Month: October 2022

COA of Formula: C8H8O2In 2019 ,《CuO nanoparticles as a reusable catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives under solvent-free conditions》 appeared in Journal of the Iranian Chemical Society. The author of the article were Patil, Sonatai; Mane, Ananda; Dhongade-Desai, Savita. The article conveys some information:

Nanostructured CuO was successfully utilized for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives I (R = H, 4-Cl, 4-NO2, etc.) via one-pot multicomponent reaction using phthalhydrazide, malononitrile and aromatic aldehydes under solvent-free conditions. Utilization of non-toxic and inexpensive catalyst, improved yields in short reaction times, wide substrate scope and easy purification of products are the important features of the developed protocol. The CuO nanocatalyst presents good reusability over five catalytic cycles. The experimental process involved the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4COA of Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.COA of Formula: C8H8O2

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Ether | (C2H5)2O – PubChem

Recommanded Product: 60656-87-3In 2022 ,《α,β-Unsaturated β-Methyl-δ-lactones in Nitrile Oxide Cycloaddition Reactions. Synthesis of Saturated Lactones and Lactams》 was published in Russian Journal of Organic Chemistry. The article was written by Mineyeva, I. V.. The article contains the following contents:

New isoxazoline derivatives have been synthesized in high yields by cycloaddition of acetonitrile oxide to α,β-unsaturated β-methyl-δ-lactones. These unsaturated lactones have been used to obtain β-Me branched saturated lactones and lactams, as well as lactones with an inverted configuration of hydroxy group, following the divergent approach. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Recommanded Product: 60656-87-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C5H13NO2In 2020 ,《Controllable Soil Degradation Rate of 5-Substituted Sulfonylurea Herbicides as Novel AHAS Inhibitors》 was published in Journal of Agricultural and Food Chemistry. The article was written by Zhou, Shaa; Meng, Fan-Fei; Hua, Xue-Wen; Li, Yong-Hong; Liu, Bin; Wang, Bao-Lei; Chen, Jie; Chen, An-Liang; Li, Zheng-Ming. The article contains the following contents:

Chlorsulfuron has been applied in wheat fields as a recognized herbicide worldwide, yet it was officially banned in China since 2014 for its soil persistence problem. On the basis of our previous research that 5-dimethylamino distinctively accelerated degradation rate in soils, a modified amino moiety (Ia-c) and monosubstituted amino group (Id-e) were introduced onto the fifth position of the benzene ring in sulfonylurea structures, as well as heterocyclic amino substituents (If-g) to seek a suitable soil degradation rate during such an in situ crop rotation system. Referring to the biol. data and ScAHAS inhibition and ScAHAS docking results, they turned out to be AHAS inhibitors with high potent herbicidal activities. The various influence on soil degradation rate along with crop safety indicated that different substituents on the fifth position have exerted an apparent impact. Their united study of structure-activity-safety-degradation relationship has great potential to provide valuable information for further development of eco-friendly agrochems. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Computed Properties of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Computed Properties of C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: Bis(4-methoxyphenyl)amineIn 2020 ,《Doped but Stable: Spirobisacridine Hole Transporting Materials for Hysteresis-Free and Stable Perovskite Solar Cells》 was published in Journal of the American Chemical Society. The article was written by Drigo, Nikita; Roldan-Carmona, Cristina; Franckevicius, Marius; Lin, Kun-Han; Gegevicius, Rokas; Kim, Hobeom; Schouwink, Pascal A.; Sutanto, Albertus A.; Olthof, Selina; Sohail, Muhammad; Meerholz, Klaus; Gulbinas, Vidmantas; Corminboeuf, Clemence; Paek, Sanghyun; Nazeeruddin, Mohammad Khaja. The article contains the following contents:

Four spirobisacridine (SBA) hole-transporting materials were synthesized and employed in perovskite solar cells (PSCs). The mols. bear electronically inert alkyl chains of different length and bulkiness, attached to in-plane N atoms of nearly orthogonal spiro-connected acridines. Di-p-methoxyphenylamine (DMPA) substituents tailored to the central SBA-platform define electronic properties of the materials mimicking the structure of the benchmark 2,2′,7,7′-tetrakis(N,N-di-4-methoxyphenylamino)-9,9′-spirobifluorene (spiro-MeOTAD), while the alkyl pending groups affect mol. packing in thin films and affect the long-term performance of PSCs. Devices with SBA-based hole transporting layers (HTL) attain efficiencies on par with spiro-MeOTAD. More importantly, solar cells with the new HTMs are hysteresis-free and demonstrate good operational stability, despite being doped as spiro-MeOTAD. The best performing MeSBA-DMPA retained 88% of the initial efficiency after a 1000 h aging test under constant illumination. The results clearly demonstrate that SBA-based compounds are potent candidates for a design of new HTMs for PSCs with improved longevity. The experimental process involved the reaction of Bis(4-methoxyphenyl)amine(cas: 101-70-2Name: Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Name: Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: N,N-Dimethylformamide Dimethyl AcetalIn 2022 ,《New Synthesis of Tetrahydroisoquinolines》 was published in Russian Journal of Organic Chemistry. The article was written by Dyachenko, I. V.; Dyachenko, V. D.; Dorovatovskii, P. V.; Khrustalev, V. N.; Nenajdenko, V. G.. The article contains the following contents:

The reaction of cyclohexylidenecyanothioacetamide with N,N-dimethylformamide di-Me acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is formed, and refluxing in benzene leads to 2-cyano-3-(dimethylamino)prop-2-enethioamide. The structure of these products was studied by XRD analysts. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Name: N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease》 was written by Kalindjian, S. Barret; Kadnur, Sanjay V.; Hewson, Christopher A.; Venkateshappa, Chandregowda; Juluri, Suresh; Kristam, Rajendra; Kulkarni, Bheemashankar; Mohammed, Zainuddin; Saxena, Rohit; Viswanadhan, Vellarkad N.; Aiyar, Jayashree; McVey, Donna. Recommanded Product: 5-Methoxy-4-methylpyridin-3-amine And the article was included in Journal of Medicinal Chemistry on April 14 ,2016. The article conveys some information:

Chemokine receptor 9 (CCR9), a cell surface chemokine receptor which belongs to the G protein-coupled receptor, 7-trans-membrane superfamily, is expressed on lymphocytes in the circulation and is the key chemokine receptor that enables these cells to target the intestine. It has been proposed that CCR9 antagonism represents a means to prevent the aberrant immune response of inflammatory bowel disease in a localized and disease specific manner and one which is accessible to small mol. approaches. One possible reason why clin. studies with vercirnon, a prototype CCR9 antagonist, were not successful may be due to a relatively poor pharmacokinetic (PK) profile for the mol. We wish to describe work aimed at producing new, orally active CCR9 antagonists based on the 1,3-dioxoisoindoline skeleton. This study led to a number of compounds that were potent in the nanomolar range and which, on optimization, resulted in several possible preclin. development candidates with excellent PK properties. In the experimental materials used by the author, we found 5-Methoxy-4-methylpyridin-3-amine(cas: 77903-28-7Recommanded Product: 5-Methoxy-4-methylpyridin-3-amine)

5-Methoxy-4-methylpyridin-3-amine(cas: 77903-28-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 5-Methoxy-4-methylpyridin-3-amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays》 was written by Parodi, Alice; Righetti, Giada; Pesce, Emanuela; Salis, Annalisa; Tasso, Bruno; Urbinati, Chiara; Tomati, Valeria; Damonte, Gianluca; Rusnati, Marco; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico. Quality Control of N,N-Dimethylformamide Dimethyl AcetalThis research focused onVX809 hybrid derivative preparation cystic fibrosis CFTR F508del; Aminoarylthiazole; CFTR Corrector; Cystic fibrosis; Docking; F508del-CFTR; Surface plasmon resonance. The article conveys some information:

Cystic fibrosis (CF) is the autosomal recessive disorder most recurrent in Caucasian populations. It is caused by different mutations in the cystic fibrosis transmembrane regulator protein (CFTR) gene, with F508del being the most common. During the last years, small-mol. therapy chosen to contrast CF relied on compounds that correct CFTR misfolding and ER retention (correctors such as VX-809), or defective channel gating (potentiators such as VX-770). Combination therapy with the two series of drugs has been applied, leading to the approval of several multi-drugs such as Orkambi. Despite this, this treatment proved to be only partially effective making the search for novel modulators an urgent need to contrast CF. Recently, we reported compound 2a as reference compound of a series of aminoarylthiazole-VX-809 hybrid derivatives exhibiting promising F508del-CFTR corrector ability. Herein, we report exploring the docking mode of the prototype VX-809 and of 2a in order to derive useful guidelines for the rational design of novel optimized analogs. To demonstrate exptl. their effective F508del-CFTR-binding and rescuing potential, the most promising derivatives had been synthesized and evaluated in biol. assays including YFP functional assay on F508del-CFTR CFBE41o-cells, trans epithelial elec. resistance (TEER) and surface plasmon resonance (SPR). This multidisciplinary strategy led to the discovery of a second series of hybrids including 7j and 7m endowed with higher potency than the prototype. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of 4-trifluoromethyl-2H-chromenes via the reaction of 2-(trifluoroacetyl)phenols with vinyltriphenylphosphonium chloride》 was written by Golubev, Alexander S.; Ostapchuk, Petr N.; Strelkova, Tatiana V.; Kagramanov, Nikolai D.; Suponitsky, Kyrill Yu.; Takazova, Rina U.; Chkanikov, Nikolai D.. Category: ethers-buliding-blocksThis research focused ontrifluoroacetyl phenol vinyltriphenylphosphonium chloride Schweizer reaction; trifluoromethyl chromene preparation. The article conveys some information:

Substituted on the benzene ring 4-CF3-2H-chromenes were prepared from substituted 2-(trifluoroacetyl)phenols and vinyltriphenylphosphonium chloride according to the Schweizer protocol in moderate to excellent yields. The influence of the type and the position of aromatic ring substituents on yields of 4-CF3-2H-chromenes were investigated. It was shown that 4-CF3-2H-chromenes were convenient precursors to 4-CF3-coumarins. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Category: ethers-buliding-blocks)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cheng, Chen; Hartwig, John F. published an article on February 21 ,2014. The article was titled 《Rhodium-Catalyzed Intermolecular C-H Silylation of Arenes with High Steric Regiocontrol》, and you may find the article in Science (Washington, DC, United States).Electric Literature of C14H21BO3 The information in the text is summarized as follows:

Regioselective C-H functionalization of arenes has widespread applications in synthetic chem. The regioselectivity of these reactions is often controlled by directing groups or steric hindrance ortho to a potential reaction site. Here, authors report a catalytic intermol. C-H silylation of unactivated arenes that manifests very high regioselectivity through steric effects of substituents meta to a potential site of reactivity. The silyl moiety can be further functionalized under mild conditions but is also inert toward many common organic transformations, rendering the silylarene products useful building blocks. The remote steric effect that we observe results from the steric properties of both the rhodium catalyst and the silane. In the experiment, the researchers used 2-(4-Methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 214360-63-1Electric Literature of C14H21BO3)

2-(4-Methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 214360-63-1) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Electric Literature of C14H21BO3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2014,Liu, Zhenzhen; Lin, Qiuning; Sun, Yun; Liu, Tao; Bao, Chunyan; Li, Fuyou; Zhu, Linyong published 《Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo-Uncaged-Thiol Michael Addition Reaction [Erratum to document cited in CA161:181639]》.Advanced Materials (Weinheim, Germany) published the findings.Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Due to an error in the mol. structure, the macrocycles in the Table of Contents, Scheme 1, and Figure S1 were incorrect; the corrected structure is given. In the experiment, the researchers used many compounds, for example, tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem