Category: 35896-58-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, A new synthetic method of this compound is introduced below., SDS of cas: 35896-58-3

General procedure: A solution of compounds 1, 4, 5 (2.5 mmol) in THF (10 mL) was diluted with water (5 mL), and an excess solution of cerricammonium nitrate (CAN) (3.9 g, 7 mmol) in 10 mL water was added at 0 C. The mixture was stirred at room temperature for 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the THF was removed under a vacuum at 40 C, and the crude mixture was extracted with three portions of CH2Cl2 (20 mL). The orange extracts were washed with brine until neutrality, then dried over anhydrous Na2SO4 and concentrated in vacuo. The crude products were purified by a silica-gel column chromatography with petroleum ether and EtOAc as eluent to give the desired benzoquinones 2, 7, 6.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Jin; Li, Shuo; Yang, Tao; Yang, Jian; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 710 – 713;,
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Some common heterocyclic compound, 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, molecular formula is C11H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1,2,3,4-Tetramethoxy-5-methylbenzene

Step 3a: Synthesis of 1-Bromo-2,3,4,5-tetramethoxy-6-methyl benzeneTo a stirred solution of l,2,3,4-tetramethoxy-5-methylbenzene (obtained in Step 2a) (1.60 g, 7.54 mmol) in DCM (50 mL), a solution of bromine (0.41 mL, 7.92 mmol) in DCM (15 mL) was slowly added, and the resulting mixture was stirred at room temperature for 1 h. Water was added, the organic layer was separated and washed with 1 M NaOH and brine. The combined organic layers were dried over sodium sulphate and concentrated to dryness to give the product as yellow oil (2.00 g, 91%).Yield: 91%. TLC: R/= 0.80 petroleum ether:EtOAc 90:10 v/v. Spectroscopic data were as those reported in the literature by Tremblay, M. S. et al, Org. Lett. 2005, 7, 2417

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35896-58-3, its application will become more common.

Reference:
Patent; NICOX SCIENCE IRELAND; BLANGETTI, Marco; FRUTTERO, Roberta; GASCO, Alberto; GIORGIS, Marta; LAZZARATO, Loretta; ROLANDO, Barbara; ALMIRANTE, Nicoletta; STORONI, Laura; WO2015/155234; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, molecular formula is C11H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 35896-58-3

To a stirred solution of 5a (4.24 g, 20 mmol) in CH2Cl2 (30 mL) was added dichloromethyl methyl ether (6.89 g, 60 mmol) at 0 C followed by addition of TiCl4 (11.38 g, 60 mmol)41 S. Ohkawa, S. Terao, Z. Terashit, Y. Shibouta and K. Nishikawa, J. Med. Chem. 34 (1991), p. 267. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (36)41 (see Scheme 4). The resulting mixture was stirred for 4 h at ambient temperature and then poured into ice water. After stirring vigorously for 10 min, the organic layer was separated. It was washed with water, dried, and evaporated. The residue was chromatographed on silica gel to give 5b (90%) as a light yellow liquid. 1H NMR (500.0 MHz, CDCl3, 298 K): 3.99 (s, 12H, 4× -OCH3), 2.25 (s, 3H, -CH3), 10.45 (s, H, -CHO) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35896-58-3, its application will become more common.

Related Products of 35896-58-3, These common heterocyclic compound, 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2,3,4,5-tetramethoxytoluene (2.12 g, 10 mmol) and 1,1-dichlorodimethyl ether (1.8 mL, 20 mmol) in DCM (200 mL) was stirred at room temperature (rt), then the solution was allowed to cool to 0 oC and was added titanium tetrachloride (2.18 mL, 20 mmol). The mixture was allowed to warm to rt and stirred for 4 hours. The ice water was added slowly to quench the reaction and extracted with DCM, washed with brine and dried over Na2SO4, filtered and evaporated in vacuo. The resulting residue was purified by flash column chromatography on silica gel (EtOAc / petroleum ether = 1 / 20) to yield the target products (2 g, 83%) as colorless oil. 1H NMR (400 MHz, CDCl3) delta 10.43 (s, 1H), 4.02 (s, 3H), 3.94 (s, 3H), 3.91 (s, 3H), 3.76 (s, 3H), 2.46 (s, 3H). MS (ESI): m/z 241.1 [M+H]+.

The synthetic route of 35896-58-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ding, Yuyang; Tang, Fei; Xue, Xiaoqian; Luo, Jinfeng; Hussain, Muzammal; Huang, Yanhui; Wang, Zhen; Jiang, Hao; Tu, Zhengchao; Zhang, Jiancun; Bioorganic Chemistry; vol. 89; (2019);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, molecular formula is C11H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 35896-58-3

Compound 3 (0.32 g, 1.5 mmol) was dissolved in acetonitrile (2 mL), and an excess of asolution of K2S2O8 (1.6 g, 6 mmol) in 3mL water was added at 25 C. The reactionmixture was stirred at room temperature for 1 h. The progress of the reaction was monitoredby TLC. After completion of the reaction, the mixture was extracted withdichloromethane (10mL 3). The organic layers were washed with brine until neutrality,then dried over anhydrous Na2SO4 and concentrated in vacuo. The crude productwas purified by a silica-gel column chromatography with petroleum ether and EtOAc(3:1) to give CoQ0, 0.26 g, 96%, red needles, m.p 56-57 C (lit5 57-59 C). IR: (cm1)3590, 3415, 1661, 1603, 1291, 1226, 999. 1H NMR (400 MHz, CDCl3) d 6.44 (q,J1.7 Hz, 1H), 4.02 (s, 3H, OCH3), 4.00 (s, 3H, OCH3), 2.04 (d, J1.6 Hz, 3H,CH3). 13C NMR (101 MHz, CDCl3) d 184.4 (C5O), 184.2(C5O), 145.0, 144.8, 144.0,131.2, 61.2 (OCH3), 61.1 (OCH3), 15.4 (CH3). GC-MS (EI): m/z 182. The spectroscopicdata are in accord with the literature

The chemical industry reduces the impact on the environment during synthesis 1,2,3,4-Tetramethoxy-5-methylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Qiu, Yong-Fu; Yan, Yi-Yu; Lu, Bin; Tang, Lei; Zhai, Yu-Lin; Chen, Ke-Xin; Wang, Jin; Organic Preparations and Procedures International; vol. 51; 6; (2019); p. 602 – 605;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 35896-58-3

2,3,4,5-Tetramethoxytoluene 3 (2.1 g, 10 mmol) and NaBr (1.1 g, 10 mmol) were dissolved in AcOH (5 mL), a solution of 30% H2O2 (1.2 mL, 10 mmol) was added dropwise over 5 min at room temperature. The mixture was stirred and heated at 40 C for 1 h and quenched with H2O( 5 mL) and extracted with diethyl ether (3 ¡Á 30 mL). The combined organic phases were washed with saturated NaHCO3(3 ¡Á 10 mL) until pH 7, then dried over anhydrous Na2SO4,and evaporated under reduced pressure to give yellow oil 4 (2.9 g) in quantatitive yield. 1H NMR (400 MHz, CDCl3) delta 3.92 (s, 3H, OCH3), 3.91(s, 3H, OCH3), 3.85 (s, 3H, OCH3), 3.79 (s, 3H, OCH3),2.30 (s, 3H, CH3). 13C NMR (101 MHz, CDCl3)delta 148.3, 147.2, 146.3,145.5, 127.3, 114.3, 61.4 (OCH3), 61.1 (OCH3), 60.9(OCH3), 60.8 (OCH3), 15.9 (CH3). GC-MS (EI): m/z = 290.

Statistics shows that 35896-58-3 is playing an increasingly important role. we look forward to future research findings about 1,2,3,4-Tetramethoxy-5-methylbenzene.

Reference:
Article; Qiu, Yong-Fu; Lu, Bin; Yan, Yi-Yu; Luo, Wan-Yue; Wang, Jin; Hu, Xiao; Chemical Papers; vol. 73; 11; (2019); p. 2745 – 2748;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem