Month: October 2022

In 2019,Journal of Molecular Structure included an article by Sanad, Sherif M. H.; Hanna, Demiana H.; Mekky, Ahmed E. M.. Recommanded Product: 4637-24-5. The article was titled 《Regioselective synthesis of novel antibacterial pyrazole-benzofuran hybrids: 2D NMR spectroscopy studies and molecular docking》. The information in the text is summarized as follows:

The acetyl derivative bearing benzofuran moiety, its enaminone and different hydrazines are used as synthons for the regioselective synthesis of substituted pyrazoles. Their structures were elucidated by 2D 1H-1H COSY, 1H-1H NOESY and 1H-13C HMBC NMR, spectrometry. Also, a series of novel pyrazole-benzofuran hybrids have been synthesized by the regioselective cycloaddition of enaminone to hydrazonyl chlorides. The series was elucidated by IR, 1H-NMR, 13C-NMR, 2D1H-1H COSY, 1H-1H NOESY and 1H-13C HMBC NMR spectrometry as well as elemental analyses. The series was subjected for testing their antimicrobial activities. Pyrazole derivative I showed the highest inhibitory activity against all different bacterial strains with min. inhibitory concentration values of 7.81, 15.6, 15.6 and 3.91 μg/mL against Staphylococcus aureus, Streptococcus mutans, Escherichia coli and Klebsiella pneumonia, resp., as compared to standard drugs for gram-pos. and neg. bacterial strains. The structure-activity relationship studies and mol. docking were performed to explain the inhibitory activities. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Recommanded Product: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Research on Chemical Intermediates included an article by Salami, Masoumeh; Ezabadi, Ali. Application In Synthesis of 2-Methoxybenzaldehyde. The article was titled 《A caffeine-based ionic liquid as a novel and eco-friendly catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions》. The information in the text is summarized as follows:

A new Bronsted acidic ionic liquid has been synthesized using caffeine and p-toluenesulfonic acid as precursors. The IL was fully characterized by FT-IR, 1H NMR, 13C NMR, MS, elemental anal., as well as Hammett acidity function. The prepared reagent is efficiently able to catalyze the synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions. Various advantages associated with this method include novelty and easy preparation of catalyst, simple work-up procedure and purification, short reaction times, high product yields, and easy recovery and reusability of the catalyst. After reading the article, we found that the author used 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Application In Synthesis of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Chinese Journal of Chemical Physics included an article by Yao, Yong-lin; Zhu, Mei-ying; Zhao, Zhuo; Liu, Wen-gang; Tong, Bi-hai; Li, Ming-yang. SDS of cas: 33100-27-5. The article was titled 《Density functional theory study of selectivity of crown ethers to Li+ in spent lithium-ion batteries leaching solutions》. The information in the text is summarized as follows:

It is a challenge to recover lithium from the leaching solution of spent lithium-ion batteries, and crown ethers are potential extractants due to their selectivity to alkali metal ions. The theor. calculations for the selectivity of crown ethers with different structures to Li ions in aqueous solutions were carried out based on the d. functional theory. The calculated results of geometries, binding energies, and thermodn. parameters show that 15C5 has the strongest selectivity to Li ions in the three crown ethers of 12C4, 15C5, and 18C6. B15C5 has a smaller binding energy but more neg. free energy than 15C5 when combined with Li+, leading to that the lithium ions in aqueous solutions will combine with B15C5 rather than 15C5. The exchange reactions between B15C5 and hydrated Li+, Co2+, and Ni2+ were analyzed and the results show that B15C5 is more likely to capture Li+ from the hydrated ions in an aqueous solution containing Li+, Co2+, and Ni2+. This study indicates that it is feasible to extract Li ions selectively using B15C5 as an extractant from the leaching solution of spent lithium-ion batteries. (c) 2019 American Institute of Physics. In the experiment, the researchers used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5SDS of cas: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. SDS of cas: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Chen, Jie; Guo, Pan; Zhang, Jianguo; Rong, Jiaxin; Sun, Wangbin; Jiang, Yaojia; Loh, Teck-Peng. Name: N,N-Dimethylformamide Dimethyl Acetal. The article was titled 《Synthesis of Functionalized α-Vinyl Aldehydes from Enaminones》. The information in the text is summarized as follows:

An efficient RhII-catalyzed synthesis of functionalized α-vinyl aldehydes with high E/Z stereoselectivity was developed. The reaction mediates the cyclopropanation of enaminones with vinyl carbenoids that are generated from cyclopropenes in situ to give the aminocyclopropane intermediates. Selective C-C bond cleavage of the cyclopropane intermediates leads to formation of α-vinyl aldehyde derivatives with high E/Z selectivity. This method proceeds at room temperature under very mild reaction conditions and works with a broad substrate scope.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Improved Synthetic Process of Dimethyl 4-Oxo-4H-pyran-3,5-dicarboxylate》 were Hu, Xinquan; Ding, An; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Jin, Liqun. And the article was published in Organic Process Research & Development in 2019. Product Details of 4637-24-5 The author mentioned the following in the article:

A reported two-step procedure for preparing di-Me 4-oxo-4H-pyran-3,5-dicarboxylate was extensively optimized. It was found that the reactions can be carried out in toluene as a single solvent and the product was directly obtained by a simple filtration. More importantly, considering potential solvent recovering and recycling, the effluent of the process can be remarkably reduced. This new process facilitated the potential scale-up with com. significance. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Product Details of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Miscible-Immiscible Transition of Deep Eutectic Solvents in Water Switched by CO2》 were Wan, Wenrui; Xiong, Dazhen; Zhang, Qian; Wang, Jianji. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. Application of 150-19-6 The author mentioned the following in the article:

It is very important to develop “”smart”” solvents that can integrate the advantages of homogeneous and heterogeneous reactions into one chem. process for enhanced reaction rate and minimal environmental impact. In designing these solvents, the applicability of the systems to real processes strongly depends on the phase behavior of the systems. In this work, a novel class of CO2 driven miscible-immiscible transition of deep eutectic solvents (DESs) have been explored. These DESs are composed of alkanolamine compounds as hydrogen bond acceptor (HBA) and phenolic compounds as hydrogen bond donor (HBD). They exhibit unique phase behavior with H2O: miscible with water in the absence of CO2, but immiscible with water in the presence of CO2 at room temperature and ambient pressure. Reversible liquid-liquid phase transition of such DESs-H2O mixtures can be realized by alternatively bubbling of CO2 and N2 under ambient conditions. Spectroscopic investigations show that the mechanism behind miscible-immiscible transition of DESs involves breaking of the hydrogen bonds between HBD and HBA by H2CO3 generated by bubbling CO2 through aqueous solution, because the acidity of H2CO3 is stronger than that of HBAs. And then HBAs react with H2CO3 to form ammonium salts. The salting-out effect of ammonium salts leads to the formation of an ammonium-salts-rich top phase and an HBD-rich bottom phase. When CO2 is removed by bubbling of N2, reversible process is achieved. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Application of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Farming thermoelectric paper》 were Abol-Fotouh, Deyaa; Dorling, Bernhard; Zapata-Arteaga, Osnat; Rodriguez-Martinez, Xabier; Gomez, Andres; Reparaz, J. Sebastian; Laromaine, Anna; Roig, Anna; Campoy-Quiles, Mariano. And the article was published in Energy & Environmental Science in 2019. Computed Properties of C10H20O5 The author mentioned the following in the article:

Waste heat to electricity conversion using thermoelec. generators is emerging as a key technol. in the forthcoming energy scenario. Carbon-based composites could unleash the as yet untapped potential of thermoelectricity by combining the low cost, easy processability, and low thermal conductivity of biopolymers with the mech. strength and good elec. properties of carbon nanotubes (CNTs). Here we use bacteria in environmentally friendly aqueous media to grow large area bacterial nanocellulose (BC) films with an embedded highly dispersed CNT network. The thick films (≈10μm) exhibit tuneable transparency and color, as well as low thermal and high elec. conductivity Moreover, they are fully bendable, can conformally wrap around heat sources and are stable above 500 K, which expands the range of potential uses compared to typical conducting polymers and composites. The high porosity of the material facilitates effective n-type doping, enabling the fabrication of a thermoelec. module from farmed thermoelec. paper. Because of vertical phase separation of the CNTs in the BC composite, the grown films at the same time serve as both the active layer and separating layer, insulating each thermoelec. leg from the adjacent ones. Last but not least, the BC can be enzymically decomposed, completely reclaiming the embedded CNTs. After reading the article, we found that the author used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《An efficient base and H2O2 free protocol for the synthesis of phenols in water and oxygen using spinel CuFe2O4 magnetic nanoparticles》 was published in Journal of Coordination Chemistry in 2020. These research results belong to Chutia, Rituparna; Chetia, Bolin. Recommanded Product: m-Methoxyphenol The article mentions the following:

An efficient base and H2O2 free protocol was used for the synthesis of phenols from boronic acids using biogenic CuFe2O4 magnetic nanoparticles as catalyst at room temperature in water and oxygen. The catalyst was prepared using the flowers of Lantana camara. The size of the nanoparticles was 4.27 nm. Base free and ligand free protocol, less time, excellent yields, room temperature, biogenic synthesis of the catalyst, use of O2 as an environmentally friendly oxidant are the advantages of the present protocol. The recyclability of the catalyst was for 5 cycles without loss of magnetic property or catalytic activity. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential》 was published in Current Pharmaceutical Biotechnology in 2020. These research results belong to Mishra, Sonali; Singh, Shilpi; Ali, Arif; Gupta, Amit C.; Shanker, Karuna; Bawankule, Dnyaneshwar U.; Luqman, Suaib. Related Products of 673-22-3 The article mentions the following:

Background: Phenylpropylene biosynthesis pathway plays a crucial role in the vanillin and their derivative(s) production in the plants. The intermediate of vanillin synthesis i.e. cinnamic acid (CA) is converted into 2-Hydroxy 4-MethoxyBenzaldehyde (HMB) in Decalepis arayalpathra having a number of therapeutic value. Objective: Microwave-assisted modifications in cinnamic acid were planned for potential anticancer properties with better yield and efficiency. The present study also confirms the presence of HMB and its precursor i.e. cinnamic acid in D. arayalpathra tubers. Methods: We used a single step Microwave Assisted Synthesis (MAS) to modify cinnamic acid, and then examined the synthetic and natural cinnamic acid derivatives anticancer potential against six human cancer (K-562, WRL-68, A549, A431, MCF-7, and COLO-201) and two normal (L-132 and HEK-293) cell lines at 2, 10 and 50μg/mL concentrations Results: β-bromostyrene and β -nitrostyrene have shown inhibition with IC50 values ranging 0.10-21μM and 0.03-0.06μM, resp. to the cancer cell lines. β-bromostyrene was the most potent anticancer derivative of CA with better cellular safety and biocompatibility. Conclusion: The present study of microwave-assisted synthesis demonstrates a single-step modification in cinnamic acid. MAS is a fast, reliable, and robust method. The resultant compounds have shown in-vitro anticancer activity against human lung carcinoma and breast adenocarcinoma. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Related Products of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Related Products of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Structure-based discovery of novel 4-(2-fluorophenoxy)quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Nan, Xiang; Li, Hui-Jing; Fang, Sen-Biao; Li, Qin-Ying; Wu, Yan-Chao. Formula: C5H13NO2 The article mentions the following:

In this study, two novel series of 6,7-dimethoxy-4-(2-fluorophenoxy)quinoline derivatives containing α-acyloxycarboxamide I [R1 = Me, n-Pr, t-Bu, cyclohexyl, phenyl; R2 = cyclopentyl, 2-thienyl, Ph, etc.] or α-acylaminoamide II [R3 = H, n-Bu, Ph, etc.] scaffolds were designed, synthesized and evaluated for their in-vitro biol. activities against c-Met kinase and four cancer cell lines (H460, HT-29, MKN-45 and MDA-MB-231). Most of the target compounds I and II exhibited moderate to significant potency and possessed selectivity for H460 and HT-29 cancer cell lines. The preliminary structure-activity relationships indicated that α-acyloxycarboxamide or α-acylaminoamide as 5-atom linker contributed to the antitumor potency. Among these compounds, compound I [R1 = t-Bu, R2 = 4-fluorophenyl] (c-Met IC50 = 2.43 nM, a multitarget tyrosine kinase inhibitor) exhibited the most potent inhibitory activities against H460, HT-29 and MDA-MB-231 cell lines with IC50 of 0.14 ± 0.03μM, 0.20 ± 0.02μM and 0.42 ± 0.03μM, which were 1.7-, 1.3- and 1.6-fold more active than foretinib, resp. In addition, concentration-dependent assay and time-dependent assay indicated compound I [R1 = t-Bu, R2 = 4-fluorophenyl] inhibited the proliferation of H460 cell in a time and concentration dependent manner. Moreover, docking studies revealed the common mode of interaction with the c-Met binding site, suggesting that compound I [R1 = t-Bu, R2 = 4-fluorophenyl] is a potential candidate for cancer therapy deserving further study. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem