Month: October 2022

Xie, Zuoti; Diez Cabanes, Valentin; Van Nguyen, Quyen; Rodriguez-Gonzalez, Sandra; Norel, Lucie; Galangau, Olivier; Rigaut, Stephane; Cornil, Jerome; Frisbie, C. Daniel published their research in ACS Applied Materials & Interfaces on December 1 ,2021. The article was titled 《Quantifying Image Charge Effects in Molecular Tunnel Junctions Based on Self-Assembled Monolayers of Substituted Oligophenylene Ethynylene Dithiols》.HPLC of Formula: 74029-40-6 The article contains the following contents:

A number of factors contribute to orbital energy alignment with respect to the Fermi level in mol. tunnel junctions. Here, we report a combined exptl. and theor. effort to quantify the effect of metal image potentials on the HOMO to Fermi level offset, εh, for mol. junctions based on self-assembled monolayers (SAMs) of oligophenylene ethynylene dithiols (OPX) on Au. Our exptl. approach involves the use of both transport and photoelectron spectroscopy to extract the offsets, εhtrans and εhUPS, resp. We take the difference in these quantities to be the image potential energy eVimage. In the theor. approach, we use d. functional theory (DFT) to calculate directly eVimage between pos. charge on an OPX mol. and the neg. image charge in the Au. Both approaches yield eVimage ~-0.1 eV per metal contact, meaning that the total image potential energy is ~-0.2 eV for an assembled junction with two Au contacts. Thus, we find that the total image potential energy is 25-30% of the total offset εh, which means that image charge effects are significant in OPX junctions. Our methods should be generally applicable to understanding image charge effects as a function of mol. size, for example, in a variety of SAM-based junctions. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6HPLC of Formula: 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. HPLC of Formula: 74029-40-6 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2014,Noguchi, Takao; Roy, Bappaditya; Yoshihara, Daisuke; Tsuchiya, Youichi; Yamamoto, Tatsuhiro; Shinkai, Seiji published 《Translation of Dicarboxylate Structural Information to Fluorometric Optical Signals through Self-Assembly of Guanidinium-Tethered Oligophenylenevinylene》.Chemistry – A European Journal published the findings.Computed Properties of C9H19NO4 The information in the text is summarized as follows:

Although self-assembly has realized the spontaneous formation of nanoarchitectures, the nanoscopic expression of chem. structural information at the mol. level can alternatively be regarded as a tool to translate mol. structural information with high precision. A newly developed guanidinium-tethered oligophenylenevinylene exhibits characteristic fluorescence (FL) responses toward L- and meso-tartarate, wherein the different self-assembly modes, termed J- or H-type aggregation, are directed according to the mol. information encoded as the chem. structure. This morphol. difference originates from the geometric anti vs. gauche conformational difference between L- and meso-tartarate. A similar morphol. difference can be reproduced with the geometric C=C bond difference between fumarate and maleate. In the present system, the dicarboxylate structural information is embodied in the inherent threshold concentration of the FL response, the signal-to-noise ratio, and the maximum FL wavelength. Self-assembly is meticulous enough to sense subtle differences in mol. information and thus demonstrate the potential ability of self-assembly for the expression of a FL sensory system. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Computed Properties of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Harris, Blair; Bitner, Benjamin; Thomas, Logan published 《Differin® and depilation, a word of warning.》.Journal of cosmetic dermatology published the findings.SDS of cas: 106685-40-9 The information in the text is summarized as follows:

BACKGROUND: Retinoid products are becoming increasingly popular due to their efficacy and mild side effect profile. A few cases of epidermal stripping with wax depilation have been reported, but all have been associated with oral retinoid use. AIMS: We aim to increase awareness of this adverse effect. METHODS: N/A Results: N/A Conclusion: While retinoid products are effective and have a low side effect profile, they may still cause adverse effects including the possibility of epidermal stripping with wax depilation. In the experimental materials used by the author, we found 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9SDS of cas: 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.SDS of cas: 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Meng, Qingqing; Wang, Zengtao; Cui, Jiahua; Cui, Qing; Dong, Jinyun; Zhang, Qijing; Li, Shaoshun published 《Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection》.Journal of Medicinal Chemistry published the findings.HPLC of Formula: 139115-91-6 The information in the text is summarized as follows:

Cytochrome P 450 1B1 (CYP1B1) was found to be universally expressed in various tumors. Herein, we reported near-IR fluorescent imaging probes for tumor detection via visualizing CYP1B1. After introducing the linker to a CYP1B1 selective inhibitor we found previously, we got the resulting compound 5b which kept strong inhibition ability against CYP1B1 (IC50 = 8.7 ± 1.2 nM) and high selectivity. Then, in vitro microscope studies and cell binding assay of probes indicated that the corresponding probe 6b could specifically be accumulated in CYP1B1 overexpressed colorectal cancer cell HCT-15 and showed satisfying binding affinity to target. During the in vivo noninvasive optical imaging, 6b was proved to rapidly lighten tumor in vivo as early as 6 h after injection. This work is the first attempt to visualize CYP1B1 for noninvasive imaging of tumor which could provide new approach for tumor diagnosis. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6HPLC of Formula: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. HPLC of Formula: 139115-91-6 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Ye, Fei; Berger, Florian; Jia, Hao; Ford, Joseph; Wortman, Alan; Boergel, Jonas; Genicot, Christophe; Ritter, Tobias. Recommanded Product: 2-Methoxybenzaldehyde. The article was titled 《Aryl Sulfonium Salts for Site-Selective Late-Stage Trifluoromethylation》. The information in the text is summarized as follows:

Incorporation of the CF3 group into arenes has found increasing importance in drug discovery. Herein, we report the first photoredox-catalyzed cross-coupling of aryl thianthrenium salts with a copper-based trifluoromethyl reagent, which enables a site-selective late-stage trifluoromethylation of arenes. The reaction proceeds with broad functional group tolerance, even for complex small mols. on gram scale. The method was further extended to produce pentafluoroethylated derivatives In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Recommanded Product: 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Recommanded Product: 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Applied Organometallic Chemistry included an article by Moradi, Parisa; Hajjami, Maryam; Valizadeh-Kakhki, Fatemeh. Name: 1-Bromo-3-methoxybenzene. The article was titled 《Biochar as heterogeneous support for immobilization of Pd as efficient and reusable biocatalyst in C-C coupling reactions》. The information in the text is summarized as follows:

Biochar nanoparticles (BNPs) was modified with 3-choloropropyltrimtoxysilane and further 2-(thiophen-2-yl)-1H-benzo[d]imidazole was anchored on its surface. Then, palladium nanoparticles were fabricated on the surface of the modified BNPs and further the catalytic application was studied as recyclable biocatalyst in carbon-carbon coupling reactions such as Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions to afford biaryl compounds R-R1 [R = Ph, 3,4-FC6H3; R1 = Ph, 4-BrC6H4, 2-naphthyl, etc.] and phenyl-acrylates R2CH=CHR3 [R2 = CO2Bu, CO2Me, CN; R3 = Ph, 2-MeC6H4, 4-MeOC6H4, etc.] was reported. The structure of the catalyst was characterized using SEM, transmission electron microscopy, energy-dispersive X-ray spectroscopy, thermogravimetric anal., X-ray diffraction and at. absorption spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Name: 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Name: 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Advanced Synthesis & Catalysis included an article by Choudhuri, Khokan; Maiti, Saikat; Mal, Prasenjit. Formula: C12H10S2. The article was titled 《Iodine(III) Enabled Dehydrogenative Aryl C-S Coupling by in situ Generated Sulfenium Ion》. The information in the text is summarized as follows:

An umpolung based one pot and direct C-S coupling approach under metal free and mild condition were described. Electrophile sulfenium ions were generated in situ from thiols RSH (R = Ph, Et, 4-nitrophenyl, 3-chlorophenyl, etc.) using iodine(III) reagent PhI(OAc)2 (PIDA) and subsequently used for aromatic electrophilic substitution (EArS) to synthesize diaryl sulfides R1SR (R1 = 2,4,6-trimethylphenyl, 4-methoxyphenyl, 2,4-dimethylphenyl, etc.). Also by using of appropriate amount of PIDA, cascaded synthesis of C-S and S=O bonds led to aryl sulfinyl arenes R1S(O)R in one pot. Covalent self-sorting or competitive experiments further confirmed the involvement of sulfenium ion in the EArS. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Formula: C12H10S2 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Journal of Molecular Structure included an article by Davarpanah, Jamal; Ghahremani, Mahboubeh; Najafi, Ozhan. Formula: C8H8O2. The article was titled 《Synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives via Hantzsch reaction using nicotinic acid as a green and reusable catalyst》. The information in the text is summarized as follows:

A rapid, efficient and eco-friendly protocol has been developed for the preparation of various 1,4-dihydropyridine and polyhydroquinoline derivatives in the presence of nicotinic acid as a green and dual catalyst under solvent-free conditions. In this reaction, nicotinic acid shows a highly catalytic nature, easy to handle procedure, short reaction time, recycle exploitation and excellent isolated yields. Furthermore, the 1H and 13C chem. shift and X-ray spectra values together with the structural parameters of 1,4-dihydropyridine and polyhydroquinoline have been computed and the scaled values have been compared with the corresponding exptl. NMR and X-ray spectra. As a result, the calculated 1H and 13C chem. shift and X-ray spectra show a good agreement with the exptl. results. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Formula: C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A Convenient Synthetic Route of Diethyl (4-Oxo-chromeno[2,3-d]pyrimidin-2(5)-yl)phosphonates》 were Ali, Tarik E.; Assiri, Mohammed A.; Hassanin, Noha M.; Yahia, I. S.; Hussien, Mai S. A.. And the article was published in Journal of Heterocyclic Chemistry in 2019. Quality Control of N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

Novel di-Et (4-oxo-3,4-dihydro-2H-chromeno[2,3-d]pyrimidin-2-yl)phosphonate as two enantiomers and di-Et (4-oxo-1,5-dihydro-4H-chromeno[2,3-d]pyrimidin-5-yl) phosphonate were obtained in easy procedure via reaction of 2-imino-2H-chromene-3-carboxamide, DMF dimethyl-acetal, and di-Et phosphite in a simple one pot. Possible reaction mechanisms are proposed. The structures of the obtained products were confirmed by elemental analyses and spectral tools. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Quality Control of N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Adapalene suppressed the proliferation of melanoma cells by S-phase arrest and subsequent apoptosis via induction of DNA damage》 were Li, Hongyang; Wang, Cheng; Li, Lingjun; Bu, Wenbo; Zhang, Mengli; Wei, Jun; Tao, Lei; Qian, Kun; Ma, Pengcheng. And the article was published in European Journal of Pharmacology in 2019. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The author mentioned the following in the article:

Malignant melanoma was the leading cause of mortality among the skin-associated cancer owing to its highly metastatic feature, increasing incidence and drug resistance requirement. Retinoids played important roles in the treatment of cancer via the activation of retinoid acid receptor (RAR) or retinoid X receptor (RXR). Our present study showed that the third-generation retinoid adapalene exhibited strong inhibitory effects on the proliferation of melanoma cells than other retinoids, such as all-trans-retinoic acid (ATRA), isotretinoin, acitretin and bexarotene, and adapalene exerted significant inhibitory effects on the colony formation of melanoma cells. Further study confirmed that adapalene treatment triggered dramatic S phase arrest and apoptosis, and S phase arrest was the potential mechanism of apoptosis induction. In addition, adapalene treatment dramatically regulated the expression of S phase-related protein, and increased the protein level of DNA damage marker,which were consistent with the results of the induction of the tail moment in comet assays. Meanwhile, DNA damage response was activated and the DNA repair pathway was simultaneously inhibited by adapalene treatment, which might furtherly potentiate S phase arrest and subsequent apoptosis. Taken together, these results showed that adapalene exhibited strong anti-cancer activity, and might be a candidate agent for the clin. treatment of melanoma. After reading the article, we found that the author used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem