Reference of 115144-40-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 115144-40-6 as follows.
1, 2-Difluoro-4-methoxy-benzene (100mg, 0. 69MMOL) and sodium methan- ethiolate (148mg, 2. 08MMOL) were dissolved in N, N-dimethylformamide (2mL) and the reaction mixture stirred at 60C for 18 hours. Additional sodium METHANETHIOLATE (99mg, 139MMOL) was added and the reaction mixture was heated to 100C for 18 hours. The reaction mixture was diluted with water and extracted with ether (x 2). The ether extracts were washed with water (x 2), dried (MGS04) and then concentrated under reduced pressure. The residue was taken up in a pentane: ether 1: 1 solution (2mL) and filtered through a plug of silica in a pipette, and then washed through with a pentane: ether 1: 1 solution (5mL). The solution was concentrated under reduced pressure to yield the title product as a colourless oil, 135mg. H NMR (CDCI3, 300MHZ) 8 : 2.45 (s, 3H), 3.80 (s, 3H), 6.65 (dd, 1H), 6.80 (DD, 1 H), 6.95 (dd, 1 H).
According to the analysis of related databases, 115144-40-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/9964; (2005); A1;,
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