Month: October 2022

Product Details of 2398-37-0In 2020 ,《Engineering the charge-transfer state to facilitate spin-orbit charge transfer intersystem crossing in spirobis[anthracene]diones》 was published in Angewandte Chemie, International Edition. The article was written by Lv, Meng; Yu, Yang; Sandoval-Salinas, Maria E.; Xu, Jianhua; Lei, Zuhai; Casanova, David; Yang, Youjun; Chen, Jinquan. The article contains the following contents:

Spiro conjugation has been proposed to dictate the efficiency of charge transfer, which could directly affect the spin-orbit charge transfer intersystem crossing (SOCT-ISC) process. However, this process has yet to be exemplified. Herein, we prepared three spirobis[anthracene]diones, in which two benzophenone moieties are locked in close proximity and differentially functionalized to fine-tune the charge transfer state. Its feasibility for SOCT-ISC was theor. predicted, then exptl. evaluated. Through fine-tuning the spiro conjugation coupling and varying the solvent dielec. constants, ISC rate constants were engineered to vary in a dynamic range of three orders of magnitude, from 7.8×108 s-1 to 1.0×1011 s-1, which is the highest ISC rate reported for SOCT-ISC system to our knowledge. Our findings substantiate the key factors for effective SOCT-ISC and offer a new avenue for the rational design of heavy atom free triplet sensitizers. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Self-Waveguide Single-Benzene Organic Crystal with Ultralow-Temperature Elasticity as a Potential Flexible Material》 was written by Liu, Bin; Lu, Zhuoqun; Tang, Baolei; Liu, Hao; Liu, Huapeng; Zhang, Zuolun; Ye, Kaiqi; Zhang, Hongyu. Reference of N,N-Dimethylformamide Dimethyl AcetalThis research focused onwaveguide benzene crystal ultralow temperature elasticity potential flexible material; elasticity; flexible crystals; optical waveguides; organic crystals; ultralow temperature. The article conveys some information:

A highly emissive aromatic crystal combining ultralow-temperature elasticity and self-waveguide properties (when a crystal is excited, it emits light from itself, which travels through the crystal to the other end) based on a simple single-benzene emitter, is reported. This crystal displayed excellent elastic bending ability in liquid N (LN). Preliminary experiments on optical waveguiding in the bent crystal demonstrated that the light generated by the crystal itself could be confined and propagated within the crystal body between 170 and -196°. These results not only suggest a guideline for designing functional organic crystals with ultralow-temperature elasticity but also expand the application region of flexible materials to extreme environments, such as space technol. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Reference of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Reference of N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Syntheses related to etiojervane. III. The synthesis of 1,8-dimethyl – 7 – methoxy – 1,2,3,4,4a,9a – hexahydrofluoren – 2-one》 was published in Journal of Organic Chemistry in 1962. These research results belong to Barnes, Roderick A.; Sedlak, Michael. Application of 33797-34-1 The article mentions the following:

cf. CA 57, 2156h. The cyclization of 1-(methoxybenzyl)cyclohexanol did not yield a hexahydrofluorene but rather a substance believed to be 2-methoxy-5,6,7,8,9,10-hexahydro-5,9-methano-benzocyclooctene (I). In an alternate approach the alkylation of Hagemann’s ester with benzyl chloride was found to take place at the 2-position. The alkylation products from benzyl chloride and substituted benzyl chlorides could be cyclized either before or after reduction of the double bond to fluorene derivatives The carboxyl group of 7-methoxy-1,8-dimethyl-1,2,3,4,4a,9a-hexahydrofluorene-2-carboxylic acid was degraded to yield II, which should be readily convertible to a degradation product of jervine. In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Application of 33797-34-1)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Application of 33797-34-1 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 197163-57-8On May 13, 2021 ,《Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis》 appeared in Journal of Medicinal Chemistry. The author of the article were Mammoliti, Oscar; Palisse, Adeline; Joannesse, Caroline; El Bkassiny, Sandy; Allart, Brigitte; Jaunet, Alex; Menet, Christel; Coornaert, Beatrice; Sonck, Kathleen; Duys, Inge; Clement-Lacroix, Philippe; Oste, Line; Borgonovi, Monica; Wakselman, Emanuelle; Christophe, Thierry; Houvenaghel, Nicolas; Jans, Mia; Heckmann, Bertrand; Saniere, Laurent; Brys, Reginald. The article conveys some information:

Mounting evidence from the literature suggests that blocking S1P2 receptor (S1PR2) signaling could be effective for the treatment of idiopathic pulmonary fibrosis (IPF). However, only a few antagonists have been so far disclosed. A chem. enablement strategy led to the discovery of a pyridine series with good antagonist activity. A pyridazine series with improved lipophilic efficiency and with no CYP inhibition liability was identified by scaffold hopping. Further optimization led to the discovery of 40 (GLPG2938)(I), a compound with exquisite potency on a phenotypic IL8 release assay, good pharmacokinetics, and good activity in a bleomycin-induced model of pulmonary fibrosis. In the part of experimental materials, we found many familiar compounds, such as 2-Ethoxy-6-methylpyridin-4-amine(cas: 197163-57-8Application of 197163-57-8)

2-Ethoxy-6-methylpyridin-4-amine(cas: 197163-57-8) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application of 197163-57-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Yen Ting; Seto, Christopher T. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the α-ketoacid motif》.Related Products of 660848-57-7 The author mentioned the following in the article:

Protein tyrosine phosphatases (PTPases) regulate intracellular signal transduction pathways by controlling the level of tyrosine phosphorylation in cells. These enzymes play an important role in a variety of diseases including type II diabetes and infection by the bacterium Yersinia pestis, which is the causative agent of bubonic plague. This report describes the synthesis, using parallel solution-phase methods, of a library of 104 potential inhibitors of PTPases. The library members are based on the bis(aryl α-ketocarboxylic acid) motif that incorporates a carboxylic acid on the central benzene linker. This carboxylic acid was coupled with a variety of different aromatic amines through an amide linkage. The aromatic component of the resulting amides is designed to make contacts with residues that surround the active site of the PTPase. The library was screened against the Yersinia PTPase and PTP1B. Based upon the screening results, four members of the library were selected for further study. These four compounds were evaluated against the Yersinia PTPase, PTP1B, TCPTP, CD45, and LAR. Compound 14 has an IC50 value of 590 nM against PTP1B and is a reversible competitive inhibitor. This affinity represents a greater than 120-fold increase in potency over compound 2, the parent structure upon which the library was based. A second inhibitor, compound 12, has an IC50 value of 240 nM against the Yersinia PTPase. In general, the selectivity of the inhibitors for PTP1B was good compared to LAR, but modest when compared to TCPTP and CD45. In addition to this study using 2-Methoxy-5-(trifluoromethoxy)aniline, there are many other studies that have used 2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7Related Products of 660848-57-7) was used in this study.

2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Related Products of 660848-57-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Liu, Yu; Fares, Matthew; Dunham, Noah P.; Gao, Zi; Miao, Kun; Jiang, Xueyuan; Bollinger, Samuel S.; Boal, Amie K.; Zhang, Xin published 《AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress》.Angewandte Chemie, International Edition published the findings.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Drug-induced proteome stress that involves protein aggregation may cause adverse effects and undermine the safety profile of a drug. Safety of drugs is regularly evaluated using cytotoxicity assays that measure cell death. However, these assays provide limited insights into the presence of proteome stress in live cells. A fluorogenic protein sensor is reported to detect drug-induced proteome stress prior to cell death. An aggregation prone Halo-tag mutant (AgHalo) was evolved to sense proteome stress through its aggregation. Detection of such conformational changes was enabled by a fluorogenic ligand that fluoresces upon AgHalo forming soluble aggregates. Using 5 common anticancer drugs, we exemplified detection of differential proteome stress before any cell death was observed Thus, this sensor can be used to evaluate drug safety in a regime that the current cytotoxicity assays cannot cover and be generally applied to detect proteome stress induced by other toxins. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Agrawalla, Bikram Keshari; Wang, Tao; Riegger, Andreas; Domogalla, Matthias P.; Steinbrink, Kerstin; Doerfler, Thilo; Chen, Xi; Boldt, Felix; Lamla, Markus; Michaelis, Jens; Kuan, Seah Ling; Weil, Tanja published 《Chemoselective Dual Labeling of Native and Recombinant Proteins》.Bioconjugate Chemistry published the findings.Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

The attachment of two different functionalities in a site-selective fashion represents a great challenge in protein chem. The authors report site specific dual functionalization of peptides and proteins capitalizing on reactivity differences of cysteines in their free (thiol) and protected, oxidized (disulfide) forms. The dual functionalization of interleukin 2 and EYFP proceeded with no loss of bioactivity in a stepwise fashion applying maleimide and disulfide rebridging allyl-sulfone groups. In order to ensure broader applicability of the functionalization strategy, a novel, short peptide sequence that introduces a disulfide bridge was designed and site-selective dual labeling in the presence of biogenic groups was successfully demonstrated. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Journal of the American Chemical Society included an article by Liu, Yu; Wolstenholme, Charles H.; Carter, Gregory C.; Liu, Hongbin; Hu, Hang; Grainger, Leeann S.; Miao, Kun; Fares, Matthew; Hoelzel, Conner A.; Yennawar, Hemant P.; Ning, Gang; Du, Manyu; Bai, Lu; Li, Xiaosong; Zhang, Xin. Product Details of 139115-91-6. The article was titled 《Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence》. The information in the text is summarized as follows:

We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores. Combining photophys. anal., X-ray crystallog., and theor. calculation, we show that fluorescence is triggered by inhibition of twisted-intramol. charge transfer of these fluorophores in the rigid microenvironment of viscous solvent or protein aggregates. Bioorthogonal conjugation of the fluorophore to Halo-tag fused protein-of-interests allows for fluorogenic detection of both misfolded and aggregated species in live cells. Unlike other methods, our method is capable of detecting previously invisible misfolded soluble proteins. This work provides the first application of fluorescent protein chromophores to detect protein conformational collapse in live cells. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Product Details of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Journal of Dermatological Treatment included an article by Chlebus, Ewa; Serafin, Monika; Chlebus, Marcin. Category: ethers-buliding-blocks. The article was titled 《Is maintenance treatment in adult acne important Benefits from maintenance therapy with adapalene, and low doses of alpha and beta hydroxy acids》. The information in the text is summarized as follows:

Adult acne is a chronic disease with uncontrolled exacerbations, associated with a psychol. burden of the patient and medical expenses. The aim of the study was to check the efficacy of maintenance therapy of adult acne. It is essential part of treatment as adult acne usually has a long-lasting and recurring course. In the study, the efficacy of maintenance therapy in patients with adult acne is evaluated. In this study, 100 patients (aged 25-39 years of age) with mild and moderate adult acne were enrolled. The maintenance therapy (adapalene 0.1% three times a week and low doses of alpha and beta hydroxy acids) led to a significant decrease in the number of acne lesions (from 31.3 to 12.25; p < .001) and severity of seborrhea (p < .001). Maintenance therapy brings significant improvements in the reduction of non-inflammatory and inflammatory lesions in patients with mild and moderate adult acne. In the experiment, the researchers used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Category: ethers-buliding-blocks)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
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In 2019,Upsala journal of medical sciences included an article by Brboric, Anja; Vasylovska, Svitlana; Saarimäki-Vire, Jonna; Espes, Daniel; Caballero-Corbalan, José; Larfors, Gunnar; Otonkoski, Timo; Lau, Joey. Category: ethers-buliding-blocks. The article was titled 《Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.》. The information in the text is summarized as follows:

Background: Murine boundary cap-derived neural crest stem cells (NCSCs) are capable of enhancing islet function by stimulating beta cell proliferation as well as increasing the neural and vascular density in the islets both in vitro and in vivo. This study aimed to isolate NCSC-like cells from human bone marrow.Methods: CD271 magnetic cell separation and culture techniques were used to purify a NCSC-enriched population of human bone marrow. Analyses of the CD271+ and CD271- fractions in terms of protein expression were performed, and the capacity of the CD271+ bone marrow cells to form 3-dimensional spheres when grown under non-adherent conditions was also investigated. Moreover, the NCSC characteristics of the CD271+ cells were evaluated by their ability to migrate toward human islets as well as human islet-like cell clusters (ICC) derived from pluripotent stem cells.Results: The CD271+ bone marrow population fulfilled the criterion of being multipotent stem cells, having the potential to differentiate into glial cells, neurons as well as myofibroblasts in vitro. They had the capacity to form 3-dimensional spheres as well as an ability to migrate toward human islets, further supporting their NCSC identity. Additionally, we demonstrated similar migration features toward stem cell-derived ICC.Conclusion: The results support the NCSC identity of the CD271-enriched human bone marrow population. It remains to investigate whether the human bone marrow-derived NCSCs have the ability to improve transplantation efficacy of not only human islets but stem cell-derived ICC as well. In the experiment, the researchers used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Category: ethers-buliding-blocks)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem