Month: October 2022

In 2022,Yuan, Jinping; Jain, Pankaj; Antilla, Jon C. published an article in Journal of Organic Chemistry. The title of the article was 《Chiral Phosphoric Acid-Catalyzed Enantio- and Diastereoselective Allylboration of Aldehydes with β,γ-Substituted Allylboronates》.Recommanded Product: 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

The catalytic asym. addition of β,γ-substituted allylboronates to aldehydes was described. Promoted by 5 mol % chiral H3PO4, the reactions were broadly applicable, scalable, and efficient, allowing for the formation of 3,4-anti/syn-homoallylic alcs. bearing adjacent tertiary or quaternary stereogenic centers in a highly enantio- and diastereoselective manner (≤99% ee and dr >20:1). The rigid chair-like transition state involving the chiral H3PO4 contributed to the highly controlled reaction. In the part of experimental materials, we found many familiar compounds, such as 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Recommanded Product: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Li, Haiwei; Wang, Shouxin; Ma, Wenxiao; Cheng, Boyang; Yi, Yanliang; Ma, Xinyuan; Xiao, Sulong; Zhang, Lihe; Zhou, Demin published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders》.Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:

Influenza hemagglutinin that drives viral entry into cells via the membrane fusion process is an up-and-coming antiviral drug target. Herein, we described for the first time the design, synthesis, and biol. characteristics of a new class of pentacyclic triterpenoid-based proteolysis targeting chimeras (PROTACs) to enhance the degradation of hemagglutinin target. Among these PROTACs, V3 (I) showed the best degradation effect on the hemagglutinin with a median degradation concentration of 1.44 μM in a ubiquitin and proteasome-dependent manner and broad-spectrum anti-influenza A virus activity but not affected the entry of influenza virus. Moreover, i.v. injection of V3 (I) protected mice against influenza A virus-induced toxic effects. Further diazirine-containing photo-crosslinking mass spectrometric anal. of hemagglutinin complexes indicated crosslinking to Asn15, Thr31, and Asn27, a novel target of hemagglutinin. Taken together, our data revealed that oleanolic acid-based PROTACs could degrade hemagglutinin protein, providing a new direction toward the discovery of potential anti-influenza drugs. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C7H9BO3In 2019 ,《UV Light-mediated regioselective methylsulfanyl discrimination via Pd-catalyzed cross-coupling reactions of 2,4-dimethylsulfanylpyrido[2,3-d]pyrimidines》 appeared in Journal of Sulfur Chemistry. The author of the article were Riadi, Yassine. The article conveys some information:

An effective and novel photochem. method for the preparation of 2,4-disubstituted pyrido[2,3-d]pyrimidines is reported from 2,4-dimethylsulfanyl-pyrido[2,3-d]pyrimidines through a Liebeskind-Srogl coupling reaction involving an original selective Me sulfanyl discrimination using UV light as a source of energy. Our strategies involve a two-step and a one-pot approach with reaction times of 11-18 h and yields ranging between 72 and 94%. The two strategies are compared. In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7Computed Properties of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Computed Properties of C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2011 ,《Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins》 was published in Nature Chemical Biology. The article was written by Neklesa, Taavi K.; Tae, Hyun Seop; Schneekloth, Ashley R.; Stulberg, Michael J.; Corson, Timothy W.; Sundberg, Thomas B.; Raina, Kanak; Holley, Scott A.; Crews, Craig M.. The article contains the following contents:

The ability to regulate any protein of interest in living systems with small mols. remains a challenge. The authors hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic the partially denatured state of the protein, thus engaging the cellular quality control machinery to induce its proteasomal degradation The authors designed and synthesized bifunctional small mols. to bind a bacterial dehalogenase (the HaloTag protein) and present a hydrophobic group on its surface. Hydrophobic tagging of the HaloTag protein with an adamantyl moiety induced the degradation of cytosolic, isoprenylated and transmembrane HaloTag fusion proteins in cell culture. The authors demonstrated the in vivo utility of hydrophobic tagging by degrading proteins expressed in zebrafish embryos and by inhibiting Hras1G12V-driven tumor progression in mice. Therefore, hydrophobic tagging of HaloTag fusion proteins affords small-mol. control over any protein of interest, making it an ideal system for validating potential drug targets in disease models. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C7H7BrOIn 2021 ,《Visible Light Mediated Photocatalytic N-Radical Cascade Reactivity of γ,δ-Unsaturated N-Arylsulfonylhydrazones: A General Approach to Structurally Diverse Tetrahydropyridazines》 was published in Journal of Organic Chemistry. The article was written by Azzi, Emanuele; Ghigo, Giovanni; Parisotto, Stefano; Pellegrino, Francesco; Priola, Emanuele; Renzi, Polyssena; Deagostino, Annamaria. The article contains the following contents:

The photocatalytic synthesis of different tetrahydropyridazines I (R = H, Me; R1 = Me, Ph; R2 = Me, Ph, naphthalen-2-yl, pyridin-2-yl, etc.), II (Ar = Ph, 4-methylphenyl, 2,4,6-trimethylphenyl; R3 = H, Me), III and (7R)-2-(mesitylsulfonyl)-3,4,4,7-tetramethyl-2,3,4,4a,5,6,7,8-octahydrocinnoline starting from γ,δ-unsaturated N-arylsulfonylhydrazones ArS(O)2NHN=C(R2)CH2C(CH3)(R1)CH=CHR3 were described. Simple structural changes of substrates result into three different pathways beginning from a common N-hydrazonyl radical, which evolves through a domino carboamination/dearomatization, a HAT process, or a photoinduced radical Smiles rearrangement to afford diverse tetrahydropyridazines I, II, III and (7R)-2-(mesitylsulfonyl)-3,4,4,7-tetramethyl-2,3,4,4a,5,6,7,8-octahydrocinnoline. All reactions are carried out in very mild conditions, and the quite inexpensive [Ru(bpy)3]Cl2 is used as the catalyst. Preliminary mechanism studies about luminescence and electrochem. characterization of the involved species are presented. Computational studies allow to rationalize the mechanism in accord with the exptl. findings. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Synthetic Route of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Synthetic Route of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 673-22-3In 2020 ,《Colorimetric textile sensor for the simultaneous detection of NH3 and HCl gases》 was published in Polymers (Basel, Switzerland). The article was written by Park, Young Ki; Oh, Hyun Ju; Bae, Jong Hyuk; Lim, Jee Young; Lee, Hee Dong; Hong, Seok Il; Son, Hyun Sik; Kim, Jong H.; Lim, Seung Ju; Lee, Woosung. The article contains the following contents:

For the immediate detection of strong gaseous alkalis and acids, colorimetric textile sensors based on halochromic dyes are highly valuable for monitoring gas leakages. To date, colorimetric textile sensors for dual-gas detection have usually been fabricated by electrospinning methods. Although nanofibrous sensors have excellent pH sensitivity, they are difficult to use com. because of their low durability, low productivity, and high production costs. In this study, we introduce novel textile sensors with high pH sensitivity and durability via a facile and low-cost screen-printing method. To fabricate these textiles sensors, Dye 3 and RhYK dyes were both incorporated into a polyester fabric. The fabricated sensors exhibited high detection rates (<10 s) and distinctive color changes under alk. or acidic conditions, even at low gas concentrations Furthermore, the fabricated sensors showed an outstanding durability and reversibility after washing and drying and were confirmed to contain limited amounts of hazardous materials. Thus, our results show that the fabricated textile sensors could be used in safety apparel that changes its color in the presence of harmful gases. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Directed oxidative coupling of thiols in the synthesis of unsymmetrical disulfides》 was written by Burmistrova, D. A.; Smolyaninov, I. V.; Berberova, N. T.. Recommanded Product: 1,2-DiphenyldisulfaneThis research focused onunsym disulfide preparation; thiol oxidative coupling. The article conveys some information:

Oxidative coupling of two different thiols bearing aliphatic, alicyclic, aromatic, and hetero-aromatic moieties promoted by mild oxidizing agents, viz., sterically hindered o-benzo(imino)-quinones, carried out in N-methylpyrrolidone at room temperature led to unsym. disulfides RSSR1 [R = n-Pr, c-hexyl, Ph, etc.; R1 = c-pentyl, Ph, 4-pyridyl, etc.]. Among the studied oxidizers, the most active was 3,6-di-tert-butyl-o-benzoquinone, which, in contrast to 3,5-di-tert-butyl-o-benzoquinone, was not involved in the Michael addition Under the optimal reaction conditions, the yields of the target unsym. disulfides reach 81%. In the experiment, the researchers used 1,2-Diphenyldisulfane(cas: 882-33-7Recommanded Product: 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Recommanded Product: 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Khan, Muhammad S.; Al-Mandhary, Muna R. A.; Al-Suti, Mohammed K.; Corcoran, Timothy C.; Al-Mahrooqi, Yaqoub; Attfield, J. Paul; Feeder, Neil; David, William I. F.; Shankland, Kenneth; Friend, Richard H.; Koehler, Anna; Marseglia, Elisabeth A.; Tedesco, Emilio; Tang, Chiu C.; Raithby, Paul R.; Collings, Jonathan C.; Roscoe, Karl P.; Batsanov, Andrei S.; Stimson, Lorna M.; Marder, Todd B. published an article on January 31 ,2003. The article was titled 《Synthesis and optical characterisation of platinum(II) poly-yne polymers incorporating substituted 1,4-diethynylbenzene derivatives and an investigation of the intermolecular interactions in the diethynylbenzene molecular precursors》, and you may find the article in New Journal of Chemistry.Name: 1,4-Diethynyl-2,5-dimethoxybenzene The information in the text is summarized as follows:

A series of 1,4-diethynylbenzene derivatives, H-CC-R-CC-H with R = C6H3NH2 (I), C6H3F (II), C6H2F2-2,5 (III), C6F4 (IV), C6H2(OMe)2-2,5 (V) and C6H2(OC8H17-n)2-2,5 (VI) were synthesized and their crystal structures were determined by single crystal (I, II, III, IV) or powder (V, VI) x-ray diffraction. The CCH···πCC hydrogen bonds dominating structure H-CC-R-CC-H are gradually replaced by CC-H···F ones with the increase of fluorination (II → IV), or completely replaced by CCH···N and NH···πCC bonds in I, and CCH···O in V and VI. The related platinum-based polymers, trans-[-Pt(PnBu3)2-CC-R-CC-]n (R = as above and C6H4,) were prepared and characterized by spectroscopic methods and thermogravimetry, which show that the amino and methoxy derivatives have lowest thermal stability whereas the fluorinated ones exhibit increasing thermal stability with increasing fluorination. Optical spectroscopic measurements reveal that substituents on the aromatic spacer group do not create strong donor-acceptor interactions along the rigid backbone of the organometallic polymers. In addition to this study using 1,4-Diethynyl-2,5-dimethoxybenzene, there are many other studies that have used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Name: 1,4-Diethynyl-2,5-dimethoxybenzene) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Name: 1,4-Diethynyl-2,5-dimethoxybenzene They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Pediatric dermatology included an article by Treesirichod, Arucha; Chaithirayanon, Suthida; Wongjitrat, Nattakarn. Related Products of 106685-40-9. The article was titled 《Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans.》. The information in the text is summarized as follows:

BACKGROUND: There have been few published randomized controlled trials for the treatment of childhood acanthosis nigricans (AN) to date. OBJECTIVE: To assess the efficacy of topical 0.1% adapalene gel compared to 0.025% tretinoin cream in the treatment of childhood AN. METHODS: An 8-week, randomized, split-neck, comparative study between topical 0.1% adapalene gel and 0.025% tretinoin cream for the treatment of neck hyperpigmentation associated with AN was performed. M index measured by a narrowband reflectance spectrophotometer and both investigator’s global evaluation (IGE) and parent’s global evaluation (PGE) scales were used to evaluate efficacy. RESULTS: There was no statistically significant difference between 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of AN-associated hyperpigmentation (P = 0.56). Mean differences in M indices between week 0 and week 8 of 0.1% adapalene and 0.025% tretinoin treatment were 24.2 ± 7.9% and 23.8 ± 8.3% improvement, respectively. Regarding treatment efficacy, 90.0% and 85.0% of participants had more than 75% improvement in IGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. In addition, 75.0% and 65.0% of participants had more than 75.0% improvement in PGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. LIMITATIONS: Lack of histopathological evaluations. CONCLUSIONS: We found no significant difference between topical 0.1% adapalene gel and 0.025% tretinoin in the treatment of AN.6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Related Products of 106685-40-9) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Related Products of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Farmacia (Bucharest, Romania) included an article by Imre, Silvia; Al Hussein, Stela Mariana; Pascu, Andreea; Oltean, Laura Elena; Dogaru, Maria-Titica; Al Hussein, Hamida; Muntean, Daniela-Lucia; Tero-Vescan, Amelia. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid. The article was titled 《Concomitant HPLC analysis of adapalene and nadifloxacin in the presence of glycolic acid》. The information in the text is summarized as follows:

Reversed phase HPLC-UV is the most common anal. method applied in pharmaceutical anal., but there are cases when its versatility is challenged, such as simultaneous separation of analytes with very different polarity and lipophilicity. A fast HPLC-UV method for the simultaneous determination of nadifloxacin (NDX) and adapalene (ADP) in the presence of glycolic acid (GA) was developed and anal. performances of the method were verified. Different alkane-type reversed phases (RP8 and RP18 columns, with different lengths and particle sizes) and different mobile phases were tested. Finally, a C18 column (33 x 4.6 mm, 3 mm) and a mobile phase consisted of 15 mM orthophosphoric acid solution and acetonitrile were selected. Determinations were performed with a run time of 4 min. The method was linear, accurate and precise over the selected concentration ranges of ADP and NDX. The developed method can be used for rapid quantification ADP and NDX without GA interference for in vitro release studies from topical formulations, through different types of diffusion membranes. In the experiment, the researchers used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem