Gyulavari, Pal; Szokol, Balint; Szabadkai, Istvan; Brauswetter, Diana; Banhegyi, Peter; Varga, Attila; Marko, Peter; Boros, Sandor; Illyes, Eszter; Szantai-Kis, Csaba; Kreko, Marcell; Czudor, Zsofia; Orfi, Laszlo published the artcile< Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B>, Safety of n-Propylsulphamoyl chloride, the main research area is benzothiophene carboxamide derivative preparation Aurora kinase inhibitor cancer; Aurora kinase; Benzothiophene-3-carboxamide; Cancer; Kinase inhibitor; Targeted therapy.
Aurora kinases as regulators of cell division have become promising therapeutic targets recently. Here we report novel, low mol. weight benzothiophene-3-carboxamide derivatives designed and optimized for inhibiting Aurora kinases. The most effective compound 36 inhibits Aurora kinases in vitro in the nanomolar range and diminishes HCT 116 cell viability blocking cytokinesis and inducing apoptosis. According to western blot anal., the lead mol. inhibits Aurora kinases equipotently to VX-680 (Tozasertib) and similarly synergizes with other targeted drugs.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents (drug potential as). 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Safety of n-Propylsulphamoyl chloride.
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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem