Category: Uncategorized
Fan, Bao-Min et al. published their research in Angewandte Chemie, International Edition in 2012 | CAS: 16356-02-8
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks
Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts was written by Fan, Bao-Min;Yang, Qing-jing;Hu, Jun;Fan, Cai-ling;Li, Si-feng;Yu, Lu;Huang, Chao;Tsang, Wing Wai;Kwong, Fuk Yee. And the article was included in Angewandte Chemie, International Edition in 2012.Category: ethers-buliding-blocks This article mentions the following:
The first successful iridium-catalyzed asym. hydroalkynylation of norbornadienes with terminal alkynes to provide alkynylnorbornenes with high to excellent enantioselectivities (up to 97% ee) was reported. A broader substrate scope can be presented on either a norbornadiene or alkyne moiety. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Category: ethers-buliding-blocks).
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem
Ramulu, K. et al. published their research in Rasayan Journal of Chemistry in 2013 | CAS: 605-94-7
2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks
Identification, isolation and characterization of potential degradation product in idebenone drug substance was written by Ramulu, K.;Rao, B. M.;Rao, N. Someswara. And the article was included in Rasayan Journal of Chemistry in 2013.Category: ethers-buliding-blocks This article mentions the following:
In the stress degradation studies of Idebenone, one major unknown base degradation impurity was identified by LC-MS. This impurity was isolated using preparative high performance liquid chromatog. Based on the spectral data (1H NMR, 13C NMR, DEPT, MS, HR-MS and IR), this degradation impurity is characterized as 2-hydroxy-5-(10-hydroxydecyl)-3-methoxy-6-methylcyclohexa-2,5-diene-1,4-dione. The details of stress studies, identification, isolation, characterization, formation and mechanism of this impurity is discussed and presented in detail. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Category: ethers-buliding-blocks).
2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem
Ishino, Saqura et al. published their research in Tetrahedron Letters in 2020 | CAS: 111-77-3
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Product Details of 111-77-3
Change in the rate of pseudo[1]rotaxane formation by elongating the alkyl-chain-substituted diphenylethynylene linked to permethyl α-cyclodextrin was written by Ishino, Saqura;Masai, Hiroshi;Shimada, Sotaro;Terao, Jun. And the article was included in Tetrahedron Letters in 2020.Product Details of 111-77-3 This article mentions the following:
Herein, we report the kinetics of pseudo[1]rotaxane formation from permethyl α-cyclodextrin attached to a flexible-chain-substituted diphenylethynylene. When the chain is an alkyl group, the rate of formation shows different trends over three regions of chain length: deceleration (chain length = 1-3), acceleration (4-8), and re-deceleration (>12). This behavior is driven by a relative decrease in the ΔH of the transition. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Product Details of 111-77-3).
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Product Details of 111-77-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem