Month: October 2022

Bai, Jin-Hua; Qi, Xiu-Juan; Sun, Wei; Yu, Tian-Yang; Xu, Peng-Fei published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Nickel-Catalyzed Intramolecular Decarbonylative Coupling of Aryl Selenol Esters》.Recommanded Product: 1-Bromo-3-methoxybenzene The article contains the following contents:

A method for Ni-catalyzed intramol. decarbonylative coupling, which enabled the conversion of areneselenol esters to diaryl selenides was described. The inexpensive and readily available catalyst was employed under mild reaction conditions for the construction of structurally diverse diaryl selenides, including heterocyclic and natural product derivatives After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Recommanded Product: 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ali, Mubarak; Nasir, Saima; Froehlich, Kristina; Ramirez, Patricio; Cervera, Javier; Mafe, Salvador; Ensinger, Wolfgang published their research in Advanced Materials Interfaces in 2021. The article was titled 《Size-Based Cationic Molecular Sieving through Solid-State Nanochannels》.SDS of cas: 33100-27-5 The article contains the following contents:

The mol. sieving behavior of soft-etched polyimide membranes having neg. charged nanochannels is described exptl. and theor. using alkali metal-crown ether cationic complexes and alkylammonium cations. To this end, the elec. conduction and current rectification obtained with different alkali electrolyte solutions (LiCl, NaCl, and KCl) and crown ether mols. (12-crown-4, 15-crown-5, and 18-crown-6) are studied. The results suggest that only the [Li(12C4)]+ complex can readily permeate through the nanochannels because significant current decreases are obtained in the cases of the [Na(15C5)]+ and [K(18C6)]+ complexes. In solutions of organic cations ranging from ammonium (NH4+) to alkylammonium (R4N+) with increasing mol. size, only the smaller ions can conduct high elec. currents, suggesting again that the membrane channels are in the nanometer range. Taken together, the observed current decreases and rectification phenomena demonstrate that the functionalized membranes allow a versatile combination of mol. and electrostatic sieving. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5SDS of cas: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. SDS of cas: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Litvinova, Yulia M.; Gayfulin, Yakov M.; Samsonenko, Denis G.; Dorovatovskiy, Pavel V.; Lazarenko, Vladimir A.; Brylev, Konstantin A.; Mironov, Yuri V. published their research in Inorganica Chimica Acta in 2021. The article was titled 《Coordination polymers based on rhenium octahedral chalcocyanide cluster [Re6Se8(CN)6]4- and lanthanide ions solvated with dimethylformamide》.Category: ethers-buliding-blocks The article contains the following contents:

The authors demonstrate influence of the source of organic ligand on the formation of supramol. structures based on the octahedral metal clusters. Two series of coordination polymers based on the rhenium clusters [Re6Se8(CN)6]4- and Ln3+ complexes (Ln = Sm, Eu, Tb, Dy) with DMF were obtained. The first series was obtained by direct addition of DMF in the reaction mixture The series consist of the compounds crystallizing in trigonal crystal system, R3c space group, and possessing a framework porous structures composed of cluster anions and [Ln(DMF)3(H2O)2]3+ complexes. Compounds of the second series were obtained as a result of in situ generation of DMF by hydrolysis of N,N-dimethylformamide di-Me acetal (DMF DMA). These compounds were crystallized in orthorhombic crystal system, Pnma space group, and possessed a layered structure consisting of cluster anions and [Ln(DMF)2(H2O)2]3+ complexes. The difference in the structures formed depends on the source of DMF rather than other reaction conditions. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Deqiang; Ding, Wanjian; Hou, Guohua; Zi, Guofu; Walter, Marc D. published their research in Chemistry – A European Journal in 2021. The article was titled 《Uranium versus Thorium: Synthesis and Reactivity of [η5-1,2,4-(Me3C)3C5H2]2U[η2-C2Ph2]》.Synthetic Route of C12H10S2 The article contains the following contents:

The synthesis, electronic structure, and reactivity of a uranium metallacyclopropene were comprehensively studied. Addition of diphenylacetylene (PhCCPh) to the uranium phosphinidene metallocene [η5-1,2,4-(Me3C)3C5H2]2U:P-2,4,6-tBu3C6H2 (1) yields the stable uranium metallacyclopropene, [η5-1,2,4-(Me3C)3C5H2]2U[η2-C2Ph2] (2). Based on d. functional theory (DFT) results the 5f orbital contributions to the bonding within the metallacyclopropene U-(η2-C:C) moiety increases significantly compared to the related ThIV compound [η5-1,2,4-(Me3C)3C5H2]2Th[η2-C2Ph2], which also results in more covalent bonds between the [η5-1,2,4-(Me3C)3C5H2]2U2+ and [η2-C2Ph2]2- fragments. Although the thorium and uranium complexes are structurally closely related, different reaction patterns are therefore observed For example, 2 reacts as a masked synthon for the low-valent uranium(II) metallocene [η5-1,2,4-(Me3C)3C5H2]2UII when reacted with Ph2E2 (E = S, Se), alkynes and a variety of hetero-unsaturated mols. such as imines, ketazine, bipy, nitriles, organic azides, and azo derivatives In contrast, five-membered metallaheterocycles are accessible when 2 is treated with isothiocyanate, aldehydes, and ketones.1,2-Diphenyldisulfane(cas: 882-33-7Synthetic Route of C12H10S2) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Synthetic Route of C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liang, Zhanqun; Lv, Kang; Zhou, Shaofang; Zhu, Changlei; Bao, Xiaoguang published an article in 2021. The article was titled 《Visible-light photocatalytic preparation of alkenyl thioethers from 1,2,3-thiadiazoles and Hantzsch esters: synthetic and mechanistic investigations》, and you may find the article in Organic Chemistry Frontiers.Electric Literature of C9H10O2 The information in the text is summarized as follows:

A protocol to synthesize trisubstituted alkenyl thioethers I (R1 = Ph, 3-ClC6H4, 2-naphthyl, 2-thienyl, etc.; R2 = i-Pr, cyclohexyl, PhCH2, PhCMe2, etc.) through a direct S-alkylation of 1,2,3-thiadiazoles II with C-radical precursors, 4-alkyl-1,4-dihydropyridines III (R3 = EtO2C, t-BuO2C, CN), driven by visible-light photocatalysis is disclosed. A broad range of primary, secondary and tertiary C-radical precursors is suitable for this reaction and the desired products can be obtained in good to excellent yields under mild conditions. Remarkably, high stereoselectivity with Z-alkenyl thioethers was achieved in the presence of a Cu(OAc)2 catalyst. Synergistic exptl. and computational studies were carried out to shed light on the mechanisms of this reaction, in which the quenching pathway of an excited photocatalyst (*RuII) could be altered in the presence of the Cu(OAc)2 catalyst. A reductive quenching pathway (RuII/*RuII/RuI/RuII) was proposed in the absence of the Cu(OAc)2 catalyst while an oxidative quenching pathway (RuII/*RuII/RuIII/RuII) was suggested with the assistance of the Cu(OAc)2 catalyst. In addition, the origin of the Z-selectivity of the product was discussed. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Faal, Masoud; Mahyari, Mojtaba; Hosseini, Seyed Ghorban; Tavangar, Saeed; Zarei, Mohammad Ali published an article in 2021. The article was titled 《Synthesis of poly(2,4,6-trinitrophenyl acetal acrylate) as a new energetic binder and calculation of its heat of formation: A theoretical and experimental study》, and you may find the article in Reactive & Functional Polymers.Recommanded Product: 4637-24-5 The information in the text is summarized as follows:

In recent years, acrylate binders were widely used in PBX production High loading of explosives and processability are the prominent features of these binders that researchers are trying to improve the energetic properties of these binders. In this research, a novel energetic binder of poly (2,4,6-trinitrophenylacetal acrylate) (PATNP) was synthesized through acetalization reaction Poly(glycerol monoacrylate) with 2,4,6-trinitrophenyl acetaldehyde in the presence of p-toluene sulfonic acid (PTSA) as the catalyst. The polymer structure was confirmed using 1H NMR and FT-IR. Thermal anal. obtained from the TGA curve of polymer shows that the addition of TNT derivatives significantly changes the thermal decomposition processes. In the TGA curve of PATNP, two main weight losses were observed with a decomposition percentage of 38 and 37%. The glass transition temperatures (Tg) of poly(glycerol monoacrylate) and PATNP were measured by DSC, and their Tg were obtained at -51° and -43°, resp. The heat of formation (HOF) and the HOMO-LUMO gap of PATNP was calculated using DFT computational method and compared with HTPB, AHTPB, and GAP binders. The HOF of PATNP for the monomer and dimer was obtained as 70.67 and 263.26 J/g, resp. The HOMO-LUMO gap for TNPA and PATNP was calculated at 3.7296 and 4.152 eV, resp. The obtained energetic polymer can have a potential application as the binder of PBXs. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mekky, Ahmed E. M.; Ahmed, Mohamed S. Mohamed; Sanad, Sherif M. H.; Abdallah, Zeinab A. published an article in 2021. The article was titled 《Bis(benzofuran-enaminone) hybrid possessing piperazine linker: Versatile precursor for microwave assisted synthesis of bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines)》, and you may find the article in Synthetic Communications.Recommanded Product: 4637-24-5 The information in the text is summarized as follows:

Herein efficient procedures for the synthesis of new piperazine-linked bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines) using bis(benzofuran-enaminone) hybrid as a key intermediate are reported. For this purpose, bis(enaminone) was reacted with a new series of 3-amino-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridines in pyridine under microwave irradiation at 120° for 90 min to afford the target bis(pyrimidines). In a two-steps synthetic route, bis(enaminone) was used to prepare a novel bis(3-amino-1H-pyrazolo[3,4-b]pyridine). Next, the former hybrid was reacted with two equivalent of the appropriate enaminones as well as arylidinemalononitriles in pyridine under microwave irradiation at 120° for 2 h to afford the target bis(pyrimidines). Furthermore, a mixture of bis(pyrazolopyridine) reacted with two equivalent of 1,3-diketones and β-ketoesters in glacial acetic acid was microwave irradiated at 130° for 90 min to give bis(2,4-disubstituted pyrimidines) and bis(2-substituted pyrimidin-4(1H)-ones), resp. The structures of the new hybrids were confirmed via considering their elemental analyses as well as their spectral data. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Recommanded Product: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Liang, Xinyu; Wen, Kaikai; Shi, Qinqin; Zhang, Bei-Bei; Pei, Shurui; Lin, Qijie; Ma, Bowei; Wang, Song; Zhang, Meng; Li, Xiang; Wang, Zhi-Xiang; Huang, Hui published an article in Chemistry – A European Journal. The title of the article was 《The Aryl Sulfide Synthesis via Sulfide Transfer》.Application of 2398-37-0 The author mentioned the following in the article:

Aryl sulfides are in great demands in drugs and materials sciences. To avoid using nucleophilic and noxious thiols, many efforts have been focused on exploring novel sulfide resources. Herein, a reductive Pd-catalyzed, Ni-mediated method to synthesize aryl sulfides via a sulfide transfer reaction is developed. The utility and scope of this reaction is exemplified by various aryl electrophiles and aryl sulfides. Mechanistic studies reveal two competing catalytic cycles of sulfide transfer and aryl transfer in this reaction, where the former one is favored over the later one because of the large energy barrier difference during the transmetalation. Moreover, two important chems. are late-stage functionalized by this method, exhibiting the potential applications in drugs and materials science. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Rao, Desaboini Nageswara; Ji, Xincai; Miller, Stephen C. published an article in Chemical Science. The title of the article was 《Silicon functionalization expands the repertoire of Si-rhodamine fluorescent probes》.Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:

Reported a broad range of silyl modifications that enabled brighter dyes, further red-shifting, new ways to modulate fluorescence and the introduction of handles for dye attachment, including fluorogenic labeling agents for nuclear DNA, SNAP-tag and HaloTag labeling. Modifications to the bridging silicon were therefore of broad utility to improve and expanded the applications of all Si-dyes.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Teunissen, M; Ahrens, N S; Snel, L; Narcisi, R; Kamali, S A; van Osch, G J V M; Meij, B P; Mastbergen, S C; Sivasubramaniyan, K; Tryfonidou, M A published an article in Stem cell research & therapy. The title of the article was 《Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints.》.Quality Control of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The author mentioned the following in the article:

BACKGROUND: Synovial membrane-derived mesenchymal progenitor cells (SM-MPCs) are a promising candidate for the cell-based treatment of osteoarthritis (OA) considering their in vitro and in vivo capacity for cartilage repair. However, the OA environment may adversely impact their regenerative capacity. There are no studies for canine (c)SM-MPCs that compare normal to OA SM-MPCs, even though dogs are considered a relevant animal model for OA. Therefore, this study compared cSM-MPCs from normal and OA synovial membrane tissue to elucidate the effect of the OA environment on MPC numbers, indicated by CD marker profile and colony-forming unit (CFU) capacity, and the impact of the OA niche on tri-lineage differentiation. METHODS: Normal and OA synovial membrane were collected from the knee joints of healthy dogs and dogs with rupture of the cruciate ligaments. The synovium was assessed by histopathological OARSI scoring and by RT-qPCR for inflammation/synovitis-related markers. The presence of cSM-MPCs in the native tissue was further characterized with flow cytometry, RT-qPCR, and immunohistochemistry, using the MPC markers; CD90, CD73, CD44, CD271, and CD34. Furthermore, cells isolated upon enzymatic digestion were characterized by CFU capacity, and a population doublings assay. cSM-MPCs were selected based on plastic adherence, expanded to passage 2, and evaluated for the expression of MPC-related surface markers and tri-lineage differentiation capacity. RESULTS: Synovial tissue collected from the OA joints had a significantly higher OARSI score compared to normal joints, and significantly upregulated inflammation/synovitis markers S100A8/9, IL6, IL8, and CCL2. Both normal and OA synovial membrane contained cells displaying MPC properties, including a fibroblast-like morphology, CFU capacity, and maintained MPC marker expression over time during expansion. However, OA cSM-MPCs were unable to differentiate towards the chondrogenic lineage and had low adipogenic capacity in contrast to normal cSM-MPCs, whereas they possessed a higher osteogenic capacity. Furthermore, the OA synovial membrane contained significantly lower percentages of CD90+, CD44+, CD34+, and CD271+ cells. CONCLUSIONS: The OA environment had adverse effects on the regenerative potential of cSM-MPCs, corroborated by decreased CFU, population doubling, and chondrogenic capacity compared to normal cSM-MPCs. OA cSM-MPCs may be a less optimal candidate for the cell-based treatment of OA than normal cSM-MPCs. In the experimental materials used by the author, we found 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Quality Control of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Quality Control of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem