Category: 115144-40-6

Related Products of 115144-40-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 115144-40-6 as follows.

1, 2-Difluoro-4-methoxy-benzene (100mg, 0. 69MMOL) and sodium methan- ethiolate (148mg, 2. 08MMOL) were dissolved in N, N-dimethylformamide (2mL) and the reaction mixture stirred at 60C for 18 hours. Additional sodium METHANETHIOLATE (99mg, 139MMOL) was added and the reaction mixture was heated to 100C for 18 hours. The reaction mixture was diluted with water and extracted with ether (x 2). The ether extracts were washed with water (x 2), dried (MGS04) and then concentrated under reduced pressure. The residue was taken up in a pentane: ether 1: 1 solution (2mL) and filtered through a plug of silica in a pipette, and then washed through with a pentane: ether 1: 1 solution (5mL). The solution was concentrated under reduced pressure to yield the title product as a colourless oil, 135mg. H NMR (CDCI3, 300MHZ) 8 : 2.45 (s, 3H), 3.80 (s, 3H), 6.65 (dd, 1H), 6.80 (DD, 1 H), 6.95 (dd, 1 H).

According to the analysis of related databases, 115144-40-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/9964; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 115144-40-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115144-40-6, name is 3,4-Difluoroanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3,4-Difluoroanisole was similarly converted to 2,3-difluoro-6-(methoxy)benzyl bromide (Examples 74A, 75A), and 1-fluoro-3-(trifluoromethoxy)benzene converted to 2-fluoro-6-(trifluoromethoxy)benzyl bromide (Examples 77A, 78A). 2-Chloro-6-(trifluoromethoxy)benzyl alcohol (Examples 89A, 90A) was prepared in similar manner, except that lithium diisopropylamide was used in the formylation reaction, rather than n-butyllithium.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Difluoroanisole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc; US6313100; (2001); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 115144-40-6, These common heterocyclic compound, 115144-40-6, name is 3,4-Difluoroanisole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a) 7.29 ml (66.3 mmol) of titanium tetrachloride were added while stirring to a solution, cooled to 0, of 5.73 g (39.8 mmol) of 3,4-difluoroanisole in 30 ml of anhydrous dichloromethane. Subsequently, the mixture was treated dropwise over 10 minutes with 3.51 ml (39.6 mmol) of 1,1-dichloromethyl methyl ketone and stirred at room temperature for one hour. The mixture was poured into 100 ml of ice-water, extracted twice with 150 ml of dichloromethane each time and the combined organic phases were washed once with 100 ml of water and once with 100 ml of saturated sodium chloride solution. After drying over magnesium sulphate concentration was carried out in a vacuum. The crude product obtained was purified by column chromatography on silica gel (hexane/ethyl acetate 4:1). There were obtained 5.8 g (84%) of 4,5-difluoro-2-methoxybenzaldehyde as a white solid with m.p. 74.

Statistics shows that 3,4-Difluoroanisole is playing an increasingly important role. we look forward to future research findings about 115144-40-6.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; EP906301; (2002); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 115144-40-6,Some common heterocyclic compound, 115144-40-6, name is 3,4-Difluoroanisole, molecular formula is C7H6F2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 3; 1-FLUORO-4-METHOXY-2-METHYLSULFANYL-BENZENE; 1, 2-Difluoro-4-methoxy-benzene (100mg, 0. 69MMOL) and sodium methanethiolate (148mg, 2. 08MMOL) were dissolved in N, N-dimethylformamide (2mL) and the reaction mixture stirred at 60C for 18 hours. Additional sodium METHANETHIOLATE (99mg, 139MMOL) was added and the reaction mixture heated to 100C for 18 hours. The reaction mixture was diluted with water and extracted with ether (x2). The ether extracts were washed with water (x2), dried over magnesium sulphate and concentrated in vacuo. The residue was taken up in pentane: ether 1: 1 mixture (2mL) and filtered through a plug of silica in a pipette, washing through with pentane: ether 1: 1 mixture (5mL). The solution was concentrated in vacuo to yield the title product as a colourless oil, 135mg. HNMR (CDC13, 300MHZ) : A = 2.45 (s, 3H), 3.80 (s, 3H), 6.65 (dd, 1 H), 6.80 (dd, 1 H), 6.95 (t, 1 H) ppm

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Difluoroanisole, its application will become more common.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/9966; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 115144-40-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 115144-40-6 as follows.

1, 2-Difluoro-4-methoxy-benzene (100mg, 0. 69MMOL) and sodium methan- ethiolate (148mg, 2. 08MMOL) were dissolved in N, N-dimethylformamide (2mL) and the reaction mixture stirred at 60C for 18 hours. Additional sodium METHANETHIOLATE (99mg, 139MMOL) was added and the reaction mixture was heated to 100C for 18 hours. The reaction mixture was diluted with water and extracted with ether (x 2). The ether extracts were washed with water (x 2), dried (MGS04) and then concentrated under reduced pressure. The residue was taken up in a pentane: ether 1: 1 solution (2mL) and filtered through a plug of silica in a pipette, and then washed through with a pentane: ether 1: 1 solution (5mL). The solution was concentrated under reduced pressure to yield the title product as a colourless oil, 135mg. H NMR (CDCI3, 300MHZ) 8 : 2.45 (s, 3H), 3.80 (s, 3H), 6.65 (dd, 1H), 6.80 (DD, 1 H), 6.95 (dd, 1 H).

According to the analysis of related databases, 115144-40-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/9964; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 115144-40-6, name is 3,4-Difluoroanisole, A new synthetic method of this compound is introduced below., Computed Properties of C7H6F2O

Preparation 4 1-FL UORO-4-METHOXV-2-METHYLSULFANYL-BENZENE 1, 2-Difluoro-4-methoxy-benzene (100mg, 0. 69MMOL) and sodium methanethiolate (148mg, 2. 08MMOL) were dissolved in N, N-DIMETHYLFORMAMIDE (2mL) and the reaction mixture stirred at 60C for 18 hours. Additional sodium methanethiolate (99mg, 139MMOL) was added and the reaction mixture heated to 100C for 18 hours. The reaction mixture was diluted with water and extracted with ether (x 2). The ether extracts were washed with water (x 2), dried over magnesium sulphate and concentrated in vacuo. The residue was taken up in pentane: ether 1: 1 mixture (2mL) and filtered through a plug of silica in a pipette, washing through with pentane: ether 1: 1 mixture (5mL). The reaction mixture was concentrated in vacuo to yield the title product as a colourless oil, 135mg. 1HNMR (CDCI3, 300MHZ) : 2.45 (s, 3H), 3.80 (s, 3H), 6.65 (dd, 1H), 6.80 (dd, 1H), 6.95 (t, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/9965; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A common compound: 115144-40-6, name is 3,4-Difluoroanisole, belongs to ethers-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 115144-40-6

a) 7.29 ml (66.3 mmol) of titanium tetrachloride were added while stirring to a solution, cooled to 0, of 5.73 g (39.8 mmol) of 3,4-difluoroanisole in 30 ml of anhydrous dichloromethane. Subsequently, the mixture was treated dropwise over 10 minutes with 3.51 ml (39.6 mmol) of 1,1-dichloromethyl methyl ketone and stirred at room temperature for one hour. The mixture was poured into 100 ml of ice-water, extracted twice with 150 ml of dichloromethane each time and the combined organic phases were washed once with 100 ml of water and once with 100 ml of saturated sodium chloride solution. After drying over magnesium sulfate concentration was carried out in a vacuum. The crude product obtained was purified by column chromatography on silica gel (hexane/ethyl acetate 4:1). There were obtained 5.8 g (84%) of 4,5-difluoro-2-methoxybenzaldehyde as a white solid with m.p. 74.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 115144-40-6, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoffmann-La Roche Inc.; US5955495; (1999); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem