Month: October 2022

The author of 《Enantioselective Palladium-Catalyzed Cross-Coupling of α-Bromo Carboxamides and Aryl Boronic Acids》 were Li, Bowen; Li, Tiejun; Aliyu, Muinat A.; Li, Zhen Hua; Tang, Wenjun. And the article was published in Angewandte Chemie, International Edition in 2019. HPLC of Formula: 10365-98-7 The author mentioned the following in the article:

We herein report an enantioselective palladium-catalyzed cross-coupling between α-bromo carboxamides and aryl boronic acids, generating a series of chiral α-aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asym. palladium-catalyzed coupling of α-bromo carbonyl compounds In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Ni0 NPs anchored on acid-activated montmorillonite (Ni0-Mont) as a highly efficient and reusable nanocatalyst for synthesis of biscoumarins and bisdimedones》 were Rahmani, Soleiman; Zeynizadeh, Behzad. And the article was published in Research on Chemical Intermediates in 2019. Electric Literature of C8H8O2 The author mentioned the following in the article:

Ni0 nanoparticles were immobilized on acid-activated montmorillonite (Ni0-Mont) by anchoring Ni(OAc)2·4H2O on modified micro/mesoporous montmorillonite followed by reduction with ethylene glycol. The prepared clay composite system was then characterized using Fourier-transform IR (FT-IR) spectroscopy, SEM, energy-dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) anal., and Brunauer-Emmett-Teller (BET) anal. SEM anal. revealed perfect dispersion of metallic nickel nanoparticles with size distribution of 6-41 nm on the clay matrix. Micro/mesoporous montmorillonite was prepared by activation of Na+-montmorillonite with HCl (4 M) under controlled conditions. The catalytic activity of the prepared Ni0-Mont clay was studied in one-pot microwave-assisted synthesis of biscoumarins and bisdimedones via Knoevenagel reaction of aromatic aldehydes with 4-hydroxycoumarin or dimedone in solvent-free conditions. All reactions were carried out at room temperature within 5-15 min (for biscoumarins) and 5-20 min (for bisdimedones) to afford the products in high to excellent yield. The reusability of the Ni0-Mont catalyst was also investigated in seven consecutive cycles, without significant loss of catalytic activity. In the experimental materials used by the author, we found 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
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《Manganese-Catalyzed Hydroarylation of Unactivated Alkenes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Liu, Ting; Yang, Yunhui; Wang, Congyang. Name: 3-Methoxyphenylboronic acid The article mentions the following:

Transition-metal-catalyzed hydroarylation of unactivated alkenes with strategic use of remote coordinating functional groups has received significant attention recently to address the issues of both low reactivity and poor selectivity. The bidentate 8-aminoquinoline amide group is the most successfully adopted in unactivated alkenes for Pd and Ni catalysis. The authors describe the first manganese-catalyzed hydroarylation of unactivated alkenes bearing diverse simple functionalities with arylboronic acids. A series of δ- and γ-arylated amides, ketones, pyridines, and amines was accessed with excellent regioselectivity and in high yields. Hydroalkenylation of unactivated alkenes also is applicable under this manganese-catalysis regime. The method features earth-abundant manganese catalysis, easily available substrates, broad functional-group tolerance, and excellent regioselective control. The results came from multiple reactions, including the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Name: 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Name: 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Adverse events related to topical drug treatments for acne vulgaris》 was published in Expert Opinion on Drug Safety in 2020. These research results belong to Otlewska, Agnieszka; Baran, Wojciech; Batycka-Baran, Aleksandra. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The article mentions the following:

A review. : Acne vulgaris is a widespread skin disease. Topical therapy is a standard treatment for mild to moderate acne. Given the complex pathophysiol. of acne, various agents with complementary action are nowadays frequently combined to increase the efficacy of therapy.: This review focus on safety profile of topical agents used for the treatment of acne vulgaris, including topical retinoids, benzyl peroxide, azelaic acid, topical antibiotic, and combined agents. Data from clin. trials but also metanalyses, systematic reviews, and other secondary analyses are presented.: In general, topical agents used for acne vulgaris have a favorable safety profile. The most commonly reported AEs were associated with local skin irritation, usually mild to moderate in intensity, intermittent, and rarely led to the cessation of therapy. Irritative potential seems to be highest for BPO and topical retinoids. Due to the possibility of development of Cutibacterium acnes resistance, topical antibiotics should not be used in monotherapy but as a part of combination therapy. In female adolescent and adults of childbearing potential, topical retinoids should be used with caution, because they are contraindicated in pregnant females (FDA Pregnancy category) C (adapalene, tretinoin) and X (tazarotene). In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies》 was written by Othman, Ismail M. M.; Gad-Elkareem, Mohamed A. M.; Anouar, El Hassane; Snoussi, Mejdi; Aouadi, Kaiss; Kadri, Adel. Category: ethers-buliding-blocks And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

Thirteen fused pyridine derivatives have been designed, synthesized. Their in vitro antimicrobial activity was investigated against some pathogenic bacteria and fungi and the majority of them showed excellent to moderate activity, especially compounds I and II displaying the potent inhibitory effect against K. pneumoniae with MIC values of 2.44 mM and 8.10 mM, resp. Their pharmacokinetic assessment also revealed promising druglikeness characteristics and ADME properties. The binding interactions of the most active analogs were performed through mol. docking against Staphylococcus aureus tyrosyl-tRNA synthetase. Results revealed that the enhanced activity of compound I can be modulated by the establishment, in 10-tyrosyltRNA synthetase complex, of hydrogen bond interactions between the lone pair of sulfur atom of the thiophen-3-amine ring and the hydrogen atom of the hydroxyl group of TYR 170 of 3.80 Å . These findings suggest that analogs I and II can be served as best candidates for designing and discovering of novel antimicrobial agents. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Green synthesis of 1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives using a new bifunctional base-ionic liquid hybrid magnetic nanocatalyst》 was written by Hamidinasab, Mahdia; Bodaghifard, Mohammad Ali; Mobinikhaledi, Akbar. Synthetic Route of C8H8O2 And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

The ionic liquid-base N,N,2,2,6,6-hexamethyl-N-(3-(trimethoxysilyl)propyl)piperidin-4-ammonium iodide was grafted onto titana-coated NiFe2O4 nanoparticles for obtaining an efficient and reusable ionic liquid-base hybrid nanocatalyst. The structure of hybrid nanoparticles was characterized using FT-IR (Fourier-transform IR spectroscopy), field emission SEM, EDS (energy-dispersive X-ray spectroscopy), EDS map scan, Brunauer-Emmett-Teller surface area anal., CHN (elemental anal.), vibrating sample magnetometer and thermogravimetric anal. techniques. Furthermore, this novel hybrid catalyst was used in one-pot three-component synthesis of 3-amino-1-aryl-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives I [R = H, 2-Cl, 4-NO2, etc.] under green and environmentally benign conditions. This protocol avoids the use of harmful catalysts, toxic solvents and harsh reaction conditions. The products were synthesized in excellent yields within short reaction time and identified using elemental anal., FT-IR, 1H NMR and 13C NMR spectroscopies. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Changyuan; Qiu, Yun; Zhang, Jiantao; Chen, Lulu; Xu, Shuting; Guo, Huosheng; Luo, Jian; Tan, Yao published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《CAN-mediated Oxidative Coupling-Reaction of Xanthenes with Enaminones》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:

An efficient CAN-mediated C-C bond formation in the oxidative reactions of xanthenes with enaminones under mild reaction conditions was described. A variety of 9H-xanthene-9-ylidene aldehydes I [R = H, 2-Cl, 3-Ph, etc.; R1 = Ph, 2-thienyl, cyclohexyl, etc.; X = O, NMe, S] could be synthesized in up to 90% yield via one-pot manner with good functional group compatibility, which achieved the simultaneous construction of carbon-carbon double bond and carbon-oxygen double bond. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Weirich, Luisa; Merten, Christian published their research in Physical Chemistry Chemical Physics in 2021. The article was titled 《Induced VCD and conformational chirality in host-guest complexes of a chiral ammonium salt with crown ethers》.Name: 1,4,7,10,13-Pentaoxacyclopentadecane The article contains the following contents:

The hydrogen bonded complexes of the chiral ammonium salt α-methylbenzyl ammonium chloride (MBA-H+Cl-) and the achiral crown ethers 18c6 and 15c5 serve as model systems to investigate the effect of host-guest complex formation on the conformational preferences of the macrocycles. We demonstrate that the intermol. interactions result in new VCD signatures, that can be assigned to vibrational modes of the crown ethers. Based on a detailed conformational anal., we investigate the origin of these signatures and discuss induced VCD (iVCD) and conformational chirality as possible sources of VCD intensity. The macrocycle in the MBA-H+/18c6 complex prefers either an achiral D3d-sym. conformation, which gives rise to iVCD, or chiral conformations, that feature individual contributions to the VCD spectrum. For the MBA-H+/15c5 complex, the contributions of the macrocycle to the VCD signatures are less pronounced and found to arise solely from conformational chirality. Therefore, anal. of the VCD signatures confirms that the small chiral guest mol. is able to affect the conformational preferences of a macrocyclic host. The study thus demonstrates the suitability of VCD spectroscopy for the characterization of analogous supramol. host-guest complexes. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Name: 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Name: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

McKee, Nida A.; McKee, Michael L. published their research in Physical Chemistry Chemical Physics in 2021. The article was titled 《Evaluation of packing single and multiple atoms and molecules in the porous organic cage CC3-R》.Application of 33100-27-5 The article contains the following contents:

The absorption of multiple atoms and mols., including Kr, Xe, CH4, CO2, C2H2, H2O, and SF6, within CC3-R, a Porous Organic Cage (POC), was calculated and analyzed. The CC3-R mol. has one central cavity and four window sites. Most adsorbents were modeled with either one unit in the central cavity, four units in the window sites, or with five units in both sites. For Xe, the most favorable site was the central one. The CO2 mol. binds about 3 kcal mol-1 in free energy more strongly than CH4 in the central cavity of CC3-R at 300 K which may be enough to allow useful discrimination. Four C2H2 units and four CO2 units are calculated to bind similarly inside CC3-R (ΔH(298 K) = -8.6 and -7.7 kcal mol-1 per unit, resp.). Since H2O is smaller, more waters can easily fit inside. For twelve water mols., the binding enthalpy per water is ΔH(298 K) = -16.4 kcal mol-1. For comparison, the binding enthalpy of (H2O)12 at the same level of theory (B3LYP/6-31G(d,p)-D3BJ//M06-2X/6-31G(d)) is predicted to be -12.3 kcal mol-1 per water. Finally, the dimerization of CC3-R and the association of CC3-R with CC3-S was studied as well as 3 to 9 iodine atoms enclosed in CC3-R. In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application of 33100-27-5) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xavier, Tania; Pichon, Christophe; Presset, Marc; Le Gall, Erwan; Condon, Sylvie published an article in 2021. The article was titled 《Efficient Preparation of Methyl 2-Oxo-3-aryl (heteroaryl)-2H-pyran-5-carboxylate via Pd-Catalyzed Negishi Coupling》, and you may find the article in European Journal of Organic Chemistry.Application In Synthesis of 1-Bromo-3-methoxybenzene The information in the text is summarized as follows:

Me 3-bromocoumalate, readily obtained from Me 2-pyrone-5-carboxylate (Me coumalate), is easily substituted by cross-coupling reactions with arylzinc reagents ArZnBr (R = Ph, 3-acetylphenyl, thiophen-2-yl, etc.) under palladium catalysis, leading to Me 2-oxo-3-aryl (heteroaryl)-2H-pyran-5-carboxylates I. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application In Synthesis of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Application In Synthesis of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem