Month: October 2022

In 2017,Katoh, Taisuke; Yoshikawa, Masato; Yamamoto, Takeshi; Arai, Ryosuke; Nii, Noriyuki; Tomata, Yoshihide; Suzuki, Shinkichi; Koyama, Ryoukichi; Negoro, Nobuyuki; Yogo, Takatoshi published 《Parallel fluorescent probe synthesis based on the large-scale preparation of BODIPY FL propionic acid》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

We describe a methodol. for quick development of fluorescent probes with the desired potency for the target of interest by using a method of parallel synthesis, termed as Parallel Fluorescent Probe Synthesis (Parallel-FPS). BODIPY FL propionic acid 1 is a widely used fluorophore, but it is difficult to prepare a large amount of 1, which hinders its use in parallel synthesis. Optimization of a synthetic scheme enabled us to obtain 50 g of 1 in one batch. With this large quantity of 1 in hand, we performed Parallel-FPS of BODIPY FL-labeled ligands for estrogen related receptor-α (ERRα). An initial trial of the parallel synthesis with various linkers provided a potent ligand for ERRα (Reporter IC50 = 80 nM), demonstrating the usefulness of Parallel-FPS.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Spaeth, Andreas; Graeler, Andre; Maisch, Tim; Plaetzer, Kristjan published 《CureCuma-cationic curcuminoids with improved properties and enhanced antimicrobial photodynamic activity》.European Journal of Medicinal Chemistry published the findings.Related Products of 139115-91-6 The information in the text is summarized as follows:

The naturally occurring photosensitizer curcumin has excellent biocompatibility, but its antimicrobial photodynamic efficacy is limited by (i) weak adherence to Gram(-) cell walls, (ii) low (photo-)stability and (iii) limited solubility in water. In this study novel curcuminoids bearing cationic substituents were prepared by different synthetic routes. The derivatives exhibit excellent water solubility, improved photostability and low aggregation. All novel curcuminoids showed antibacterial photodynamic effects (>3 log10 reduction of CFU) against Escherichia coli and Staphylococcus aureus upon blue light illumination. In contrast to natural curcumin, effective photokilling of E. coli was possible without the addition of permeabilizing agents. Ten micromolar of the most active compound achieved a 7 log10 decrease of E. coli after light activation with a fluence of 33.8 J/cm2, whereas S. aureus was inactivated by more than 4 log10 at a fluence of 5.3 J/cm2. Overall the reduction in bacterial count was at least 100-fold more effective with these new curcuminoids in comparison to natural curcumin. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Related Products of 139115-91-6 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Rubner, Stefan; Scharow, Andrej; Schubert, Sabine; Berg, Thorsten published 《Selective Degradation of Polo-like Kinase 1 by a Hydrophobically Tagged Inhibitor of the Polo-Box Domain》.Angewandte Chemie, International Edition published the findings.Product Details of 139115-91-6 The information in the text is summarized as follows:

Hydrophobic tagging (HT) of bioactive compounds can induce target degradation via the proteasomal pathway. The first application of hydrophobic tagging to an existing inhibitor of protein-protein interactions is now presented. We developed Poloxin-2HT by fusing an adamantyl tag to Poloxin-2, an inhibitor of the polo-box domain (PBD) of the protein kinase Plk1, which is a target for tumor therapy. Poloxin-2HT selectively reduced the protein levels of Plk1 in HeLa cells and had a significantly stronger effect on cell viability and the induction of apoptosis than the untagged PBD inhibitor Poloxin-2. The change in cellular phenotype associated with the addition of the hydrophobic tag to Poloxin-2 demonstrated that Poloxin-2HT targets Plk1 in living cells. Our data validate hydrophobic tagging of selective inhibitors of protein-protein interactions as a novel strategy to target and destroy disease-relevant proteins.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of 139115-91-6 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Science (Washington, DC, United States) included an article by Smaligo, Andrew J.; Swain, Manisha; Quintana, Jason C.; Tan, Mikayla F.; Kim, Danielle A.; Kwon, Ohyun. Related Products of 882-33-7. The article was titled 《Hydrodealkenylative C(sp3)-C(sp2) bond fragmentation》. The information in the text is summarized as follows:

1,1-Substituted alkenyl-substituted carbocycles such as I underwent chemoselective hydrodealkenylation of C(sp3)-C(sp2) bonds by treatment with O3 in MeOH at -78° followed by FeSO4 and PhSH with warming to ambient temperature to yield carbocycles such as II. The reactions are performed in nonanhydrous solvents and open to the air, are complete within 30 min, and deliver their products in high yields, even on decagram scales. The method was used for the conversion of terpenes to synthetic intermediates not easily available by other methods; five of the intermediates were used in formal syntheses of natural products and an unnatural steroid. Methylene carbocycles and endocyclic alkenes underwent oxidative cleavage to yield Me esters or lactones and 1,3-dioxolanes (after acetalization with ethylene glycol), resp. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Related Products of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Related Products of 882-33-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《High-Performance Electrofluorochromic Switching Devices Using a Novel Arylamine-Fluorene Redox-Active Fluorophore》 were Corrente, Giuseppina A.; Fabiano, Eduardo; La Deda, Massimo; Manni, Francesca; Gigli, Giuseppe; Chidichimo, Giuseppe; Capodilupo, Agostina-L.; Beneduci, Amerigo. And the article was published in ACS Applied Materials & Interfaces in 2019. Application of 101-70-2 The author mentioned the following in the article:

Fluorescent light modulation by small elec. potentials has gained huge interest in the past few years. This phenomenon, called electrofluorochromism, is of the utmost importance for applications in optoelectronic devices. Huge efforts are being addressed to developing electrofluorochromic systems with improved performances. One of the most critical issue is their low cyclability, which hampers their widespread use. It mostly depends on the intrinsic reversibility of the electroactive/fluorophore mol. system and on device architecture. Here the authors show a novel fluorene-based mixed-valence electrofluorochromic system that allows direct electrofluorochromic switching and exhibits incomparable electrochem. reversibility and device cyclability of >10,000 cycles. In the part of experimental materials, we found many familiar compounds, such as Bis(4-methoxyphenyl)amine(cas: 101-70-2Application of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《One step phenol synthesis from benzene catalysed by nickel(II) complexes》 were Muthuramalingam, Sethuraman; Anandababu, Karunanithi; Velusamy, Marappan; Mayilmurugan, Ramasamy. And the article was published in Catalysis Science & Technology in 2019. SDS of cas: 150-19-6 The author mentioned the following in the article:

Nickel(II)complexes of N4-ligands have been synthesized and characterized as efficient catalysts for the hydroxylation of benzene using H2O2. All the complexes exhibited Ni2+ → Ni3+ oxidation potentials of around 0.966-1.051 V vs. Ag/Ag+ in acetonitrile. One of the complexes has been structurally characterized and adopted an octahedral coordination geometry around the nickel(II) center. The complexes catalyzed direct benzene hydroxylation using H2O2 as an oxygen source and afforded phenol up to 41% with a turnover number (TON) of 820. This is unprecedentedly the highest catalytic efficiency achieved to date for benzene hydroxylation using 0.05 mol% catalyst loading and five equivalent of H2O2. The benzene hydroxylation reaction possibly proceeds via the key intermediate bis(μ-oxo)dinickel(III) species, which was characterized by HR-MS, vibrational and electronic spectral methods, for almost all complexes. The formation constant of the key intermediate was calculated to be 5.61-9.41 × 10-2 s-1 by following the appearance of an oxo-to-Ni(III) LMCT band at around 406-413 nm. The intermediates are found to be very short-lived (t1/2, 73-123 s). The geometry of one of the catalytically active intermediates was optimized by DFT and its spectral properties were calculated by TD-DFT calculations, which are comparable to exptl. spectral data. The kinetic isotope effect (KIE) values (0.98-1.05) support the involvement of nickel-bound oxygen species as an intermediate. The isotope-labeling experiments using H218O2 showed 92.46% incorporation of 18O, revealing that H2O2 is the key oxygen supplier to form phenol. The catalytic efficiencies of complexes are strongly influenced by the geometrical configuration of intermediates, and stereoelectronic and steric properties, which are fine-tuned by the ligand architecture. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6SDS of cas: 150-19-6) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.SDS of cas: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Quantum Chemical Modeling of the Adsorption of Crown Ethers of Different Structures on Surfaces of Lithium and Carbon》 was published in Russian Journal of Physical Chemistry A in 2020. These research results belong to Tulibaeva, G. Z.; Yarmolenko, O. V.; Shestakov, A. F.. Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane The article mentions the following:

Abstract: Theor. studies are performed of the adsorption of crown ethers of different structures (15-crown-5, dibenzo-18-crown-6 and 3-pentadecyl-2,4-dioxo-16-crown-5) on surfaces of lithium and carbon, the main anode materials in secondary lithium power sources. The energies of adsorption of these crown ethers and the bonding energies of lithium ions with crown ether in the free and adsorbed states are calculated using the PBE d. functional. It is shown that the mols. of 15-crown-5 and 3-pentadecyl-2,4-dioxo-16-crown-5 form flat structures, contributing to the stack folding of subsequent crown ether mols. There are steric hindrances for dibenzo-18-crown-6, since one of the benzene rings is oriented perpendicularly. It is found that 3-pentadecyl-2,4-dioxo-16-crown-5 promotes the transfer of lithium ion from the electrolyte volume to the surface of both lithium and carbon better than the other two crown ethers. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Macropinocytosis as a key determinant of peptidomimetic uptake in cancer cells》 was written by Yoo, Daniel Y.; Barros, Stephanie A.; Brown, Gordon C.; Rabot, Christian; Bar-Sagi, Dafna; Arora, Paramjit S.. Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Peptides and peptidomimetics represent the middle space between small mols. and large proteins-they retain the relatively small size and synthetic accessibility of small mols. while providing high binding specificity for biomol. partners typically observed with proteins. During the course of our efforts to target intracellular protein-protein interactions in cancer, we observed that the cellular uptake of peptides is critically determined by the cell line-specifically, we noted that peptides show better uptake in cancer cells with enhanced macropinocytic indexes. Here, we describe the results of our anal. of cellular penetration by different classes of conformationally stabilized peptides. We tested the uptake of linear peptides, peptide macrocycles, stabilized helixes, β-hairpin peptides, and cross-linked helix dimers in 11 different cell lines. Efficient uptake of these conformationally defined constructs directly correlated with the macropinocytic activity of each cell line: high uptake of compounds was observed in cells with mutations in certain signaling pathways. Significantly, the study shows that constrained peptides follow the same uptake mechanism as proteins in macropinocytic cells, but unlike proteins, peptide mimics can be readily designed to resist denaturation and proteolytic degradation Our findings expand the current understanding of cellular uptake in cancer cells by designed peptidomimetics and suggest that cancer cells with certain mutations are suitable mediums for the study of biol. pathways with peptide leads. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Karale, Uttam B.; Shinde, Akash U.; Babar, Dattatraya A.; Sangu, Komal G.; Vagolu, Siva Krishna; Eruva, Vamshi K.; Jadav, Surender S.; Misra, Sunil; Dharmarajan, Sriram; Rode, Haridas B. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2021. The article was titled 《3-Aryl-substituted imidazo[1,2-a]pyridines as antituberculosis agents》.Application In Synthesis of 1-Bromo-3-methoxybenzene The article contains the following contents:

3-Aryl-substituted imidazo[1,2-a]pyridines I [R1 = H, 6-Me, 7-Me, 8-Me; R2 = 4-tolyl, 2-naphthyl, 2-(4-methylanilino)-4-(trifluoromethyl)phenyl, etc.] were reported as potent antituberculosis agents. A small library of 3-aryl-substituted imidazo[1,2-a]pyridines I were synthesized using direct arylation followed by nitro reduction and finally Pd-catalyzed C-N coupling reactions. The compounds I thus obtained were evaluated against Mycobacterium tuberculosis H37Rv. Compound I [R1 = H, R2 = 3-cyanophenyl] was identified as an antituberculosis lead with a min. inhibitory concentration of 2.3μg/mL against M. tuberculosis H37Rv. This compound I [R1 = H, R2 = 3-cyanophenyl] showed a selectivity index of 35. The docking of compound I [R1 = H, R2 = 3-cyanophenyl] in the active site of the M. tuberculosis cytochrome bc1 complex cytochrome b subunit (Mtb QcrB) revealed key π-π interactions of I [R1 = H, R2 = 3-cyanophenyl] with the Tyr389 and Trp312 residues of Mtb QcrB. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application In Synthesis of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application In Synthesis of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Moraes, Maiara C.; Lenardao, Eder J.; Barcellos, Thiago published their research in ARKIVOC (Gainesville, FL, United States) in 2021. The article was titled 《Synthesis of C4-substituted coumarins via Pechmann condensation catalyzed by sulfamic acid. Insights into the reaction mechanism by HRMS analysis》.SDS of cas: 150-19-6 The article contains the following contents:

A series of functionalized C4-substituted coumarins were synthesized by exploring the reaction of activated and non-activated phenols and β-ketoesters under solvent-free conditions in the presence of sulfamic acid as a Bronsted acid catalyst. Fifteen examples were prepared with moderate to excellent yields (50% to 90%) using 10 mol % of the catalyst. Furthermore, it was possible from the proposed methodol. to scale up the synthesis of coumarins to obtain up to 11 g of product. This work also provides a preliminary insight into the reaction mechanism using high-resolution mass spectrometry anal. The key cinnamic acid derivative intermediate was detected, implying that under the evaluated conditions, the mechanistic pathway starts with an aromatic electrophilic substitution followed by dehydration reaction and intramol. transesterification. In the part of experimental materials, we found many familiar compounds, such as m-Methoxyphenol(cas: 150-19-6SDS of cas: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneSDS of cas: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem