Tag: M.W=50-100

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Formula: C4H11NO.

Vastl, Julian;Kartika, Rendy;Park, Kichul;Cho, Art E.;Spiegel, David A. research published 《 Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis》, the research content is summarized as follows. Efforts to emulate biol. oligomers have given rise to a host of useful technologies, ranging from solid-phase peptide and nucleic acid synthesis to various peptidomimetic platforms. Herein, the authors introduce a novel class of peptide-like oligomers called “peptidines” wherein each carbonyl O-atom within poly-N-alkyl glycine oligomers is replaced with a functionalized N-atom. Compared to peptoids or peptides, the presence of this amidine N-substituent in peptidines effectively doubles the number of diversification sites per monomeric unit, and can decrease their overall conformational flexibility. The authors have developed iterative solution- and solid-phase protocols for the straightforward assembly of peptidines containing diverse backbone and amidine substituents, derived from readily available primary and secondary amines. The authors have also performed crystallog. and computational studies, which demonstrate a strong preference for the trans (E) amidine geometry. Given their straightforward synthetic preparation and high functional group d., peptidines have the potential to serve as useful tools for library generation, peptide mimicry, and the identification of biol. active small mols.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Formula: C4H11NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Computed Properties of 38256-93-8.

Verevkin, Sergey P.;Konnova, Maria E.;Zherikova, Kseniya V.;Pimerzin, Aleksey A. research published 《 Sustainable hydrogen storage: Thermochemistry of amino-alcohols as seminal liquid organic hydrogen carriers》, the research content is summarized as follows. Amino-alcs. are considered for sustainable hydrogen storage systems based on catalytic peptide formation. Exptl. and theor. thermochem. studies of amino-alcs. have been performed, including vapor pressure measurements, combustion calorimetry, and quantum-chem. calculations The standard molar enthalpies of vaporization of amino-alcs. were calculated from the temperature dependence of the vapor pressures measured by the transpiration method. Energies of combustion for six amino-alcs. were measured using the high-precision combustion calorimetry. The available in the literature primary data on vapor pressures, enthalpies of vaporization, and enthalpies of formation of amino-alcs. were collected and evaluated. The exptl. standard molar gas-phase enthalpies of formation of amino-alcs. were derived from the evaluated results. The high-level G3B3, G3MP2, and G4 quantum-chem. methods were used to establish consistency of the exptl. and theor. results. The surprisingly low enthalpy of reaction of the reversible dehydrogenation of 2-amino-ethanol, calculated from the exptl. data, makes this liquid organic hydrogen carrier system (LOHC) promising for further optimization and development.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Computed Properties of 38256-93-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Computed Properties of 38256-93-8.

Song, Jianing;Zhu, Yuqin;Zu, Weidong;Duan, Chunqi;Xu, Junyu;Jiang, Fei;Wang, Xinren;Li, Shuwen;Liu, Chenhe;Gao, Qianqian;Li, Hongmei;Zhang, Yanmin;Tang, Weifang;Lu, Tao;Chen, Yadong research published 《 The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth》, the research content is summarized as follows. In this study, a series of quinoline derivatives I [R = H, OH, (2-methoxyethyl)(methyl)aminyl, 4-methylpiperazin-1-yl, etc.; R¹ = 3-hydroxy-3-methylbut-1-yn-1-yl, 2-(1-hydroxycyclopentyl)ethynyl, 3-hydroxy-3-(1,3-thiazol-2-yl)but-1-en-1-yl, etc.; R² = H, Me] were obtained through rational design and chem. synthesis. Among them, the representative compounds I [R = (2-methoxyethyl)(methyl)aminyl, R¹ = 3-hydroxy-3-(1,3-thiazol-2-yl)but-1-yn-1-yl, R² = H (II); and R = R² = H, R¹ = 3-hydroxy-3-(1,3-thiazol-2-yl)but-1-yn-1-yl (III)] have excellent inhibitory activities on LPS-induced macrophage (J774) nitric oxide release and anti-Con A-stimulated primary T cell proliferation. This evaluation method has good universality and overcomes the obstacles mentioned above, which are faced by the current inhibitor research to a certain extent. Besides, the compound’s II and III toxicity against the growth of T cells under non-stress conditions was evaluated, for the first time, as an indicator for the investigation to avoid potential safety risks. Pharmacokinetic properties evaluation of the less toxic compound III confirmed its good metabolic behavior (especially oral properties, F% = 21.7%), and subsequent development value.

Computed Properties of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Name: 2-Methoxy-N-methylethanamine.

Stokes, Stephen;Martin, Nathaniel G. research published 《 A simple and efficient synthesis of N-benzoyl ureas》, the research content is summarized as follows. A novel, operationally simple, method for the preparation of acyl ureas is described. The procedure is high yielding and tolerant of a wide range of functional groups.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Name: 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Formula: C4H11NO.

Tassoti, Sebastian;Walenta, Martin;Poecheim, Alexander;Buchberger, Kathrin;Kunert, Olaf;Zangger, Klaus research published 《 Solvent-independent determination of heteroatom protonation states from NMR spectra by differential deuterium isotope shifts》, the research content is summarized as follows. The NMR-spectroscopy based structure elucidation of organic mols. containing heteroatoms is often obstructed by the difficulties in determining the heteroatom protonation states. Here we describe a simple but broadly applicable approach for the determination of the protonation states of heteroatoms. Differential deuterium isotope shifts observed upon the addition of small amounts of H₂O or D₂O to any solvent can be used to determine the protonation states of heteroatoms.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Formula: C4H11NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Recommanded Product: 2-Methoxy-N-methylethanamine.

Shao, Min;Chen, Xiaojuan;Yang, Fang;Song, Xiaojuan;Zhou, Yang;Lin, Qianmeng;Fu, Ying;Ortega, Raquel;Lin, Xiaojing;Tu, Zhengchao;Patterson, Adam V.;Smaill, Jeff B.;Chen, Yongheng;Lu, Xiaoyun research published 《 Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4》, the research content is summarized as follows. A series of aminoindazole derivatives I [R¹ = 1-(2,6-dichloro-3-fluoro-phenyl)ethyl, 1-(2,6-dichlorophenyl)ethyl, (1R)-1-(3,5-dichloro-4-pyridyl)ethyl, (3,5-dichloro-4-pyridyl)methyl, 1-(3,5-dichloro-4-pyridyl)propyl; R² = H, Me, Cl, etc.; R³ = H, MeO; R⁴ = H, 4-methylpiperazin-1-yl, morpholino, etc.] was designed and synthesized as new irreversible inhibitors of wild-type and gatekeeper mutant FGFR4. One representative compound I [R¹ = (1R)-1-(3,5-dichloro-4-pyridyl)ethyl, R² = F, R³ = H, R⁴ = 4-morpholino-1-piperidyl] exhibited excellent potency against FGFR4, FGFR4^V550L and FGFR4^V550M with nanomolar activity in both the biochem. and cellular assays while sparing FGFR1/2/3. While compound I [R¹ = (1R)-1-(3,5-dichloro-4-pyridyl)ethyl, R² = F, R³ = H, R⁴ = 4-morpholino-1-piperidyl] demonstrated modest in vivo antitumor efficacy in nude mice bearing the Huh-7 xenograft model consistent with its unfavorable pharmacokinetic properties, it provided a promising new starting point for future drug discovery combating FGFR4 gatekeeper mediated resistance in HCC patients.

Recommanded Product: 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. HPLC of Formula: 38256-93-8.

Shekh-Ahmad, Tawfeeq;Bialer, Meir;Yavin, Eylon research published 《 Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue》, the research content is summarized as follows. Summary: Background: Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs. 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA) is an inactive cyclopropyl analog of VPA that serves as a starting material for the synthesis of CNS-active compounds Methods: New conjugation products between N,N’-dimethylethanolamine to VPA and TMCA to form N,N-dimethylethanolamine valproate (DEVA) and N,N-dimethylethanolamine 2,2,3,3-tetramethylcyclopropionate were synthesized and their anticonvulsant activity was assessed in the maximal electroshock seizure (MES) and s.c. metrazol (scMet) seizure tests and the hippocampal kindling model in mice and/or rats. An amide analog of DEVA (DEVAMIDE) was also synthesized and evaluated. The pharmacokinetics of DEVA and DEVAMIDE was comparatively evaluated in rats. Results: In rats DEVA acted as a prodrug of VPA and had ED₅₀ values of 73 mg/kg and 158 mg/kg in the MES and the hippocampal kindling models, resp. At these two anticonvulsant models DEVA was seven-times more potent than VPA. DEVAMIDE was active in the MES test at doses of 100 mg/kg (mice) and its rat-MES-ED₅₀ = 38.6 mg/kg however, its protective index (PI = TD₅₀/ED₅₀) was twice lower than DEVA’s PI. The TMCA analogs were inactive at the mice MES and scMet models. DEVA underwent rapid metabolic hydrolysis to VPA and consequently, in its pharmacokinetic anal. only VPA plasma levels were monitored. In contrast, DEVAMIDE was stable in whole blood. Conclusion: DEVA acts in rats as a prodrug of VPA yet shows a more potent anticonvulsant activity than VPA. DEVAMIDE acted as the drug on its own and was more potent than DEVA at the rat-MES test.

HPLC of Formula: 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. SDS of cas: 38256-93-8.

Siewert, Riko;Zherikova, Kseniya V.;Verevkin, Sergey P. research published 《 Non-Covalent Interactions in Molecular Systems: Thermodynamic Evaluation of the Hydrogen-Bond Strength in Amino-Ethers and Amino-Alcohols》, the research content is summarized as follows. The intramol. hydrogen bond (intra-HB) is one of the best-known examples of non-covalent interactions in mols. Among the different types of intramol. hydrogen bonding, the NH···O hydrogen bond in amino-alcs. and amino-ethers is one of the weakest. In contrast to the strong OH···N intramol. hydrogen bond, the strength of the NH···O bond can hardly be measured with conventional spectroscopic methods, even for simple amino-alcs., since the band belonging to the NH···O conformer merges with the free OH band. In this work, we developed a combination of G4 calculations, and a method based on exptl. vaporization enthalpies to determine the NH···O hydrogen bonding strength. The archetypal compounds for this study are 2-amino-1-ethanol and 3-amino-1-propanol as well as their resp. methoxy analogs. Based on these mols., different series were studied to investigate various factors influencing NH···O intra-HB strength. In the first series, the influence of alkylation near the hydroxy or methoxy group and the amino group in sterically hindered aminoalcs. was examined In the second series, the influence of alkylation of the amino-group was investigated. In the third series, the effect of extending the alkyl chain between functional groups was studied.

SDS of cas: 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. COA of Formula: C4H11NO.

Savych, Olena;Kuchkovska, Yuliya O.;Bogolyubsky, Andrey V.;Konovets, Anzhelika I.;Gubina, Kateryna E.;Pipko, Sergey E.;Zhemera, Anton V.;Grishchenko, Alexander V.;Khomenko, Dmytro N.;Brovarets, Volodymyr S.;Doroschuk, Roman;Moroz, Yurii S.;Grygorenko, Oleksandr O. research published 《 One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles》, the research content is summarized as follows. Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds

COA of Formula: C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Application of C4H11NO.

Sawatzky, Ryan S.;Ferguson, Michael J.;Stradiotto, Mark research published 《 Thieme Chemistry Journals Awardees – Where Are They Now? Efficient Cross-Coupling of Secondary Amines/Azoles and Activated (Hetero)Aryl Chlorides Using an Air-Stable DPEPhos/Nickel Pre-Catalyst》, the research content is summarized as follows. Synthesis and characterization of the new air-stable pre-catalyst (DPEPhos)Ni(2-mesityl)Br (I) is reported, along with the application of this pre-catalyst in the cross-coupling of secondary amines/azoles with activated (hetero)aryl chlorides to afford tertiary (hetero)anilines. The performance of I in these cross-couplings is competitive with some of the best and/or most widely employed nickel catalysts for such transformations.

Application of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem