Month: September 2022

Wang, Wei;Wang, Zijun;Zhang, Li;Liu, Yuntao;Chen, Dongfeng published 《Effect of isomeric oxydianiline on crystalline behavior and properties of semicrystalline copolyimides》 in 2014. The article was appeared in 《Gaofenzi Cailiao Kexue Yu Gongcheng》. They have made some progress in their research.Related Products of 2657-87-6 The article mentions the following:

To investigate the effect of isomer on crystallinities of copolyimides, two copolyimides were synthesized by introducing 4,4′-oxydianiline (4,4′-ODA) or 3,4′-oxydianiline (3,4′-ODA) to 3,3′,4,4′-biphenyltetracarboxylic dianhydride (s-BPDA)/1,3-bis (4-aminophenoxy) benzene (TPER). And the mole ratio of ODA and TPER is both 1:9. The homopolyimide based on s-BPDA/TPER/phthalic anhydride (PA) was also prepared and it was abbreviated as TPER PI. Copolyimide containing 4,4′-ODA or 3,4′-ODA was abbreviated as PI a and PI b, resp. TGA, DSC, DMA and WXRD were used to study the crystalline behaviors and properties of the polymers. Three polymers display different cold crystallization temperatures and melting temperatures after being quenched from melts by DSC and they also display different melting behaviors after being slowly cooled from melts. Since 3,4′-ODA has more twisted structure, PI b displays the lowest melting temperature (T_m), the lowest crystallization rate, and the lowest storage modulus above T_g. After being isothermally crystallized at different temperatures for 1 h, PI a displays a triple-melting behaviors as same as TPER PI, however, PI b displays a duple-melting behaviors. Positions of some diffraction peaks of PI b were found to be changed after being isothermally crystallized at different temperatures In a word, introduction of 4,4′-ODA and 3,4′-ODA greatly affects crystalline behaviors of the copolyimides.3-(4-Aminophenoxy)aniline (cas: 2657-87-6) were involved in the experimental procedure.

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Related Products of 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iacazio, Gilles;Perissol, Claude;Faure, Bruno published 《A new tannase substrate for spectrophotometric assay》. The research results were published in《Journal of Microbiological Methods》 in 2000.Product Details of 2235-01-0 The article conveys some information:

A new tannase substrate, protocatechuic acid p-nitrophenyl ester, I, was synthesized using modern synthetic methods. The synthesis was designed to be performed by non-specialized chemists. It only involves four steps, three of which are protection-deprotection, and uses standard methods of separation and purification, such as recrystallization and column chromatog. over silica. Under tannase action, protocatechuic acid p-nitrophenyl ester, I, releases p-nitrophenol, which is easily measured spectrophotometrically either at 350 nm for pH values < 6 or at 400 nm for pH values of 6-7 (yellow). The pH-response and the catalytic parameters of a crude Penicillium sp. tannase preparation were determined using I as substrate, thus showing the usefulness of this substrate in determining tannase activity. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of DimethoxydiphenylmethaneIn 2017, Wu, Zhiyong;Leboeuf, David;Retailleau, Pascal;Gandon, Vincent;Marinetti, Angela;Voituriez, Arnaud published 《Enantioselective gold(I)-catalyzed rearrangement of cyclopropyl-substituted 1,6-enynes into 2-oxocyclobutyl-cyclopentanes》. 《Chemical Communications (Cambridge, United Kingdom)》published the findings. The article contains the following contents:

A gold(I)-catalyzed cycloisomerization/ring expansion sequence allows the highly enantioselective synthesis of 2-oxocyclobutylcyclopentane derivatives from cyclopropyl-substituted enynes [e.g., I → cis-II + trans-III (87%, cis/trans = 4.9/1, 99% ee cis) when conducted in wet toluene]. The bimetallic [(R)-MeO-DTBM-BIPHEP-(AuCl)₂] complex was found to be the best precatalyst, affording the desired cyclobutanones in high yields and enantioselectivities (up to 99% ee). The usefulness of the method was further demonstrated by preparing the tricyclic core scaffold of russujaponol D (IV). And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Safety of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hasegawa, Masatoshi;Fujii, Mari;Wada, Yuriko published 《Approaches to improve the film ductility of colorless cycloaliphatic polyimides》 in 2018. The article was appeared in 《Polymers for Advanced Technologies》. They have made some progress in their research.Application In Synthesis of 3-(4-Aminophenoxy)aniline The article mentions the following:

This study described approaches for improving the film ductility of colorless cycloaliphatic polyimides (PIs). An unexpected toughening effect was observed when a PI derived from pyromellitic dianhydride (PMDA) and 4,4′-methylenebis(cyclohexylamine) was modified by copolymerization with a low isophoronediamine (IPDA) content of 5 to 30 mol%, despite there being no film-forming ability in the homo PMDA/IPDA system. For example, at an IPDA content of 20 mol%, the copolymer showed significantly improved film toughness (maximum elongation at break, ε_b max = 57%), excellent optical transparency (light transmittance at 400 nm, T₄₀₀ = 83.7%), and a high glass transition temperature (T_g = 317°C). This toughening effect can be interpreted on the basis of the concept of chain slippage. In this study, the PIs derived from bicyclo[2.2.2]octane-2,3,5,6-tetracarboxylic dianhydride (H-BTA) with various diamines were also systematically investigated to evaluate the potential of H-BTA-derived systems. The combinations of H-BTA with ether-containing diamines led to highly tough PI films (ε_b max > 100%) with very high T_gs, strongly contrasting with the results of an earlier study. The observed excellent properties are related to the steric structure of H-BTA. Our interest also extended to the solution processability. A copolyimide derived from H-BTA with a sulfone-containing diamine and an ether-containing diamine achieved a very high optical transparency (T₄₀₀ = 86.8%), a very high T_g (313°C), and good ductility (ε_b max = 51%) while maintaining solution processability. Thus, these approaches enabled us to dramatically improve the ductility of cycloaliphatic PI films that have, to date, been considered brittle. To complete the study, the researchers used 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Application In Synthesis of 3-(4-Aminophenoxy)anilineEthers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 2235-01-0《Product subclass 7: organometallic compounds of potassium》 was published in 2006. The authors were Mordini, Alessandro;Valacchi, M., and the article was included in《Science of Synthesis》. The author mentioned the following in the article:

A review of the preparation and application of potassium organometallic compounds in organic synthesis. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. SDS of cas: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Franchini, Silvia;Sorbi, Claudia;Linciano, Pasquale;Carnevale, Gianluca;Tait, Annalisa;Ronsisvalle, Simone;Buccioni, Michela;Del Bello, Fabio;Cilia, Antonio;Pirona, Lorenza;Denora, Nunzio;Iacobazzi, Rosa Maria;Brasili, Livio published 《1,3-Dioxane as a scaffold for potent and selective 5-HT_1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity》. The research results were published in《European Journal of Medicinal Chemistry》 in 2019.Application of 2235-01-0 The article conveys some information:

A series of compounds generated by ring expansion/opening and mol. elongation/simplification of the 1,3-dioxolane scaffold were prepared and tested for binding affinity at 5-HT_1AR and α₁ adrenoceptors. The compounds with greater affinity were selected for further functional studies. N-((2,2-diphenyl-1,3-dioxan-5-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-ammonium hydrogen oxalate I emerged as highly potent full agonist at the 5-HT_1AR (pKi 5-HT_1A = 8.8; pD₂ = 9.22, %E_max = 92). The pharmacokinetic data in rats showed that the orally administered I has a high biodistribution in the brain compartment. Thus, I was further investigated in-vivo, showing an anxiolytic and antidepressant effect. Moreover, in the formalin test, the above compound was able to decrease the late response to the noxious stimulus, indicating a potential use in the treatment of chronic pain. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Application of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C12H12N2O《Studies of formation mechanism, structure, and properties of network copolymers obtained by cocuring of rolivsan thermosetting resins with aromatic diamines》 was published in 2019. The authors were Zaitsev, B. A.;Kleptsova, L. G.;Shvabskaya, I. D., and the article was included in《International Journal of Polymer Science》. The author mentioned the following in the article:

Rolivsan thermosetting resins (ROLs) demonstrate high glass-transition temperatures and excellent processability. In our work, high-temperature properties of ROLs were significantly improved using a novel technique for structural and chem. modification of microheterogeneous network polymers. This technique involves, among other procedures, cocuring of rolivsan resins with aromatic diamines (ADA). The most noticeable increase in storage moduli and glass transition temperatures (T_g) of these copolymers was achieved when ROLs were modified with 10-15 weight% of ADA and the resulting blends were subjected to thermal treatment in air in the temperature range 180 to 320°C for several hours. FTIR, ¹³C NMR spectroscopy, and dynamic mech. and thermal analyzes were used for studying the structure and properties of the obtained products. It was demonstrated that the mechanism of formation of ROL-ADA copolymers includes the following high-temperature reactions: (i) three-dimensional radical copolymerization of unsaturated ROL components and (ii) cleavage of heat-sensitive methacrylate crosslinking units inside the polymer network. The second process is accompanied by formation of pending units of methacrylic acid and methacrylic anhydride, which participate in condensation reactions with ADA.3-(4-Aminophenoxy)aniline (cas: 2657-87-6) were involved in the experimental procedure.

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Synthetic Route of C12H12N2O The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Yan;Yin, Hong-liang;Wang, Li-li;Sun, Xiao-qiang published 《Synthesis of heterocyclic ethers chiral ligands》 in 2014. The article was appeared in 《Huaxue Shiji》. They have made some progress in their research.Application In Synthesis of Dimethoxydiphenylmethane The article mentions the following:

Using L-tartaric acid and benzophenone as reactants, a family of heterocyclic ether chiral ligands ((4S,5S)-2,2-diphenyl-5-((pyridin-2-ylmethoxy) methyl)-1,3-dioxolane-4-yl) methanol I and 2,2′-((((4S, 5S)-2,2-dip-henyl-1,3-dioxolane-4,5-diyl) bis (methylene)) bis (oxy) bis (methylene)) dipyridine II were synthesized via esterification, ketal and reduction reactions. There were two methene groups between the chiralcenter and the ligand atoms, this increased the flexible of chiral ligands, and the catalytic performance was primarily discussed. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application In Synthesis of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Winters, Jonas;Dehaen, Wim;Binnemans, Koen published 《γ-Valerolactone-based organic electrolyte solutions: a benign approach to polyaramid dissolution and processing》. The research results were published in《Green Chemistry》 in 2020.Computed Properties of C12H12N2O The article conveys some information:

Polyaramids are polymers that consist of aromatic repeating units that are connected via amide bonds. From their chem. structure, an extensive intermol. hydrogen-bond network arises, which makes them very difficult to dissolve in conventional organic solvents. A commonly used solvent system is N-methylpyrrolidone (NMP) mixed with CaCl2, where the chloride ions can break up the intermol. hydrogen bonds. Organic electrolyte solutions (OESs) are proposed as a green alternative solvent system. OESs are created by diluting ionic liquids (ILs) with an organic co-solvent. gamma-Valerolactone (GVL) was selected as a green, renewable co-solvent. The solubility in OESs was tested for three commonly produced polyaramids: poly-p-phenylene terephthalamide (PPTA), poly-m-phenylene isophthalamide (PMIA) and copoly(p-phenylene/3,4′-diphenylether terephthalamide) (ODA/PPTA). Some OESs were excellent solvents for PMIA and ODA/PPTA, with [C8MIm][Cl]/GVL yielding solubilities as high as 23.7 wt% and 7.4 wt%, resp., rivalling the currently used solvent systems. PPTA, on the other hand, was completely insoluble in all OESs. GVL was found to work synergistically with ILs, while acetonitrile and ethanol acted as a non-solvent and anti-solvent, resp. OESs made from GVL and imidazolium ILs were suitable solvents for fiber spinning, as was demonstrated using a 3D-printed spinning setup. The Kamlet-Taft parameters of the OES were determined from which boundary conditions for dissolution To complete the study, the researchers used 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Computed Properties of C12H12N2OEthers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zaitsev, B. A.;Kleptsova, L. G.;Shvabskaya, I. D. published 《Heat-resistant network copolymers based on rolivsans modified with aromatic diamines》 in 2017. The article was appeared in 《Russian Journal of Applied Chemistry》. They have made some progress in their research.Application In Synthesis of 3-(4-Aminophenoxy)aniline The article mentions the following:

Thermochem. transformations of rolivsans with aromatic diamines were studied by IR and NMR (¹H, ¹³C) spectroscopy and by dynamic mech., thermal, and elemental anal. The heat resistance of rolivsans is considerably enhanced by their modification with small additions (10±5%) of an aromatic diamine with curing at 150-300 (320)°C. The experimental procedure involved many compounds, such as 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Application In Synthesis of 3-(4-Aminophenoxy)anilineEthers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem