M.W=50-100 Archives - Page 18 of 27 - Ethers-buliding-blocks

Zhu, Yuqin team published research in Journal of Medicinal Chemistry in 2020 | 38256-93-8

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Application In Synthesis of 38256-93-8

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application In Synthesis of 38256-93-8.

Zhu, Yuqin;Ma, Yuxiang;Zu, Weidong;Song, Jianing;Wang, Hua;Zhong, You;Li, Hongmei;Zhang, Yanmin;Gao, Qianqian;Kong, Bo;Xu, Junyu;Jiang, Fei;Wang, Xinren;Li, Shuwen;Liu, Chenhe;Liu, Haichun;Lu, Tao;Chen, Yadong research published 《 Identification of N-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis》, the research content is summarized as follows. A series of N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives with NF-κB inducing kinase (NIK) inhibitory activity were obtained through structure-based drug design and synthetic chem. Among them, 4-(3-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-morpholinophenyl)-2-(thiazol-2-yl)but-3-yn-2-ol (12f)(I) was identified as a highly potent NIK inhibitor, along with satisfactory selectivity. The pharmacokinetics of 12f and its ability to inhibit interleukin 6 secretion in BEAS-2B cells were better than compound 1 developed by Amgen. Oral administration of different doses of 12f in an imiquimod-induced psoriasis mouse model showed effective alleviation of psoriasis, including invasive erythema, swelling, skin thickening, and scales. The underlying pathol. mechanism involved attenuation of proinflammatory cytokine and chemokine gene expression, and the infiltration of macrophages after the treatment of 12f. This work provides a foundation for the development of NIK inhibitors, highlighting the potential of developing NIK inhibitors as a new strategy for the treatment of psoriasis.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Xianjun team published research in Journal of Organic Chemistry in 2021 | 38256-93-8

Application of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Xu, Xianjun;Feng, Huangdi;Van der Eycken, Erik V. research published 《 Microwave-Assisted Cu(I)-Catalyzed Synthesis of Unsymmetrical 1,4-Diamino-2-butynes via Cross-A³-Coupling/Decarboxylative A³-Coupling》, the research content is summarized as follows. 1,4-Diamino-2-butynes display both chem. and physiol. properties. Here a highly efficient synthesis avenue to generate unsym. 1,4-diamino-2-butynes has been developed by microwave-assisted Cu(I)-catalyzed cross-A3-coupling/decarboxylative coupling of two different amines, formaldehyde, and propiolic acid through a domino process. This multicomponent reaction provides a series of target products in moderate to good yields with high chemoselectivity.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yamazaki, Shoko team published research in ChemistrySelect in 2018 | 38256-93-8

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Safety of 2-Methoxy-N-methylethanamine.

Yamazaki, Shoko;Naito, Taku;Tatsumi, Taiki;Kakiuchi, Kiyomi research published 《 Synthesis of Piperidines via Intramolecular Hydride Transfer from α-Amino sp³ Carbon Atoms to Ethenetricarboxylate-Derived Fragments and Further Cyclization》, the research content is summarized as follows. The cyclization of amides derived from ethenetricarboxylic acid bearing tert-amino groups wsa examined The amides were efficiently converted to piperidine derivatives (2-piperidones) upon heating in a polar solvent (e. g., DMSO or DMF) via intramol. hydride transfer and subsequent ring closure. The reaction was less efficient in the presence of a Lewis acid. The reactivity varies depending on the alkyl substituents of tert-amino groups, probably due to steric effects. The hydride transfer/cyclization mechanism was investigated by DFT calculations The reaction of the carboxylic acid and relatively bulky diamines such as diisopropyl-substituted diamine in the presence of amide condensation reagents at 60 ° gave the piperidine derivatives in a one-pot reaction. The reaction of the diisopropylamine substituted piperidine product with primary amines gave secondary amine-substituted piperidines.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yamazaki, Shoko team published research in Journal of Organic Chemistry in 2017 | 38256-93-8

Yamazaki, Shoko;Naito, Taku;Niina, Mamiko;Kakiuchi, Kiyomi research published 《 Lewis Acid Catalyzed Cyclization Reactions of Ethenetricarboxylates via Intramolecular Hydride Transfer》, the research content is summarized as follows. Catalytic cyclization of amides of ethenetricarboxylate bearing ether and acetal groups has been examined The reaction of the amides bearing cyclic ether and acetal groups in the presence of Lewis acid such as Sc(OTf)₃ gave spirocyclic piperidine derivatives as major products. The cyclized products may be formed via intramol. hydride transfer. The reaction mechanism was examined by the DFT calculations The scope and limitations of the hydride transfer/cyclization reactions of amides of ethenetricarboxylates was investigated, and morpholine formation by intramol. oxy-Michael addition was also found.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yan, Zijuan team published research in Organic Chemistry Frontiers in 2022 | 38256-93-8

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Application of C4H11NO.

Yan, Zijuan;Liu, Feipeng;Wang, Xuchao;Qiang, Qing;Li, Yongjie;Zhang, Yao;Rong, Zi-Qiang research published 《 Redox-neutral dehydrogenative cross-coupling of alcohols and amines enabled by nickel catalysis》, the research content is summarized as follows. Presented herein was a facile and straightforward synthetic method for the construction of amides RC(O)NR¹R² [R = Pr, phenethyl, 3-MeC₆H₄, etc.; R¹ = H, Me; R² = 2-methoxyethyl, Ph, Bn, etc.; R¹R² = (CH₂)₄, (CH₂)₅, (CH₂)₂O(CH₂)_O, etc.] via Ni/NHC-catalyzed amidation of alcs. with amines. The strategy exhibits various advantages over existing methods, including base metal catalysis, com. available catalyst, removal of oxidant, good yields (up to 95%), good functional group tolerance and substrate generality. Moreover, the nature of the reaction was revealed by NMR spectroscopy and isolation of intermediates.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Zhaohui team published research in ACS Chemical Neuroscience in 2016 | 38256-93-8

HPLC of Formula: 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Yang, Zhaohui;Li, Linlang;Zheng, Jiyue;Ma, Haikuo;Tian, Sheng;Li, Jiajun;Zhang, Hongjian;Zhen, Xuechu;Zhang, Xiaohu research published 《 Identification of a New Series of Potent Adenosine A_2A Receptor Antagonists Based on 4-Amino-5-carbonitrile Pyrimidine Template for the Treatment of Parkinson’s Disease》, the research content is summarized as follows. Adenosine receptor A2A antagonists have emerged as potential treatment for Parkinson’s disease in the past decade. The authors have recently reported a series of adenosine receptor antagonists using heterocycles as bioisosteres for a potentially unstable acetamide. These compounds, while showing excellent potency and ligand efficiency, suffered from moderate cytochrome P 450 inhibition and high clearance. Here the authors report a new series of adenosine receptor A2A antagonists based on a 4-amino-5-carbonitrile pyrimidine template. Compounds from this new template exhibit excellent potency and ligand efficiency with low cytochrome P 450 inhibition. Although the clearance remains moderate to high, the leading compound, when dosed orally as low as 3 mg/kg, demonstrated excellent efficacy in the haloperidol induced catalepsy rat model for Parkinson’s disease.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yngve, Ulrika team published research in Chemistry & Biodiversity in 2012 | 38256-93-8

Synthetic Route of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Yngve, Ulrika;Soederman, Peter;Svensson, Mats;Rosqvist, Susanne;Arvidsson, Per I. research published 《 Imidazopyridine-Based Inhibitors of Glycogen Synthase Kinase 3: Synthesis and Evaluation of Amide Isostere Replacements of the Carboxamide Scaffold》, the research content is summarized as follows. In this study, we explored the effect of bioisostere replacement in a series of glycogen synthase kinase 3 (GSK3) inhibitors based on the imidazopyridine core. The synthesis and biol. evaluation of a number of novel sulfonamide, 1,2,4-oxadiazole, and thiazole derivatives as amide bioisosteres, as well as a computational rationalization of the obtained results are reported.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wormald, Michael M. team published research in Bioorganic & Medicinal Chemistry Letters in 2019 | 38256-93-8

Electric Literature of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Wormald, Michael M.;Ernst, Glen;Wei, Huijun;Barrow, James C. research published 《 Synthesis and characterization of novel isoform-selective IP6K1 inhibitors》, the research content is summarized as follows. Diaminopurines and diaminopurine analogs such as (methoxyindolylethylamino)purine I were prepared as selective inositol hexakisphosphate kinases (IP6K) inhibitors. Selected diaminopurines such as I were selective inhibitors of IP6K1 over IP6K2 and IP6K3; I was a more potent inhibitor of IP6K1 and was more water-soluble than the previously known pan-IP6K inhibitor TNP.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Yong-Jin team published research in Bioorganic & Medicinal Chemistry Letters in 2014 | 38256-93-8

Safety of 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Wu, Yong-Jin;He, Huan;Gao, Qi;Wu, Dedong;Bertekap, Robert;Westphal, Ryan S.;Lelas, Snjezana;Newton, Amy;Wallace, Tanya;Taber, Matthew;Davis, Carl;Macor, John E.;Bronson, Joanne research published 《 Discovery of a cyclopentylamine as an orally active dual NK₁ receptor antagonist-serotonin reuptake transporter inhibitor》, the research content is summarized as follows. Cyclopentylamine 4 was identified as a potent dual NK₁R antagonist-SERT inhibitor. This compound demonstrated significant oral activity in the gerbil forced swimming test, suggesting that dual NK₁R antagonists-SERT inhibitors may be useful in treating depression disorders.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xie, Yiyue team published research in Journal of Medicinal Chemistry in 2020 | 38256-93-8

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Formula: C4H11NO.

Xie, Yiyue;Tummala, Padmaja;Oakley, Aaron J.;Deora, Girdhar Singh;Nakano, Yuji;Rooke, Melissa;Cuellar, Matthew E.;Strasser, Jessica M.;Dahlin, Jayme L.;Walters, Michael A.;Casarotto, Marco G.;Board, Philip G.;Baell, Jonathan B. research published 《 Development of benzenesulfonamide derivatives as potent glutathione transferase omega-1 inhibitors》, the research content is summarized as follows. Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-mol. inhibitors are sought. The potent reactivity of the active-site cysteine has resulted in reported inhibitors that act by covalent labeling. In this study, structure-activity relationship (SAR) elaboration of the reported GSTO1-1 inhibitor C1-27 was undertaken. Compounds were evaluated for inhibitory activity toward purified recombinant GSTO1-1 and for indicators of target engagement in cell-based assays. As covalent inhibitors, the k_inact/K_I values of selected compounds were determined, as well as in vivo pharmacokinetics anal. Cocrystal structures of key novel compounds in complex with GSTO1-1 were also solved. This study represents the first application of a biochem. assay for GSTO1-1 to determine k_inact/K_I values for tested inhibitors and the most extensive set of cell-based data for a GSTO1-1 inhibitor SAR series reported to date. Our research culminated in the discovery of 25, which we propose as the preferred biochem. tool to interrogate cellular responses to GSTO1-1 inhibition.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem