Month: October 2022

Wang, Shihaozhi; Yang, Jiale; Li, Dianjun; Yang, Jinhui published the artcile< Copper-Catalyzed Cascade N-Dealkylation/N-Methyl Oxidation of Aromatic Amines by Using TEMPO and Oxygen as Oxidants>, Name: 2-Methoxy-N-methylaniline, the main research area is aryl formamide preparation; amine aryl cascade dealkylation oxidation catalyst copper.

A novel tandem N-dealkylation and N-Me aerobic oxidation of tertiary aromatic amines to N-arylformamides ArNC(O)H [Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.] using copper and TEMPO was developed. This methodol. suggested an alternative synthetic route from N-methylarylamines to N-arylformamides ArNC(O)H.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Name: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zha, Gao-Feng; Fang, Wan-Yin; Li, You-Gui; Leng, Jing; Chen, Xing; Qin, Hua-Li published the artcile< SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes>, Quality Control of 52244-70-9, the main research area is alkyne chemoselective preparation; phenyltriazole phenylacetylene preparation; sulfuryl fluoride DMSO mediated oxidative dehydrogenation elimination alc; beta hydroxy amide secondary alc oxidative elimination sulfuryl fluoride; sequential oxidative elimination primary alc azide alkyne cycloaddition azidobenzene; oxidative elimination primary alc Sonogashira coupling iodobenzene.

Terminal and internal alkynes were prepared directly from primary alcs. and secondary alcs. and β-hydroxyamides by oxidative dehydrogenation and dehydration using sulfuryl fluoride as the leaving group source and DMSO as oxidant; the method does not require transition metal reagents or catalysts. The method was used in one-pot preparations of phenyltriazoles and phenylacetylenes using the oxidative dehydrogenation/elimination reaction in sequence with azide-alkyne cycloaddition with Ph azide and Sonogashira coupling with iodobenzene.

Journal of the American Chemical Society published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gyulavari, Pal; Szokol, Balint; Szabadkai, Istvan; Brauswetter, Diana; Banhegyi, Peter; Varga, Attila; Marko, Peter; Boros, Sandor; Illyes, Eszter; Szantai-Kis, Csaba; Kreko, Marcell; Czudor, Zsofia; Orfi, Laszlo published the artcile< Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B>, Safety of n-Propylsulphamoyl chloride, the main research area is benzothiophene carboxamide derivative preparation Aurora kinase inhibitor cancer; Aurora kinase; Benzothiophene-3-carboxamide; Cancer; Kinase inhibitor; Targeted therapy.

Aurora kinases as regulators of cell division have become promising therapeutic targets recently. Here we report novel, low mol. weight benzothiophene-3-carboxamide derivatives designed and optimized for inhibiting Aurora kinases. The most effective compound 36 inhibits Aurora kinases in vitro in the nanomolar range and diminishes HCT 116 cell viability blocking cytokinesis and inducing apoptosis. According to western blot anal., the lead mol. inhibits Aurora kinases equipotently to VX-680 (Tozasertib) and similarly synergizes with other targeted drugs.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents (drug potential as). 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Safety of n-Propylsulphamoyl chloride.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

King, Frank D.; Aliev, Abil E.; Caddick, Stephen; Tocher, D. A. published the artcile< A novel synthesis of (di)-benzazocinones via an endocyclic N-acyliminium ion cyclization>, Category: ethers-buliding-blocks, the main research area is benzazocinone preparation; acyliminium cyclization.

The triflic acid-mediated endocyclic N-acyliminium ion cyclization provides a facile synthesis of (di)-benzazocinones, e.g. I (R = H, 14-Cl, 15-Br, etc.). On reduction of the 10-Ph derivative, an unusually nonpolar tertiary alkylamine II was obtained.

Organic & Biomolecular Chemistry published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liu, Wei; Lavagnino, Marissa N.; Gould, Colin A.; Alcazar, Jesus; MacMillan, David W. C. published the artcile< A biomimetic SH2 cross-coupling mechanism for quaternary sp3-carbon formation>, Related Products of 6482-24-2, the main research area is ester alkyl bromide photoredox cross coupling iron.

Bimol. homolytic substitution (SH2) is an open-shell mechanism that is implicated across a host of biochem. alkylation pathways. Surprisingly, however, this radical substitution manifold has not been generally deployed as a design element in synthetic C-C bond formation. Authors found that the SH2 mechanism can be leveraged to enable a biomimetic sp3-sp3 cross-coupling platform that furnishes quaternary sp3-carbon centers, a long-standing challenge in organic mol. construction. This heteroselective radical-radical coupling uses the capacity of iron porphyrin to readily distinguish between the SH2 bond-forming roles of open-shell primary and tertiary carbons, combined with photocatalysis to generate both radical classes simultaneously from widely abundant functional groups. Mechanistic studies confirm the intermediacy of a primary alkyl-Fe(III) species prior to coupling and provide evidence for the SH2 displacement pathway in the critical quaternary sp3-carbon bond formation step.

Science (Washington, DC, United States) published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Related Products of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Duan, Jicheng; Du, Yun-Fei; Pang, Xiaobo; Shu, Xing-Zhong published the artcile< Ni-catalyzed cross-electrophile coupling between vinyl/aryl and alkyl sulfonates: synthesis of cycloalkenes and modification of peptides>, Synthetic Route of 52244-70-9, the main research area is vinyl triflate alkyl sulfonate Nickel catalyst reductive cross coupling; peptide alkyl tosylate Nickel catalyst cross coupling.

The coupling reactions between vinyl/aryl and alkyl C-O electrophiles that can be derived from chem. feedstocks and naturally occurring functional groups was reported. This method provided an efficient approach to the synthesis of a wide range of functionalized, and/or secondary alkyl substituted cycloalkenes that are difficult to synthesize by conventional methods. The reaction proceeded with broad substrate scope, and tolerated various functional groups such as alc., aldehyde, ketone, ester, amide, alkene, alkyne, heterocycles, organotin and organosilicon compounds The synthetic utility of this method was demonstrated by providing facile access to important building blocks. The possibility to apply this method for late-stage modification of peptides was also demonstrated. A broad range of functionalized alkyl groups was selectively introduced into tyrosine in peptides via C-C bond formation, which was a challenge to the existing procedures.

Chemical Science published new progress about Alkanesulfonates Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Synthetic Route of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Martin, Adam D.; Easun, Timothy L.; Argent, Stephen P.; Lewis, William; Blake, Alexander J.; Schroder, Martin published the artcile< The effect of carboxylate position on the structure of a metal organic framework derived from cyclotriveratrylene>, Recommanded Product: (4-Bromo-3-methoxyphenyl)methanol, the main research area is cyclotriveratrylene carboxylate cobalt zinc metal organic framework preparation structure; crystal mol structure cyclotriveratrylene carboxylate cobalt zinc MOF.

Two cyclotriveratrylene-based ligands H3L1 and H3L2 have been synthesized using microwave heating and used in the formation of 1 [Zn2(L1)(DMA)2(CH3COO)] and 2 [Zn6(L2)4(DMA)6(H2O)5] (DMA = N,N-dimethylacetamide). 1 Displays an unusual trigonal paddlewheel node geometry, while Zn(II) paddlewheels are observed in 2. However, the stacking of CTV mols. in 1 is replaced by an uncommon mol. capsule structure in 2.

CrystEngComm published new progress about Crystal structure. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Recommanded Product: (4-Bromo-3-methoxyphenyl)methanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Baricelli, Pablo J.; Rodriguez, Mariandry; Melean, Luis G.; Borusiak, Margarita; Crespo, Isis; Pereira, Juan C.; Rosales, Merlin published the artcile< Hydroformylation of natural olefins with the [Rh(COD)(μ-OMe)]2/TPPTS complex in BMI-BF4/toluene biphasic medium: observations on the interfacial role of CTAB in reactive systems>, HPLC of Formula: 52244-70-9, the main research area is aldehyde preparation hydroformylation natural olefin rhodium catalyst ionic liquid.

The complex [Rh(COD)(μ-OMe)]2 in presence of TPPTS (TPPTS = triphenylphosphinetrisulfonate) was evaluated as catalyst precursor for the in situ hydroformylation of natural olefins (eugenol, estragole and safrole) in biphasic media BMIm-BF4/toluene. Under moderate reaction conditions, the substrates showed the following reactivity order: eugenol > estragole > safrole. The rhodium system showed a high activity and selectivity towards the desired aldehydes. It was found that the use of cetyltrimethylammoniun bromide (CTAB) as phase transfer agent inhibits the hydroformylation reaction. The catalytic phase can be recycled up to four times without evident loss of activity or selectivity. In this work we report the use of an ionic liquid with hydrophilic character, without using water in the reaction medium.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, HPLC of Formula: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem