Month: October 2022

De Smet, Gilles; Bai, Xingfeng; Mensch, Carl; Sergeyev, Sergey; Evano, Gwilherm; Maes, Bert U. W. published an article in 2022. The article was titled 《Selective Nickel-Catalyzed Hydrodeacetoxylation of Aryl Acetates》, and you may find the article in Angewandte Chemie, International Edition.Recommanded Product: m-Methoxyphenol The information in the text is summarized as follows:

Ni-catalyzed hydrodeacetoxylation of aryl acetates (Ar-OAc) with HBpin in a green carbonate solvent selectively delivered the corresponding deoxygenated arenes (ArH). The method was also applicable to highly challenging guaiacyl and syringyl acetates, leaving -OMe groups intact without arene reduction Renewable 4-propylguaiacol obtained from pine could also be transformed without significant loss in yield vs. oil derived feedstock. The observed chemoselectivity for Ar-OAc vs. ArO-Ac bond cleavage was rationalized based on mechanistic experiments and DFT calculations ArOH side-product formation was attributed to direct competitive Ni-catalyzed reduction of the C=O bond. Hydrodeacyloxylation of a set of aryl alkanoates featured interesting chemoselectivity with a dramatic influence of the length and structure of the alkyl chain on catalysis. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,AL-Shammri, Khairiah Nasser; Elkanzi, Nadia A. A.; Arafa, Wael A. A.; Althobaiti, Ibrahim O.; Bakr, Rania B.; Moustafa, Shaima Mohamed Nabil published an article in Arabian Journal of Chemistry. The title of the article was 《Novel indan-1,3-dione derivatives: Design, green synthesis, effect against tomato damping-off disease caused by Fusarium oxysporum and in silico molecular docking study》.Category: ethers-buliding-blocks The author mentioned the following in the article:

An effective method for synthesizing series of twenty-two new compounds was performed starting from reaction of 1,2,3-indenetrione thiourea, and Et cyanoacetate under microwave irradiation and / or 2-(1,3-dioxo-1H-inden-2(3H)-ylidene) hydrazine carbothioamide with acetic anhydride. The designed new compounds have been successfully examined in-vitro for their antifungal activities. The relation between the structure of the synthesized compounds and their activity against tomato damping-off disease caused by Fusarium oxysporum fungi was studied and favorable results were obtained. The antifungal studies indicated that few compounds exerted the highest antifungal activities, while 7′-thioxo-7′,8′-dihydrospiro[indene-2,5′-pyrimido[4,5-d][1,3]oxazine]-1,3,4′(6’H)-trione and Et 6′-(4-hydroxybenzylideneamino)-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro [indene-2,4′-pyrimidine]-5′-carboxylate recorded the lowest effect. The obtained results confirmed the possibility of the application of Et 6′-amino-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro[indene-2,4′-pyrimidine]-5′-carboxylate as a new effective regulator of the vegetative growth of tomatoes. The mol. docking anal. was performed within succinate dehydrogenase (SDH) as a target enzyme in order to rationalize the promising findings obtained for the active compounds In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Ravuru, Shanmuk Srinivas; Jana, Animesh; De, Sirshendu published an article in Advanced Materials Interfaces. The title of the article was 《Discretization and Encapsulation of Palladium inside the Cavity of Crown Ether within the Interlayer of Layered Double Hydroxide for Enhanced Activity: A Case Study with Hydrogenation Reaction》.Electric Literature of C10H20O5 The author mentioned the following in the article:

The activity of the noble metal-based heterogeneous catalysts is limited by weak metal-support interactions, aggregation, and low surface to volume (S/V) ratio. The activity can be augmented in many ways. Among them, the discretization of the active sites and redistribution of electron d. around the metal atom is an important one. In this work, these two phenomena are studied concerning a model reaction, hydrogenation of p-nitrophenol (p-NP). Herein, 1,4,7,10,13-pentaoxacyclopentadecane ether is introduced in the basal space of layered double hydroxide (LDH) to encapsulate noble Pd0 atom inside the cavity of the crown mol. strategically. The modified LDH (Pda-ECC-L0.10@in situ CoAl LDH) augments the properties, like, high S/V ratio and nonaggregation of active sites by forming nonagglomerative discrete catalytic (DNSC) sites within the cavity of crown ether in the basal space. The developed catalyst exhibits higher turnover frequency demonstrating the improved activity due to the formed DNSC sites and redistributes electron d. around the Pd atoms by LDH layers and crown mols. Thus, the present material synthesis route can be considered as a stand-alone method for preparation of the supported sub-nanometer noble metal catalyst with higher activity and can be exploited for reactions where noble metal catalyst are used. In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Electric Literature of C10H20O5) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Electric Literature of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2020 ,《Highly functionalized N-1-(2-pyridinylmethyl)-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: Synthesis, characterization, crystal structure and DFT studies》 appeared in Journal of Molecular Structure. The author of the article were Al-thamili, Dhaifallah M.; Almansour, Abdulrahman I.; Arumugam, Natarajan; Kansiz, Sevgi; Dege, Necmi; Soliman, Saied M.; Azam, Mohammad; Kumar, Raju Suresh. The article conveys some information:

Highly functionalized N-1-(2-pyridinylmethyl)-3,5-bis[(E)-2-methoxy/fluorophenylmethylidene]-tetrahydro-4(1H)-pyridinone have been synthesized in good yields. The mol. structure of the synthesized compounds was elucidated by NMR spectroscopy and further confirmed by single crystal X-ray crystallog. studies. The Hirshfeld anal. reveals that the mol. packing of N-1-(2-Pyridinylmethyl)-3,5-bis[(E)-(2-methoxylphenyl)methylidene]tetrahydro-4(1H)-pyridinone is mainly controlled by N…H (4.9%), C…H (30.6%) and H…H (52.4%) contacts, whereas the mols. are packed by strong F…H (16.8-16.9%), N…H (5.4%) and O…H (5.2-5.4%) as well as weak C…C (3.9-4.5%), H…H (39.7-39.9%) and C…H (24.8-25.8%) contacts in N-1-(2-Pyridinylmethyl)-3,5-bis[(E)-(4-fluorophenyl)methylidene]tetrahydro-4(1H)-pyridinone. DFT calculations are used in order to predict the electronic properties of studied compounds The NMR data obtained exptl. correlated well with the calculated findings. In the experimental materials used by the author, we found 2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 673-22-3In 2021 ,《Unsymmetrical Pyridoxal-Based Bisazomethines》 appeared in Russian Journal of General Chemistry. The author of the article were Bagautdinova, R. H.; Kibardina, L. K.; Burilov, A. R.; Pudovik, M. A.. The article conveys some information:

The reaction of equimolar amounts of pyridoxal and 1,2-propylenediamine led to the formation of monoimine I, which exists as cyclic imidazolidine tautomer II. The latter reacts with aromatic aldehydes ArCHO to form unsym. bisazomethines, e.g., III. The reaction of II with Ph isocyanate produces a compound containing a carbamate group, IV, and the reaction with hydrochloric acid leads to the formation of a salt-based furopyridine. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C10H20O5In 2019 ,《Tunable Reduction of 2,4,6-Tri(4-pyridyl)-1,3,5-Triazine: From Radical Anion to Diradical Dianion to Radical Metal-Organic Framework》 appeared in Angewandte Chemie, International Edition. The author of the article were Tang, Shuxuan; Ruan, Huapeng; Feng, Rui; Zhao, Yue; Tan, Gengwen; Zhang, Li; Wang, Xinping. The article conveys some information:

The reduction of 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT) with alkali metals resulted in four radical anion salts (1, 2, 4 and 5) and one diradical dianion salt (3). Single-crystal x-ray diffraction and ESR spectroscopy reveal that 1 contains the monoradical anion TPT.- stacked in one-dimensional (1D) with K+(18c6) and 2 can be viewed as a 1D magnetic chain of TPT.-, while 4 and 5 form radical metal-organic frameworks (RMOFs). 1D pore passages, with a diameter of 6.0 Å, containing solvent mols. were observed in 5. Variable-temperature EPR measurements show that 3 has an open-shell singlet ground state that can be excited to a triplet state, consistent with theor. calculation The work suggests that the direct reduction approach could lead to the formation of RMOFs. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Synthetic Route of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Synthetic Route of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 673-22-3In 2020 ,《Indian sarsaparilla, Hemidesmus indicus (L.) R. Br. ex Schult: tissue culture studies》 appeared in Applied Microbiology and Biotechnology. The author of the article were Kher, Mafatlal M.; Shekhawat, Mahipal S.; Nataraj, M.; Teixeira da Silva, Jaime A.. The article conveys some information:

A review. Abstract: Hemidesmus indicus (L.) R. Br. ex Schult is commonly known as anantmul or Indian sarsaparilla. The roots of this plant, which display a wide range of medicinal, biol., and phytopharmaceutical properties, are used in the pharmaceutical and food industries. Conventionally, the plant is propagated by seed germination or vegetatively, but the efficacy of traditional methods has some limitations: plants derived from seed germination are prone to seed-borne diseases, or plantlet production using vegetative propagation is limited. In contrast, plant tissue culture allows for large-scale propagation and secondary metabolite production in vitro without sacrificing plants from their natural habitats. Many efforts have been made over 40 years of research to establish efficient micropropagation protocols to speed up cultivation of this plant, including callus-mediated in vitro propagation, somatic embryogenesis, and shoot multiplication using cotyledenory nodes, stem segments, shoot tips, and nodal explants. Among these explants, nodal explants are the most commonly used for H. indicus micropropagation. The application of adenine sulfate, citric acid, ascorbic acid, and arginine may be useful in preventing explant browning, premature leaf senescence, and shoot tip abscission during in vitro culture. This review provides insight into micropropagation, use of synthetic seeds for short-term germplasm preservation, and in vitro production of secondary metabolites such as 2-hydroxy-4-methoxybenzaldehyde, lupeol, vanillin, and rutin, from in vitro root and callus cultures. Furthermore, unexplored and possible innovative areas of research in Hemidesmus biotechnol. are also discussed. Key Points: • Hemidesmus indicus has multiple therapeutic applications. • H. indicus roots are used in confectionary and pharmacy. • This review comprehensively assesses H. indicus tissue culture. • Challenges and future research of H. indicus biotechnol. are discussed. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 4637-24-5In 2022 ,《Regio- and stereoselective synthesis of spiro-heterocycles bearing the pyrazole scaffold via [3+2] cycloaddition reaction》 was published in Journal of Molecular Structure. The article was written by Islam, Mohammad Shahidul; Haukka, Matti; Soliman, Saied M.; Al-Majid, Abdullah Mohammed; Rahman, A. F. M. Motiur; Bari, Ahmed; Barakat, Assem. The article contains the following contents:

The utility of one-pot multicomponent based [3+2] cycloaddition reaction transformation to prepare a new two hybrids of spirooxindoles engrafted with pyrazole skeleton I (R1 = H and Cl; R2 = F and Cl) was reported. Upon treatment of the electron-deficient olefins based pyrazole motif with in situ the generated azomethine ylides (AY) of sarcosine with the 6-chloro-isatin afforded spiroadducts. To enlighten the regio- and diastereo-selectivity of these spiroheterocycles, single crystal X-ray diffraction anal. was presented. Using Hirshfeld calculations, many short distance contacts such as O…H, Cl…H, N…H, H…C, C…C and Cl…S have a great impact on the mol. packing and the crystal stability of I (R1 = H; R2 = F) and I (R1 = Cl; R2 = Cl). The latter showed some Cl…Cl inter halogen interactions (Cl1…Cl3; 3.358 Å ). Both compounds are polar where I (R1 = Cl; R2 = Cl) (3.995 Debye) has higher dipole moment than I (R1 = H; R2 = F) (3.414 Debye). The NMR chem. shifts were calculated and found in excellent correlations between the calculated and exptl. data were obtained (R2 = 0.94-0.98). In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of 2-(Benzyloxy)acetaldehydeIn 2021 ,《Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer》 was published in Journal of the American Chemical Society. The article was written by Liu, Chen-Fei; Luo, Xiaohua; Wang, Hongyu; Koh, Ming Joo. The article contains the following contents:

Catalytic amounts of a dimeric Ni(I) complex and an exogenous alkoxide base promoted Markovnikov-selective hydroarylation(alkenylation) of unactivated and activated olefins using organo bromides or triflates derived from widely available phenols and ketones was reported for the synthesis of substituted alkanes. Products bearing aryl- and alkenyl-substituted tertiary and quaternary centers could be isolated in up to 95% yield and >99:1 regioisomeric ratios. Contrary to previous dual-catalytic methods that rely on metal-hydride atom transfer (MHAT) to the olefin prior to carbofunctionalization with a cocatalyst, mechanistic evidence points toward a nonradical reaction pathway that begins with site-selective carbonickelation across the C=C bond followed by hydride transfer using alkoxide as the hydride source. Utility of the single-catalyst protocol is highlighted through the synthesis of medicinally relevant scaffolds. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Quality Control of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Quality Control of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A click chemistry approach for the synthesis of cyclic ureido tethered coumarinyl and 1-aza coumarinyl 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis H37Rv and their in silico studies》 was written by Khanapurmath, Netravati; Kulkarni, Manohar V.; Joshi, Shrinivas D.; Anil Kumar, G. N.. Application of 150-19-6This research focused ontriazole preparation SAR mol docking antitubercular activity; 4-(Azidomethyl)-2H-chromen-2-ones/quinolin-2(1H)-ones; Click triazole; Mycobacterium tuberculosis H37Rv; Surflex-Dock algorithm. The article conveys some information:

Nucleoside bases like uracil, pharmacophoric triazoles and benzimidazolones have been used during the present study to design mol. matrixes for antitubercular activity, employing Click Chem. Click triazoles I (R = H, 6-Me, 6-OMe, 5,7-di-Me; X = O, NH), II (R = H, 6-Me, 6-OMe, 7-Me, 5,7-di-Me; X = O, NH), and III (R = H, 7-OMe, 6-Cl, 8-Me, etc.; X = O, NH) have been obtained by the reaction of 4-(azidomethyl)-2H-chromen-2-ones/quinolin-2(1H)-ones and propargyl ethers derived from theophylline/6-Me uracil/2-benzimidazolone resp. In addition to spectral data structures have been confirmed by single crystal X-ray diffraction studies in case of 6-methyl-1,3-di-prop-2-ynyl-1H-pyrimidine-2,4-dione and theophylline mono triazole I (R = 5,7-dimethyl). Theophylline linked mono triazoles, I and 6-Me uracil linked bis triazoles, II have been found to inhibit Mycobacterium tuberculosis H37Rv with MIC values in the range 55.62-115.62μM. Benzimidazolone bis triazoles, III showed better activity with MIC in the range 2.33-18.34μM. Mol. modeling studies using Surflex-Dock algorithm supported the results. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Application of 150-19-6) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem