Tag: M.W=50-100

Remeur, Camille team published research in ACS Catalysis in 2017 | 38256-93-8

HPLC of Formula: 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. HPLC of Formula: 38256-93-8.

Remeur, Camille;Kelly, Christopher B.;Patel, Niki R.;Molander, Gary A. research published 《 Aminomethylation of Aryl Halides Using α-Silylamines Enabled by Ni/Photoredox Dual Catalysis》, the research content is summarized as follows. In the presence of the ruthenium photocatalyst [Ru(bipy)3](PF6–)2 and the nickel catalyst [Ni(dtbpy)(OH2)4]Cl2 (dtbpy = 4,4′-di-tert-butyl-2,2′-bipyridine), aryl bromides and iodides such as 4-bromobenzonitrile underwent chemoselective aminomethylation reactions with aminomethylsilanes such as 1-(dimethylphenylsilylmethyl)piperidine in DMF under irradiation with blue LED for 24-36 h at ambient temperature to yield benzylic amines such as 4-(1-piperidinylmethyl)benzonitrile in 41-70% yields. The low oxidation potential of the silylmethyl amines enabled facile single electron transfer (SET) oxidation of the amine followed by rapid desilylation; the resultant α-amino radicals were competent to undergo nickel-mediated cross-coupling with aryl bromides and iodides.

HPLC of Formula: 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Richard-Bildstein, Sylvia team published research in Journal of Medicinal Chemistry in 2020 | 38256-93-8

Application In Synthesis of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Application In Synthesis of 38256-93-8.

Richard-Bildstein, Sylvia;Aissaoui, Hamed;Pothier, Julien;Schafer, Gabriel;Gnerre, Carmela;Lindenberg, Eleanor;Lehembre, Francois;Pouzol, Laetitia;Guerry, Philippe research published 《 Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239》, the research content is summarized as follows. The chemokine receptor CXCR7, also known as ACKR3, is a seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies such as neurol. diseases, autoimmune diseases, and cancers. By binding and scavenging the chemokines CXCL11 and CXCL12, CXCR7 regulates their extracellular levels. From an original high-throughput screening campaign emerged an arylketoamide hit among others. The hit-to-lead optimization led to the discovery of a novel chemotype series of acylaminopiperidinecarboxamides. This series provided CXCR7 antagonists that block CXCL11- and CXCL12-induced ss-arrestin recruitment. Further structural modifications on the acylaminopiperidinecarboxamide framework yielded compounds with high CXCR7 antagonistic activities and balanced ADMET properties. The effort described herein culminated in the discovery of ACT-1004-1239 I. Biol. characterization of I demonstrated that it is a potent, insurmountable antagonist. Oral administration of I in mice up to 100 mg/kg led to a dose-dependent increase of plasma CXCL12 concentration

Application In Synthesis of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rosca, Sorin-Claudiu team published research in Organometallics in 2014 | 38256-93-8

Application of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Application of C4H11NO.

Rosca, Sorin-Claudiu;Roisnel, Thierry;Dorcet, Vincent;Carpentier, Jean-Francois;Sarazin, Yann research published 《 Potassium and Well-Defined Neutral and Cationic Calcium Fluoroalkoxide Complexes: Structural Features and Reactivity》, the research content is summarized as follows. The fluorinated aminoether alcs. (1-aza-12-crown-4)CH2C(CF3)2OH ({RO1F}H), (MeOCH2CH2)2NCH2C(CF3)2OH ({RO2F}H), and (MeOCH2CH2)(Me)NCH2C(CF3)2OH ({RO3F}H) have been synthesized and used to prepare the heteroleptic calcium amido complexes {ROxF}Ca(N(SiMe2R)2) (4–7; x = 2, 3, R = H, Me). The ability to form stable complexes varies with the chelating and electron-donating ability of the aminoether alkoxide ligand, as exemplified by the authors’ failure to isolate cleanly the elusive {RO1F}Ca(N(SiMe2R)2). X-ray diffraction studies show that, in the solid state, intramol. Ca···F interactions help reach coordinative saturation in the dimeric [{RO2F}Ca(N(SiMe3)2)]2 ([4]2), [{RO2F}Ca(N(SiMe2H)2)]2 ([5]2), [{RO3F}Ca(N(SiMe3)2)]2 ([6]2), and [{RO3F}Ca(N(SiMe2H)2)]2 ([7]2), which crystallized free of solvent coligands. Similar stabilizing K···F patterns were found in the polymetallic potassium fluoroalkoxides [{RO1F}K]2 ([1]2), [{RO2F}K]4 ([2]4), and [{RO3F}K]4 ([3]4); [2]4 and [3]4 form heterocubanes in the solid state. Examination of the XRD data for [1]2-[7]2 shows that metal···F interactions can be favored over binding of Oether atoms for calcium and potassium. Pulse-gradient spin-echo NMR spectroscopy shows that the complexes remain aggregated in aromatic solvents. The solvent-free salts [{ROxF}Ca+]·[H2N{B(C6F5)3}2–] (x = 1 (8), 2 (9), 3 (10)) were obtained by treating 4–7 with [H(OEt2)2+]·[H2N{B(C6F5)3}2–] or by reacting Ca(N(SiMe3)2)2 with [{ROxF}HH+]·[H2N{B(C6F5)3}2–]; the solid-state structures of [8·H2O]2 and [9·H2O]2 again showed Ca···F contacts. Complexes 5–7 are promising catalysts for the regiospecific anti-Markovnikov hydrophosphination of styrene with diphenylphosphine, affording TOF values as high as 52 molsubst molCa-1 h-1 with up to 400 equiv of substrates within 1-2 h at 60°.

Application of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pinaud, Marine team published research in Journal of Organic Chemistry in 2022 | 38256-93-8

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Name: 2-Methoxy-N-methylethanamine

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Name: 2-Methoxy-N-methylethanamine.

Pinaud, Marine;Le Gall, Erwan;Presset, Marc research published 《 Mixed Aliphatic Organozinc Reagents as Nonstabilized Csp3-Nucleophiles in the Multicomponent Mannich Reaction》, the research content is summarized as follows. The use of mixed aliphatic organozinc reagents in the multicomponent Mannich reaction was described. A large variety of primary, secondary and tertiary organozinc reagents, secondary amines and aromatic or aliphatic aldehydes could be used for the straightforward preparation of densely substituted amines. The three-component reaction could addnl. be performed starting from alkyl halides under reductive (Barbier-type) conditions.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Name: 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pinto, Donald J. P. team published research in Journal of Medicinal Chemistry in 2017 | 38256-93-8

Computed Properties of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Computed Properties of 38256-93-8.

Pinto, Donald J. P.;Orwat, Michael J.;Smith, Leon M.;Quan, Mimi L.;Lam, Patrick Y. S.;Rossi, Karen A.;Apedo, Atsu;Bozarth, Jeffrey M.;Wu, Yiming;Zheng, Joanna J.;Xin, Baomin;Toussaint, Nathalie;Stetsko, Paul;Gudmundsson, Olafur;Maxwell, Brad;Crain, Earl J.;Wong, Pancras C.;Lou, Zhen;Harper, Timothy W.;Chacko, Silvi A.;Myers, Joseph E.;Sheriff, Steven;Zhang, Huiping;Hou, Xiaoping;Mathur, Arvind;Seiffert, Dietmar A.;Wexler, Ruth R.;Luettgen, Joseph M.;Ewing, William R. research published 《 Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)》, the research content is summarized as follows. Factor XIa (FXIa) is a blood coagulation enzyme that is involved in the amplification of thrombin generation. Mounting evidence suggests that direct inhibition of FXIa can block pathol. thrombus formation while preserving normal hemostasis. Preclin. studies using a variety of approaches to reduce FXIa activity, including direct inhibitors of FXIa, have demonstrated good antithrombotic efficacy without increasing bleeding. Based on this potential, the authors targeted the efforts at identifying potent inhibitors of FXIa with a focus on discovering an acute antithrombotic agent for use in a hospital setting. Herein the authors describe the discovery of a potent FXIa clin. candidate, I (FXIa Ki = 0.7 nM), with excellent preclin. efficacy in thrombosis models and aqueous solubility suitable for i.v. administration. BMS-962212 is a reversible, direct, and highly selective small mol. inhibitor of FXIa.

Computed Properties of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Praz, Jezabel team published research in Advanced Synthesis & Catalysis in 2012 | 38256-93-8

Category: ethers-buliding-blocks, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Category: ethers-buliding-blocks.

Praz, Jezabel;Guenee, Laure;Aziz, Sarwar;Berkessel, Albrecht;Alexakis, Alexandre research published 《 Evaluation of the Chiral DIANANE Backbone as Ligand for Organolithium Reagents》, the research content is summarized as follows. Novel endo,endo-2,5-diaminonorbonane-derived tertiary C2-sym. diamines were synthesized via the one-pot reductive amination of enantiomerically pure norbornane-2,5-dione. These ligands were applied to various catalytic reactions such as asym. deprotonation, asym. bromine-lithium exchange, and enantioselective addition of aryl- and alkylithium reagents to aromatic aldimines.

Category: ethers-buliding-blocks, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Punia, Bhupinder Singh team published research in Journal of AOAC International in 2017 | 38256-93-8

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Recommanded Product: 2-Methoxy-N-methylethanamine

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Recommanded Product: 2-Methoxy-N-methylethanamine.

Punia, Bhupinder Singh;Yadav, Praveen Kumar;Bumbrah, Gurvinder Singh;Sharma, Rakesh Mohan research published 《 Analysis of Illicit liquor by headspace gas chromatography-mass spectrometry (HS-GC-MS): a preliminary study》, the research content is summarized as follows. Illicit liquors are illegally manufactured to evade taxes and represent the majority of unrecorded liquors in developing countries. Because there are no standards, the composition of illicit liquors varies greatly from sample to sample. In the current study, we analyzed the volatile components of 27 different illicit liquors via samples collected from various locations in the northern region of India. Ethanol content varied drastically and methanol was not present in any of the samples. The components found can be categorized into different groups, namely alcs., esters, acids, nitrogen-containing components, ketones, and aldehydes. Some components-such as 1-propanol; 1-pentanol; 1-butanol; d-limonene; phenylethyl alcs.; anethole; and decanoic, octanoic, and pentanoic acids-were frequently encountered.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Recommanded Product: 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Qian, Yimin team published research in Journal of Medicinal Chemistry in 2011 | 38256-93-8

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Safety of 2-Methoxy-N-methylethanamine

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Safety of 2-Methoxy-N-methylethanamine.

Qian, Yimin;Wertheimer, Stanley J.;Ahmad, Mushtaq;Cheung, Adrian Wai-Hing;Firooznia, Fariborz;Hamilton, Matthew M.;Hayden, Stuart;Li, Shiming;Marcopulos, Nicholas;McDermott, Lee;Tan, Jenny;Yun, Weiya;Guo, Liang;Pamidimukkala, Anjula;Chen, Yingsi;Huang, Kuo-Sen;Ramsey, Gwendolyn B.;Whittard, Toni;Conde-Knape, Karin;Taub, Rebecca;Rondinone, Cristina M.;Tilley, Jefferson;Bolin, David research published 《 Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes》, the research content is summarized as follows. Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl CoA. DGAT-1 deficient mice demonstrate resistance to weight gain on high fat diet, improved insulin sensitivity, and reduced liver triglyceride content. Inhibition of DGAT-1 thus represents a potential novel approach for the treatment of obesity, dyslipidemia, and metabolic syndrome. In this communication, we report the identification of the lead structure 6 and our lead optimization efforts culminating in the discovery of potent, selective, and orally efficacious carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamides. In particular, compound 29 (I) (DGAT-1 enzyme assay, IC50 = 57 nM; CHO-K1 cell triglyceride formation assay, EC50 = 0.5 μM) demonstrated dose dependent inhibition of weight gain in diet induced obese (DIO) rats (0.3, 1, and 3 mg/kg, PO, qd) during a 21-day efficacy study. Furthermore, compound 29 demonstrated improved glucose tolerance determined by an oral glucose tolerance test (OGTT).

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Safety of 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Okereke Stanley, C. team published research in Journal of Medicinal Plants Research in 2017 | 38256-93-8

Related Products of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Related Products of 38256-93-8.

Okereke Stanley, C.;Arunsi Uche, O.;Nosiri, Chidi I.;Constance, Nwadike research published 《 Gas chromatography mass spectrometry/Fourier transform infrared (GC-MS/FTIR) spectral analyses of Tithonia diversifolia (Hemsl.) A. Gray leaves》, the research content is summarized as follows. This study was aimed at investigating the gas chromatog. combined with GC-MS and FT-IR spectral analyses of methanolic extract of leaves of T. diversifolia (Hemsl.) A.Gray using standard anal. methods. Results showed the existence of 29 bioactive compounds: Ethylene oxide, 1-Butanamine, 3-methyl-, N-(3-Methylbutyl) acetamide, Cyclopentane, 2-n-octyl-, Cyclobutanol, dl-Phenylephrine, Phenylephrine, Hexadecanoic acid, Me ester, 1,3-Cyclohexanediol, Amphetamine, n-Hexadecanoic acid, 8-[NAziridylethylamino]-2,6-dimethyloctene-2, Benzenemethanol, .alpha.-[(methylamino)methyl]-, folic acid, acetic acid, hydroxy[(1-oxo-2-propenyl)amino]-, cis-Vaccenic acid, Octadecanoic acid, acetic acid, [(aminocarbonyl)amino]oxo-, cis-11-Eicosenoic acid, 4-Fluorohistamine, 2,3 Dimethoxyamphetamine, Benzeneethanamine, 2-fluoro-.beta. ,5-dihydroxy-N-methyl-, 2-Propenamide, N-(1-cyclohexylethyl)-, Erucic acid, Acetamide, 2,2,2-trichloro-, 2-Methoxy-Nmethylethylamine, acetic acid, chloro-, pentyl ester, p-Hydroxynorephedrine and Metaraminol; with Cis-vaccenic acid, n-Hexadecanoic acid and Octadecanoic acid as the most predominant bioactive compounds residents in the plant. The FT-IR showed the existence of alcs., phenols, aldehydes, ketones, alkanes and primary amines. It is opined that the methanolic extract of leaves of T. diversifolia (Hemsl.) A.Gray could be relied upon in traditional medicine for the management of certain infections.

Related Products of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Park, Kaapjoo team published research in Bioorganic & Medicinal Chemistry in 2014 | 38256-93-8

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Reference of 38256-93-8

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Reference of 38256-93-8.

Park, Kaapjoo;Lee, Byoung Moon;Hyun, Kwan Hoon;Lee, Dong Hoon;Choi, Hyun Ho;Kim, Hyunmi;Chong, Wonee;Kim, Kyeong Bae;Nam, Su Youn research published 《 Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus》, the research content is summarized as follows. Novel heteroaryl-containing benzamide derivatives were synthesized and screened using an in vitro assay measuring increases in glucose uptake and glucokinase activity stimulated by 10 mM glucose in rat hepatocytes. From a library of synthesized compounds, 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-Me pyridin-2-yl)-benzamide (19e) was identified as a potent glucokinase activator with assays demonstrating an EC50 of 315 nM and the induction of a 2.23 fold increase in glucose uptake. Compound 19e exhibited a glucose AUC reduction of 32% (50 mg/kg) in an OGTT study with C57BL/6J mice compared to 28% for metformin (300 mg/kg). Single treatment of the compound in C57BL/J6 and ob/ob mice elicited basal glucose lowering activity, while in a two-week repeated dose study with ob/ob mice, the compound significantly decreased blood glucose levels with no evidence of hypoglycemia risk. In addition, 19e exhibited favorable pharmacokinetic parameters in mice and rats and excellent safety margins in liver and testicular toxicity studies. Compound 19e was therefore selected as a development candidate for the potential treatment of type 2 diabetes.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Reference of 38256-93-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem