Month: October 2022

In 2019,Journal of Organic Chemistry included an article by Luo, Zhongfeng; Xiong, Li; Liu, Tingting; Zhang, Yuqi; Lu, Siqi; Chen, Yuwen; Guo, Weijie; Zhu, Yulin; Zeng, Zhuo. HPLC of Formula: 10365-98-7. The article was titled 《Palladium-Catalyzed Decarbonylative Suzuki-Miyaura Coupling of Amides To Achieve Biaryls via C-N Bond Cleavage》. The information in the text is summarized as follows:

The palladium-catalyzed decarbonylative Suzuki-Miyaura coupling of amides via selective amide C-N bond cleavage was reported, which afforded mild access to substitute biaryl products in the presence of low catalyst loading with NaHCO3 as the base in good yields within 4 h (29 examples). The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic & Biomolecular Chemistry included an article by Kumar, Vipin; Banert, Klaus; Ray, Devalina; Saha, Biswajit. Application of 882-33-7. The article was titled 《An atom-economical and regioselective metal-free C-5 chalcogenation of 8-aminoquinolines under mild conditions》. The information in the text is summarized as follows:

A general and simple metal-free protocol for expedient C-H functionalization leading to the regioselective generation of C-5 chalcogenated 8-aminoquinoline analogs I [R = H, Me, 5-(((tert-butoxy)carbonyl)amino)pentan-2-yl; R1 = H, OMe, Me; R2 = Ph, Pr, 4-chlorophenyl, etc.; Z = S, Se] in up to 90% yield at room temperature (25 °C) has been established. This methodol. is an eco-friendly approach to the atom-economical utilization of diaryl/dialkyl chalcogenides R2ZZR2 for direct access to chalcogenated quinolines and is scalable to the gram scale without considerable decrease in the yield of the product. It represents a practical alternative to the existing metal-catalyzed functionalization of 8-aminoquinoline derivatives with broad functional group tolerance. The controlled experiments suggest that the reaction possibly proceeds through an ionic pathway at room temperature Furthermore, the potentiality for the functionalization of free amines in chalcogenated-8-aminoquinolines I provides an attractive perspective for further elaboration of the amine substituent through chem. manipulations. The applicability of the standardized method has been augmented through late-stage antimalarial drug diversification of primaquine analogs. In the experiment, the researchers used 1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Application of 882-33-7 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Applied Organometallic Chemistry included an article by Varzi, Zahra; Maleki, Ali. Synthetic Route of C8H8O2. The article was titled 《Design and preparation of ZnS-ZnFe2O4: a green and efficient hybrid nanocatalyst for the multicomponent synthesis of 2,4,5-triaryl-1H-imidazoles》. The information in the text is summarized as follows:

In the present work, a new protocol was introduced for the preparation of an efficient hybrid nanocatalyst ZnS-ZnFe2O4 via the co-precipitation method as well as its application in the synthesis of 2,4,5-triaryl-1H-imidazoles derivatives, e.g., I, starting from various aromatic aldehydes, benzil and ammonium acetate under ultrasonic irradiation in ethanol. ZnS-ZnFe2O4 was characterized by Fourier transform IR (FT-IR) spectroscopy, energy-dispersive X-ray spectroscopy (EDS) anal., SEM (SEM) image, X-ray diffraction (XRD) pattern and vibrating sample magnetometer (VSM) curve. This method has advantages such as high efficiency of the heterogeneous catalyst, the use of environmentally-friendly solvent, high yields, short reaction times and easy isolation of the products and chromatog.-free purification Our outcomes illustrated that the present nanocatalyst with nearly spherical and Cauliflower-like morphol. and average particle size of 36 nm could be applied as an effective and magnetically recyclable catalyst without any significant decreasing of activity. Furthermore, the synergic effect of bimetallic Lewis acids was studied for the synthesis of imidazole derivatives In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Excited-State Kinetics of an Air-Stable Cyclometalated Iron(II) Complex》 were Steube, Jakob; Burkhardt, Lukas; Paepcke, Ayla; Moll, Johannes; Zimmer, Peter; Schoch, Roland; Woelper, Christoph; Heinze, Katja; Lochbrunner, Stefan; Bauer, Matthias. And the article was published in Chemistry – A European Journal in 2019. Formula: C5H13NO2 The author mentioned the following in the article:

The title complex class with an Earth-abundant metal ion has been repeatedly suggested as a chromophore and potential photosensitizer on the basis of quantum chem. calculations Synthesis and photophys. properties of the parent complex [Fe(pbpy)(tpy)]+ (Hpbpy=6-phenyl-2,2′-bipyridine and tpy=2,2′:6′,2′′-terpyridine) of this new chromophore class are now reported. Ground-state characterization by X-ray diffraction, electrochem., spectroelectrochem., UV/Vis, and X-ray spectroscopy in combination with DFT calculations proves the high impact of the cyclometalating ligand on the electronic structure. The photophys. properties are significantly improved compared to the prototypical [Fe(tpy)2]2+ complex. In particular, the metal-to-ligand absorption extends into the near-IR and the 3MLCT lifetime increases by 5.5, whereas the metal-centered excited triplet state is very short-lived. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Hole-Transporting Materials Incorporating Carbazole into Spiro-Core for Highly Efficient Perovskite Solar Cells》 were Zhu, Xiang-Dong; Ma, Xing-Juan; Wang, Ya-Kun; Li, Yun; Gao, Chun-Hong; Wang, Zhao-Kui; Jiang, Zuo-Quan; Liao, Liang-Sheng. And the article was published in Advanced Functional Materials in 2019. Application In Synthesis of Bis(4-methoxyphenyl)amine The author mentioned the following in the article:

Hole-transporting materials (HTMs) play a significant role in hole transport and extraction for perovskite solar cells (PeSCs). As an important type of HTMs, the spiro-architecture-based material is widely used as small organic HTM in PeSCs with good photovoltaic performances. The skeletal modification of spiro-based HTMs is a critical way of modifying energy level and hole mobility. Thus, many spiro alternatives are developed to optimize the spiro-type HTMs. Herein, a novel carbazole-based single-spiro-HTM named SCZF-5 is designed and prepared for efficient PeSCs. In addition, another single-spiro HTM SAF-5 with reported 10-phenyl-10H-spiro[acridine-9,9′-fluorene] (SAF) core is also synthesized for comparison. Through varying from SAF core to SCZF core as well as comparing with the classic 9,9′-spiro-bifluorene, it is found that the new HTM SCZF-5 exhibits more impressive power conversion efficiency (PCE) of 20.10% than SAF-5 (13.93%) and the com. HTM spiro-OMeTAD (19.11%). On the other hand, the SCZF-5-based device also has better durability in lifetime testing, indicating the newly designed SCZF by integrating carbazole into the spiro concept has good potential for developing effective HTMs. In the experiment, the researchers used Bis(4-methoxyphenyl)amine(cas: 101-70-2Application In Synthesis of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application In Synthesis of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Optimization of nanostructured lipid carriers loaded with retinoids by central composite design》 were Pinto, Fatima; de Barros, Dragana P. C.; Reis, Catarina; Fonseca, Luis P.. And the article was published in Journal of Molecular Liquids in 2019. COA of Formula: C28H28O3 The author mentioned the following in the article:

The aim of this study was to design and optimize a new formulation of lipid nanoparticles for the topical administration of retinoids. The standard procedure involves nanostructured lipid carriers (NLCs) synthesized by the miniemulsion methodol., using sunflower oil as a bioactive ingredient and retinyl palmitate (RP) as model retinoid. A 5-factor, 3-level central composite design was used to predict responses and construct 3D-response contour plots. The independent variables were the concentration of total lipids, solid lipid, surfactant, encapsulated retinoid and number of carbons on the solid lipid fatty acid chain length, in function of the selected responses as the particle size, surface charge of the nanoparticles and the encapsulation efficiency (EE %) at 3 levels. Exptl. trials were performed at all 31 possible combinations. An optimized NLC composition of 2.5% total lipids, 2.0% myristic acid and 0.5% sunflower oil and 1.5% of surfactant Tween 80 was reached. DSC anal. indicated that the melting temperatures of the three optimized NLCs loaded with the retinoids were above 40°C, proving to be suitable for use in topical administration. The in vitro drug release studies were conducted for 48 h, using a dialysis regenerated cellulose membrane. The results demonstrated a very well-controlled release of RP and TRT, which improves the stability of these active compounds and confirms a high encapsulation efficiency. The results came from multiple reactions, including the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9COA of Formula: C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.COA of Formula: C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans》 was published in Journal of Organic Chemistry in 2020. These research results belong to Ghosh, Arun K.; Belcher, Miranda R.. COA of Formula: C9H10O2 The article mentions the following:

Lewis acid-catalyzed rearrangements of 4,5-dihydro-1,3-dioxepines have been investigated. Rearrangement of vinyl acetals under a variety of conditions resulted in cis- and trans-2,3-disubstituted THF derivatives in a highly stereoselective manner. Rearrangements at lower temperatures typically provided the cis-2,3-disubstituted THF carbaldehydes. At higher temperatures, the corresponding trans-2,3-disubstituted THF carbaldehydes are formed. The requisite substrates for the vinyl acetal rearrangement were synthesized via ring-closing olefin metathesis of bis(allyoxy)methyl derivatives using Grubbs second-generation catalyst followed by olefin isomerization using a catalytic amount of RuCl2(PPh3)3. We examined the substrate scope using substituted aromatic and aliphatic derivatives Addnl., the rearrangement was utilized in the synthesis of a stereochem.-defined bis-tetrahydrofuran (bis-THF) derivative, which is one of the key structural elements of darunavir, an FDA-approved drug for the treatment of HIV/AIDS. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Molecularly imprinted polymer and computational study of (E)-4-(2-cyano-3-(dimethylamino)acryloyl)benzoic acid from poly(ethylene terephthalate) plastic waste》 was published in Current Analytical Chemistry in 2020. These research results belong to Fahim, Asmaa M.; Wasiniak, Bartlomiej; Lukaszewicz, Jerzy P.. Safety of N,N-Dimethylformamide Dimethyl Acetal The article mentions the following:

Molecularly imprinted polymers (MIPs) are utilized in the separation of a pure compound from complex matrixes. A stable template-monomer complex generates MIPs with the highest affinity and selectivity for the template. In this investigation, degradation of poly(ethylene terephthalate) PET afforded the (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (TAM) which used TAM as template which interacts with methacrylic Acid (MAA) monomer, in the presence of CH3CN as progen. The TAM-MMA complex interactions are dependent on stable hydrogen bonding interaction between the carboxylic acid group of TAM and the hydroxyl group of MMA with minimal interference of porogen CH3CN. The DFT/B3LYP/6-31+G model chem. was used to optimize their structures and frequency calculations The binding energies between TAM with different monomers showed the most stable molar ratio of 1:4 which was confirmed through exptl. anal. The present work describes the synthesis of (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (TAM) from PET waste and formation of molecularly imprinted polymer from TAM with the methacrylic acid monomer. The optimization of mol. imprinted was stimulated via DFT/B3LYP/6-31G (d). The imprinted polymer film was characterized via thermal anal., pore size, FT-IR and SEM. The most stable molecularly imprinted polymers (MIPs) showed binding energy of TAM(MMA4) = -2063.456 KJ/mol with a small value of mesopores (10-100 Å). Also, the sorption capability of TAM-MIPs showed 6.57 mg/g using STP-MIP-9VC. Moreover, the average pore size ranged between 0.2-1 nm with the BET surface about 300 m2/g. The proposed TAM exhibited a high degree of selectivity for MMA in comparison with other different monomers through hydrogen bond interaction, which was thermally stable, good reproducibility and excellent regeneration capacity and elucidated in the computational study and anal. anal. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Safety of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Safety of N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Native amine-directed site-selective C(sp3)-H arylation of primary aliphatic amines with aryl iodides》 was published in Chinese Chemical Letters in 2020. These research results belong to Pramanick, Pranab K.; Zhou, Zhibing; Hou, Zhenlin; Ao, Yufei; Yao, Bo. Product Details of 529-28-2 The article mentions the following:

A simple and efficient method for site-selective C(sp3)-H arylation of primary aliphatic amines by aryl iodides were established. In the presence of only 5 mol% Pd(OAc)2, a wide range of aliphatic amines including O-benzyl and O-silyl amino alcs. were arylated at γ- or δ-positions by aryl iodides containing a broad scope of functional groups. The synthetic application of this method had also been demonstrated by large-scale synthesis, the synthesis of a fingolimod analog and the conjugation with natural D-menthol and fluorescent 1,8-naphthalimide. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Product Details of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Product Details of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)-H functionalization》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Wan, Zi-juan; Yuan, Xiao-feng; Luo, Jun. COA of Formula: C7H7IO The article mentions the following:

An intriguing and mild method for visible light induced regioselective addition of arylpropiolic acids by attacking exclusively at the 3-position with cyclic/acyclic ethers was developed. A variety of 3,3-bis-substituted acrylic acids were successfully obtained in moderate to excellent yields. A plausible reaction mechanism involving an energy transfer induced radical addition in the presence of visible light and photocatalyst was proposed. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2COA of Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.COA of Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem