economy reaction from propylene oxide and methanol. The ionic liquid showed excellent catalytic performance exhibiting 95.4% conversion of propylene oxide (PO) and 94.6% selectivity to 1-methoxy-2-propanol. It is also an effective catalyst for the reaction of PO with other primary alcs. to yield corresponding ethers. In addition this catalyst can be recovered and reused. The high activity and selectivity can probably be ascribed to its basicity and/or the strong polarity and electrostatic field of the reaction medium caused by the ionic liquid

Journal of Chemical Technology and Biotechnology published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Jiawei published the artcileNano metal oxides as efficient catalysts for selective synthesis of 1-methoxy-2-propanol from methanol and propylene oxide, COA of Formula: C4H10O2, the publication is RSC Advances (2018), 8(8), 4478-4482, database is CAplus.

Nano metal oxides such as Fe₂O₃, Fe₃O₄, CuO, NiO, ZnO and SnO₂ were prepared and characterized using XRD, SEM and TEM anal. These as-prepared metal oxide materials were used as catalysts for the etherification of methanol with propylene oxide (PO). The results showed that α-Fe₂O₃ exhibited outstanding catalytic performance with 97.7% conversion and 83.0% selectivity to MP-2 at 160 °C for 8 h. Furthermore, the relationship between the catalytic activity or selectivity and surface basicity or energy gap was investigated. This catalyst could be easily recovered and reused due to its heterogeneous catalytic nature.

RSC Advances published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C7H10N2O2, COA of Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Zheng published the artcileSteam-Assisted in Situ Prepared TS-1 with Hierarchical Pores and Tunable Acid Sites Grown on Carbon Nanotubes Decorated Nickel Foam, HPLC of Formula: 1589-47-5, the publication is Industrial & Engineering Chemistry Research (2020), 59(7), 2761-2772, database is CAplus.

The TS-1 particles grown on carbon nanotubes decorated nickel foam (denoted as MTS-1S) are successfully synthesized by a steam-assisted crystallization method that does not waste the gels and is more convenient, economical, and efficient than the traditional hydrothermal method. MTS-1S possesses a hierarchical porous structure of micropores, mesopores, and macropores and a high content of titanium in the skeleton, which is beneficial for the diffusion of reactants and products and exhibits excellent catalytic performance for the epoxidation of propylene. The impact of water on the formation of acid sites has been demonstrated by d. functional theory (DFT). The acid sites of MTS-1S can be tuned by controlling the amount of water at the bottom of autoclave during steam-assisted crystallization, which significantly increases the selectivity to propylene oxide. Finally, the impact of acid sites of Si-OH and Ti-OH groups (Ti located in a defect structure, adjacent to Si-OH) on the reaction of epoxidation of propylene is confirmed by simulation.

Industrial & Engineering Chemistry Research published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C14H10O4S2, HPLC of Formula: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Das, Rima published the artcileI₂-TEMPO as an efficient oxidizing agent for the one-pot conversion of alcohol to amide using FeCl₃ as the catalyst, Related Products of ethers-buliding-blocks, the publication is Catalysis Communications (2012), 48-53, database is CAplus.

A high yield one-pot method for the synthesis of amides from alcs. is described. The aldehyde was generated in situ using iodine-TEMPO as oxidizing agent followed by intermediate oxime formation through reaction with NH₂OH·HCl and finally rearrangement of oxime catalyzed by FeCl₃.

Catalysis Communications published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Barber, Christopher G. published the artcile1-Amido-1-phenyl-3-piperidinylbutanes – CCR5 antagonists for the treatment of HIV: Part 2, Safety of 2-Methoxyacetamide, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(5), 1499-1503, database is CAplus and MEDLINE.

Optimization of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.

Bioorganic & Medicinal Chemistry Letters published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Safety of 2-Methoxyacetamide.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Manley, Peter J. published the artcileA new synthesis of naphthyridinones and quinolinones: palladium-catalyzed amidation of o-carbonyl-substituted aryl halides, HPLC of Formula: 16332-06-2, the publication is Organic Letters (2004), 6(14), 2433-2435, database is CAplus and MEDLINE.

An alternative to the Friedlaender condensation for the synthesis of naphthyridinones, e.g., I, and quinolinones has been discovered. Palladium-catalyzed amidation of halo aromatics substituted in the ortho position by a carbonyl functional group or its equivalent with primary or secondary amides leads to the formation of substituted naphthyridinones and quinolinones.

Organic Letters published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, HPLC of Formula: 16332-06-2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Elamin, Khalid published the artcileGlass transition and relaxation dynamics of propylene glycol-water solutions confined in clay, Related Products of ethers-buliding-blocks, the publication is Journal of Chemical Physics (2014), 141(3), 034505/1-034505/8, database is CAplus and MEDLINE.

The mol. dynamics of aqueous solutions of propylene glycol (PG) and propylene glycol methylether (PGME) confined in a two-dimensional layer-structured Na-vermiculite clay has been studied by broadband dielec. spectroscopy and differential scanning calorimetry. As typical for liquids in confined geometries the intensity of the cooperative α-relaxation becomes considerably more suppressed than the more local β-like relaxation processes. In fact, at high water contents the calorimetric glass transition and related structural α-relaxation cannot even be observed, due to the confinement. Thus, the intensity of the viscosity related α-relaxation is dramatically reduced, but its time scale as well as the related glass transition temperature T_g are for both systems only weakly influenced by the confinement. In the case of the PGME-water solutions it is an important finding since in the corresponding bulk system a pronounced non-monotonic concentration dependence of the glass transition related dynamics has been observed due to the growth of hydrogen bonded relaxing entities of water bridging between PGME mols. [J. Sjostrom, J. Mattsson, R. Bergman, and J. Swenson, Phys. Chem. B 115, 10013 (2011)]. The present results suggest that the same type of structural entities are formed in the quasi-two-dimensional space between the clay platelets. It is also observed that the main water relaxation cannot be distinguished from the β-relaxation of PG or PGME in the concentration range up to intermediate water contents. This suggests that these two processes are coupled and that the water mols. affect the time scale of the β-relaxation. However, this is most likely true also for the corresponding bulk solutions, which exhibit similar time scales of this combined relaxation process below T_g. Finally, it is found that at higher water contents the water relaxation does not merge with, or follow, the α-relaxation above T_g, but instead crosses the α-relaxation, indicating that the two relaxation processes are independent of each other. This can only occur if the two processes do not occur in the same parts of the confined solutions Most likely the hydration shell of the interlayer Na⁺ ions is causing this water relaxation, which does not participate in the α-relaxation at any temperature (c) 2014 American Institute of Physics.

Journal of Chemical Physics published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bolton, P. D. published the artcileHydrolysis of amides. III. Dilute acid hydrolysis of amides of the type RCH2CONH2, COA of Formula: C3H7NO2, the main research area is amides acid hydrolysis kinetics; acid hydrolysis kinetics amides; hydrolysis acid kinetics amides.

Rate constants over a range of temperature, enthalpies of activation, and entropies of activation are reported for the dilute acid hydrolysis of n-valeramide, isovaleramide, 3,3-dimethylbutanamide, phenylacetamide, cyclohexylacetamide, methoxyacetamide, bromoacetamide, and chloroacetamide. The rate constants of the first six amides together with those of two other alkyl-substituted acetamides determined earlier are almost perfectly correlated by the Taft linear steric energy relation. The enthalpies of activation, also, show a linear dependence on the steric parameter, Es. The results obtained for the halo amides indicate that the acid hydrolysis of amides may show a slight sensitivity to polar effects.

Australian Journal of Chemistry published new progress about Entropy. 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, COA of Formula: C3H7NO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nau, Heinz published the artcileWeak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo, Name: 2-Methoxyacetamide, the main research area is acidic drug accumulation fetus teratogenesis.

Among the 11 drugs or chems. which are well-documented human teratogens, 8 (or their main metabolites) are weak acids whereas none is a weak base. Moreover, 23 out of 32 acids tested were teratogenic in at least 1 animal species. The acidic property of drugs may therefore be an important determinant of teratogenicity. The intracellular pH (pHi) of the mouse and rat embryo is higher than that of maternal plasma, as determined by the relative accumulation of dimethadione  [695-53-4]. The antiepileptic drug valproic acid  [99-66-1] and its pharmacol. active unsaturated metabolite accumulate in embryonic tissue to higher concentrations than in maternal plasma, whereas the essentially neutral amide of valproic acid (valpromide  [2430-27-5]) or ethosuximide  [77-67-8] do not accumulate in the embryo; in the rat the pHi of the embryo decreases with advancing gestation; in general agreement with the pH partiton hypothesis, the exposure of the embryo to valproic acid also decreases significantly during that period. Furthermore, the amides of 2 weak acid teratogens, valpromide and methoxyacetamide  [16332-06-2], and ethosuximide, are much less teratogenic than their acid counterparts. Thus, weakly acidic drugs, by virtue of their physicochem. nature, accumulate in the early embryo with its relatively high pHi.

Nature (London, United Kingdom) published new progress about Drugs. 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Name: 2-Methoxyacetamide.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem