Month: October 2022

In 2022,Li, Rongrong; Yang, Xinzheng; Ping, Hongming published an article in Catalysis Science & Technology. The title of the article was 《A radical mechanism for C-H bond cross-coupling and N2 activation catalysed by β-diketiminate iron complexes》.Related Products of 33100-27-5 The author mentioned the following in the article:

Our d. functional theory calculations reveal a radical mechanism for N2 fixation and conversion to N(SiMe3)3 and PhN(SiMe3)2 catalyzed by a diketiminate-supported iron system. We found that the Na(15-crown-5) radical plays an essential role as a co-catalyst in the reaction for the formation of the Me3Si radical and a stable intermediate. The attack of two Me3Si· radicals to distal nitrogen and the Ph migration to proximal nitrogen gradually weaken and activate the NN bond. The turnover-limiting step in the whole catalytic reaction is the activation of the C-H bond with a free energy barrier of 20.3 kcal mol-1. MO anal. of dinitrogen complexes indicates that the π back-bonding interactions between iron and N2 orbitals have major contributions to N2 fixation. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Related Products of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Related Products of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Iali, Wissam; Suleiman, Rami K.; El Ali, Bassam published an article in Applied Organometallic Chemistry. The title of the article was 《Highly efficient NHC-iridium(I) catalyzed disulfide bond forming reaction》.Recommanded Product: 1,2-Diphenyldisulfane The author mentioned the following in the article:

The N-heterocyclic carbene (NHC) iridium(I) complex [IrCl (COD)(IMes)] [IMes = 1,3-bis(2,4,6-trimethylphenyl) imidazole-2-ylidene] showed an excellent catalytic activity in the reactions of the aerobic oxidative coupling of thiols into disulfides RSSR1 [R = R1 = nPr, Ph, (CH2)2OH, etc.]. The use of oxygen of air as a green oxidant allowed the thiols to be quant. converted into the corresponding disulfides under mild conditions and in a short reaction time. The replacement of chloride ligand on the iridium by the strong-donating thiolate ligand yielded an electron-rich and sensitive-to-oxygen active species [Ir(S-R)(COD)(IMes)] at room light and subsequently promoted the catalytic oxidative coupling reactions. This active species was successfully isolated and characterized by X-ray diffraction and found also to be essential in revealed a plausible mechanism for this Ir-catalyzed transformation. The D. Functional Theory (DFT)-calculated free energy profile of the proposed mechanism of catalyst system could reasonably account for the key role of air in pursuing the catalytic reaction. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Recommanded Product: 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Recommanded Product: 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Kondoh, Azusa; Hirozane, Takayuki; Terada, Masahiro published an article in Chemistry – A European Journal. The title of the article was 《Formal umpolung addition of phosphites to 2-azaaryl Ketones under chiral Broensted base catalysis: enantioselective protonation utilizing [1,2]-phospha-Brook rearrangement》.Product Details of 2398-37-0 The author mentioned the following in the article:

The formal enantioselective umpolung addition of dialkyl phosphites to 2-azaaryl ketones was developed under Broensted base catalysis. The reaction involved the enantioselective protonation of the transient α-oxygenated (2-azaaryl)methyl anion generated through the 1,2-addition of the anion of dialkyl phosphite to the 2-azaaryl ketone and the subsequent [1,2]-phospha-Brook rearrangement. A chiral bis(guanidino)iminophosphorane organosuperbase efficiently catalyzed the reaction to provide enantio-enriched phosphates in high yields with good to high enantioselectivities. This is a rare example of the catalytic enantioselective protonation of transient carbanions other than enolates, constructing a trisubstituted stereogenic center α to 2-azaarenes. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

COA of Formula: C9H19NO4In 2018 ,《Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome》 appeared in ACS Infectious Diseases. The author of the article were Webster, Lauren A.; Thomas, Michael; Urbaniak, Michael; Wyllie, Susan; Ong, Han; Tinti, Michele; Fairlamb, Alan H.; Boesche, Markus; Ghidelli-Disse, Sonja; Drewes, Gerard; Gilbert, Ian H.. The article conveys some information:

The folate pathway has been extensively studied in a number of organisms, with its essentiality exploited by a number of drugs. However, there has been little success in developing drugs that target folate metabolism in the kinetoplastids. Despite compounds being identified which show significant inhibition of the parasite enzymes, this activity does not translate well into cellular and animal models of disease. Understanding to which enzymes antifolates bind under physiol. conditions and how this corresponds to the phenotypic response could provide insight on how to target the folate pathway in these organisms. To facilitate this, the authors have adopted a chem. proteomics approach to study binding of compounds to enzymes of folate metabolism Clin. and literature antifolate compounds were immobilized onto resins to allow for “”pull-down”” of the proteins in the “”folateome””. Using competition studies, proteins which bind the beads specifically and nonspecifically were identified in parasite lysate (Trypanosoma brucei and Leishmania major) for each antifolate compound followed by tryptic digest, Tandem Mass Tag (TMT) labeling of peptides and LC-MS/MS. This method was further exploited by creating a combined folate resin (Folate beads). The resin could pull down upto 9 proteins from the “”folateome””. This information could be exploited to better understand folate metabolism in kinetoplastids and other organisms. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 2-MethoxybenzaldehydeIn 2019 ,《Pyranopyrazoles as efficient antimicrobial agents: Green, one pot and multicomponent approach》 appeared in Bioorganic Chemistry. The author of the article were Reddy, Guda Mallikarjuna; Garcia, Jarem Raul; Zyryanov, Grigory V.; Sravya, Gundala; Reddy, Nemallapudi Bakthavatchala. The article conveys some information:

Innovative therapeutic heterocycles having precisely thiadiazolyl-pyranopyrazole fragments were prepared by using the ecofriendly synthetic route. Entire compounds formed in quant. yields. All the composites tested for their antimicrobial effectiveness against four microbial, two beneficial fungi’s and accurately measured the min. inhibitory concentrations (MIC and MBC/MFC), along with some initial structure activity relationships (SARs) also discussed. From the biol. outcomes, the motif 6f provided an outstanding activity against all six pathogens. The possible presence of a nitro substituent on this composite may undoubtedly enhance the activity. In addition, amalgams 6d, 6g and 6l displayed promising antimicrobial results. This may be justified to the presence of electron capture group attached to the benzene ring, while the combinations 6j and 6k were zero effect towards all bacterial strains. The other compounds were excellent to low antimicrobial efficiency. The intriguing point was observed that all the active compounds had in common immense antibacterial effectiveness on Gram-neg. bacteria than Gram-pos. one and more antifungal activity on A. niger compare to other fungus. All things considered and suggested that this outstanding green synthetic approach is used to develop biol. active compounds On top of that, biol. results confirmed that these biol. energetic motifs suitable for addnl. preclin. examine with the aim of standing novel innovative drugs.2-Methoxybenzaldehyde(cas: 135-02-4Reference of 2-Methoxybenzaldehyde) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Reference of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2020 ,《Ultrasound assisted synthesis of pyrazolo[1,5-a]pyrimidine-antipyrine hybrids and their anti-inflammatory and anti-cancer activities》 appeared in European Journal of Chemistry. The author of the article were Kaping, Shunan; Sunn, Melboureen; Singha, Laishram Indira; Vishwakarma, Jai Narain. The article conveys some information:

A series of antipyrinyl-pyrazolo[1,5-a]pyrimidines have been synthesized by reactions of aminopyrazole (4) with various formylated active proton compounds in the presence of KHSO4 (aqueous media), under ultrasound irradiation The structures of the compounds have been established with the help of spectral and anal. data. N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide (6a) was further subjected to X-ray crystallog. studies to avoid any ambiguity of the derived structures. Crystal data for compound 6a, C51H46N12O5 (M =907.00 g/mol): triclinic, space group P-1 (number 2), a = 9.9554(3) Å, b = 14.0875(4) Å, c = 17.4572(4) Å, a = 79.676(2)°, β= 85.283(2)°, γ= 72.647(2)°, V = 2297.97(11) Å3, Z = 2, T = 296.15 K, μ(MoKa) = 0.088 mm-1, Dcalc = 1.311 g/cm3, 29732 reflections measured (4.174° = 2T = 57.068°), 10681 unique (Rint = 0.0400, Rsigma = 0.0533) which were used in all calculations The final R1 was 0.0566 (I > 2s(I)) and wR2 was 0.1663 (all data). The novel compounds were also screened for their biol. activities. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 106685-40-9In 2019 ,《The role of topical retinoids in prevention and treatment of atropliic acne scarring: understanding the importance of early effective treatment》 appeared in Journal of Drugs in Dermatology. The author of the article were Tan, Jerry; Tanghetti, Emil; Baldwin, Hilary; Gold, Linda Stein; Lain, Edward. The article conveys some information:

A review. Atrophic acne scarring is a frequent occurrence among acne patients. These facial marks are often very emotionally distressing for the patient and can result in adverse impact to quality of life. While most clinicians consider scarring as a sequela of moderate to severe acne, recent studies have found that scars are also associated with mild acne. Risk factors include time to effective treatment, severity of acne, family history, and excoriations. New data shows that early and effective acne treatment can reduce the development of new scars, confirming the widespread perception of this approach in prevention. It is also becoming clear that the inflammatery process drives both the development of acne lesions and atrophic scars. This implies that inhibiting activation of inflammatory pathways early is key to preventing scars. Data also suggests a useful role for adapalene for the treatment of well-established acne scars with scar remodeling accompanied by the production of new collagen and elastic tissue. Acne guidelines and recommendations continue to highlight the central role of retinoids, with fixed-dose combination retinoids being particularly important due to targeting of multiple inflammatory pathophysiol. factors and for patient convenience. Higher concentrations of retinoids such as adapalene 0.3%/benzoyl peroxide 2.5% (A0.3/BPO2.5) have shown increased efficacy, particularly among patients with moderately severe and severe acne – a population at high risk for scarring. Further, controlled study of A0.3/BP02.5 in patients with moderate acne (mean, 40 acne lesions per half face) and mild-moderate scarring demonstrated A0.3/BPO2.5 was significantly superior to vehicle in reducing scar counts from baseline over 24 wk. While scar counts lessened on the A0.3/BPO2.5 side, counts increased on the vehicle side during the study. This occurred in the setting of active acne, where the efficacy of A/BPO is well known, emphasizing the dual actions of A0.3/BPO2.5 in both treatment and prevention. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9SDS of cas: 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.SDS of cas: 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acidIn 2021 ,《Meningeal Multipotent Cells: A Hidden Target for CNS Repair》 appeared in NeuroMolecular Medicine. The author of the article were Hayakawa, Kazuhide; Snyder, Evan Y.; Lo, Eng H.. The article conveys some information:

A review. Abstract: Traditionally, the primary role of the meninges is thought to be structural, i.e., to act as a surrounding membrane that contains and cushions the brain with cerebrospinal fluid. During development, the meninges is formed by both mesenchymal and neural crest cells. There is now emerging evidence that subsets of undifferentiated stem cells might persist in the adult meninges. In this mini-review, we survey representative studies of brain-meningeal interactions and discuss the hypothesis that the meninges are not just protective membranes, but instead contain multiplex stem cell subsets that may contribute to central nervous system (CNS) homeostasis. Further investigations into meningeal multipotent cells may reveal a “”hidden”” target for promoting neurovascular remodeling and repair after CNS injury and disease. After reading the article, we found that the author used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 1,4,7,10,13-PentaoxacyclopentadecaneIn 2020 ,《Specific Host-Guest Interactions in the Crown Ether Complexes with K+ and NH4+ Revealed from the Vibrational Relaxation Dynamics of the Counteranion》 was published in Journal of Physical Chemistry B. The article was written by Zhou, Dexia; Hao, Hongxing; Ma, Yinhua; Zhong, Hongmei; Dai, Ya’nan; Cai, Kaicong; Mukherjee, Somnath; Liu, Jing; Bian, Hongtao. The article contains the following contents:

The specific host-guest interactions in the corresponding complexes of K+ and NH4+ with typical crown ethers were investigated by using FTIR and ultrafast IR spectroscopies. The counteranions, i.e., SCN-, were employed as a local vibrational probe to report the structural dynamics of the complexation. It was found that the vibrational relaxation dynamics of the SCN- was strongly affected by the cations confined in the cavities of the crown ethers. The time constant of the vibrational population decay of SCN- in the complex of NH4+ with the 18-crown-6 was determined to be 6 ± 2 ps, which is ~30 times faster than that in the complex of K+ with the crown ethers. Control experiments showed that the vibrational population decay of SCN- depended on the size of the cavities of the crown ethers. A theor. calculation further indicated that the nitrogen atom of SCN- showed preferential coordination to the K+ ions hosted by the crown ethers, while the NH4+ can form hydrogen bonds with the oxygen atoms in the studied crown ethers. The geometric constraints formed in the complex of crown ethers can cause a specific interaction between the NH4+ and SCN-, which can facilitate the intermol. vibrational energy redistribution of the SCN-. The experimental process involved the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acidIn 2019 ,《Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study》 was published in Cutaneous and Ocular Toxicology. The article was written by Zheng, Yue; Yin, Songchao; Xia, Yue; Chen, Jian; Ye, Congxiu; Zeng, Quanrong; Lai, Wei. The article contains the following contents:

Topical drugs for mild to moderate acne include adapalene (ADA) and benzoyl peroxide(BPO). Supramol. salicylic acid (SSA), a modified SA preparation, is considered as a new effective therapeutic scheme. To compare the safety and efficacy of 2% supramol. SA (2% SSA) with 0.01% adapalene plus 5% benzoyl peroxide (5%BPO +0.1%ADA) for treatment of facial acne. This was an open-label, split face, randomized and single-center clin. trial. Subjects with mild to moderate acne were enrolled. Two percent SSA cream were randomly applied on one side of the face while 5%BPO +0.1%ADA gel was applied on the opposite side for 28 days. The numbers of acne lesions, along with side effects of the targeted area were evaluated by the investigators at day 0, day 14, and day 28. Skin water content, TEWL and skin lightening indexes were measured at the same time. A total of 31 of acne patients completed the trial. Dates showed that 2% SSA had similar effects to 5%BPO +0.1%ADA in reducing papules/pustules (47.9% vs. 49.8%), non-inflammatory lesions (43.1% vs. 42.7%) and total lesions (44.1% vs. 45.6%; all p > 0.05) at day 28. The skin barrier (skin hydration value and TEWL value), skin brightness (L* value) and erythema (a* values) indicators showed no statistical differences in the left and right sides of the face (p > 0.05). This study demonstrated that 2% SSA has a similar efficacy with 5%BPO +0.1%ADA in mild to moderate acne treatment. This might be a useful pilot study that could be used to support further larger clin. trials. The experimental process involved the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem