Month: October 2022

《Synthesis of some chalcone derivatives, in vitro and in silico toxicity evaluation》 was published in Rasayan Journal of Chemistry in 2020. These research results belong to Kristanti, A. N.; Suwito, H.; Aminah, N. S.; Haq, K. U.; Hardiyanti, H. D.; Anggraeni, H.; Faiza, N.; Anto, R. S.; Muharromah, S.. Electric Literature of C8H8O2 The article mentions the following:

The objevtives of this study was to synthesize some chalcone derivatives I [R = 4-F, 4-N(Me)2, 2-OMe, etc.] using conventional Claisen-Schmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing mol. docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2′-hydroxychalcone and 4-chloro-2′-hydroxychalcone gave very low IC50, but both did not showed potential apoptosis activity, while in docking anal. 4-chloro-2′-hydroxychalcone showed the best results. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Permeation selectivity of alkali metal ions through crown ether based ion channels》 was published in Journal of Molecular Liquids in 2020. These research results belong to Ahmed, Arsalan; Hashmi, Muhammad Ali; Ayub, Khurshid. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane The article mentions the following:

Synthetic ion channels mimic the natural ion channels for various biol. activities such as drug delivery, signal transduction, as biosensors and as antibacterial agents. Among the synthetic ion channels, crown ether-based ion channels show greater selectivity for K+ and Na+, compared to other metal ions. These synthetic ion channels can therefore be utilized for the selective transport of K+ and Na+ which is important for various biol. processes. In this work, theor. insight for the permeability and selectivity of crown ether-based ion channels is provided. Permeability is studied by passing the alkali metal ion directly through the crown ether macrocyclic cavity, as well as through the empty spaces present in the packings. For this purpose, 18-crown-6, 15-crown-5 ether and their substituted derivatives have been studied. The results show that 18-crown-6-ethers are more selective for K+, while 15-crown-5 ethers are selective for Li+. Moreover, the results show that the ion transport can also occur through the empty spaces present in crown ether packings. The factors responsible for the greater selectivity of ions through a certain system are the sizes of the ion and cavity. Furthermore, substituents on the crown ether cycle help the system to form columnar packing which is found to decrease the permeation barrier for passing ions.1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Safety of 1,4,7,10,13-Pentaoxacyclopentadecane) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A paradigm shift for a new class of proton exchange membranes with ferrocyanide proton-conducting groups providing enhanced oxidative stability》 was written by Zhang, Xiangwen; Li, Yi; Liu, Xin; Zhang, Junfeng; Yin, Yan; Guiver, Michael D.. Synthetic Route of C10H20O5 And the article was included in Journal of Membrane Science in 2020. The article conveys some information:

A new class of proton exchange membranes (PEMs) containing ferrocyanide groups as both proton-conducting/radical scavenger components are fabricated. Here, the ferrocyanide groups are bonded to a com. fluoroelastomer polymer main chain, resulting in ferrocyanide-coordinated PEMs (CFC) for proton exchange membrane fuel cells (PEMFCs). The CFC PEMs show a larger hydrophilic morphol. phase than Nafion 212 membrane, even in the CFC having lower ion exchange capacity, owing to stronger electrostatic forces among ferrocyanide groups than traditional sulfonic groups. Compared with Nafion 212, CFC membranes present inferior proton conductivity in water. However, they show much lower activation energy for proton transport in water, and considerably higher proton conductivity than Nafion 212 under low relative humidity (RH). This is related to the larger hydrophilic domains that may construct better-connected channels for proton transport, especially at low membrane hydration levels. As a result, CFC membranes exhibit better power output than Nafion 212 in PEMFC evaluations under low RH conditions. The chem. accelerated stress test (AST) demonstrates that the radical scavenging ability of ferrocyanide group is effective for greatly reducing electrochem. oxidation The experimental process involved the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Synthetic Route of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Synthetic Route of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Dopant-Free Hole-Transport Materials Based on 2,4,6-Triarylpyridine for Inverted Planar Perovskite Solar Cells》 was written by Duan, Liangsheng; Chen, Yu; Jia, Jingwen; Zong, Xueping; Sun, Zhe; Wu, Quanping; Xue, Song. Related Products of 101-70-2 And the article was included in ACS Applied Energy Materials in 2020. The article conveys some information:

New building blocks of cores and periphery groups for organic hole-transporting materials (HTMs) have been paid much attention for recent development in perovskite solar cells (PSCs). In this work, we applied facile synthesis to join a 2,4,6-triarylpyridine building block for new HTMs based on a pyridine core by cheap industrial initial materials. The three small mols., namely, D104, D105, and D106, were used in the pristine state. To the best of our knowledge, pyridine-cored dopant-free HTMs have not been reported in PSCs. The changing periphery 4-methoxyphenyl and bis(4-methoxyphenyl)amine groups formed different Y-shapes. Under 1 sun conditions, the devices achieved an increased power conversion efficiency (PCE) of 16.28%, 17.40%, and 18.24% for D104, D105, and D106. They displayed great potential with improved stability in inverted planar PSCs. The unencapsulated device in ambient environment (30% RH) based on D104, D105, and D106 retained 33%, 70%, and 75% of the initial PCE after 275 h. The results came from multiple reactions, including the reaction of Bis(4-methoxyphenyl)amine(cas: 101-70-2Related Products of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Related Products of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis and cytotoxicity of (-)-homo-renieramycin G and its derivatives》 was written by Ma, Yantao; Pan, Xuan; Guan, Baohe; Zhang, Guangyan; Liu, Zhanzhu. Electric Literature of C9H10O2 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

(-)-Homo-renieramycin G (I) and its twenty derivatives were prepared from L-tyrosine Me ester via a multi-step route. Their cytotoxicities were tested against four human cancer cell lines (A549, HeLa, KB and BGC-823). (-)-Renieramycin G and (-)-homo-renieramycin G showed comparable cytotoxicity against these four cancer cell lines, which indicated that the expansion of ring C from the six-membered 1,4-piperazinone to the seven-membered 1,4-diazepanone had no obvious impact on the cytotoxicity. The compound with Me side chain and compounds with heterocyclic aromatic side chains at C-23 exhibited the most potent cytotoxicity with the IC50 values at the level of 10-6 M. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Tetraphenylbutadiene-Based Symmetric 3D Hole-Transporting Materials for Perovskite Solar Cells: A Trial Trade-off between Charge Mobility and Film Morphology》 was written by Chen, Jian; Xia, Jianxing; Gao, Wei-Jie; Yu, Hui-Juan; Zhong, Jun-Xing; Jia, Chunyang; Qin, Yuan-Shou; She, Zhigang; Kuang, Dai-Bin; Shao, Guang. Recommanded Product: Bis(4-methoxyphenyl)amine And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

Two three-dimensional sym. tetraphenylbutadiene derivatives decorated with diphenylamine or triphenylamine fragments are first prepared for use as hole-transporting materials (HTMs) in perovskite solar cells (PSCs). The HTMs are acquired using straightforward synthetic methods and facile purification techniques. The thermal stability, photophys. properties, electrochem. behaviors, computational study, hole mobility, X-ray diffraction, hole transfer dynamics, hydrophobicity, surface morphol., and photovoltaic performances of the HTMs are discussed. The highest power conversion efficiency (PCE) of CJ-04-based cell is 13.75%, which is increased to 20.06% when CJ-03 is used as HTM, superior to the PCE of the cell based on 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenylamine)-9,9′-spirobifluorene (spiro-OMeTAD) (18.90%). The preparation cost of CJ-03 accounts for merely 23.1% of the price of com. spiro-OMeTAD, while the concentration of CJ-03 solution used in the device fabrication (60.0 mg mL-1) is lower compared with that of the spiro-OMeTAD solution (72.3 mg mL-1). These results corroborate that the screw-like HTMs with a highly distorted configuration are facilely available and promising candidates for PSCs. More importantly, a practical solution is proposed to achieve moderate charge mobility and good film-formation ability of the HTMs simultaneously. In the experiment, the researchers used many compounds, for example, Bis(4-methoxyphenyl)amine(cas: 101-70-2Recommanded Product: Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Recommanded Product: Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Jiaqi; Luo, Yingying; Zhang, Yixuan; Chen, Yue; Gao, Fei; Ma, Yue; Xian, Dongmei; You, Zhonglu published their research in Journal of Coordination Chemistry in 2021. The article was titled 《Synthesis, crystal structure, and urease inhibition of an end-on azido-bridged dinuclear copper(II) complex with an oxidized tridentate Schiff base ligand》.Category: ethers-buliding-blocks The article contains the following contents:

An end-on azido-bridged dinuclear Cu(II) complex, [Cu2L2(μ1,1-N3)2], where L is the deprotonated form of N-(2-hydroxy-4-methoxybenzylidene)picolinamide (HL), was prepared by the reaction of 5-methoxy-2-[(pyridin-2-ylmethylimino)methyl]phenol (HL’) with Cu bromide and Na azide in MeOH. The structure of the complex was characterized by elemental anal., IR and UV-visible spectra, and single crystal x-ray diffraction. The complex possesses crystallog. inversion symmetry, with the two Cu ions (3.36 Å) bridged by two end-on azido bridges. Each Cu ion is in a square pyramidal coordination. The original ligand HL’ was unexpectedly oxidized to HL under mild conditions during preparation of the complex. The complex has excellent urease inhibitory activity. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pal, Ashutosh published an article in 2021. The article was titled 《Synthesis of salicylate and salicylamide alcohols for the preparation of phosphorodiamidates and ifosfamide prodrugs》, and you may find the article in Oriental Journal of Chemistry.Application In Synthesis of 2-(Benzyloxy)acetaldehyde The information in the text is summarized as follows:

Different types of salicylate and salicylamide alcs. for the preparation of phosphorodiamidates and ifosfamide prodrugs were reported. In drug discovery and development, prodrugs were well-known for pharmacokinetic effects of pharmacol. nimble products. Almost 10% of drugs permitted, whole world were classified as prodrugs, where the application of a prodrug method during initial stages of development was an emergent fashion. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sayer, James R.; Wallden, Karin; Koss, Hans; Allan, Helen; Daviter, Tina; Gane, Paul J.; Waksman, Gabriel; Tabor, Alethea B. published an article in 2021. The article was titled 《Design, synthesis, and evaluation of peptide-imidazo[1,2-a]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525》, and you may find the article in Journal of Peptide Science.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

Helicobacter pylori (H. pylori) infections were implicated in the development of gastric ulcers and various cancers: however, the success of current therapies is compromised by rising antibiotic resistance. The virulence and pathogenicity of H. pylori is mediated by the type IV secretion system (T4SS), a multiprotein macromol. nanomachine that transfers toxic bacterial factors and plasmid DNA between bacterial cells, thus contributing to the spread of antibiotic resistance. A key component of the T4SS is the VirB11 ATPase HP0525, which is a hexameric protein assembly. The authors have previously reported the design and synthesis of a series of novel 8-amino imidazo[1,2-a]pyrazine derivatives as inhibitors of HP0525. In order to improve their selectivity, and potentially develop these compounds as tools for probing the assembly of the HP0525 hexamer, the authors have explored the design and synthesis of potential bivalent inhibitors. The authors used the structural details of the subunit-subunit interactions within the HP0525 hexamer to design peptide recognition moieties of the subunit interface. Different methods (cross metathesis, click chem., and cysteine-malemide) for bioconjugation to selected 8-amino imidazo[1,2-a]pyrazines were explored, as well as peptides spanning larger or smaller regions of the interface. The IC50 values of the resulting linker-8-amino imidazo[1,2-a]pyrazine derivatives, and the bivalent inhibitors, were related to docking studies with the HP0525 crystal structure and to mol. dynamics simulations of the peptide recognition moieties. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.COA of Formula: C9H19NO4Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Qi-Liang; Liu, Ying; Liang, Lei; Li, Zhi-Hao; Qu, Gui-Rong; Guo, Hai-Ming published an article in 2022. The article was titled 《Facilitating Rh-Catalyzed C-H Alkylation of (Hetero)arenes and 6-Arylpurine Nucleosides (Nucleotides) with Electrochemistry》, and you may find the article in Journal of Organic Chemistry.Recommanded Product: 10365-98-7 The information in the text is summarized as follows:

An electrochem. approach to promote the ortho C-H alkylation of (hetero)arenes via rhodium catalysis under mild conditions was described. This approach features mild conditions with high levels of regio- and monoselectivity that tolerated a variety of aromatic and heteroaromatic groups and offered a widely applicable method for late-stage diversification of complex mol. architectures including tryptophan, estrone, diazepam, nucleosides and nucleotides. Alkyl boronic acids, esters and alkyl trifluoroborates were demonstrated as suitable coupling partners. The isolation of key rhodium intermediates and mechanistic studies provided strong support for a rhodium(III/IV or V) regime. The results came from multiple reactions, including the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem