Month: October 2022

The author of 《Intracellular Notch1 Signaling in Cancer-Associated Fibroblasts Dictates the Plasticity and Stemness of Melanoma Stem/Initiating Cells》 were Du, Yan; Shao, Hongwei; Moller, Mecker; Prokupets, Rochelle; Tse, Yee Ting; Liu, Zhao-Jun. And the article was published in Stem Cells (Durham, NC, United States) in 2019. Product Details of 106685-40-9 The author mentioned the following in the article:

Cancer stem cells (CSCs) play critical roles in cancer initiation, metastasis, recurrence, and drug resistance. Recent studies have revealed involvement of cancer-associated fibroblasts (CAFs) in regulating CSCs. However, the intracellular mol. mechanisms that determine the regulatory role of CAFs in modulating the plasticity of CSCs remain unknown. Here, we uncovered that intracellular Notch1 signaling in CAFs serves as a mol. switch, which modulates tumor heterogeneity and aggressiveness by inversely controlling stromal regulation of the plasticity and stemness of CSCs. Using mesenchymal stem cell-derived fibroblasts (MSC-DF) harboring reciprocal loss-of-function and gain-of-function Notch1 signaling, we found that MSC-DFNotch1-/- prompted cocultured melanoma cells to form more spheroids and acquire the phenotype (CD271+ and Nestin+) of melanoma stem/initiating cells (MICs), whereas MSC-DFN1IC+/+ suppressed melanoma cell sphere formation and mitigated properties of MICs. Our data demonstrate that intracellular Notch1 signaling in CAFs is a mol. switch dictating the plasticity and stemness of MICs, thereby regulating melanoma aggressiveness, and therefore that targeting the intracellular Notch1 signaling pathway in CAFs may present a new therapeutic strategy for melanoma. The amounts of CD271+ MIC regulated by MSC-DF carrying high or low Notch1 pathway activity is well correlated with capability of melanoma metastasis, supporting that melanoma metastasis is MIC-mediated. Consistently, when cografted with melanoma cells into NOD scid gamma (NSG) mice, MSC-DFNotch1-/- increased, but MSC-DFN1IC+/+ decreased, the amounts of CD271+ MIC in melanoma tissue. MSC-DFNotch1-/- increased stemness of CD271+ MIC, which resultantly exhibited stronger aggressiveness in vitro and in vivo, by upregulating Sox2/Oct4/Nanog expression. In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Product Details of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Product Details of 106685-40-9

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Selective RAR agonists for acne vulgaris: A narrative review.》 was published in Journal of cosmetic dermatology in 2020. These research results belong to Kassir, Martin; Karagaiah, Priyanka; Sonthalia, Sidharth; Katsambas, Andreas; Galadari, Hassan; Gupta, Mrinal; Lotti, Torello; Wollina, Uwe; Abdelmaksoud, Ayman; Grabbe, Stephan; Goldust, Mohamad. Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The article mentions the following:

BACKGROUND: Acne vulgaris is a chronic disfiguring inflammatory disease of adolescents and adults affecting up to 90% of the population around the world. The sequence of etiopathogenesis in acne is not completely understood but involves abnormalities in sebum production, follicular plugging, proliferation of propionibacterium acnes, and chronic inflammation. AIMS: This review aims to summarize the features of the topical selective RAR agonists in treating acne vulgaris with a special emphasis on the 4th generation topical retinoid trifarotene. METHODS: Studies were identified by searching electronic databases (MEDLINE and PubMed) till August 2019 and reference lists of respective articles. Only articles published in English language were included. RESULTS: Topical retinoids have been first line of treatment for more than 30 years now in treating mild to moderate acne vulgaris. Third generation retinoids like adapalene and tazarotene are selective RAR and γ agonists, having an additional anti-inflammatory action along with their comedolytic effects and work well in combinations with topical antibiotics, due to the stability of chemical composition. CONCLUSION: Trifarotene is a new 4th generation retinoid with selective action on RAR-γ receptor alone, which is specific for skin, and it is safe for long-term maintenance therapy with good efficacy and tolerability.6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

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《Alternating Current Electrolysis for the Electrocatalytic Synthesis of Mixed Disulfide via Sulfur-Sulfur Bond Metathesis towards Dynamic Disulfide Libraries》 was published in Chemistry – A European Journal in 2020. These research results belong to Sattler, Lars Erik; Otten, Chris Josef; Hilt, Gerhard. Safety of 1,2-Diphenyldisulfane The article mentions the following:

A novel approach of electrolysis using a.c. was applied in the S-S bond metathesis of sym. disulfides towards unsym. disulfides. As initially expected, a statistical distribution in disulfides was obtained. Also, the influence of electrode polarization by a.c. was studied on a two-disulfide matrix. The highly dynamic nature of this chem. resulted in the creation of dynamic disulfide libraries by expansion of the matrixes, consisting of up to six sym. disulfides. Mixing of matrixes and stepwise expanding of a matrix by using a.c. electrolysis were realized. After reading the article, we found that the author used 1,2-Diphenyldisulfane(cas: 882-33-7Safety of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Safety of 1,2-Diphenyldisulfane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor》 was written by Comeo, Eleonora; Kindon, Nicholas D.; Soave, Mark; Stoddart, Leigh A.; Kilpatrick, Laura E.; Scammells, Peter J.; Hill, Stephen J.; Kellam, Barrie. Related Products of 139115-91-6 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Among class A G protein-coupled receptors (GPCR), the human adenosine A2A receptor (hA2AAR) remains an attractive drug target. However, translation of A2AAR ligands into the clinic has proved challenging and an improved understanding of A2AAR pharmacol. could promote development of more efficacious therapies. Subtype-selective fluorescent probes would allow detailed real-time pharmacol. investigations both in vitro and in vivo. In the present study, two families of fluorescent probes were designed around the known hA2AAR selective antagonist preladenant (SCH 420814). Both families of fluorescent antagonists retained affinity at the hA2AAR, selectivity over all other adenosine receptor subtypes and allowed clear visualization of specific receptor localization through confocal imaging. Furthermore, the Alexa Fluor 647-labeled conjugate allowed measurement of ligand binding affinities of unlabeled hA2AAR antagonists using a bioluminescence resonance energy transfer (NanoBRET) assay. The fluorescent ligands developed here can therefore be applied to a range of fluorescence-based techniques to further interrogate hA2AAR pharmacol. and signaling.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Related Products of 139115-91-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Hang; Yan, Zhong-zuo; Guo, Meng-bi; An, Ran; Wang, Xin; Zhang, Rui; Mou, Yan-hua; Hou, Zhuang; Guo, Chun published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections》.Application In Synthesis of 1-Bromo-3-methoxybenzene The article contains the following contents:

A series of selenium-containing miconazoles. compounds I, II [R = H, 3-F, 2-Me, etc. ; X= F, Cl], III [R = H, 3-F, 2-Me, etc.; X= F, C] were identified as potent antifungal drugs in our previous study. Representative compound I (MIC = 0.01μg/mL against C.alb. 5314) proved efficacious in inhibiting the growth of fungal pathogens. However, further study showed lead compound I exhibited potential hemolysis, significant cytotoxic effect and unfavorable metabolic stability and was therefore modified to overcome these drawbacks. In this article, the further optimization of selenium-containing miconazole derivatives resulted in the discovery of similarly potent compound II [R = 4-F ; X= F] (MIC = 0.02μg/mL against C.alb. 5314), exhibiting a superior pharmacol. profile with decreased rate of metabolism, cytotoxic effect and hemolysis. Furthermore, compound II [R = 4-F ; X= F] showed fungicidal activity against Candida albicans and significant effects on the treatment of resistant Candida albicans infections. Meanwhile, compound II [R = 4-F ; X= F] not only could reduce the ergosterol biosynthesis pathway by inhibiting CYP51, but also inhibited biofilm formation. More importantly, compound II [R = 4-F ; X= F] also shows promising in vivo efficacy after i.p. injection and the PK study of compound II [R = 4-F ; X= F] was evaluated. In addition, mol. docking studies provide a model for the interaction between the compound II [R = 4-F ; X= F] and the CYP51 protein. Overall, it was believed that these selenium-containing miconazole compounds can be further developed for the potential treatment of fungal infections. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application In Synthesis of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application In Synthesis of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Bo; Yang, Chenxin; Wang, Xinhao; Li, Guangwu; Peng, Wangwang; Xiao, Huiping; Luo, Shenglian; Xie, Sheng; Wu, Jishan; Zeng, Zebing published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Synthesis and Structural Elucidation of Bisdibenzocorannulene in Multiple Redox States》.Reference of 3-Methoxyphenylboronic acid The article contains the following contents:

An anti-folded bowl-shaped bisdibenzocorannulene (BDBC) featuring a new chair-cyclohexane-like hexagon as a bridge of two dibenzocorannulene moieties was reported. The neutral compound showed multiple redox-active properties and could be converted to the corresponding redox states through chem. reduction or oxidation Chem. reduction of BDBC by stoichiometric addition of metallic potassium in the presence of [18]crown-6 ether, provided a radical anion BDBC.- and a dianion BDBC2-, resp.; while chem. oxidation by silver hexafluoroantimonate(V), converted the neutral compound to an open-shell singlet diradical dication (BDBC••)2+. The structural consequences of both electron-reduction and oxidation were closely related to the release of ring-strain of the bowl-shaped π-scaffold and imposed steric hindrance of the hexagonal bridge. In addition, the unusual open-shell nature of the dication could mainly be attributed to the changing of localized antiaromaticity in the closed-shell structure to delocalized character in the biradical, and thus the emergence of weakly bonded π-electrons.3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Salihovic, Mirsada; Pazalja, Mirha; Spirtovic Halilovic, Selma; Veljovic, Elma; Mahmutovic-Dizdarevic, Irma; Roca, Suncica; Novakovic, Irena; Trifunovic, Snezana published their research in Journal of Molecular Structure in 2021. The article was titled 《Synthesis, characterization, antimicrobial activity and DFT study of some novel Schiff bases》.Related Products of 135-02-4 The article contains the following contents:

Two new Schiff bases I (R = Cl, OMe) derived from L-cysteine and substituted benzaldehyde were synthesized. DFT calculations were based on global chem. reactivity indexes calculated using the B3LYP/6-31G*, B3LYP/6-31G**, and B3LYP/6-31+G* theory levels. Exptl. and theor. obtained values for FT-IR and NMR (1H, 13C) of test compounds showed good agreement. The reactivity descriptors of B3LYP (E, EHOMO, ELUMO, dipole moment, Δε, μ, η, ω) were calculated to predict the stability of newly synthesized compounds The microbiol. activity of the compounds was tested on several Gram-pos. bacteria: Staphylococcus aureus, Bacillus subtilis, Clostridium sporogenes, Microccocus luteus and Microccocus flavus. The following Gram-neg. bacteria were used to test the compounds: Escherichia coli, Pseudomonas aeruginosa Proteus hauseri, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Enteritidis. Also, the activity on the following yeasts was examined: Candida albicans, Saccharomyces cerevisiae and fungal strain Aspergillus brasilliensis. The Schiff base with chlorine in the structure has the best antimicrobial action against all tested microorganisms. The selected quantum chem. descriptors calculated for both compounds have a close relationship with the antimicrobial activity. After reading the article, we found that the author used 2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Related Products of 135-02-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Santos, Jose; Calbo, Joaquin; Sandoval-Torrientes, Rafael; Garcia-Benito, Ines; Kanda, Hiroyuki; Zimmermann, Iwan; Arago, Juan; Nazeeruddin, Mohammad Khaja; Orti, Enrique; Martin, Nazario published an article in 2021. The article was titled 《Hole-Transporting Materials for Perovskite Solar Cells Employing an Anthradithiophene Core》, and you may find the article in ACS Applied Materials & Interfaces.Product Details of 33100-27-5 The information in the text is summarized as follows:

A decade after the report of the first efficient perovskite-based solar cell, development of novel hole-transporting materials (HTMs) is still one of the main topics in this research field. Two of the main advance vectors of this topic lie in obtaining materials with enhanced hole-extracting capability and in easing their synthetic cost. The use of anthra[1,9-bc:5,10-b′c′]dithiophene (ADT) as a flat π-conjugated frame for bearing arylamine electroactive moieties allows obtaining two novel highly efficient HTMs from very cheap precursors. The solar cells fabricated making use of the mixed composition (FAPbI3)0.85(MAPbBr3)0.15 perovskite and the novel ADT-based HTMs show power conversion efficiencies up to 17.6% under 1 sun illumination compared to the 18.1% observed when using the benchmark compound 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenylamine)-9,9′-spirobifluorene (spiro-OMeTAD). Detailed d. functional theory calculations allow rationalization of the observed opto-electrochem. properties and predict a flat mol. structure with a low reorganization energy that supports the high conductivity measured for the best-performing HTM. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Product Details of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Product Details of 33100-27-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rakipov, Ilnaz T.; Semenov, Konstantin N.; Petrov, Artem A.; Akhmadiyarov, Aydar A.; Khachatrian, Artashes A.; Fakhurtdinova, Aliya R.; Solomonov, Boris N. published an article in 2021. The article was titled 《Thermochemistry of Solution, Solvation and Hydrogen Bonding of Chloroform in Linear and Cyclic Ethers》, and you may find the article in Journal of Solution Chemistry.Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane The information in the text is summarized as follows:

In this work the thermochem. of solution, solvation and hydrogen bond formation of chloroform in linear and cyclic ethers was studied. The infinite dilution solution enthalpies of chloroform in di-Et ether, diglyme, 1,4-dioxane, THF, 12-crown-4 and 15-crown-5 were measured at 298.15 K. The solvation and hydrogen bonding enthalpies of chloroform in the ethers were calculated It was found that the hydrogen bonding enthalpies of chloroform in the ethers are significantly higher for linear than for cyclic ethers. The hydrogen bonding of ethers with chloroform was discussed in cases when ethers act as a solute or solvent. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hoshikawa, Shoki; Yanai, Hikaru; Martin-Mejias, Irene; Lazaro-Milla, Carlos; Aragoncillo, Cristina; Almendros, Pedro; Matsumoto, Takashi published an article in 2021. The article was titled 《Synthesis of Polycyclic Aromatic Hydrocarbons Decorated by Fluorinated Carbon Acids/Carbanions》, and you may find the article in Chemistry – A European Journal.Related Products of 10365-98-7 The information in the text is summarized as follows:

The carboarylation reaction of biphenyl-alkynes was successfully triggered by electrophilic attack of 1,1-bis(triflyl)ethylene on the alkyne moiety to give polycyclic aromatic hydrocarbons (PAHs), e.g., I, decorated by superacidic carbon acid functionality. Neutralization of thus obtained acids with NaHCO3 yielded the corresponding sodium salts, e.g., II•Na+, which showed improved solubility in both aqueous and organic solvents. The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Related Products of 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Related Products of 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem