Month: October 2022

In 2019,Journal of the American Chemical Society included an article by Xu, Jiancong; Chen, Jingjing; Gao, Feng; Xie, Shuguang; Xu, Xiaohua; Jin, Zhong; Yu, Jin-Quan. Related Products of 150-19-6. The article was titled 《Sequential Functionalization of meta-C-H and ipso-C-O Bonds of Phenols》. The information in the text is summarized as follows:

The use of a template as a linchpin motif in directed remote C-H functionalization is a versatile yet relatively underexplored strategy. We have developed a template-directed approach to realizing one-pot sequential palladium-catalyzed meta-selective C-H olefination of phenols, and nickel-catalyzed ipso-C-O activation and arylation. Thus, this bifunctional template converts phenols to synthetically useful 1,3-disubstituted arenes. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Related Products of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRelated Products of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Chinese Journal of Chemical Engineering included an article by Han, Hongjing; Li, Jinxin; Wang, Haiying; Xue, Feng; Chen, Yanguang; Zhang, Yanan; Wang, Yizhen; Zhang, Mei. Recommanded Product: m-Methoxyphenol. The article was titled 《Catalytic depolymerization of calcium lignosulfonate by NiMgFeOx derived from sub-micron sized NiMgFe hydrotalcite prepared by introducing hydroxyl compounds》. The information in the text is summarized as follows:

A new method for regulating the synthesis of NiMgFe hydrotalcites (NMF LDHs) with the addition of hydroxyl compounds was proposed. A series of NMF LDHs were prepared by the above method, and then were calcined to obtain the NiMgFeOx(NMFOx) samples. The NMFOxsamples were characterized by XRD, SEM, TG-DTG, XPS and CO2-TPD, resp. The catalytic performance of NMFOx for depolymerizing calcium lignosulfonate (CLS) was evaluated by hydrothermal reaction. The results showed that the addition of hydroxyl compounds favored reducing the particle sizes of NMF LDHs. For the depolymerization of CSL, the yield of liquid product increased from 45% to 75.8% with the addition of NMFOx-ethanol (NMFOxET). The liquid products were mainly phenolics, aromatics, ketones and esters. The total selectivity of oxy-containing compounds was over 90.6%, among them, the phenolics were approx. 35.2%. The valence of Ni and Fe, crystalline phase and basicity almost remained unchanged. The NMFOx-ET samples were recycled for the depolymerization of CLS, moreover, the NMFOx-ET samples had high activity and stability after 4 cycles. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Wang, Huamin; Zhang, Junyou; Tu, Youshao; Zhang, Junliang. Related Products of 673-22-3. The article was titled 《Phosphine-Catalyzed Enantioselective Dearomative [3+2]-Cycloaddition of 3-Nitroindoles and 2-Nitrobenzofurans》. The information in the text is summarized as follows:

Over the past years, the metal-catalyzed dearomative cycloaddition of 3-nitroindoles and 2-nitrobenzofurans have emerged as a powerful protocol to construct chiral fused heterocyclic rings. However, organocatalytic dearomative reaction of these two classes of heteroarenes has become a long-standing challenging task. Herein, a report on the first example of phosphine-catalyzed asym. dearomative [3+2]-cycloaddition of 3-nitroindoles and 2-nitrobenzofurans, which provides a new, facile, and efficient protocol for the synthesis of chiral 2,3-fused cyclopentannulated indolines and dihydrobenzofurans by reacting with allenoates and MBH carbonates, resp. through a dearomative [3+2]-cycloaddn has been described. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Related Products of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Related Products of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Isolation of cyclic penta(ethylene oxide) from mixtures with its linear analog by combining selective intercalation into graphite oxide and solvent approaches》 were Ruiz, Daniel; Alegria, Angel; Barroso-Bujans, Fabienne. And the article was published in Separation and Purification Technology in 2019. Recommanded Product: 33100-27-5 The author mentioned the following in the article:

Cyclic oligomers of poly(ethylene oxide)s intercalate slower into graphite oxide (GO) than their linear analogs from the melt. In present study these kinetic differences are exploited to isolate 15-crown-5 (15C5) from mixtures with linear penta(ethylene glycol) (5EG) by using 2 approaches: (a) melt intercalation and solvent extraction and (b) intercalation from solution and filtration. In both cases fractions highly enriched in the cyclic component are obtained by using an appropriate selection of the solvent. Solvents that do not penetrate the interlayer space of GO (such as CCl4 and toluene) increases the cyclic fraction from 50% in the initial mixture to values ≤99%. On the contrary, solvents that penetrate the interlayer space of GO produce fractions with low content of 15C5. The ability of nonpenetrating solvents to achieve an effective isolation of 15C5 demonstrates that separation is driven by a faster intercalation of 5EG into unswollen GO, without solvent assistance, and the permanence of 15C5 in solution These results are discussed in the light of data collected by x-ray diffraction, DSC and gel permeation chromatog. This study provides substantial evidence of a very promising separation method for a topol. purification of cyclic poly(ethylene oxide)s with GO. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Aza-Piancatelli Cyclization as a Platform for the Preparation of Scaffolds of Natural Compounds: Application to the Total Synthesis of Bruceolline D》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Marin, Lucile; Force, Guillaume; Gandon, Vincent; Schulz, Emmanuelle; Leboeuf, David. Application of 60656-87-3 The article mentions the following:

The aza-Piancatelli cyclization provides an expedient synthesis of 4-aminocyclopentenone building blocks that may be converted into aminocyclopentitols, which are heavily represented motifs among natural products. However, its use as a key step in total synthesis was still unprecedented. Here, we disclose our in-depth investigations regarding this reaction in order to access highly complex structures representing the core of some natural mols. The applicability of the cyclization was highlighted by the 3-step total synthesis of bruceolline D. Thus, we anticipate that this work will lay the ground for further applications in total synthesis. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application of 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Application of 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Gold-Catalyzed Chemoselective Couplings of Polyfluoroarenes with Aryl Germanes and Downstream Diversification》 was published in Journal of the American Chemical Society in 2020. These research results belong to Dahiya, Amit; Fricke, Christoph; Schoenebeck, Franziska. Quality Control of 1-Iodo-2-methoxybenzene The article mentions the following:

This report describes the chemoselective coupling of polyfluoroarenes with aryl germanes in the presence of aromatic C-I, C-Br, C-Cl, C-OTf, and C-SiMe3 groups, as well as demonstrates the further downstream diversification to give richly functionalized and highly fluorinated polyarenes. The strategy relies on an in situ Umpolung of the FnArH, followed by selective Au(I)/Au(III)-catalyzed coupling with electron-poor or -rich aryl germanes, even in the presence of challenging ortho-substituents, and widens the currently available coupling space in oxidative gold catalysis to previously inaccessible electron-poor/electron-poor biaryls.1-Iodo-2-methoxybenzene(cas: 529-28-2Quality Control of 1-Iodo-2-methoxybenzene) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Quality Control of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors》 was written by Jia, Haiyong; Yu, Ji; Du, Xianhong; Cherukupalli, Srinivasulu; Zhan, Peng; Liu, Xinyong. SDS of cas: 4637-24-5 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

This study focous on scaffold hopping, bioisosterism, and pharmacophore hybrid-based strategies to design and synthesize six series of various heterocycle derivatives (pyrazole, thiazole, pyrazine, pyrimidine, and pyridine) and screened for in vitro anti-HBV non-nucleoside activity. Drug candidate NZ-4 and AT-130 were used as lead compounds Several compounds exhibited prominent anti-HBV activity compared to lead compound NZ-4 and pos. drug Lamivudine, especially compound II-8b, showed the most prominent anti-HBV DNA replication activity (IC50 = 2.2 ± 1.1μM). Also compounds IV-8e and VII-5b showed the best in vitro anti-HBsAg secretion (IC50 = 3.8 ± 0.7μM, CC50 > 100μM) and anti-HBeAg secretion (IC50 = 9.7 ± 2.8μM, CC50 > 100μM) resp. Besides, II-8b was interact HBV capsid protein with good affinity constants (KD = 60.0μM), which was equivalent to lead compound NZ-4 (KD = 50.6μM). The preliminary structure-activity relationships (SARs) of the newly synthesized compounds were summarized, which may help researchers to discover more potent anti-HBV agents. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5SDS of cas: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Supported Palladium-Gold Catalyzed Carbonylative Methylthioesterification of Aryl Iodides using Oxalic acid and DMSO as CO and CH3SH Surrogates》 was written by Sharma, Ajay Kumar; Ram, Shankar; Sheetal; Mehara, Pushkar; Chauhan, Arvind Singh; Das, Pralay. Recommanded Product: 1-Iodo-2-methoxybenzene And the article was included in Asian Journal of Organic Chemistry in 2020. The article conveys some information:

The polystyrene supported palladium-gold (Pd-Au@PS) catalyst was prepared and well characterized by HR-TEM, EDX, Elemental Mapping, XPS and P-XRD anal. The Pd-Au@PS NPs displayed the superior catalytic activity than their monometallic forms. First time, the catalyst was applied for methylthioesterification reaction of aryl iodides RI (R = Ph, 4-methylphenyl, naphthalen-1-yl, thiophen-2-yl, etc.) with oxalic acid and DMSO as in situ carbon monoxide (CO) and Me mercaptan (CH3SH) precursor. Yet, there is no report available where DMSO has been applied as CH3SH source for methylthioester RC(O)SCH3 synthesis. The CH3SH and CO are likely to poison the metal catalyst, whereas in Pd-Au@PS catalyst, the beneficial inter-electronic interaction between Pd and Au metals makes the catalyst highly reactive, poisoning resistant and recyclable during the transformation. Moreover, the developed protocol exhibits excellent functional group tolerance for various aryl iodides to deliver the desired products in moderate to very good yields. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-2-methoxybenzene(cas: 529-28-2Recommanded Product: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Recommanded Product: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hu, Zhiyong; Wei, Xiao-Jing; Handelmann, Jens; Seitz, Ann-Katrin; Rodstein, Ilja; Gessner, Viktoria H.; Goossen, Lukas J. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Coupling of Reformatsky reagents with aryl chlorides enabled by ylide-functionalized phosphine ligands》.Computed Properties of C7H7BrO The article contains the following contents:

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies. In addition to this study using 1-Bromo-3-methoxybenzene, there are many other studies that have used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Computed Properties of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ke, Quanli; Khalil, Ibrahim; Smeyers, Brent; Li, Zheng; de Oliveira-Silva, Rodrigo; Sels, Bert; Sakellariou, Dimitrios; Dusselier, Michiel published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《A Cooperative OSDA Blueprint for Highly Siliceous Faujasite Zeolite Catalysts with Enhanced Acidity Accessibility》.Computed Properties of C10H20O5 The article contains the following contents:

A cooperative OSDA strategy is demonstrated, leading to novel high-silica FAU zeolites with a large potential for disruptive acid catalysis. In bottom-up synthesis, the symbiosis of choline ion (Ch+) and 15-crown-5 (CE) was evidenced, in a form of full occupation of the sodalite (sod) cages with the trans Ch+ conformer, induced by the CE presence. CE itself occupied the supercages along with addnl. gauche Ch+, but in synthesis without CE, no trans was found. The cooperation, and thus the fraction of trans Ch+, was closely related to the Si/Al ratio, a key measure for FAU stability and acidity. As such, a bottom-up handle for lowering the Al-content of FAU and tuning its acid site distribution is shown. A mechanistic study demonstrated that forming sod cages with trans Ch+ is key to the nucleation of high-silica FAU zeolites. The materials showed superior performances to com. FAU zeolites and those synthesized without cooperation, in the catalytic degradation of polyethylene. In the experiment, the researchers used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem