Category: 583-19-7

Adding a certain compound to certain chemical reactions, such as: 583-19-7, name is 1-Bromo-2-ethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 583-19-7, Application In Synthesis of 1-Bromo-2-ethoxybenzene

Synthesis of Compound 67.2. [0740] Into a 100-mL 3-necked round-bottom flask was placed Mg (1.55 g) and 10 mL of tetrahydrofuran. Then 1-bromo-2-ethoxybenzene (1 g) and 1,2-dibromoethane (100 mg, 0.53 mmol, 0.01 equiv) were added to initiate the reaction. Then a second batch of 1-bromo-2-ethoxybenzene (9 g) were dissolved in 40 mL THF was added dropwise. The resulting solution was stirred for 2 h at room temperature. The mixture was directly used in the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-ethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nimbus Apollo, Inc.; Harriman, Geraldine C.; Masse, Craig E.; Harwood, James; Bhat, Sathesh; Greenwood, Jeremy Robert; US2013/123231; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 583-19-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-19-7, name is 1-Bromo-2-ethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(1) 4-(3-bromo-4-ethoxyphenyl)-4-oxobutanoic acid To a suspension of bromo-2-ethoxybenzene (12.0 g) and succinic anhydride (6.9 g) in dichloromethane (40 mL) was gradually added aluminum chloride (19.0 g) under ice-cooling, and the mixture was heated with stirring at 50C for 0.5 hr. The reaction mixture was cooled, and poured into concentrated hydrochloric acid (100 mL)-ice. The mixture was stirred for 1 hr, and extracted with ethyl acetate. The obtained organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 4-(3-bromo-4-ethoxyphenyl)-4-oxobutanoic acid (6.5 g) as crude crystals. 1H-NMR (CDCl3)delta: 1.51(3H, t, J=7.2Hz), 2.74(2H, t, J=6.6Hz), 3.34(2H, t, J=6.6Hz), 4.19(2H, q, J=7.2 Hz), 6.92(1H, d, J=8.7Hz), 7.92(1H, dd, J=8.7Hz, 2.4Hz), 8.19(1H, d, J=2.4Hz)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-ethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1845081; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 583-19-7,Some common heterocyclic compound, 583-19-7, name is 1-Bromo-2-ethoxybenzene, molecular formula is C8H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate V.1 (X1 = Br, X2 = Cl): 1-bromo-2-ethoxybenzene-1-sulfonyl chloride; To a solution of 9 g (45 mmol) of 1-bromo-2-ethoxybenzene (intermediate VI.1) in 220 mL of dichloromethane, a solution of 9 mL (135 mmol) of chlorosulfonic acid in 16 mL of dichloromethane was added for one hour at -5C. Then it was stirred for an additional 1 hour, at room temperature. The reaction mixture was carefully poured over about 500 g of crushed ice and the resulting phases were allowed to decant and were separated. The organic phase was washed, successively, with 220 mL of a 5% Na2CO3 aqueous solution, 220 mL of NaHCO3 saturated aqueous solution, 220 mL of water and 220 mL of brine. Then, it was dried over anhydrous sodium sulfate and evaporated to dryness to obtain 11.91 g (89% yield) of 1-bromo-2-ethoxybenzene-1-sulfonyl chloride as a yellow oil. 1H NMR (CDCl3, 200 MHz) delta (ppm): 8.21 (d, J = 2.2 Hz, 1H); 7.96 (dd, J = 2.2 Hz, J = 9.2 Hz, 1H) ; 7.01 (d, J = 9.2 Hz, 1H); 4.24 (q, J = 7.0 Hz, 2H) ; 1.55 (t, J = 7.0 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-ethoxybenzene, its application will become more common.

Reference:
Patent; Galenicum Health, S.l.; EP2168967; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A common heterocyclic compound, 583-19-7, name is 1-Bromo-2-ethoxybenzene, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 583-19-7.

Reference Example 160 In THF (120 ml) was dissolved 1-bromo-2-ethoxybenzene (12.0 g). To the mixture was added dropwise at -78 C. 1.6M n-butyllithium/hexane (41.1 ml), and the mixture was stirred for 1 hour. To the mixture was added dropwise a solution of trimethylborate (12.4 g) in THF (12.4 ml), and the mixture was stirred for 30 minutes and warmed to room temperature. To the mixture was added 2N hydrochloric acid (48 ml), and the mixture was stirred for 15 minutes. The reaction mixture was extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was washed with hexane/isopropylether to give 2-ethoxyphenyl borate (7.1 g). 1H-NMR (200 MHz, DMSO-d6) delta 1.37 (3H, t, J=7.0 Hz), 4.09 (2H, q, J=7.0 Hz), 6.89-6.99 (1H, m), 7.33-7.42 (1H, dd, J=7.2, 1.6 Hz), 7.66 (2H, s).

The synthetic route of 1-Bromo-2-ethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6235771; (2001); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-19-7, name is 1-Bromo-2-ethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., 583-19-7

3-(2-bromoacetyl)-8-chloro-2H-chromen-2-one (150 mg, 0.54 mmol) and l-bromo-2-ethoxybenzene (108 mg, 0.54 mmol) were reacted in a microwave in the presence of CS2CO3 (528 mg, 1.62 mmol), Pd2(dba)3 (40mg, 0.054mmol.), xantphose (60mg, 0.108mmol), and dioxane (2 mL) at 160C for 15 minutes. The resulting product was then purified by pre-HPLC to yield 8-chloro-3-(2-(2-ethoxyphenylamino)thiazol-4-yl)-2H-chromen-2-one (20 mg, 10%) as a yellow solid. ESI-MS (EI+, m/z): 399.1 [M+l]+; 1HNMR (500 MHz, DMSO-<): delta 1.40 (t, J = 7 Hz, 3H), 4.14 (q, J= 7 Hz, 2H), 6.99-7.05 (m, 3H), 7.39 (t, J = 8 Hz, 1H), 7.76-7.79 (m, 2H), 7.93 (t, J= 7 Hz, 1H), 8.48-8.49 (m, 1H), 8.65 (s, 1H), 9.54 (s, 1H). If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it. Reference:
Patent; DISCOVERYBIOMED, INC.; SCHWIEBERT, Erik; STREIFF, John; DIXON, John; GAO, Hongwu; WO2014/152213; (2014); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem