Month: October 2022

In 2019,Journal of Drugs in Dermatology included an article by Kircik, Leon H.. Product Details of 106685-40-9. The article was titled 《Anti-inflammatory dose doxycycline plus adapalene 0.3% and benzoyl peroxide 2.5% Gel for severe acne》. The information in the text is summarized as follows:

Acne is primarily an inflammatory disease. Anti-inflammatory dose doxycycline (40mg: 30mg immediate release and 10mg delayed release beads) is approved for the treatment of rosacea but with demonstrated efficacy for acne. Fixed combination adapalene C.3% and benzoyl peroxide 2.5% gel is a once-daily formulation approved for the topical management of acne vulgaris. It has both antiinflammatory and anti-comedogenic properties. Options for management of severe acne are somewhat limited; many patients are not candidates for or refuse treatment with isotretinoin. Systemic antibiotics may be indicated; acne treatment guidelines emphasize antibiotic stewardship in light of increasing concerns about antibiotic resistance and call for the judicious use of conventional systemic antibiotics. This single-center, open label pilot study involving 20 subjects with severe acne assessed the effects of combination treatment using anti-inflammatory dose doxycycline plus adapalene 0.3% and benzoyl peroxide 2.5% gel on IGA scores as well as inflammatory lesion, non-inflammatory lesion, and nodule counts. By week 12, 95% of subjects had at least a 2-grade improvement in IGA scores. Reductions in inflammatory and non-inflammatory lesion counts were statistically significant beginning at week 4 and continuing through week 12. By week 4, the percentage of patients with O nodules was 70%, compared to baseline of 20%. Further improvements were seen through week 12. Treatment was welltolerated with no serious treatment-related adverse events. Combination treatment with anti-inflammatory dose doxycycline plus combination adapalene 0.3% and benzoyl peroxide 2.5% gel is safe and effective for management of severe acne. In the experiment, the researchers used many compounds, for example, 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Product Details of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Product Details of 106685-40-9

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated》 were Geraldy, Magalie; Morgen, Michael; Sehr, Peter; Steimbach, Raphael R.; Moi, Davide; Ridinger, Johannes; Oehme, Ina; Witt, Olaf; Malz, Mona; Nogueira, Mauro S.; Koch, Oliver; Gunkel, Nikolas; Miller, Aubry K.. And the article was published in Journal of Medicinal Chemistry in 2019. Formula: C9H19NO4 The author mentioned the following in the article:

The discovery of isoenzyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biol. functions of individual HDACs and for validating HDACs as drug targets. The isoenzyme HDAC10 contributes to chemotherapy resistance and has recently been described to be a polyamine deacetylase, but no studies toward selective HDAC10 inhibitors have been published. Using two complementary assays, the authors found tubastatin A, an HDAC6 inhibitor, to potently bind HDAC10. The authors synthesized tubastatin A derivatives and found that a basic amine in the cap group was required for strong HDAC10 binding. HDAC10 inhibitors mimicked knockdown by causing dose-dependent accumulation of acidic vesicles in a neuroblastoma cell line. Furthermore, docking into human HDAC10 homol. models indicated that a hydrogen-bond between a cap group nitrogen and the gatekeeper residue Glu272 was responsible for potent HDAC10 binding. Taken together, the authors’ data provide an optimal platform for the development of HDAC10-selective inhibitors, as exemplified with the tubastatin A scaffold. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Formula: C9H19NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Analysis of lithium separation by modified zeolite using fuzzy logic: equilibrium, kinetics and thermodynamic》 were Farhadi, Mehraz; Rashidi, Abbas; Mallah, Mohammad Hassan. And the article was published in Desalination and Water Treatment in 2019. Product Details of 33100-27-5 The author mentioned the following in the article:

Modified natural zeolite with crown ethers such as 12crown4, 15crown5, 6crown18 and benzo- 15crown5 have been characterized using Fourier transform infra-red, scanning electron microscope and Brunauer-Emmett-Teller instruments. Concentration of 0.01 mg/L of complexing agent and modification time of 240 h were obtained as optimum parameters. Effective parameters such as pH, adsorbent dose, contact time, type and concentration of crown ethers, ion strength, and initial concentration of lithium ion and temperature of complex formation were also investigated and optimized in this adsorption process. Under the optimized exptl. conditions pH equal to 7, one gram of adsorbent in 2 mL solution of 0.01 mg/L and temperature of 40°C, the most lithium adsorption (87%) was acquired. The effect of interference ions on the adsorption process was also considered. The results showed that Freundlich model is one of the best descriptive models for this process. The adsorption kinetics of lithium on modified zeolite follows the pseudo second-order model. Thermodn. parameters were calculated and shown that adsorption process is an endothermic and spontaneous process. Statistical anal. of exptl. results was done by fuzzy logic tool of MATLAB software and three-dimensional diagrams of different parameters effect on the adsorption percentage were also presented. The experimental process involved the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Product Details of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Product Details of 33100-27-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Highly atom-economical, catalyst-free, and solvent-free phosphorylation of chalcogenides》 were Choudhary, Rakhee; Singh, Pratibha; Bai, Rekha; Sharma, Mahesh C.; Badsara, Satpal Singh. And the article was published in Organic & Biomolecular Chemistry in 2019. Synthetic Route of C12H10S2 The author mentioned the following in the article:

Silica gel promoted, catalyst-free and solvent-free S-P, Se-P and Te-P bond formations are described, giving chalcogen-substituted phosphorus esters. A variety of disulfides coupled with diarylphosphine oxides provide the corresponding phosphinothioates in excellent yields. For the first time, diselenides and ditellurides reacted with dialkyl phosphites under catalyst-free conditions to provide the corresponding phosphoroselenoates and phosphorotelluroates, resp., in good to excellent yields. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Synthetic Route of C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Synthetic Route of C12H10S2 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《First reported cases of actinic folliculitis treated successfully with topical retinoid.》 was published in Clinical and experimental dermatology in 2020. These research results belong to Rahman, S; Powell, J; Al-Ismail, D. Application of 106685-40-9 The article mentions the following:

Actinic folliculitis (AF) is a rare recurrent seasonal photodermatosis, relatively newly characterized by nonpruritic, monomorphic pustules and papules appearing 4-24 h after exposure to sunlight. Lesions usually affect the face but also appear on the upper chest and arms. Resolution normally occurs within 7-10 days with cessation of sunlight exposure. AF is resistant to standard treatments used for acne vulgaris and acne rosacea, with only oral retinoids previously being reported as effective. We report the first two cases, to our knowledge, of AF responding extremely effectively to a topical retinoid. After reading the article, we found that the author used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Application of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Multiwalled carbon nanotubes crowned with nickel-ferrite magnetic nanoparticles assisted heterogeneous catalytic strategy for the synthesis of benzo[d]imidazo[2,1-b]thiazole scaffolds》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Geedkar, Deepika; Kumar, Ashok; Sharma, Pratibha. Recommanded Product: 673-22-3 The article mentions the following:

Present manuscript elicits an account of the sonication promoted multicomponent reactions strategy assisted by multiwalled carbon nanotubes embraced with nickel-ferrite (NiFe2O4-CNTs) magnetic nanoparticles, as a heterogeneous catalyst to synthesize a novel series of pharmacol. active benzo[d]imidazo[2,1-b]thiazole scaffolds I [R1 = H, 4-OH, 4-Cl, etc.; R2 = H, 4-Me, 2-OH, etc.]. The synthesis of these biol. active derivatives was achieved via A3 coupling involving 2-aminobenzothiazole, pertinent aryl aldehydes and Ph acetylene derivatives, proceeded in PEG 400 as green solvent under aerobic conditions to afford the products in good to excellent yields. The higher environmental compatibility and sustainability factors such as higher ecoscale score, smaller E-factor and appreciable atom economy put this etiquette under the parasol of green chem. precepts. The characterization of synthesized catalysts was attained through varied techniques viz. powder X-ray diffraction, field emission SEM with energy-dispersive X-ray spectroscopy, Raman, FT-IR, VSM and TGA-DTA-DTG analyzes, dispersion studies, and nitrogen porosimetry analyzes. The structures of the synthesized compounds were also endorsed by extensive spectroscopic studies (FT-IR, 1H and 13C NMR, mass) and elemental analyzes. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Triethylammonium Hydrogen Sulfate [Et3NH][HSO4] as an Efficient Ionic Liquid Catalyst for the Synthesis of Coumarin Derivatives》 was published in Polycyclic Aromatic Compounds in 2020. These research results belong to Karimi-Jaberi, Zahed; Masoudi, Behzad; Rahmani, Atefeh; Alborzi, Kiana. Computed Properties of C7H8O2 The article mentions the following:

Triethylammonium hydrogen sulfate [Et3NH][HSO4] has been studied to be an efficient ionic liquid catalyst for the synthesis of biol. potent coumarin derivatives Thus, 4-substituted coumarins have been synthesized through the Pechmann condensation of phenols with β-ketoesters in the presence of [Et3NH][HSO4]. Also, 4-hydroxycoumarin was reacted with various aldehydes using this catalyst to obtain the α,α’-benzylidene bis(4-hydroxycoumarin) derivatives In addition, this efficient and privileged ionic liquid catalyst has been described in the synthesis of pyrano[3,2-c]coumarin derivatives by condensation of 4-hydroxycoumarin with chalcones. The optimization conditions carried out in the present study revealed that 20 mol% of ionic liquid catalyst under solvent-free condition at 110° are the best conditions for the synthesis of coumarin-derivatives in good to excellent yields. The present methodol. is a facile and green approach offering several advantages, such as excellent yield of products, minimizing production of chem. wastes, shorter reaction profile, mild reaction conditions, simple operational procedure, and easy preparation/separation of catalyst as a non-corrosive and stable ionic liquid After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Computed Properties of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneComputed Properties of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Titania-silica nanoparticles ensemblies assisted heterogeneous catalytic strategy for the synthesis of pharmacologically significant 2,3-diaryl-3,4-dihydroimidazo[4,5-b]indole scaffolds》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Geedkar, Deepika; Kumar, Ashok; Reen, Gagandeep Kour; Sharma, Pratibha. Recommanded Product: 673-22-3 The article mentions the following:

Present paper elicits the multicomponent reaction (MCR) strategy assisted by titania nanoparticles hosted on silica (TiO2.SiO2 NPs) as heterogeneous catalyst to synthesize a series of pharmacol. significant 2,3-diaryl-3,4-dihydroimidazo[4,5-b]indole derivatives The decrease in reaction time, low catalyst loading, high product yield (up to 92%), and excellent reusability of the catalyst (up to 7 cycles) put this protocol under the umbrella of green chem. tenets. Characterization of catalysts was achieved through a number of techniques viz., energy-dispersive X-ray (EDX) spectroscopy, field emission SEM (FESEM), powder X-ray diffraction (XRD), fourier transform IR (FTIR) spectra of adsorbed pyridine, temperature-programmed desorption of ammonia, and porosity measurements by nitrogen adsorption (Brunauer-Emmett-Teller [BET] method). Also, the structures of synthesized compounds were corroborated on the basis of FTIR, NMR (NMR), mass, and elemental analyses data. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper(I)-Catalyzed Synthesis of Functionalized Indolizinones from Substituted Pyridine Homologated Ynones》 was written by Sahoo, Sushree Ranjan; Sarkar, Debayan; Henkel, Felix; Reuter, Hans. Quality Control of 1,2-Diphenyldisulfane And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient two-component copper-catalyzed cyclization cascade approach toward highly functionalized indolizinone heterocycles has been developed from reactions of pyridine-, isoquinoline-, and quinoline ynones, via 5-exo-dig cyclization. The catalysis involves the activation by diorgano diselenide and diorgano disulfide and also their incorporation into the indolizinone core. In addition, the obtained substituted indolizinones were readily transformed into 1-(organochalcogenyl)indolizin-2-ols, which are important building blocks in organic synthesis. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Quality Control of 1,2-Diphenyldisulfane) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Quality Control of 1,2-Diphenyldisulfane They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A near-infrared excitation/emission fluorescent probe for imaging of endogenous cysteine in living cells and zebrafish》 was written by Xie, Ruihua; Li, Yaqian; Zhou, Zile; Pang, Xiao; Wu, Cuiyan; Yin, Peng; Li, Haitao. Quality Control of 2-Hydroxy-4-methoxybenzaldehyde And the article was included in Analytical and Bioanalytical Chemistry in 2020. The article conveys some information:

The fluorescence imaging technique provides an essential tool for studying biol. systems. However, due to the interference of autofluorescence of biol. tissues, the application of short-wavelength fluorescent probes in biol. imaging was limited. The near-IR (NIR) excitation/emission fluorescent probe possesses unique advantages in optical imaging in vivo, including less light scattering, minimal photo-damage to biol. samples, deep tissue penetration, and weak autofluorescence interference from complicated biol. systems. A convenient fluorophore (E)-2-[2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl]-3- methylbenzo[d]thiazol-3-ium iodide (DXM-OH) with NIR excitation and emission was rationally designed and developed. What′s more, DXM-OH was applied to construct an “”OFF-ON”” fluorescent probe (E)-2-{2-[6-(acryloyloxy)-2,3-dihydro-1H- xanthen-4-yl]vinyl}-3-methylbenzo[d]thiazol-3-ium iodide (DXM) for sensitive and selective detection of cysteine (Cys). DXM had the advantages of good cell permeability, low toxicity, and excellent optical properties (NIR excitation/emission) and it was successfully applied to image Cys of living cells and zebrafish. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Quality Control of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Quality Control of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem