Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts was written by Fan, Bao-Min;Yang, Qing-jing;Hu, Jun;Fan, Cai-ling;Li, Si-feng;Yu, Lu;Huang, Chao;Tsang, Wing Wai;Kwong, Fuk Yee. And the article was included in Angewandte Chemie, International Edition in 2012.Category: ethers-buliding-blocks This article mentions the following:
The first successful iridium-catalyzed asym. hydroalkynylation of norbornadienes with terminal alkynes to provide alkynylnorbornenes with high to excellent enantioselectivities (up to 97% ee) was reported. A broader substrate scope can be presented on either a norbornadiene or alkyne moiety. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Category: ethers-buliding-blocks).
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem