Month: October 2022

Reference of 2-Hydroxy-4-methoxybenzaldehydeIn 2019 ,《High in Vitro and in Vivo Tumor-Selective Novel Ruthenium(II) Complexes with 3-(2′-Benzimidazolyl)-7-fluoro-coumarin》 was published in ACS Medicinal Chemistry Letters. The article was written by Qin, Qi-Pin; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Shi, Bei-Bei; Liang, Hong. The article contains the following contents:

Three novel Ru(II) complexes, namely, (RuCl2[La][DMSO]2)·H2O (Ru1), (RuCl2[Lb][DMSO]2) (Ru2), and (RuCl2[Lc][DMSO]2) (Ru3), which resp. contain 3-(2′-benzimidazolyl)coumarin (La), 3-(2′-benzimidazolyl)-7-fluoro-coumarin (Lb), and 3-(2′-benzimidazolyl)-7-methoxyl-coumarin (Lc), were first designed and characterized. Ru2 showed potent antitumor activity against NCI-H460 cells (IC50 = 0.30 ± 0.02 μM) and high selectivity between NCI-H460 cancer cells and normal HL-7702 cells. Ru2 induced NCI-H460 apoptosis via telomerase inhibition, which involved DNA damage, cell-cycle distribution, and S phase-protein down-regulation. However, Ru1 did not demonstrate such effects in NCI-H460 cells, which is undoubtedly associated with the key regulatory role of the 7-fluoro substituted group in the Lb ligand of Ru2. Ru2 exhibited considerably higher anticancer efficacy (inhibition rate [IR] = 61.3%) compared with cisplatin (IR= 25.5%) in a NCI-H460 xenograft mouse model. Thus, this coumarin Ru(II) compound is a promising Ru2-targeting telomerase anticancer agent. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Reference of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Reference of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 1,2-DiphenyldisulfaneIn 2019 ,《Biomimetic catalytic oxidative coupling of thiols using thiolate-bridged dinuclear metal complexes containing iron in water under mild conditions》 was published in Catalysis Science & Technology. The article was written by Zhang, Yahui; Yang, Dawei; Li, Ying; Zhao, Xiangyu; Wang, Baomin; Qu, Jingping. The article contains the following contents:

Thiolate-bridged heterobimetallic half-sandwich complexes [Cp’M1(μ-SCH2CH2SCH2CH2S)M2Cp*][X] (2-PF6, Cp’ = C5Me5, M1 = Ru, M2 = Fe; 4a-BPh4, Cp’ = C5Me5, M1 = Fe, M2 = Co; 4b-BPh4, Cp’ = C5HMe4, M1 = Fe, M2 = Co) were prepared as catalysts for aerial oxidative coupling of thiols into disulfides. A green and efficient approach to disulfides via oxidative coupling of thiols was developed by adopting a biomimetic thiolate-bridged iron-ruthenium complex as the catalyst. Using environmentally friendly oxygen as the oxidant, a wide range of thiols including biol. important mols. can be smoothly converted into corresponding disulfides in water. Notably, two potential intermediate species were successfully isolated and unambiguously characterized, which is essential to reveal the detailed mechanism of this transformation. This catalytic system represents a rare and desired heteronuclear bimetallic scaffold for understanding the biol. process of S-S bond formation from the viewpoint of bioinspired catalysis. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Recommanded Product: 1,2-Diphenyldisulfane) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Recommanded Product: 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1-Bromo-3-methoxybenzeneIn 2020 ,《Synthesis of Tetrahydropyridazines via Pd-Catalyzed Carboamination of Alkenyl Hydrazones》 was published in Advanced Synthesis & Catalysis. The article was written by Guo, Yajing; Zhao, Jinbo; Zhang, Qian. The article contains the following contents:

Herein a facile approach to tetrahydropyridazines, a scaffold found in many natural products and biol. active entities, via Pd-catalyzed carboamination of readily available alkenyl hydrazones with aryl and alkenyl halides was reported. Preliminary studies showed its promise for enantioselective synthesis. This work offers an expedient access to the tetrahydropyridazine scaffold bearing substitution patterns, thus significantly increasing the availability of these derivatives for downstream evaluation. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Reference of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Reference of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Reactivity of 1,2,3- and 1,2,4-Trifluorobenzenes in Palladium-Catalyzed Direct Arylation》 was written by Shi, Xinzhe; Mao, Shuxin; Soule, Jean-Francois; Doucet, Henri. Category: ethers-buliding-blocks And the article was included in Journal of Organic Chemistry on April 6 ,2018. The article conveys some information:

The higher reactivity of the C4-H bond as compared to the C5-H bond of 1,2,3-trifluorobenzene in palladium-catalyzed direct arylation allows the selective synthesis of 4-aryl-1,2,3-trifluorobenzenes in moderate to high yields. In most cases, phosphine-free Pd(OAc)2 catalyst and inexpensive KOAc base were employed. Then, from these 4-aryl-1,2,3-trifluorobenzenes, the palladium-catalyzed C-H bond functionalization of the C6-position allows the synthesis of the corresponding 4,6-diarylated 1,2,3-trifluorobenzenes. We also applied these reaction conditions to the regioselective direct C3-arylation of 1,2,4-trifluorobenzene.1,2,3-Trifluoro-4-methoxybenzene(cas: 203245-16-3Category: ethers-buliding-blocks) was used in this study.

1,2,3-Trifluoro-4-methoxybenzene(cas: 203245-16-3) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Zinc(II)cyclen-peptide conjugates interacting with the weak effector binding state of Ras》 was written by Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard. Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateThis research focused onzinc cyclen peptide conjugate Ras protein. The article conveys some information:

Zinc(II)cyclen-peptide hybrid compounds and bis-zinc(II)cyclen complexes are prepared as potential binders of the guanine nucleotide binding protein Ras, an important mol. switch in cellular signal transduction. The design of the compounds is based on the previous observation that zinc(II)cyclen complexes could serve as lead compounds for inhibitors of Ras-effector interaction and thus be able to interrupt Ras induced signal transduction. Zinc(II)cyclen selectively stabilizes conformational state 1 of active Ras, a conformational state with drastically decreased affinity to effector proteins like Raf-kinase. To achieve higher binding affinities of such Ras-Raf interaction inhibitors, zinc(II)cyclen conjugates with short peptides, derived from the sequence of the Ras-activator SOS, were prepared by solid phase synthesis protocols. Dinuclear bis-zinc(II)cyclen complexes were obtained from alkyne-azide cycloaddition reactions. NMR investigations of the prepared compounds revealed that the peptide conjugates do not lead to an increase in Ras binding affinity of the metal complex-peptide conjugates. The dinuclear zinc complexes lead to an immediate precipitation of the protein prohibiting spectroscopic investigations of their binding. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《β-1,3-glucan (schyzophyllan) can act as a one-dimensional host for creating chirally twisted poly(p-phenylene ethynylene)》 was written by Numata, Munenori; Fujisawa, Tomohisa; Li, Chun; Haraguchi, Shunichi; Ikeda, Masato; Sakurai, Kazuo; Shinkai, Seiji. Synthetic Route of C12H10O2 And the article was included in Supramolecular Chemistry in 2007. The article conveys some information:

It has been demonstrated that a chiral, insulated poly(p-phenylene ethynylene) (PPE) nano-wire can be created by a polymer wrapping method utilizing natural β-1,3-glucan polysaccharide schizophyllan (SPG). Spectroscopic and microscopic measurements have revealed that PPE adopts a rigid conformation and exists as one piece in the helical hollow constructed by two SPG chains. Moreover, the inherent helical structure of SPG can induce the chiral twisting of the insulated PPE backbone. It is believed that the present system is really applicable for designing novel chiral sensors based on PPE. In the experimental materials used by the author, we found 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Synthetic Route of C12H10O2)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Synthetic Route of C12H10O2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Journal of Chemistry included an article by Basinger, Corinne A.; Sullivan, Kaitlin; Siemer, Sarah; Oehrle, Stuart; Walters, Keith A.. Application of 74029-40-6. The article was titled 《Synthesis and preliminary characterization of a PPE-type polymer containing substituted fullerenes and transition metal ligation sites》. The information in the text is summarized as follows:

A substituted fullerene was incorporated into a PPE-conjugated polymer repeat unit. This subunit was then polymerized via Sonogashira coupling with other repeat units to create polymeric systems approaching 50 repeat units (based on GPC characterization). Bipyridine ligands were incorporated into some of these repeat units to provide sites for transition metal coordination. Photophys. characterization of the absorption and emission properties of these systems shows excited states located on both the fullerene and aromatic backbone of the polymers that exist in a thermally controlled equilibrium Future work will explore other substituted polyaromatic systems using similar methodologies. In addition to this study using 1,4-Diethynyl-2,5-dimethoxybenzene, there are many other studies that have used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Application of 74029-40-6) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Application of 74029-40-6 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Chunlei; Wang, Xiu; Shen, Lei; Deng, Wenping; Liu, Haiyun; Ge, Shenguang; Yan, Mei; Song, Xianrang published an article in Biosensors & Bioelectronics. The title of the article was 《An aldehyde group-based P-acid probe for selective fluorescence turn-on sensing of cysteine and homocysteine》.HPLC of Formula: 74029-40-6 The author mentioned the following in the article:

A highly sensitive and selective turn on fluorescent probe P-acid-aldehyde (P-CHO) is developed for the determination of cysteine (Cys) and homocysteine (Hcy). The probe is designed and synthesized by incorporating the specific functional group aldehyde group for thiols into a stable p-conjugated material 4,4′-(2,5-dimethoxy-1,4-phenylene) bis(ethyne-2,1-diyl) dibenzoic acid (P-acid). The probe fluorescence is quenched through donor photoinduced electron transfer (d-PET) between the fluorophore (P-acid) and the recognition group (aldehyde group). In the presence of thiols, Cys and Hcy can selectively react with aldehyde group of the probe because the inhibition of d-PET between fluorophore and recognition group. Therefore, a turn-on fluorescent sensor was established for the fluorescence recovery. Under the optimized conditions, the fluorescence response of probe is directly proportional to the concentration of Cys in the range of 4-95 nM L-1, with a detection limit 3.0 nM. In addition, the sensing system exhibits good selectively toward Cys and Hcy in the presence of other amino acids. It has been successfully applied for bioimaging of Cys and Hcy in living cells with low cell toxicity. After reading the article, we found that the author used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6HPLC of Formula: 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.HPLC of Formula: 74029-40-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Fabre, Benjamin; Picha, Jan; Vanek, Vaclav; Selicharova, Irena; Chrudinova, Martina; Collinsova, Michaela; Zakova, Lenka; Budesinsky, Milos; Jiracek, Jiri published 《Synthesis and evaluation of a library of trifunctional scaffold-derived compounds as modulators of the insulin receptor》.ACS Combinatorial Science published the findings.HPLC of Formula: 139115-91-6 The information in the text is summarized as follows:

We designed a combinatorial library of trifunctional scaffold-derived compounds, which were derivatized with 30 different inhouse-made azides. The compounds were proposed to mimic insulin receptor (IR)-binding epitopes in the insulin mol. and bind to and activate this receptor. This work has enabled us to test our synthetic and biol. methodol. and to prove its robustness and reliability for the solid-phase synthesis and testing of combinatorial libraries of the trifunctional scaffold-derived compounds Our effort resulted in the discovery of two compounds, which were able to weakly induce the autophosphorylation of IR and weakly bind to this receptor at a 0.1 mM concentration Despite these modest biol. results, which well document the well-known difficulty in modulating protein-protein interactions, this study represents a unique example of targeting the IR with a set of nonpeptide compounds that were specifically designed and synthesized for this purpose. We believe that this work can open new perspectives for the development of next-generation insulin mimetics based on the scaffold structure.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6HPLC of Formula: 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.HPLC of Formula: 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Yao, Hong; Wei, Guoxiang; Liu, Yanpeng; Yao, Hequan; Zhu, Zheying; Ye, Wencai; Wu, Xiaoming; Xu, Jinyi; Xu, Shengtao published 《Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies》.ACS Medicinal Chemistry Letters published the findings.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

23-Hydroxybetulinic acid (23-HBA) is a complex lupane triterpenoid, which has attracted increasing attention as an anticancer agent. However, its detailed mechanism of anticancer action remains elusive so far. To reveal its anticancer mode of action, a series of fluorescent 23-HBA derivatives conjugated with coumarin dyes were designed, synthesized, and evaluated for their antiproliferative activities. Subcellular localization and uptake profile studies of representative fluorescent 23-HBA probe 26c were performed in B16F10 cells, and the results suggested that probe 26c was rapidly taken up into B10F10 cells in a dose-dependent manner and mitochondrion was the main site of its accumulation. Further mode of action studies implied that the mitochondrial pathway was involved in 23-HBA-mediated apoptosis. Together, our results provided new clues for revealing the mol. mechanism of natural product 23-HBA for its further development into an antitumor agent. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem